Bineet Sinha | Sobhasaria Group of Institutions (original) (raw)
Papers by Bineet Sinha
ZENITH International Journal of Multidisciplinary Research, 2018
Organic preparations and procedures international, Oct 27, 2016
Raju et al. as solvent affords 1 with a purity of (78-82%) with 95% yield as an oily product. In ... more Raju et al. as solvent affords 1 with a purity of (78-82%) with 95% yield as an oily product. In this reaction, the formation of major impurities such as tetra-carbomethoxyethylene (16), dimethyl 2-chloro-2-(2-methoxyphenoxy)malonate (17), and methyl-2-(2-methoxy phenoxy)acetate (18) were observed in 2-5% a/a by HPLC (Figure 2). Using this as such for the synthesis of 3 gave less purity of 96.61% and yield of 87%. Further, this compound was converted to 6 with less yield (85.70%) and 1.20% of 19 as shown in Figure 3. Scheme 2 Harringtons's Route for the Preparation of Bosentan Monohydrate (7) Scheme 3 Navnaths's Route for the Preparation of Bosentan Monohydrate (7) Large-Scale Synthesis of Bosentan Monohydrate
Indian pacing and electrophysiology journal, 2009
Endomyocardial fibrosis is a progressive disease of unknown origin affecting children and young a... more Endomyocardial fibrosis is a progressive disease of unknown origin affecting children and young adults. It involves inflow portion of right and/or left ventricle and apex. It may be associated with thrombus. Literature regarding right ventricular endomyocardial fibrosis with thrombus is scarce. Here we report a rare case of right ventricular endomyocardial fibrosis presenting as ventricular tachycardia and echocardiographic evidence of apical thrombus. Interestingly there was no pulmonary involvement or evidence of deep venous thrombosis. This case also underscores the importance of urgent echocardiography in diagnosis of obscure cases of ventricular tachycardia.
Indian retail industry is one of the pillars of Indian economy and accounts for 14 to 15 percent ... more Indian retail industry is one of the pillars of Indian economy and accounts for 14 to 15 percent of GDP and 15 percent of employment. Indian retail is growing at fastest speed as compared to other countries with more than 2.25 billion people. Indian retail luxury market is the 12 largest in the world. So many Indian and foreign companies are showing interest in Indian Retail. Over 6000 shopping malls operating and over 800 malls are under construction in India. This is benefiting Indian retailers , foreign retailers and consumers as well. But still Indian retail industry is not developed to avail the available opportunities. There are so many challenges faced by the retail outlets. Major portion of Indian retail industry is driven by big giants like Bharti, Reliance, Future Group, Tata, Birla etc. The study will include understanding the major and minor challenges faced by the retailers like competition, less skilled human resource, government policies , tax, kiryana stores etc. A r...
Indian retail industry is one of the important pillars of Indian economy and responsible for 14 t... more Indian retail industry is one of the important pillars of Indian economy and responsible for 14 to 15 percent of GDP and 15 percent of total employment. Indian retail is growing at fastest speed as compared to other developed and developing countries with more than 2.25 billion people. Indian retail luxury market is the 12th largest in the world. So many Indian and foreign players are showing interest in Indian Retail. Over 6000 shopping malls are operational and over 800 malls are under construction in India. New retail outlets are opening in big number. But still Indian retail industry is not yet developed to avail the available opportunities. Major portion of Indian retail industry is driven by big giants like Bharti, Reliance, Future Group, Tata, Birla etc. This study will focus on the impact of retail service quality of hypermarkets on future consumption behaviour. A structured questionnaire with 32 questions was used to collect the primary data from 700 respondents shopping at...
As the globe is experiencing a rise in new technology of transportation so are customers’ expecta... more As the globe is experiencing a rise in new technology of transportation so are customers’ expectations from the new transportation modes. Indian auto industry is not different. Government of India have already asked automobile industry to abide by stringent pollution norms and work on offering future products which are environment friendly, mainly hybrid and electric vehicles. Auto manufacturers are experiencing towering demand from customers, competitors and government. Indian auto industry contributes 15 percent of GDP in 2016 is expected to inflate to 22 percent of GDP by 2022. The Indian auto industry which was of US$7 billion in 2016 is expected to reach US$17 billion by 2022 at 10-15 percent annually (IBEF). Meanwhile, Indian environment friendly technology is vey new when compared to other international market such as US, Europe & China. In 2016, Indian account very minimum global share of HEVs. China at the same time holds nearly 50 percent of global share in electric and en...
Journal of Clinical Lipidology
Only a few studies have reported on postprandial lipid responses and endothelial function in pred... more Only a few studies have reported on postprandial lipid responses and endothelial function in prediabetic subjects. None of the study has compared role of familial predisposition in determining postprandial endothelial dysfunction and postprandial hypertriglyceridemia in subjects with prediabetes. The objective was to study the postprandial triglyceride (PPTG) responses and endothelial function in prediabetic first-degree relatives of patients with diabetes. Thirty-nine subjects were recruited on the basis of oral glucose tolerance test into 3 groups: group 1, prediabetic subjects who had a first-degree relative with diabetes; group 2, prediabetic subjects without family history of diabetes; and group 3, normal glucose tolerance subjects without family history of diabetes. Oral fat challenge test was performed in all study subjects and PPTG responses were measured up to 8 hours. Postprandial endothelial function after 4 hours of fat challenge was estimated by flow-mediated dilation. Postprandial endothelial dysfunction was greatest in group 1 and significantly higher in group 1 compared with group 2 (P < .001) and group 2 compared with group 3 (P < .001). PPTG responses (TG-AUC, TG-peak, TG-6 hour, and TG-8 hour) were significantly higher in group 1 compared with groups 2 and 3. However, they were similar between groups 2 and 3. Endothelial function showed significant negative correlation with TG-6 hour and TG-8 hour. Prediabetic subjects respond to fat challenge with a greater degree of TG response and endothelial dysfunction compared with normal glucose tolerance subjects especially if they have a first-degree relative with diabetes. This may contribute to enhanced cardiovascular risk reported in prediabetic individuals.
ZENITH International Journal of Multidisciplinary Research, 2018
Organic preparations and procedures international, Oct 27, 2016
Raju et al. as solvent affords 1 with a purity of (78-82%) with 95% yield as an oily product. In ... more Raju et al. as solvent affords 1 with a purity of (78-82%) with 95% yield as an oily product. In this reaction, the formation of major impurities such as tetra-carbomethoxyethylene (16), dimethyl 2-chloro-2-(2-methoxyphenoxy)malonate (17), and methyl-2-(2-methoxy phenoxy)acetate (18) were observed in 2-5% a/a by HPLC (Figure 2). Using this as such for the synthesis of 3 gave less purity of 96.61% and yield of 87%. Further, this compound was converted to 6 with less yield (85.70%) and 1.20% of 19 as shown in Figure 3. Scheme 2 Harringtons's Route for the Preparation of Bosentan Monohydrate (7) Scheme 3 Navnaths's Route for the Preparation of Bosentan Monohydrate (7) Large-Scale Synthesis of Bosentan Monohydrate
Indian pacing and electrophysiology journal, 2009
Endomyocardial fibrosis is a progressive disease of unknown origin affecting children and young a... more Endomyocardial fibrosis is a progressive disease of unknown origin affecting children and young adults. It involves inflow portion of right and/or left ventricle and apex. It may be associated with thrombus. Literature regarding right ventricular endomyocardial fibrosis with thrombus is scarce. Here we report a rare case of right ventricular endomyocardial fibrosis presenting as ventricular tachycardia and echocardiographic evidence of apical thrombus. Interestingly there was no pulmonary involvement or evidence of deep venous thrombosis. This case also underscores the importance of urgent echocardiography in diagnosis of obscure cases of ventricular tachycardia.
Indian retail industry is one of the pillars of Indian economy and accounts for 14 to 15 percent ... more Indian retail industry is one of the pillars of Indian economy and accounts for 14 to 15 percent of GDP and 15 percent of employment. Indian retail is growing at fastest speed as compared to other countries with more than 2.25 billion people. Indian retail luxury market is the 12 largest in the world. So many Indian and foreign companies are showing interest in Indian Retail. Over 6000 shopping malls operating and over 800 malls are under construction in India. This is benefiting Indian retailers , foreign retailers and consumers as well. But still Indian retail industry is not developed to avail the available opportunities. There are so many challenges faced by the retail outlets. Major portion of Indian retail industry is driven by big giants like Bharti, Reliance, Future Group, Tata, Birla etc. The study will include understanding the major and minor challenges faced by the retailers like competition, less skilled human resource, government policies , tax, kiryana stores etc. A r...
Indian retail industry is one of the important pillars of Indian economy and responsible for 14 t... more Indian retail industry is one of the important pillars of Indian economy and responsible for 14 to 15 percent of GDP and 15 percent of total employment. Indian retail is growing at fastest speed as compared to other developed and developing countries with more than 2.25 billion people. Indian retail luxury market is the 12th largest in the world. So many Indian and foreign players are showing interest in Indian Retail. Over 6000 shopping malls are operational and over 800 malls are under construction in India. New retail outlets are opening in big number. But still Indian retail industry is not yet developed to avail the available opportunities. Major portion of Indian retail industry is driven by big giants like Bharti, Reliance, Future Group, Tata, Birla etc. This study will focus on the impact of retail service quality of hypermarkets on future consumption behaviour. A structured questionnaire with 32 questions was used to collect the primary data from 700 respondents shopping at...
As the globe is experiencing a rise in new technology of transportation so are customers’ expecta... more As the globe is experiencing a rise in new technology of transportation so are customers’ expectations from the new transportation modes. Indian auto industry is not different. Government of India have already asked automobile industry to abide by stringent pollution norms and work on offering future products which are environment friendly, mainly hybrid and electric vehicles. Auto manufacturers are experiencing towering demand from customers, competitors and government. Indian auto industry contributes 15 percent of GDP in 2016 is expected to inflate to 22 percent of GDP by 2022. The Indian auto industry which was of US$7 billion in 2016 is expected to reach US$17 billion by 2022 at 10-15 percent annually (IBEF). Meanwhile, Indian environment friendly technology is vey new when compared to other international market such as US, Europe & China. In 2016, Indian account very minimum global share of HEVs. China at the same time holds nearly 50 percent of global share in electric and en...
Journal of Clinical Lipidology
Only a few studies have reported on postprandial lipid responses and endothelial function in pred... more Only a few studies have reported on postprandial lipid responses and endothelial function in prediabetic subjects. None of the study has compared role of familial predisposition in determining postprandial endothelial dysfunction and postprandial hypertriglyceridemia in subjects with prediabetes. The objective was to study the postprandial triglyceride (PPTG) responses and endothelial function in prediabetic first-degree relatives of patients with diabetes. Thirty-nine subjects were recruited on the basis of oral glucose tolerance test into 3 groups: group 1, prediabetic subjects who had a first-degree relative with diabetes; group 2, prediabetic subjects without family history of diabetes; and group 3, normal glucose tolerance subjects without family history of diabetes. Oral fat challenge test was performed in all study subjects and PPTG responses were measured up to 8 hours. Postprandial endothelial function after 4 hours of fat challenge was estimated by flow-mediated dilation. Postprandial endothelial dysfunction was greatest in group 1 and significantly higher in group 1 compared with group 2 (P < .001) and group 2 compared with group 3 (P < .001). PPTG responses (TG-AUC, TG-peak, TG-6 hour, and TG-8 hour) were significantly higher in group 1 compared with groups 2 and 3. However, they were similar between groups 2 and 3. Endothelial function showed significant negative correlation with TG-6 hour and TG-8 hour. Prediabetic subjects respond to fat challenge with a greater degree of TG response and endothelial dysfunction compared with normal glucose tolerance subjects especially if they have a first-degree relative with diabetes. This may contribute to enhanced cardiovascular risk reported in prediabetic individuals.