Timothy Fitzgerald | Southern Cross University (original) (raw)
Papers by Timothy Fitzgerald
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Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive ge... more Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive gene on chromosome 8. Sequencing of chromosome 8 of rice in the region of the fgr locus has identified an allele of a betaine aldehyde dehydrogenase (BAD) gene common to all fragrant genotypes. The gene encoding BAD was found in the region of the BAC
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Proceedings of the National Academy of Sciences of the United States of America, Jan 27, 2011
Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest ad... more Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest adaptive selection at this locus. The extent to which environmental selection may act at additional nuclear-encoded defense loci and within the whole chloroplast genome has now been examined by analyses in two grass species. Analysis of genetic diversity in wild barley (Hordeum spontaneum) defense genes revealed much greater variation in biotic stress-related genes than abiotic stress-related genes. Genetic diversity at the Isa defense locus in wild populations of weeping ricegrass [Microlaena stipoides (Labill.) R. Br.], a very distant wild-rice relative, was more diverse in samples from relatively hotter and drier environments, a phenomenon that reflects observations in wild barley populations. Whole-chloroplast genome sequences of bulked weeping ricegrass individuals sourced from contrasting environments showed higher levels of diversity in the drier environment in both coding and nonco...
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Oncotarget, Jan 15, 2014
The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, pr... more The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer ty...
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Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by mass analysis, allow high throughput screening of large numbers of genes. These tools have accelerated the rate of
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Bookmarks Related papers MentionsView impact
... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis ... more ... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross University Toni Pacey-Miller, Southern Cross University Allison C. Crawford, Southern Cross ...
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Plant Science, 2008
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Functional & Integrative Genomics, 2014
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Advances in Biological Regulation, 2015
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Plant Biotechnology Journal, 2014
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The American Journal of Surgery, 2008
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Proceedings of the National Academy of Sciences, 2011
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Plant Signaling & Behavior, 2012
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Plant Biotechnology Journal, 2005
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Plant Biology, 2009
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Environmental and Experimental Botany, 2010
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Environmental and Experimental Botany, May 31, 2010
Fragrance in rice has been shown to result from deletions that cause the loss of function of beta... more Fragrance in rice has been shown to result from deletions that cause the loss of function of betaine aldehyde dehydrogenase 2 (BADH2). In many plant species, BADHs play a role in abiotic stress tolerance; in some plants the mechanism by which this occurs is the accumulation of glycinebetaine (GB) from betaine aldehyde. However, rice does not accumulate GB. Rice BADH2 has only moderate activity on betaine aldehyde, with much higher activity on gamma aminobutyraldehyde (GABald). It has been proposed that the ...
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Centre for Plant …
Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Pr... more Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Previous; Next >; Home > Plant Science papers > 302. Southern Cross Plant Science. Title. The gene for fragrance in rice (Presentation). Authors. Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross UniversityFollow Robert J. Henry, Southern Cross UniversityFollow Qingsheng Jin, Zhejiang Academy of Agricultural Sciences Daniel LE Waters, Southern Cross UniversityFollow. Custom Citation (Optional). ...
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L Slade …
Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by ...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive ge... more Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive gene on chromosome 8. Sequencing of chromosome 8 of rice in the region of the fgr locus has identified an allele of a betaine aldehyde dehydrogenase (BAD) gene common to all fragrant genotypes. The gene encoding BAD was found in the region of the BAC
Bookmarks Related papers MentionsView impact
Proceedings of the National Academy of Sciences of the United States of America, Jan 27, 2011
Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest ad... more Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest adaptive selection at this locus. The extent to which environmental selection may act at additional nuclear-encoded defense loci and within the whole chloroplast genome has now been examined by analyses in two grass species. Analysis of genetic diversity in wild barley (Hordeum spontaneum) defense genes revealed much greater variation in biotic stress-related genes than abiotic stress-related genes. Genetic diversity at the Isa defense locus in wild populations of weeping ricegrass [Microlaena stipoides (Labill.) R. Br.], a very distant wild-rice relative, was more diverse in samples from relatively hotter and drier environments, a phenomenon that reflects observations in wild barley populations. Whole-chloroplast genome sequences of bulked weeping ricegrass individuals sourced from contrasting environments showed higher levels of diversity in the drier environment in both coding and nonco...
Bookmarks Related papers MentionsView impact
Oncotarget, Jan 15, 2014
The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, pr... more The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer ty...
Bookmarks Related papers MentionsView impact
Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by mass analysis, allow high throughput screening of large numbers of genes. These tools have accelerated the rate of
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis ... more ... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross University Toni Pacey-Miller, Southern Cross University Allison C. Crawford, Southern Cross ...
Bookmarks Related papers MentionsView impact
Plant Science, 2008
Bookmarks Related papers MentionsView impact
Functional & Integrative Genomics, 2014
Bookmarks Related papers MentionsView impact
Advances in Biological Regulation, 2015
Bookmarks Related papers MentionsView impact
Plant Biotechnology Journal, 2014
Bookmarks Related papers MentionsView impact
The American Journal of Surgery, 2008
Bookmarks Related papers MentionsView impact
Proceedings of the National Academy of Sciences, 2011
Bookmarks Related papers MentionsView impact
Plant Signaling & Behavior, 2012
Bookmarks Related papers MentionsView impact
Plant Biotechnology Journal, 2005
Bookmarks Related papers MentionsView impact
Plant Biology, 2009
Bookmarks Related papers MentionsView impact
Environmental and Experimental Botany, 2010
Bookmarks Related papers MentionsView impact
Environmental and Experimental Botany, May 31, 2010
Fragrance in rice has been shown to result from deletions that cause the loss of function of beta... more Fragrance in rice has been shown to result from deletions that cause the loss of function of betaine aldehyde dehydrogenase 2 (BADH2). In many plant species, BADHs play a role in abiotic stress tolerance; in some plants the mechanism by which this occurs is the accumulation of glycinebetaine (GB) from betaine aldehyde. However, rice does not accumulate GB. Rice BADH2 has only moderate activity on betaine aldehyde, with much higher activity on gamma aminobutyraldehyde (GABald). It has been proposed that the ...
Bookmarks Related papers MentionsView impact
Centre for Plant …
Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Pr... more Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Previous; Next >; Home > Plant Science papers > 302. Southern Cross Plant Science. Title. The gene for fragrance in rice (Presentation). Authors. Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross UniversityFollow Robert J. Henry, Southern Cross UniversityFollow Qingsheng Jin, Zhejiang Academy of Agricultural Sciences Daniel LE Waters, Southern Cross UniversityFollow. Custom Citation (Optional). ...
Bookmarks Related papers MentionsView impact
L Slade …
Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by ...
Bookmarks Related papers MentionsView impact