Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition (original) (raw)

“…), immunological, and physical barrier [ 20 , 51 , 52 , 53 , 54 ]. Recently, several subsets of the main epithelial cells based on different transcriptional signatures were described by single cell analyses (3 for ciliated and 5 for basal and secretory cells) [ 55 ]. The first subset of ciliated cells showed markers of cilia pre-assembly such as SPAG1 , LRRC6 , and DNAAF1 , while the second expressed markers of mature ciliated cells ( TUBA1A and TUBB4B ).…”