Etifoxine impairs neither alertness nor cognitive functions of the elderly: A randomized, double-blind, placebo-controlled crossover study (original) (raw)

“…As mentioned before, etifoxine has a dual mechanism of action: (1) binding to β2 or β3 subunits of the GABA-A receptor (the anxiolytic effects of etifoxine are mainly related to this activity), and (2) interaction with TSPO, which induce increased neurosteroid synthesis in the brain [20]. The anti-amnesic effects of etifoxine may be related to both mechanisms: the increased direct and indirect GABAergic neurotransmission and the increased synthesis of neurosteroids.…”

Section: Discussionmentioning

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“…As mentioned before, etifoxine has a dual mechanism of action: (1) binding to β2 or β3 subunits of the GABA-A receptor (the anxiolytic effects of etifoxine are mainly related to this activity), and (2) interaction with TSPO, which induce increased neurosteroid synthesis in the brain [20]. The anti-amnesic effects of etifoxine may be related to both mechanisms: the increased direct and indirect GABAergic neurotransmission and the increased synthesis of neurosteroids.…”

Section: Discussionmentioning

“…Some clinical trials are also available. Deplanque et al (2018) compared the effects of lorazepam and etifoxine in healthy elderly and found no deterioration in cognitive function and alertness in comparison to the placebo group. However, lorazepam induced such deterioration in comparison to the controls [20].…”

Section: Discussionmentioning

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“…In a recent publication,63 30 healthy older (65–75 years) volunteers were tested for alertness and cognitive functions in a study comparing etifoxine (2⨰50 mg), lorazepam (2⨰1 mg), and placebo (Table 2). The randomized placebo-controlled, double-blind, crossover design included three1-day sessions separated by a washout period of 14–30 days.…”

Section: Anxiolytic Activity Of Etifoxine: Clinical Trials and Practicementioning