Timothy Fitzgerald | Southern Cross University (original) (raw)

Papers by Timothy Fitzgerald

Research paper thumbnail of Brachypodium as an emerging model for cereal–pathogen interactions

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance of rice is associated with an altered form of BAD2 on chromosome 8

Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive ge... more Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive gene on chromosome 8. Sequencing of chromosome 8 of rice in the region of the fgr locus has identified an allele of a betaine aldehyde dehydrogenase (BAD) gene common to all fragrant genotypes. The gene encoding BAD was found in the region of the BAC

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genome diversity in wild grasses under environmental stress

Proceedings of the National Academy of Sciences of the United States of America, Jan 27, 2011

Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest ad... more Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest adaptive selection at this locus. The extent to which environmental selection may act at additional nuclear-encoded defense loci and within the whole chloroplast genome has now been examined by analyses in two grass species. Analysis of genetic diversity in wild barley (Hordeum spontaneum) defense genes revealed much greater variation in biotic stress-related genes than abiotic stress-related genes. Genetic diversity at the Isa defense locus in wild populations of weeping ricegrass [Microlaena stipoides (Labill.) R. Br.], a very distant wild-rice relative, was more diverse in samples from relatively hotter and drier environments, a phenomenon that reflects observations in wild barley populations. Whole-chloroplast genome sequences of bulked weeping ricegrass individuals sourced from contrasting environments showed higher levels of diversity in the drier environment in both coding and nonco...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

Oncotarget, Jan 15, 2014

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, pr... more The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer ty...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mining genomes for improved product quality and human nutrition

Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by mass analysis, allow high throughput screening of large numbers of genes. These tools have accelerated the rate of

Bookmarks Related papers MentionsView impact

Research paper thumbnail of LE 2005a. The Gene for Fragrance in Rice

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cereal quality improvement using genomic tools

... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis ... more ... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross University Toni Pacey-Miller, Southern Cross University Allison C. Crawford, Southern Cross ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The effect of salt on betaine aldehyde dehydrogenase transcript levels and 2-acetyl-1-pyrroline concentration in fragrant and non-fragrant rice (Oryza sativa)

Plant Science, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Gene loss in the fungal canola pathogen Leptosphaeria maculans

Functional & Integrative Genomics, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

Advances in Biological Regulation, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Identification and characterization of more than 4 million intervarietal SNPs across the group 7 chromosomes of bread wheat

Plant Biotechnology Journal, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mammographic distance as a predictor of nipple-areola complex involvement in breast cancer

The American Journal of Surgery, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genome diversity in wild grasses under environmental stress

Proceedings of the National Academy of Sciences, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Analysis of adaptive ribosomal gene diversity in wild plant populations from contrasting climatic environments

Plant Signaling & Behavior, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The gene for fragrance in rice

Plant Biotechnology Journal, 2005

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Betaine aldehyde dehydrogenase in plants

Plant Biology, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance in rice (Oryza sativa) is associated with reduced yield under salt treatment

Environmental and Experimental Botany, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance in rice (< i> Oryza sativa</i>) is associated with reduced yield under salt treatment

Environmental and Experimental Botany, May 31, 2010

Fragrance in rice has been shown to result from deletions that cause the loss of function of beta... more Fragrance in rice has been shown to result from deletions that cause the loss of function of betaine aldehyde dehydrogenase 2 (BADH2). In many plant species, BADHs play a role in abiotic stress tolerance; in some plants the mechanism by which this occurs is the accumulation of glycinebetaine (GB) from betaine aldehyde. However, rice does not accumulate GB. Rice BADH2 has only moderate activity on betaine aldehyde, with much higher activity on gamma aminobutyraldehyde (GABald). It has been proposed that the ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The gene for fragrance in rice (Presentation)

Centre for Plant …

Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Pr... more Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Previous; Next >; Home > Plant Science papers > 302. Southern Cross Plant Science. Title. The gene for fragrance in rice (Presentation). Authors. Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross UniversityFollow Robert J. Henry, Southern Cross UniversityFollow Qingsheng Jin, Zhejiang Academy of Agricultural Sciences Daniel LE Waters, Southern Cross UniversityFollow. Custom Citation (Optional). ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mining genomes for improved product quality and human nutrition

L Slade …

Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Brachypodium as an emerging model for cereal–pathogen interactions

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance of rice is associated with an altered form of BAD2 on chromosome 8

Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive ge... more Fragrance is a desirable trait of Basmati and other rice varieties associated with a recessive gene on chromosome 8. Sequencing of chromosome 8 of rice in the region of the fgr locus has identified an allele of a betaine aldehyde dehydrogenase (BAD) gene common to all fragrant genotypes. The gene encoding BAD was found in the region of the BAC

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genome diversity in wild grasses under environmental stress

Proceedings of the National Academy of Sciences of the United States of America, Jan 27, 2011

Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest ad... more Patterns of diversity distribution in the Isa defense locus in wild-barley populations suggest adaptive selection at this locus. The extent to which environmental selection may act at additional nuclear-encoded defense loci and within the whole chloroplast genome has now been examined by analyses in two grass species. Analysis of genetic diversity in wild barley (Hordeum spontaneum) defense genes revealed much greater variation in biotic stress-related genes than abiotic stress-related genes. Genetic diversity at the Isa defense locus in wild populations of weeping ricegrass [Microlaena stipoides (Labill.) R. Br.], a very distant wild-rice relative, was more diverse in samples from relatively hotter and drier environments, a phenomenon that reflects observations in wild barley populations. Whole-chloroplast genome sequences of bulked weeping ricegrass individuals sourced from contrasting environments showed higher levels of diversity in the drier environment in both coding and nonco...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

Oncotarget, Jan 15, 2014

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, pr... more The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer ty...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mining genomes for improved product quality and human nutrition

Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by mass analysis, allow high throughput screening of large numbers of genes. These tools have accelerated the rate of

Bookmarks Related papers MentionsView impact

Research paper thumbnail of LE 2005a. The Gene for Fragrance in Rice

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cereal quality improvement using genomic tools

... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis ... more ... Robert J. Henry, Southern Cross University Daniel LE Waters, Southern Cross University Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross University Toni Pacey-Miller, Southern Cross University Allison C. Crawford, Southern Cross ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The effect of salt on betaine aldehyde dehydrogenase transcript levels and 2-acetyl-1-pyrroline concentration in fragrant and non-fragrant rice (Oryza sativa)

Plant Science, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Gene loss in the fungal canola pathogen Leptosphaeria maculans

Functional & Integrative Genomics, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

Advances in Biological Regulation, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Identification and characterization of more than 4 million intervarietal SNPs across the group 7 chromosomes of bread wheat

Plant Biotechnology Journal, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mammographic distance as a predictor of nipple-areola complex involvement in breast cancer

The American Journal of Surgery, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genome diversity in wild grasses under environmental stress

Proceedings of the National Academy of Sciences, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Analysis of adaptive ribosomal gene diversity in wild plant populations from contrasting climatic environments

Plant Signaling & Behavior, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The gene for fragrance in rice

Plant Biotechnology Journal, 2005

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Betaine aldehyde dehydrogenase in plants

Plant Biology, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance in rice (Oryza sativa) is associated with reduced yield under salt treatment

Environmental and Experimental Botany, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fragrance in rice (< i> Oryza sativa</i>) is associated with reduced yield under salt treatment

Environmental and Experimental Botany, May 31, 2010

Fragrance in rice has been shown to result from deletions that cause the loss of function of beta... more Fragrance in rice has been shown to result from deletions that cause the loss of function of betaine aldehyde dehydrogenase 2 (BADH2). In many plant species, BADHs play a role in abiotic stress tolerance; in some plants the mechanism by which this occurs is the accumulation of glycinebetaine (GB) from betaine aldehyde. However, rice does not accumulate GB. Rice BADH2 has only moderate activity on betaine aldehyde, with much higher activity on gamma aminobutyraldehyde (GABald). It has been proposed that the ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The gene for fragrance in rice (Presentation)

Centre for Plant …

Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Pr... more Skip to main content: My Account; FAQ; About; Home. ePublications@SCU. ePublications@SCU. < Previous; Next >; Home > Plant Science papers > 302. Southern Cross Plant Science. Title. The gene for fragrance in rice (Presentation). Authors. Louis MT Bradbury, Southern Cross University Timothy L. Fitzgerald, Southern Cross UniversityFollow Robert J. Henry, Southern Cross UniversityFollow Qingsheng Jin, Zhejiang Academy of Agricultural Sciences Daniel LE Waters, Southern Cross UniversityFollow. Custom Citation (Optional). ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mining genomes for improved product quality and human nutrition

L Slade …

Analysis of polymorphisms at the SNP level has been facilitated by the development and applicatio... more Analysis of polymorphisms at the SNP level has been facilitated by the development and application of a range of new tools. New approaches to polymorphism detection such as robust allele specific PCR, RT-PCR with novel chemistries, pyrosequencing and primer extension assay by ...

Bookmarks Related papers MentionsView impact