Galectins Control mTOR in Response to Endomembrane Damage (original) (raw)

“…M. tuberculosis strains deficient in ESX-1 or PDIM synthesis show reduced galectin-3 or galectin-8 recruitment to intracellular sites of infection[23,24,33,34]. If the endosomal membrane is damaged, cytosolic galectins bind to lumenal β-galactoside-containing glycans that become exposed on damaged vesicles, and can be visualized by immunofluorescence microscopy[23,24,33–36]. Differing from the role of ESX-1 in phagosomal permeabilization during M. tuberculosis and M. marinum infection, the involvement of M. marinum PDIM in this process has not been demonstrated.…”