Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer (original) (raw)

“…Uncovering new therapeutic modalities in TNBCs would thus potentially contribute significantly to reducing breast cancer-associated mortalities. Consistent with previous reports showing anti-cancer activity in breast cancer cells, nimbolide impaired cell proliferation or serum-free cell survival in 231MFP and HCC38 TNBC cells ( Figure 1B, Figure S1) 14,15,17 . We also show that these effects on 231MFP and HCC38 viability are due to a significant increase in apoptotic cells with nimbolide treatment, assessed by flow cytometry analysis ( Figure 1C, Figure S1).…”

Section: Effects Of Nimbolide On Breast Cancer Cell Survival Prolifesupporting

“…Nimbolide has been shown to exert multiple therapeutic effects and possesses a cyclic enone capable of reacting with cysteines [10][11][12] . In the context of cancer, nimbolide has been shown to inhibit tumorigenesis and metastasis without causing any toxicity or unwanted side effects across a wide range of cancers 10,11,[13][14][15][16][17] . While previous studies suggest that nimbolide impairs cancer pathogenicity through modulating signaling pathways and transcription factors linked to survival, growth, invasion, angiogenesis, inflammation, and oxidative stress the direct targets of nimbolide still remain poorly characterized 10,15,[18][19][20][21][22] .…”

Section: Introductionmentioning