Murat Elevli | Sakarya University Medical School (original) (raw)

Papers by Murat Elevli

Blood Coagulation & Fibrinolysis, 2010

Congenital afibrinogenemia, a very rare autosomal recessive coagulation disorder, is characterize... more Congenital afibrinogenemia, a very rare autosomal recessive coagulation disorder, is characterized by undetectable and extremely low antigen levels of fibrinogen in plasma. We report a male newborn with intracranial bleeding and diagnosed as congenital afibrinogenemia in the neonatal period. All members of the family were asymptomatic. Even though his sister and father showed extremely low fibrinogen levels, they did not have any symptoms. The most important finding of this case was a spontaneous intracranial hemorrhage at a very early stage of life. Another interesting point was the rapid resorption of this hemorrhage.

Aim: Increased frequency of deficiency due to the insufficient intake of iron, zinc, vitamin B12-... more Aim: Increased frequency of deficiency due to the insufficient intake of iron, zinc, vitamin B12-D and folic acid has been reported in the society. We aimed to investigate the rates of deficiency of these vitamins and minerals, as well as anemia frequency in children admitted to pediatric outpatient clinics of our tertiary hospital in a retrospective three-year period. Materials and Methods: The frequency of micronutrient deficiency and the relationship between them was determined using statistical methods by evaluating the levels of hematocrit and other micronutritional elements in patients admitted to the general pediatrics outpatient clinics of our hospital between 01.06.2015 and 31.05.2018. The only patient inclusion criteria were being tested for zinc, iron, iron binding, hemogram, vitamin B12, folic acid, ferritin and vitamin D for any reason. Results: After the evaluation of 64487 patients, we discovered the rates of anemia and iron, zinc, folate, vitamin D, vitamin B12 and f...

European Journal of Pediatrics

Vitamin D has an immunomodulating property that regulates the inflammatory response. In this stud... more Vitamin D has an immunomodulating property that regulates the inflammatory response. In this study, the aim was to evaluate the relationship between vitamin D levels and clinical severity and inflammation markers in children and adolescents with COVID-19. The clinical and laboratory records of 103 pediatric cases with COVID-19, whose vitamin D levels had been measured, were retrospectively reviewed. The cases were divided into groups according to their clinical severity (asymptomatic, mild, and moderate-to-severe) and vitamin D levels. The moderate-to-severe clinical group had significantly higher inflammation markers (CRP, procalcitonin, fibrinogen, Ddimer) and a lower lymphocyte count compared to both the mild and asymptomatic groups. The 25 OH vitamin D levels were also significantly lower (p < 0.001), and the ratio of vitamin D deficiency was 70.6% in the moderate-to-severe group. The vitamin D-deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups. The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = −0.496, p = <0.001), CRP (r = −0.309, p = 0.002) and fibrinogen levels (r = −0.381, p = <0.001). In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course. Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases. Prophylactic vitamin D supplementation may be considered, especially in the adolescent age group.

Turkiye Klinikleri Journal of Pediatrics, 2006

Anesthesia & Analgesia, 1987

Seventeen otherwise healthy patients were given either intravenous physiologic saline, 5 ml, or a... more Seventeen otherwise healthy patients were given either intravenous physiologic saline, 5 ml, or aminophylline, 2 mg/kg, randomly 30 min after they were given intravenous flunitrazepam in doses adequate to produce sleep and sedation during spinal anesthesia for anorectal surgery. In the control group, mean sedation scores were 1.8 +/- 0.3 and 1.0 +/- 0.4 15 and 45 min after injection of placebo. Fifteen and 45 min after the injection of aminophylline the mean scores of sedation were 0.4 +/- 0.2 and 0.2 +/- 0.2, respectively. Even though the patients in both groups appeared to be equally alert and responsive after 75 min, Trieger tests revealed that psychomotor function was still significantly impaired in the control group 90 min after the injection of placebo. The amnesic effects of flunitrazepam were not affected by aminophylline. Aminophylline may be used to reverse the sedative and psychomotor effects of flunitrazepam.

Acta Anaesthesiologica Scandinavica, 1993

... 2. Duration of the treatment with epidural morphine. Page 3. 666 S. W. HENNEBERG ET AL. ... P... more ... 2. Duration of the treatment with epidural morphine. Page 3. 666 S. W. HENNEBERG ET AL. ... Paediatrics 1986: 77: 11-15. 9. Desparmet J, Mateo J, Ecoffey C, Mazoit X. Efficacy of an epidural testdose in children anesthetized with halothane. Anes-thesiology 1990: 72: 249-251. ...

Turkish Journal of Medical Sciences, Jan 27, 2015

Turkish Association of Pediatric Surgeons, 2014

Iranian Journal of Pediatrics, 2015

Diabetes mellitus type 1 is the most common endocrine metabolic disorder occurring in childhood a... more Diabetes mellitus type 1 is the most common endocrine metabolic disorder occurring in childhood and adolescence due to the autoimmune destruction of pancreatic beta cells as a result of various environmental factors interacting with an underlying genetic predisposition. Diabetes is a risk factor for early onset atherosclerosis, and the high mortality rate seen in these patients is partially related to cardiovascular diseases. This study was conducted to compare mean platelet volume as a marker of early atherosclerosis with aortic intima-media thickness in children with type 1 diabetes and to identify its correlation with known cardiovascular risk factors. The study included 27 patients between age range of 6 and 17 years that were diagnosed with type 1 diabetes and 30 healthy children of the same age range who did not have any chronic disease. In both groups, we used the color Doppler ultrasound to measure children&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s aortic intima-media thickness and identify their mean platelet volumes. There was no significant difference between the groups regarding gender distribution, age, High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) cholesterol levels (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Also no significant difference could be documented between the patient and control groups regarding the aortic intima-media thickness and mean platelet volume (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). However, there was a significant correlation between aortic intima-media thickness and mean platelet volume (r = 0.351; P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In the present study, there was no evidence of early atherosclerosis in children with type 1 diabetes. However, mean platelet volume having a significant correlation with aortic intima-media thickness may be useful as an early marker of atherosclerosis.

TURKISH JOURNAL OF MEDICAL SCIENCES, 2015

Background/aim: The mechanism of edema formation in nephrotic syndrome is still poorly understood... more Background/aim: The mechanism of edema formation in nephrotic syndrome is still poorly understood. We aimed to evaluate the volume status in children with steroid-sensitive nephrotic syndrome (SSNS) and to emphasize the importance of echocardiography in demonstrating of volume changes.

The Pediatric Infectious Disease Journal, 1990

The incidence of tuberculosis in the United States is increasing in all age groups; 5% of all of ... more The incidence of tuberculosis in the United States is increasing in all age groups; 5% of all of these patients have central nervous system involvement. We studied childhood central nervous system tuberculosis between 1979 and 1989 and reviewed the literature for patients up to 14 years of age. The small number of patients reported in this country results in delayed diagnoses because of reduced awareness. Cranial computed tomography within 1 week of initial symptoms may reveal basilar enhancement, hydrocephalus, or infarction. When combined with cerebrospinal fluid findings atypical for common bacterial infection, these radiographic findings support the prompt initiation of antituberculous therapy. Prophylactic considerations are also discussed.

Journal of Pediatric Endocrinology and Metabolism, 2000

The aim of this prospective study was to research features of insulin resistance and metabolic sy... more The aim of this prospective study was to research features of insulin resistance and metabolic syndrome in offspring of diabetic parents and to find out whether there is a risk of developing type 2 diabetes mellitus (DM) in these children. Study participants were 30 children of parents with type 1 DM (DM1) (Group I) and 11 children of parents with type 2 DM (DM2) (Group II) who were being followed up in the Diabetes Department of Haseki Research and Training Hospital. The results were compared with a control group of 17 children in the same age group (Group III). There were no statistically significant differences between the Group I and the control group in fasting blood glucose, oral glucose tolerance test values, 1st 2nd and hour insulin, homeostasis model assessment (HOMA) values, body mass index (BMI), systolic and diastolic blood pressure, and lipid parameters, i.e. HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total cholesterol, and triglycerides. Fasting, 1st and 2nd hour blood insulin levels, HOMA values, BMI, and systolic blood pressure values were significantly higher in Group II compared to the control group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There were no statistically significant differences between Group II and the control group in lipid parameters, fasting blood glucose, OGTT values, or diastolic blood pressure. We conclude that in our population there is a tendency of insulin resistance and metabolic syndrome in the offspring of parents with DM2, and a risk for developing DM2. Thus, children of patients with DM2 should be followed up so as to recognize early metabolic defects of glucose metabolism and to plan effective preventive efforts to reduce cardiovascular and atherosclerotic risk factors.

European Journal of Pediatrics, 2012

Varicella can cause complications that are potentially serious and require hospitalization. Our c... more Varicella can cause complications that are potentially serious and require hospitalization. Our current understanding of the causes and incidence of varicella-related hospitalization in Turkey is limited and sufficiently accurate epidemiological and economical information is lacking. The aim of this study was to estimate the annual incidence of varicella-related hospitalizations, describe the complications, and estimate the annual mortality and cost of varicella in children. VARICOMP is a multi-center study that was performed to provide epidemiological and economic data on hospitalization for varicella in children between 0 and 15 years of age from October 2008 to September 2010 in Turkey. According to medical records from 27 health care centers in 14 cities (representing 49.3% of the childhood population in Turkey), 824 children (73% previously healthy) were hospitalized for varicella over the 2-year period. Most cases occurred in the spring and early summer months. Most cases were in children under 5 years of age, and 29.5% were in children under 1 year of age. The estimated incidence of varicella-related hospitalization was

Pediatr Int, 2009

Key words familial Mediterranean fever, protracted febrile myalgia, streptococcus.

The Journal of Pediatric Research, 2015

Objective: Hepcidin is a key regulator of iron homeostasis. Increased hepcidin concentrations cau... more Objective: Hepcidin is a key regulator of iron homeostasis. Increased hepcidin concentrations cause iron sequestration in enterocytes and macrophages. The role of hepcidin in children with iron-deficiency anemia and anemia of inflammation is unclear. In this study, we aimed to evaluate the use of serum hepcidin level as an index for iron deficiency and inflammation anemia in pediatric population. Furthermore, hepcidin is also known to be an acute-phase reactant induced by interleukin-6 (IL-6) during infection. Therefore, we investigated the relationships between hepcidin and inflammatory markers. Methods: This study included 50 children with anemia (13 with iron deficiency and 37 with inflammation) and 17 age-and gender-matched healthy children (control group). Parameters related to iron metabolism (ferritin, serum iron and total iron binding capacity), infection (Creactive protein, white blood cell count and neutrophil percentage) and hepcidin levels were measured. Results: Serum hepcidin levels in patients with anemia of inflammation (362.63±132.27 ng/ mL) were significantly higher than in patients with iron-deficiency anemia (234.10±93.59 ng/ mL) and healthy controls (220.44±49.52 ng/mL) (p=0.002, p<0.001, respectively). Serum hepcidin levels were positively correlated with ferritin (r=0.246, p=0.045), leucocytes (r=0.259, p=0.034) and CRP (r=0.426, p<0.001) levels in all children.

Amaç: Bu çalışmanın amacı ilaç zehirlenmesi nedeni ile yatırılan çocuklarda olay ile bağlantılı t... more Amaç: Bu çalışmanın amacı ilaç zehirlenmesi nedeni ile yatırılan çocuklarda olay ile bağlantılı tüm verileri incelemek ve bu verilere dayanarak alınabilecek önlemleri belirlemektir. Yöntem: Çalışmaya Çocuk Acil Servisi'ne ilaç zehirlenmesi nedeniyle başvuran ve yatırılarak izlenen 33'ü erkek, 68'i kız 101 hasta alındı. Olguların yaşı, cinsiyeti, alınan etken maddelere ait özellikler, ilacın alınmasından sonra ilk tıbbi müdahaleye kadar geçen süre, ailelerin tutum ve davranışları bir anket formuna kaydedildi. Bulgular: Çalışmamızda ilaç zehirlenmeleri çocuk aciline gelen hastalar içinde %1.23 oranında bulunmuştur. Olguların yaşları 2-16 yaş arasında (6.75±5.30) değişmekteydi. 52 hasta ilacı kaza ile alırken, 49'u intihar amaçlı almıştır. Kaza ile zehirlenme olgularına 2-6 yaş arasında rastlanırken intihar olguları 12 yaş ve üstü ergenlerdi. Zehirlenmeye sebep olan ilaç olarak ilk sırada parasetamol (%13.8), ikinci sırada amitriptilin (%10.7) saptandı. Sonuçlar: Zehirlenmelerin tedavisinde önemli gelişmeler olmasına rağmen yine de en etkili yöntem ailelerin bilgilendirilmesi ve koruyucu önlemlerin alınmasıdır. (Ha se ki T›p Bül te ni 2013; 51: 157-61) Anahtar Kelimeler: Çocuk, ilaç, zehirlenme

Timik epitelyal tümörler; timomalar, timik karsinoidler ve timik karsinomaları kapsamaktadır. Hem... more Timik epitelyal tümörler; timomalar, timik karsinoidler ve timik karsinomaları kapsamaktadır. Hemen hemen tamamı 20 yaş üstü olan olguların %70'i 40 yaş üstüdür. Mediastinal tümorler içinde erişkinlerdeki %30'luk oran ile karşılaştırıldığında çocuklarda %1 oranındaki görülme sıklığı tanı koymayı güçleştirir. Biz burada öksürük, ateş ve göğüs ağrısı gibi pnömoni bulguları ile gelen 12 yaşında bir kız çocuğunu sunduk. Akciğer grafisinde mediastinal genişleme ve sağda opasite görülen hastanın bilgisayarlı tomografisinde kitle saptandı. Cerrahi olarak çıkarılan kitlenin histolojik ve immünohistokimyasal incelemeleri B3 timoma olduğunu gösterdi. Olgu çocuklarda timomanın nadir görülmesi nedeni ile sunulmuştur. (The Me di cal Bul le tin of Ha se ki 2013; 51: 200-02) Anahtar Kelimeler: Çocukluk çağı, mediastinal kitle, timoma