Alexey Koronovsky | Saratov State University (original) (raw)

Papers by Alexey Koronovsky

Research paper thumbnail of Sleep spindles and spike–wave discharges in EEG: Their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis

Journal of Neuroscience Methods, 2009

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright

Research paper thumbnail of Time-delayed generators application for secure information transmission on the basis of generalized synchronization

Research paper thumbnail of Bifurcation phenomena in a semiconductor superlattice subject to a tilted magnetic field

Physics Letters A, 2015

The paper studies instabilities of charge transport in strongly coupled semiconductor superlattic... more The paper studies instabilities of charge transport in strongly coupled semiconductor superlattices with an applied electric and a tilted magnetic field. We reveal the bifurcation phenomena, which are associated with the transitions between different regimes of charge dynamics, and also investigate effects of the temperature on these bifurcations. In addition, we find out that the development of an instability can be accompanied by a graduate change of the dominant transport mechanism.

Research paper thumbnail of Separation of coexisting dynamical regimes in multistate intermittency based on wavelet spectrum energies in an erbium-doped fiber laser

Physical Review E, 2016

We propose a method for the detection and localization of different types of coexisting oscillato... more We propose a method for the detection and localization of different types of coexisting oscillatory regimes that alternate with each other leading to multistate intermittency. Our approach is based on consideration of wavelet spectrum energies. The proposed technique is tested in an erbium-doped fiber laser with four coexisting periodic orbits, where external noise induces intermittent switches between the coexisting states. Statistical characteristics of multistate intermittency, such as the mean duration of the phases for every oscillation type, are examined with the help of the developed method. We demonstrate strong advantages of the proposed technique over previously used amplitude methods.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Research paper thumbnail of Research Article Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

Copyright © 2014 Evgenia Sitnikova et al. This is an open access article distributed under the Cr... more Copyright © 2014 Evgenia Sitnikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activitymay affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) freq...

Research paper thumbnail of Coexistence of Two Different Types of Intermittency near the Boundary of Phase Synchronization in the Presence of Noise

Intermittent behavior near the boundary of phase synchronization in the presence of noise is stud... more Intermittent behavior near the boundary of phase synchronization in the presence of noise is studied. In certain range of the coupling parameter and noise intensity the intermittency of eyelet and ring intermittencies is shown to take place. Main results are illustrated using the example of two unidirectional coupled Rössler systems. Similar behavior is shown to take place in two hydrodynamical models of Pierce diode coupled unidirectional. Keywords—Chaotic oscillators, phase synchronization, noise, intermittency of intermittencies, control.

Research paper thumbnail of Two scenarios of breaking chaotic phase synchronization

Two types of phase synchronization (accordingly, two scenarios of breaking phase synchronization)... more Two types of phase synchronization (accordingly, two scenarios of breaking phase synchronization) between coupled stochastic oscillators are shown to exist depending on the discrepancy between the control parameters of interacting oscillators, as in the case of classical synchronization of periodic oscillators. If interacting stochastic oscillators are weakly detuned, the phase coherency of the attractors persists when phase synchronization breaks. Conversely, if the control parameters differ considerably, the chaotic attractor becomes phase-incoherent under the conditions of phase synchronization break.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of Effect of temperature on resonant electron transport through stochastic conduction channels in superlattices

We show that resonant electron transport in semiconductor superlattices with an applied electric ... more We show that resonant electron transport in semiconductor superlattices with an applied electric and tilted magnetic field can, surprisingly, become more pronounced as the lattice and conduction electron temperature increases from 4.2 K to room temperature and beyond. It has previously been demonstrated that at certain critical field parameters, the semiclassical trajectories of electrons in the lowest miniband of the superlattice change abruptly from fully localized to completely unbounded. The unbounded electron orbits propagate through intricate web patterns, known as stochastic webs, in phase space, which act as conduction channels for the electrons and produce a series of resonant peaks in the electron drift velocity versus electric-field curves. Here, we show that increasing the lattice temperature strengthens these resonant peaks due to a subtle interplay between the thermal population of the conduction channels and transport along them. This enhances both the electron drift velocity and the influence of the stochastic webs on the current-voltage characteristics, which we calculate by making self-consistent solutions of the coupled electron transport and Poisson equations throughout the superlattice. These solutions reveal that increasing the temperature also transforms the collective electron dynamics by changing both the threshold voltage required for the onset of self-sustained current oscillations, produced by propagating charge domains, and the oscillation frequency.

Research paper thumbnail of Lyapunov exponent corresponding to enslaved phase dynamics: Estimation from time series

Physical Review E

A method for the estimation of the Lyapunov exponent corresponding to enslaved phase dynamics fro... more A method for the estimation of the Lyapunov exponent corresponding to enslaved phase dynamics from time series has been proposed. It is valid for both nonautonomous systems demonstrating periodic dynamics in the presence of noise and coupled chaotic oscillators and allows us to estimate precisely enough the value of this Lyapunov exponent in the supercritical region of the control parameters. The main results are illustrated with the help of the examples of the noised circle map, the nonautonomous Van der Pole oscillator in the presence of noise, and coupled chaotic Rössler systems.

Research paper thumbnail of Department of Electronics,Oscillations and Waves of Saratov State University Celebrates Sixtieth Anniversary

Izvestiya of Saratov University. New series. Series: Physics

Research paper thumbnail of Rhythmic activity in EEG and sleep in rats with absence epilepsy

Brain Research Bulletin, 2016

This study examines the hypothesis that absence epilepsy is accompanied by disturbances of rhythm... more This study examines the hypothesis that absence epilepsy is accompanied by disturbances of rhythmic activity in EEG during sleep. Sleep-wake architecture and time-frequency parameters of EEG were analyzed during drowsiness and sleep in WAG/Rij rats with genetic predisposition to absence epilepsy. The incidence of seizures varied in a group of 10 rats, in which 5 individuals did not develop epileptic discharges in their EEG (asymptomatic rats). In contrast to asymptomatic, symptomatic subjects (1) displayed less percentage of wakefulness EEG pattern and more non-REM sleep, (2) showed higher beta and less delta EEG power in frontal cortex during non-REM sleep. Mid-frequency oscillations, such as sleep spindles and 5-9Hz oscillations, were detected in EEG automatically and underwent time-frequency analysis by means of skeletons of wavelet surfaces. Some mid-frequency oscillations showed "complex" frequency structure, consisting of the dominant and subdominant components. "Complex" sleep spindles more frequently appeared in asymptomatic rats than in symptomatic, whereas the dominant frequency of these spindles in symptomatic rats was higher than in asymptomatic (12.7 vs 11.9Hz). In general, low-frequency components were readily integrated in sleep spindles in asymptomatic WAG/Rij rats, and decrease in number of "complex" sleep spindles may be associated with epileptic phenotype.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

Neuroscience Journal, 2014

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of First Experimental Observation of Generalized Synchronization Phenomena in Microwave Oscillators

Physical Review Letters, 2009

In this Letter we report for the first time on the experimental observation of the generalized sy... more In this Letter we report for the first time on the experimental observation of the generalized synchronization regime in the microwave electronic systems, namely, in the multicavity klystron generators. A new approach devoted to the generalized synchronization detection has been developed. The experimental observations are in the excellent agreement with the results of numerical simulation. The observed phenomena gives a strong potential for new applications requiring microwave chaotic signals.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of On–off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy

Brain Research, 2012

Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are kn... more Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produce sleep spindle oscillations. Although both sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain. The present study describes temporal dynamics of SWD and sleep spindles as determined in long-term EEG recordings in WAG/Rij rat model of absence epilepsy. It was found that non-linear dynamics of SWD fits well to the law of ‗on-off intermittency'. Typical sleep spindles that occur during slow-wave sleep (SWS) also demonstrated ‗on-off intermittency' behavior, in contrast to high-voltage spindles during intermediate sleep stage, whose dynamics was uncertain. This implies that both SWS sleep spindles and SWD are controlled by a system-level mechanism that is responsible for regulating circadian activity and/or sleep-wake transitions.

Research paper thumbnail of Time-frequency characteristics and dynamics of sleep spindles in WAG/Rij rats with absence epilepsy

Brain Research, 2014

Absence epilepsy WAG/Rij rats Continuous wavelet transform Instantaneous frequency dynamics a b s... more Absence epilepsy WAG/Rij rats Continuous wavelet transform Instantaneous frequency dynamics a b s t r a c t In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic properties of sleep spindles. This paper examines time-frequency EEG characteristics of anterior sleep spindles in non-epileptic Wistar and epileptic WAG/Rij rats at the age of 7 and 9 months. Considering non-stationary features of sleep spindles, EEG analysis was performed using Morlet-based continuous wavelet transform.

Research paper thumbnail of Sleep spindles and spike–wave discharges in EEG: Their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis

Journal of Neuroscience Methods, 2009

Epileptic activity in the form of spike-wave discharges (SWD) appears in the electroencephalogram... more Epileptic activity in the form of spike-wave discharges (SWD) appears in the electroencephalogram (EEG) during absence seizures. A relationship between SWD and normal sleep spindles is often assumed. This study compares time-frequency parameters of SWD and sleep spindles as recorded in the EEG in the WAG/Rij rat model of absence epilepsy. Fast Fourier transformation and continuous wavelet transformation were used for EEG analysis. Wavelet analysis was performed in non-segmented full-length EEG. A specific wavelet-based algorithm was developed for the automatic identification of sleep spindles and SWD.

Research paper thumbnail of Sleep spindles and spike–wave discharges in EEG: Their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis

Journal of Neuroscience Methods, 2009

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright

Research paper thumbnail of Time-delayed generators application for secure information transmission on the basis of generalized synchronization

Research paper thumbnail of Bifurcation phenomena in a semiconductor superlattice subject to a tilted magnetic field

Physics Letters A, 2015

The paper studies instabilities of charge transport in strongly coupled semiconductor superlattic... more The paper studies instabilities of charge transport in strongly coupled semiconductor superlattices with an applied electric and a tilted magnetic field. We reveal the bifurcation phenomena, which are associated with the transitions between different regimes of charge dynamics, and also investigate effects of the temperature on these bifurcations. In addition, we find out that the development of an instability can be accompanied by a graduate change of the dominant transport mechanism.

Research paper thumbnail of Separation of coexisting dynamical regimes in multistate intermittency based on wavelet spectrum energies in an erbium-doped fiber laser

Physical Review E, 2016

We propose a method for the detection and localization of different types of coexisting oscillato... more We propose a method for the detection and localization of different types of coexisting oscillatory regimes that alternate with each other leading to multistate intermittency. Our approach is based on consideration of wavelet spectrum energies. The proposed technique is tested in an erbium-doped fiber laser with four coexisting periodic orbits, where external noise induces intermittent switches between the coexisting states. Statistical characteristics of multistate intermittency, such as the mean duration of the phases for every oscillation type, are examined with the help of the developed method. We demonstrate strong advantages of the proposed technique over previously used amplitude methods.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Research paper thumbnail of Research Article Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

Copyright © 2014 Evgenia Sitnikova et al. This is an open access article distributed under the Cr... more Copyright © 2014 Evgenia Sitnikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activitymay affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) freq...

Research paper thumbnail of Coexistence of Two Different Types of Intermittency near the Boundary of Phase Synchronization in the Presence of Noise

Intermittent behavior near the boundary of phase synchronization in the presence of noise is stud... more Intermittent behavior near the boundary of phase synchronization in the presence of noise is studied. In certain range of the coupling parameter and noise intensity the intermittency of eyelet and ring intermittencies is shown to take place. Main results are illustrated using the example of two unidirectional coupled Rössler systems. Similar behavior is shown to take place in two hydrodynamical models of Pierce diode coupled unidirectional. Keywords—Chaotic oscillators, phase synchronization, noise, intermittency of intermittencies, control.

Research paper thumbnail of Two scenarios of breaking chaotic phase synchronization

Two types of phase synchronization (accordingly, two scenarios of breaking phase synchronization)... more Two types of phase synchronization (accordingly, two scenarios of breaking phase synchronization) between coupled stochastic oscillators are shown to exist depending on the discrepancy between the control parameters of interacting oscillators, as in the case of classical synchronization of periodic oscillators. If interacting stochastic oscillators are weakly detuned, the phase coherency of the attractors persists when phase synchronization breaks. Conversely, if the control parameters differ considerably, the chaotic attractor becomes phase-incoherent under the conditions of phase synchronization break.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of Effect of temperature on resonant electron transport through stochastic conduction channels in superlattices

We show that resonant electron transport in semiconductor superlattices with an applied electric ... more We show that resonant electron transport in semiconductor superlattices with an applied electric and tilted magnetic field can, surprisingly, become more pronounced as the lattice and conduction electron temperature increases from 4.2 K to room temperature and beyond. It has previously been demonstrated that at certain critical field parameters, the semiclassical trajectories of electrons in the lowest miniband of the superlattice change abruptly from fully localized to completely unbounded. The unbounded electron orbits propagate through intricate web patterns, known as stochastic webs, in phase space, which act as conduction channels for the electrons and produce a series of resonant peaks in the electron drift velocity versus electric-field curves. Here, we show that increasing the lattice temperature strengthens these resonant peaks due to a subtle interplay between the thermal population of the conduction channels and transport along them. This enhances both the electron drift velocity and the influence of the stochastic webs on the current-voltage characteristics, which we calculate by making self-consistent solutions of the coupled electron transport and Poisson equations throughout the superlattice. These solutions reveal that increasing the temperature also transforms the collective electron dynamics by changing both the threshold voltage required for the onset of self-sustained current oscillations, produced by propagating charge domains, and the oscillation frequency.

Research paper thumbnail of Lyapunov exponent corresponding to enslaved phase dynamics: Estimation from time series

Physical Review E

A method for the estimation of the Lyapunov exponent corresponding to enslaved phase dynamics fro... more A method for the estimation of the Lyapunov exponent corresponding to enslaved phase dynamics from time series has been proposed. It is valid for both nonautonomous systems demonstrating periodic dynamics in the presence of noise and coupled chaotic oscillators and allows us to estimate precisely enough the value of this Lyapunov exponent in the supercritical region of the control parameters. The main results are illustrated with the help of the examples of the noised circle map, the nonautonomous Van der Pole oscillator in the presence of noise, and coupled chaotic Rössler systems.

Research paper thumbnail of Department of Electronics,Oscillations and Waves of Saratov State University Celebrates Sixtieth Anniversary

Izvestiya of Saratov University. New series. Series: Physics

Research paper thumbnail of Rhythmic activity in EEG and sleep in rats with absence epilepsy

Brain Research Bulletin, 2016

This study examines the hypothesis that absence epilepsy is accompanied by disturbances of rhythm... more This study examines the hypothesis that absence epilepsy is accompanied by disturbances of rhythmic activity in EEG during sleep. Sleep-wake architecture and time-frequency parameters of EEG were analyzed during drowsiness and sleep in WAG/Rij rats with genetic predisposition to absence epilepsy. The incidence of seizures varied in a group of 10 rats, in which 5 individuals did not develop epileptic discharges in their EEG (asymptomatic rats). In contrast to asymptomatic, symptomatic subjects (1) displayed less percentage of wakefulness EEG pattern and more non-REM sleep, (2) showed higher beta and less delta EEG power in frontal cortex during non-REM sleep. Mid-frequency oscillations, such as sleep spindles and 5-9Hz oscillations, were detected in EEG automatically and underwent time-frequency analysis by means of skeletons of wavelet surfaces. Some mid-frequency oscillations showed "complex" frequency structure, consisting of the dominant and subdominant components. "Complex" sleep spindles more frequently appeared in asymptomatic rats than in symptomatic, whereas the dominant frequency of these spindles in symptomatic rats was higher than in asymptomatic (12.7 vs 11.9Hz). In general, low-frequency components were readily integrated in sleep spindles in asymptomatic WAG/Rij rats, and decrease in number of "complex" sleep spindles may be associated with epileptic phenotype.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

Neuroscience Journal, 2014

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of First Experimental Observation of Generalized Synchronization Phenomena in Microwave Oscillators

Physical Review Letters, 2009

In this Letter we report for the first time on the experimental observation of the generalized sy... more In this Letter we report for the first time on the experimental observation of the generalized synchronization regime in the microwave electronic systems, namely, in the multicavity klystron generators. A new approach devoted to the generalized synchronization detection has been developed. The experimental observations are in the excellent agreement with the results of numerical simulation. The observed phenomena gives a strong potential for new applications requiring microwave chaotic signals.

Research paper thumbnail of Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, t... more The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sl...

Research paper thumbnail of On–off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy

Brain Research, 2012

Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are kn... more Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produce sleep spindle oscillations. Although both sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain. The present study describes temporal dynamics of SWD and sleep spindles as determined in long-term EEG recordings in WAG/Rij rat model of absence epilepsy. It was found that non-linear dynamics of SWD fits well to the law of ‗on-off intermittency'. Typical sleep spindles that occur during slow-wave sleep (SWS) also demonstrated ‗on-off intermittency' behavior, in contrast to high-voltage spindles during intermediate sleep stage, whose dynamics was uncertain. This implies that both SWS sleep spindles and SWD are controlled by a system-level mechanism that is responsible for regulating circadian activity and/or sleep-wake transitions.

Research paper thumbnail of Time-frequency characteristics and dynamics of sleep spindles in WAG/Rij rats with absence epilepsy

Brain Research, 2014

Absence epilepsy WAG/Rij rats Continuous wavelet transform Instantaneous frequency dynamics a b s... more Absence epilepsy WAG/Rij rats Continuous wavelet transform Instantaneous frequency dynamics a b s t r a c t In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic properties of sleep spindles. This paper examines time-frequency EEG characteristics of anterior sleep spindles in non-epileptic Wistar and epileptic WAG/Rij rats at the age of 7 and 9 months. Considering non-stationary features of sleep spindles, EEG analysis was performed using Morlet-based continuous wavelet transform.

Research paper thumbnail of Sleep spindles and spike–wave discharges in EEG: Their generic features, similarities and distinctions disclosed with Fourier transform and continuous wavelet analysis

Journal of Neuroscience Methods, 2009

Epileptic activity in the form of spike-wave discharges (SWD) appears in the electroencephalogram... more Epileptic activity in the form of spike-wave discharges (SWD) appears in the electroencephalogram (EEG) during absence seizures. A relationship between SWD and normal sleep spindles is often assumed. This study compares time-frequency parameters of SWD and sleep spindles as recorded in the EEG in the WAG/Rij rat model of absence epilepsy. Fast Fourier transformation and continuous wavelet transformation were used for EEG analysis. Wavelet analysis was performed in non-segmented full-length EEG. A specific wavelet-based algorithm was developed for the automatic identification of sleep spindles and SWD.