Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries (original) (raw)

“…And due to the changes toward a more Westernized lifestyle and dietary habits of Chinese population, its incidence has seen steady increase in recent years. During the past decade, the 5‐year relative survival rate of Chinese CRC patients has increased from 47.2% to 56.9%, which, however, was still more than 8% lower than that of the developed countries . Based on epidemiologic studies in developed countries, long‐standing CRC screening and early detection programs had a significant role in reducing morbidity and mortality …”

Section: Introductionmentioning

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“…And due to the changes toward a more Westernized lifestyle and dietary habits of Chinese population, its incidence has seen steady increase in recent years. During the past decade, the 5‐year relative survival rate of Chinese CRC patients has increased from 47.2% to 56.9%, which, however, was still more than 8% lower than that of the developed countries . Based on epidemiologic studies in developed countries, long‐standing CRC screening and early detection programs had a significant role in reducing morbidity and mortality …”

Section: Introductionmentioning

“…Therefore, methylated SEPT9 became the only blood‐based biomarker approved by FDA for CRC screening, and it has been used clinically for several years . However, the sensitivity of SEPT9 methylation for CRC detection was relatively low, especially for early stage cancers and advanced adenomas (AA) . The syndecan‐2 protein encoded by SDC2 gene functions as an integral membrane protein and is known to participate in cell proliferation, cell migration, and cell‐matrix interactions via its receptor for extracellular matrix proteins .…”

Section: Introductionmentioning

“…However, most patients receive late diagnoses and unsatisfactory treatments, which is attributed to non‐specific early symptoms. Despite more chemotherapy as well as target therapy strategies being carried out clinically, the overall 5‐year survival rate has not seen an obvious rise . Finding effective molecular targets of treatment has always been the priority issue for malignant diseases.…”

Section: Introductionmentioning

“…An individual is considered to be a cancer survivor (CS) from the time of cancer diagnosis, throughout the balance of his or her life . Better primary health care, improved early detection, and better treatment enable individuals to live longer after cancer diagnosis, and cancer may be managed as a chronic illness . Despite these advances, a cancer diagnosis continues to generate higher levels of distress than many nonneoplastic diseases .…”

Section: Introductionmentioning