David Nochlin | Seton Hall University (original) (raw)

Papers by David Nochlin

Research paper thumbnail of Neuropathological changes in the visual cortex in Alzheimer's disease

Neuroscience Research Communications, 1990

A survey of 106 cases of Alzheimer's disease (AD) indicated that senile plaques (SP) and neur... more A survey of 106 cases of Alzheimer's disease (AD) indicated that senile plaques (SP) and neurofibrillary tangles (NFT) were recorded as frequent or abundant in the visual cortex in 72% and 27% of cases respectively. Comparable estimates for other brain regions were 89% for both lesions in temporal cortex and 94% and 95% respectively in the hippocampus. In 18 cases studied in detail, the density of SP and NFT was greater in B19/18 than in B17 in cases with early onset and short duration. The density of SP and NFT in B17, B18/19 and parietal cortex was negatively correlated with age at death of the patient but not with duration of the disease. In about 50% of tissue sections examined SP and NFT were clustered at a particular depth in the cortex. Clustering was more frequent in the upper layers of the cortex and in early onset cases. It was concluded that visual stimuli that evoke activity in different areas of visual cortex might be developed as a diagnostic test for early onset AD.

Research paper thumbnail of The Arctic APP mutation leads to Alzheimers disease pathology with highly variable topographic. Acta Neuropathol Commun. 2013 Sep 10;1(1) 60

Research paper thumbnail of 33 ???Glial Bundles??? In Spinal Nerve Roots in Amyotrophic Lateral Sclerosis (Als)

J Neuropathol Exp Neurol, 1981

Research paper thumbnail of Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

Research paper thumbnail of Corpora Amylacea in Aging and Alzheimer’s Brain: Immunolocalization of Chondroitin Sulfate and Heparan Sulfate Proteoglycans

Research paper thumbnail of Management of Malignant Meningiomas

Research paper thumbnail of Congo Red Staining on 1 Micron De-Plasticized Sections for Detection of Lesions in Alzheimer??S Disease and Related Disorders

Alz Dis Assoc Disorder, 1988

Neuritic plaques (NPs), neurofibrillary tangles (NFTs) and congophilic angiopathy (CA), the three... more Neuritic plaques (NPs), neurofibrillary tangles (NFTs) and congophilic angiopathy (CA), the three characteristic lesions in Alzheimer's disease, are easily detected in paraffin sections using light microscopy and specific staining methods including Congo red and Thioflavin S. Identification of these lesions in plastic thick sections (1 micron) is more tedious and relies essentially on morphological criteria. This causes investigators to subsequently analyze large numbers of thin sections under the electron microscope. Since many researchers use electron microscopy for various aspects of Alzheimer's disease and related research, it would be advantageous to have a rapid method enabling the investigator to quickly and reliably identify in thick sections the characteristic NPs, NFTs and/or CA, which can then be used for further analysis at the ultrastructural level. In this context, the present study describes a dependable technique for identifying NPs, NFTs and/or CA in Alzheimer's disease and related disorders and involves Congo red staining on one micron sections after plastic removal.

Research paper thumbnail of Seventeen Years of Prednisone Eliminates Granulomatous Angiitis of the Nervous System (Gans) but Congophilic (??A4) Angiopathy Remains

J Neuropathol Exp Neurol, 1999

Research paper thumbnail of Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie

Laboratory Investigation a Journal of Technical Methods and Pathology, Nov 1, 1990

Research paper thumbnail of Paired Helical Fibrils in Progressive Supranuclear Palsy (PSP)

J Neuropathol Exp Neurol, 1980

Research paper thumbnail of Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain

The American Journal of Pathology, Feb 1, 1994

Research paper thumbnail of Causes of Death Associated with Alzheimer Disease: Variation by Level of Cognitive Impairment Before Death

Journal of the American Geriatrics Society, 1994

ABSTRACT

Research paper thumbnail of Paired Helical Fibrils in Progressive Supranuclear Palsy (PSP)

Journal of Neuropathology and Experimental Neurology

Research paper thumbnail of Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease

The American journal of pathology, 1996

Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the developme... more Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the development of Alzheimer's disease (AD). We examined Alzheimer's brain tissue by immunohistochemistry using a set of antibodies raised to sequences shared between PS-1 and PS-2 proteins. These antibodies reacted exclusively with a subset of neurofibrillary tangles and not with neuropil threads or dystrophic neurites. Detection of the presenilin epitope in neurofibrillary tangles was observed in sporadic Alzheimer's disease brain samples and in samples from individuals carrying PS-1 and PS-2 mutations with no qualitative difference. These data indicate that both wild-type and mutant PS proteins are involved in a common pathogenic pathway in AD.

Research paper thumbnail of Management of Malignant Meningiomas

Meningiomas - Management and Surgery, 2012

Research paper thumbnail of Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases

Neurobiology of Aging, 2000

Research paper thumbnail of A Characteristic Binding Affinity Between Heparan Sulfate Proteoglycans and the A4 Amyloid Protein of Alzheimerʼs Disease

Journal of Neuropathology and Experimental Neurology, 1989

Research paper thumbnail of Ultrastructure of Hypothalamic and Medullary Lesions Caused by an Aliphatic Triamine

Journal of Neuropathology and Experimental Neurology, 1982

The administration of an aliphatic triamine, 3,3'-methylimino-bis-(N-methylpropylamine), ... more The administration of an aliphatic triamine, 3,3'-methylimino-bis-(N-methylpropylamine), was used to produce non-necrotizing lesions in the hypothalamus and medulla oblongata of rats. The distribution of the lesions in the hypothalamus was similar to that produced by goldthioglucose, and consisted ultrastructurally of marked distention and edema of the extracellular space, with no confined to the dorsal aspect, in the region of the area postrema. The data suggest that the absence of blood-brain barrier in these sites plays a role in the production of lesions, at least in the initial stages, as has been proposed for goldthioglucose lesions.

Research paper thumbnail of Rosai-Dorfman disease manifesting as intracranial and intraorbital lesion

Journal of Neuro-Oncology, 2009

Research paper thumbnail of Multiple vascular malformation in the ?blue rubber bleb naevus? syndrome: a case with aneurysm of vein of Galen and vascular lesions suggesting a link to the Weber?Osler?Rendu syndrome

Histopathology, 1978

A case of Bean's syndrome is reported in which a wide variety of vascular malformations a... more A case of Bean's syndrome is reported in which a wide variety of vascular malformations are illustrated. Among these were multiple arterio-venous malformations including a so-called vein of Galen aneurysm. A comparison of this case with those in the literature suggests that the pathology in patients with Bean's syndrome may be more varied than heretofore recognized, and that an overlap between this syndrome and the Osler-Weber-Rendu syndrome may exist.

Research paper thumbnail of Neuropathological changes in the visual cortex in Alzheimer's disease

Neuroscience Research Communications, 1990

A survey of 106 cases of Alzheimer's disease (AD) indicated that senile plaques (SP) and neur... more A survey of 106 cases of Alzheimer's disease (AD) indicated that senile plaques (SP) and neurofibrillary tangles (NFT) were recorded as frequent or abundant in the visual cortex in 72% and 27% of cases respectively. Comparable estimates for other brain regions were 89% for both lesions in temporal cortex and 94% and 95% respectively in the hippocampus. In 18 cases studied in detail, the density of SP and NFT was greater in B19/18 than in B17 in cases with early onset and short duration. The density of SP and NFT in B17, B18/19 and parietal cortex was negatively correlated with age at death of the patient but not with duration of the disease. In about 50% of tissue sections examined SP and NFT were clustered at a particular depth in the cortex. Clustering was more frequent in the upper layers of the cortex and in early onset cases. It was concluded that visual stimuli that evoke activity in different areas of visual cortex might be developed as a diagnostic test for early onset AD.

Research paper thumbnail of The Arctic APP mutation leads to Alzheimers disease pathology with highly variable topographic. Acta Neuropathol Commun. 2013 Sep 10;1(1) 60

Research paper thumbnail of 33 ???Glial Bundles??? In Spinal Nerve Roots in Amyotrophic Lateral Sclerosis (Als)

J Neuropathol Exp Neurol, 1981

Research paper thumbnail of Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

Research paper thumbnail of Corpora Amylacea in Aging and Alzheimer’s Brain: Immunolocalization of Chondroitin Sulfate and Heparan Sulfate Proteoglycans

Research paper thumbnail of Management of Malignant Meningiomas

Research paper thumbnail of Congo Red Staining on 1 Micron De-Plasticized Sections for Detection of Lesions in Alzheimer??S Disease and Related Disorders

Alz Dis Assoc Disorder, 1988

Neuritic plaques (NPs), neurofibrillary tangles (NFTs) and congophilic angiopathy (CA), the three... more Neuritic plaques (NPs), neurofibrillary tangles (NFTs) and congophilic angiopathy (CA), the three characteristic lesions in Alzheimer's disease, are easily detected in paraffin sections using light microscopy and specific staining methods including Congo red and Thioflavin S. Identification of these lesions in plastic thick sections (1 micron) is more tedious and relies essentially on morphological criteria. This causes investigators to subsequently analyze large numbers of thin sections under the electron microscope. Since many researchers use electron microscopy for various aspects of Alzheimer's disease and related research, it would be advantageous to have a rapid method enabling the investigator to quickly and reliably identify in thick sections the characteristic NPs, NFTs and/or CA, which can then be used for further analysis at the ultrastructural level. In this context, the present study describes a dependable technique for identifying NPs, NFTs and/or CA in Alzheimer's disease and related disorders and involves Congo red staining on one micron sections after plastic removal.

Research paper thumbnail of Seventeen Years of Prednisone Eliminates Granulomatous Angiitis of the Nervous System (Gans) but Congophilic (??A4) Angiopathy Remains

J Neuropathol Exp Neurol, 1999

Research paper thumbnail of Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie

Laboratory Investigation a Journal of Technical Methods and Pathology, Nov 1, 1990

Research paper thumbnail of Paired Helical Fibrils in Progressive Supranuclear Palsy (PSP)

J Neuropathol Exp Neurol, 1980

Research paper thumbnail of Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain

The American Journal of Pathology, Feb 1, 1994

Research paper thumbnail of Causes of Death Associated with Alzheimer Disease: Variation by Level of Cognitive Impairment Before Death

Journal of the American Geriatrics Society, 1994

ABSTRACT

Research paper thumbnail of Paired Helical Fibrils in Progressive Supranuclear Palsy (PSP)

Journal of Neuropathology and Experimental Neurology

Research paper thumbnail of Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease

The American journal of pathology, 1996

Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the developme... more Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the development of Alzheimer's disease (AD). We examined Alzheimer's brain tissue by immunohistochemistry using a set of antibodies raised to sequences shared between PS-1 and PS-2 proteins. These antibodies reacted exclusively with a subset of neurofibrillary tangles and not with neuropil threads or dystrophic neurites. Detection of the presenilin epitope in neurofibrillary tangles was observed in sporadic Alzheimer's disease brain samples and in samples from individuals carrying PS-1 and PS-2 mutations with no qualitative difference. These data indicate that both wild-type and mutant PS proteins are involved in a common pathogenic pathway in AD.

Research paper thumbnail of Management of Malignant Meningiomas

Meningiomas - Management and Surgery, 2012

Research paper thumbnail of Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases

Neurobiology of Aging, 2000

Research paper thumbnail of A Characteristic Binding Affinity Between Heparan Sulfate Proteoglycans and the A4 Amyloid Protein of Alzheimerʼs Disease

Journal of Neuropathology and Experimental Neurology, 1989

Research paper thumbnail of Ultrastructure of Hypothalamic and Medullary Lesions Caused by an Aliphatic Triamine

Journal of Neuropathology and Experimental Neurology, 1982

The administration of an aliphatic triamine, 3,3'-methylimino-bis-(N-methylpropylamine), ... more The administration of an aliphatic triamine, 3,3'-methylimino-bis-(N-methylpropylamine), was used to produce non-necrotizing lesions in the hypothalamus and medulla oblongata of rats. The distribution of the lesions in the hypothalamus was similar to that produced by goldthioglucose, and consisted ultrastructurally of marked distention and edema of the extracellular space, with no confined to the dorsal aspect, in the region of the area postrema. The data suggest that the absence of blood-brain barrier in these sites plays a role in the production of lesions, at least in the initial stages, as has been proposed for goldthioglucose lesions.

Research paper thumbnail of Rosai-Dorfman disease manifesting as intracranial and intraorbital lesion

Journal of Neuro-Oncology, 2009

Research paper thumbnail of Multiple vascular malformation in the ?blue rubber bleb naevus? syndrome: a case with aneurysm of vein of Galen and vascular lesions suggesting a link to the Weber?Osler?Rendu syndrome

Histopathology, 1978

A case of Bean's syndrome is reported in which a wide variety of vascular malformations a... more A case of Bean's syndrome is reported in which a wide variety of vascular malformations are illustrated. Among these were multiple arterio-venous malformations including a so-called vein of Galen aneurysm. A comparison of this case with those in the literature suggests that the pathology in patients with Bean's syndrome may be more varied than heretofore recognized, and that an overlap between this syndrome and the Osler-Weber-Rendu syndrome may exist.