Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence (original) (raw)

“…In mid-December 2020, the United Kingdom reported a SARS-CoV-2 variant termed B.1.1.7 (20I/501Y.V1) that exhibited a rapid increase in its range and incidence following its initial detection in November (Andrew Rambaut,Nick Loman,Oliver Pybus,Wendy Barclay,Jeff Barrett,Alesandro Carabelli,Tom Connor,Tom Peacock,David L Robertson,Erik Volz, Genomics Consortium UK (CoG-UK), 2020; Volz, Mishra, et al, 2021). Since then, additional "variants of concern" have emerged, namely lineages B.1.351 (20H/501Y.V2) from S Africa (Tegally et al, 2020) and P.1 (20J/501Y.V3) and P.2 from Brazil (Voloch et al, 2020;Faria et al, 2021;Naveca, da Costa, et al, 2021;Sabino et al, 2021). A key concern is that certain polymorphisms may enhance SARS-CoV-2 infectivity or transmission, akin to what was seen for Spike D614G (Korber et al, 2020;Volz, Hill, et al, 2021), which has overtaken the original D614 form of the virus that dominated at the outset of the pandemic.…”