Ghada Elgohary | Ain Shams University (original) (raw)

Papers by Ghada Elgohary

Hematology, Transfusion and Cell Therapy, Oct 1, 2020

S24 hematol transfus cell ther. 2 0 2 0;4 2(S 1):S17-S34 MM patients with osteolytic lesions at t... more S24 hematol transfus cell ther. 2 0 2 0;4 2(S 1):S17-S34 MM patients with osteolytic lesions at the time of diagnosis, compared to those without osteolyses. Conclusion: We conclude that miR-221/222 cluster correlates with more favorable R-ISS stage, revealing a potential favorable prognostic value in MM patients. MiR-15a and miR-16 correlate with the presence of osteolytic disease in MM. The observed decreased expression of these two miRNAs in symptomatic MM patients with osteolytic lesions could constitute a possible biomarker for the occurrence of bone disease. Moreover, decreased expression of miR-16 and miR-155 in MM patients, compared to sMM patients may indicate a putative predictive biomarker able to distinguish symptomatic patients from sMM patients. This ongoing study will further reveal the possible prognostic significance of this 10 miRNAs signature studied, when response to therapy, progression-free and overall survival is available.

Minimal/ measurable residual diseases represents an independent prognostic indicator for several ... more Minimal/ measurable residual diseases represents an independent prognostic indicator for several haematological malignancies helping to predict clinical outcome and enables for further assessment of the effectiveness of treatment. The methods of detection of MRD has remarkably improved regarding sensitivity and specificity, and different methods such as real time quantitative polymerase chain reaction (RQ-PCR), multi-parametric flow cytometry (MFC), digital PCR or next generation sequencing (NGS) are currently used in clinical practice. Recently, Digital PCR has been adopted for quantitative assessment of MRD. However, the best method still needs to be determined. While enhancement in standardization of the different MRD approaches was reported, optimal timing and specific threshold for intervention need to be defined. Therefore well-designed clinical studies are required to diminish the risk of relapse and improve overall survival.

BMC Cancer, Oct 27, 2020

Background: The distress thermometer (DT) is an effective tool for identifying distress among can... more Background: The distress thermometer (DT) is an effective tool for identifying distress among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of distress among Egyptian patients with different types of cancers using DT. Methods: A total of 550 patients with newly diagnosed hematological and solid cancers who were followed up at 3 Oncology Centers in Egypt were enrolled. They completed a sociodemographic and clinical status questionnaire, the DT and the Problem List (PL) scale. Results: At a DT cutoff score of ≥4, 46% of patients had significant distress, which was related to the tumor site and stage. The most frequent problems reported were treatment decision (64.4%), worry (47%), and fears (44.5%). In univariate logistic regression analysis, participants who had significant distress described 23 out of 36 problems in the practical, family, emotional, and physical areas. After adjustment to sociodemographic and clinical characteristics, multivariable analysis confirmed that insurance, depression, fear, sadness, worry, loss of interest in usual activity, and sleep were independent factors associated with significant distress in cancer patients. Conclusions: Almost half of Egyptian patients newly diagnosed with cancer reported significant distress. Those who had significant distress described extra problems in the practical, family, emotional, and physical areas. We recommend the routine use of DT for screening Egyptian patients with cancer, as well as the involvement of the psycho-oncology and social services, at the time of their initial diagnosis.

Hematology, Transfusion and Cell Therapy, Oct 1, 2020

Objective: T helper 22 (Th22) and T helper 17 (Th17) cells that are especially a subtype of CD4+ ... more Objective: T helper 22 (Th22) and T helper 17 (Th17) cells that are especially a subtype of CD4+ T lymphocyte are known to secrete interleukin 22 (IL-22). Th22 cells have been reported to play a role in infection, chronic inflammation, tumor development, autoimmune disease pathogenesis, and cell development. However, the role and number of cells whose carrying IL-22 in patients with hematopoietic stem cell transplantation is unknown. In this study, the number of circulating cells carrying IL-22, IL-17A, TNF-␣ and IFN-␥ were investigated before hematopoietic stem cell transplantation (at stem cell infusion day) and during engraftment. Methodology: A total of 10 patients who underwent autologous or allogeneic hematopoietic stem cell transplantation consecutively at the

PubMed, 2010

A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms su... more A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms suggestive of pulmonary embolism. Transthoracic echocardiography revealed a free-floating large thrombus traversing the right atrial cavity. Transesophageal echocardiography confirmed the presence of an unattached thrombus that originated from the most proximal part of the inferior vena cava. Multi-slice computed tomography of the chest and abdomen revealed the thrombus to start from the intra-hepatic part of the inferior vena cava and extend through the right atrium. It also demonstrated multiple thrombi in the pulmonary vasculature, the largest being in the right main pulmonary artery and its lower lobe branch. The patient was triaged for surgical embolectomy under cardio-pulmonary bypass. Follow-up trans-thoracic and transesophageal echocardiography confirmed adequate removal of the thrombus. By genetic examination, she proved to have factor V 'Leiden' gene and two thrombophilia genes, all of which were positive in the heterozygous state. She had also a high serum homocysteine.

Bone Marrow Transplantation

Journal of Clinical Apheresis

Cureus

Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cance... more Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations.

Hematology/Oncology and Stem Cell Therapy

Background and objective: CAR T-cell therapy has significantly improved the outcomes of patients ... more Background and objective: CAR T-cell therapy has significantly improved the outcomes of patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL). However, most clinical trials excluded patients with central nervous system (CNS) involvement due to uncertain efficacy and safety. Material and methods: On January 1, 2022, we searched PubMed to identify all published literature associated with current commercial CAR T-cell therapies for B-NHL, including tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axicel), brexucabtagene autoleucel (brexu-cel), and lisocabtagene maraleucel (liso-cel). Studies that involved patients with either primary or secondary CNS lymphoma, and evaluated response rate, adverse events (AEs), or survival were included and summarized. Result: Herein, we summarize the results of 11 studies qualified for our inclusion criteria, reporting 58 lymphoma patients with CNS Involvement with 44 evaluable for clinical response, 25 for immune effector cell-associated neurotoxicity syndrome (ICANS) and 48 for Cytokine release syndrome (CRS). Objective response was achieved in 62% (16/26) of patients, and CR was achieved in 52% (23/44) of patients. Forty-four percent (11/25) developed ICANS, and 35% (17/48) developed severe ICANS (grade≥3). CRS was reported in 63% (15/24) of patients, while severe CRS (grade≥3) was reported in 7% (3/42) of patients. Conclusion: Based on our PubMed literature review, we conclude that CAR T-cell therapy may benefit patients with CNS lymphoma with promising response rates and acceptable AE. However, definite conclusions cannot be drawn until data with a larger sample size is available.

Leukemia Research, 2019

selected on the basis of the presence of HLA-A2, which is the HLA restriction molecule for miHA H... more selected on the basis of the presence of HLA-A2, which is the HLA restriction molecule for miHA HA-1. MiHA alleles were analysed using the PCR-SSP. Results: Among 200 healthy individuals, 45.7% had HA-1H allele and 54.2% the HA-1 R allele matching according to Hardy-Weinberg Equilibrium (HWE). Allelic variant genotype distribution in healthy population was as follows; RR with 26.5%, HH with 8% and HR with 55.5%. Among individuals with hematopoietic malignancies, the allelic frequency was for H 43.3%, and for R allele 56.6% which was not different in recipients/donor pairs. Allelic variant genotype distribution was for RR 35%, for HH 10% and for HR 55%. Ten patients were MiHA incompatibile and 50% of them developed aGVHD. Conclusion: MiHA distribution in Turkish population as a mixed ethnic Asian European population was found to be similar to the other populations. However, the study conducted by Kotzampasaki et al. from Greece, with 49 healthy bone marrow donors revealed the HA-1H, and HA-1R in a frequency of 29%, and 70%, respectively. Goulmy et al. found the HA-1H, and HA-1R as 47.6%, 52.4% in Asian/Pasific islanders, as 47.8%, and 52.2% in the black population, and as 35.9%, 64.1% in white population. This study included a large study cohort as 2262 individuals with 10 different MiHA genotyping from 16 countries, and in 6 different ethnic groups in 5 different continents. MiHA frequency n healthy Turkish population based on our study seemed to be not different from other countries. İn addition to MHAs, MiHA identification may determine the immune response type which may be predictive for the clinical outcome. As a target for posttransplant T-cell immunotherapy.

Saudi medical journal, 2008

To describe the experience in setting up a bone marrow transplant program at Ain Shams University... more To describe the experience in setting up a bone marrow transplant program at Ain Shams University, Cairo, Egypt. Sixteen patients were transplanted at Ain Shams University Bone Marrow Transplantation unit from March 2005 to January 2008. Sixteen patients were transplanted with a median age of 25 years. Indications for transplantation were chronic myeloid leukemia, acute myeloid leukemia, aplastic anemia, acute lymphoblastic leukemia, and aggressive lymphoma. Seven donors and 6 patients were positive for cytomegalovirus immunoglobulin G (IgG) antibody (Ab) pretransplant. Only one patient was positive for toxoplasma IgG Ab and another had a high titre for toxoplasma IgM Ab pretransplant. Two donors and 2 recipients were positive for hepatitis B antibody markers; however, none were positive for hepatitis B virus DNA by polymerase chain reaction (PCR). None of the patients or donors were positive for hepatitis C virus via PCR pre-transplant. Acute graft versus host disease (GVHD) was se...

PeerJ

Background Real-world evidence on factor Xa inhibitor (rivaroxaban) prescribing patterns, safety,... more Background Real-world evidence on factor Xa inhibitor (rivaroxaban) prescribing patterns, safety, and efficacy in patients with non-valvular atrial fibrillation (NVAF) and venous thromboembolism (VTE) is rare. Herein, we sought to examine the above outcomes in the largest academic center in the Kingdom of Saudi Arabia (KSA). Methods This is a retrospective observational study designed to examine the prescribing pattern, safety and real-world effectiveness of the factor Xa inhibitor rivaroxaban in patients with NVAF and VTE. Data on rivaroxaban prescriptions were collected and analyzed. Bleeding outcomes were defined as per the International Society on Thrombosis and Hemostasis (ISTH) definition. Results A total of 2,316 patients taking rivaroxaban recruited through several departments of King Saud University Medical City (KSUMC). The mean age was 61 years (±17.8) with 55% above the age of 60 and 58% were females. Deep vein thrombosis and pulmonary embolism (VTE) was the most prevale...

Medical and Clinical Research: Open Access, 2020

COVID-19 virology SARS-CoV-2, the virus causing COVID-19, is a novel betacoronavirus (large RNA v... more COVID-19 virology SARS-CoV-2, the virus causing COVID-19, is a novel betacoronavirus (large RNA virus) that shares 80% sequence homology with the earlier SARS-CoV virus that caused the SARS

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2018

Purpose To evaluate a single institution's experience with granulocyte colony-stimulating fac... more Purpose To evaluate a single institution's experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration. Methods Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm for two consecutive days or absolute neutrophil count > 1000/mm once. A subset analysis was performed on patients whose date of engraftment was known. Results In total, 216 individual patients were included in the ...

The Egyptian Journal of Haematology, 2014

Background Platelet concentrates (PCs) can be prepared by immediate processing of fresh whole blo... more Background Platelet concentrates (PCs) can be prepared by immediate processing of fresh whole blood (WB); alternatively, they can be prepared from WB stored overnight at room temperature. For blood centers, extension of WB storage time from 8 to 24 h would very useful because of significant operational and logistical benefits. This work was carried out to assess the quality of PCs prepared from WB that had been held overnight at ambient temperature compared with that of PCs prepared from fresh WB donations over a 5-day storage period. Study design and methods Thirty units of WB were collected; 15 U were kept at room temperature for 6-8 h before platelet preparation (fresh group) and 15 U were kept in a controlled environment of 20-24°C for 22-24 h before platelet preparation (overnight group). Results PCs prepared after an 8-h or a 24-h hold were comparable in platelet count per PC. CD62P expression and pH values were significantly lower in PCs prepared from 24-h hold donations. Conclusion The quality of PC may in fact improve because of the ambient overnight hold period as evidenced by lower CD62P expression throughout the storage period, which indicates a lower level of platelet activation. The lower pH values detected in overnight PCs remained within the international acceptable range. Egyptian J Haematol 39:-0 © 2014 The Egyptian Society of Haematology.

Hematology, Transfusion and Cell Therapy, Oct 1, 2020

S24 hematol transfus cell ther. 2 0 2 0;4 2(S 1):S17-S34 MM patients with osteolytic lesions at t... more S24 hematol transfus cell ther. 2 0 2 0;4 2(S 1):S17-S34 MM patients with osteolytic lesions at the time of diagnosis, compared to those without osteolyses. Conclusion: We conclude that miR-221/222 cluster correlates with more favorable R-ISS stage, revealing a potential favorable prognostic value in MM patients. MiR-15a and miR-16 correlate with the presence of osteolytic disease in MM. The observed decreased expression of these two miRNAs in symptomatic MM patients with osteolytic lesions could constitute a possible biomarker for the occurrence of bone disease. Moreover, decreased expression of miR-16 and miR-155 in MM patients, compared to sMM patients may indicate a putative predictive biomarker able to distinguish symptomatic patients from sMM patients. This ongoing study will further reveal the possible prognostic significance of this 10 miRNAs signature studied, when response to therapy, progression-free and overall survival is available.

Minimal/ measurable residual diseases represents an independent prognostic indicator for several ... more Minimal/ measurable residual diseases represents an independent prognostic indicator for several haematological malignancies helping to predict clinical outcome and enables for further assessment of the effectiveness of treatment. The methods of detection of MRD has remarkably improved regarding sensitivity and specificity, and different methods such as real time quantitative polymerase chain reaction (RQ-PCR), multi-parametric flow cytometry (MFC), digital PCR or next generation sequencing (NGS) are currently used in clinical practice. Recently, Digital PCR has been adopted for quantitative assessment of MRD. However, the best method still needs to be determined. While enhancement in standardization of the different MRD approaches was reported, optimal timing and specific threshold for intervention need to be defined. Therefore well-designed clinical studies are required to diminish the risk of relapse and improve overall survival.

BMC Cancer, Oct 27, 2020

Background: The distress thermometer (DT) is an effective tool for identifying distress among can... more Background: The distress thermometer (DT) is an effective tool for identifying distress among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of distress among Egyptian patients with different types of cancers using DT. Methods: A total of 550 patients with newly diagnosed hematological and solid cancers who were followed up at 3 Oncology Centers in Egypt were enrolled. They completed a sociodemographic and clinical status questionnaire, the DT and the Problem List (PL) scale. Results: At a DT cutoff score of ≥4, 46% of patients had significant distress, which was related to the tumor site and stage. The most frequent problems reported were treatment decision (64.4%), worry (47%), and fears (44.5%). In univariate logistic regression analysis, participants who had significant distress described 23 out of 36 problems in the practical, family, emotional, and physical areas. After adjustment to sociodemographic and clinical characteristics, multivariable analysis confirmed that insurance, depression, fear, sadness, worry, loss of interest in usual activity, and sleep were independent factors associated with significant distress in cancer patients. Conclusions: Almost half of Egyptian patients newly diagnosed with cancer reported significant distress. Those who had significant distress described extra problems in the practical, family, emotional, and physical areas. We recommend the routine use of DT for screening Egyptian patients with cancer, as well as the involvement of the psycho-oncology and social services, at the time of their initial diagnosis.

Hematology, Transfusion and Cell Therapy, Oct 1, 2020

Objective: T helper 22 (Th22) and T helper 17 (Th17) cells that are especially a subtype of CD4+ ... more Objective: T helper 22 (Th22) and T helper 17 (Th17) cells that are especially a subtype of CD4+ T lymphocyte are known to secrete interleukin 22 (IL-22). Th22 cells have been reported to play a role in infection, chronic inflammation, tumor development, autoimmune disease pathogenesis, and cell development. However, the role and number of cells whose carrying IL-22 in patients with hematopoietic stem cell transplantation is unknown. In this study, the number of circulating cells carrying IL-22, IL-17A, TNF-␣ and IFN-␥ were investigated before hematopoietic stem cell transplantation (at stem cell infusion day) and during engraftment. Methodology: A total of 10 patients who underwent autologous or allogeneic hematopoietic stem cell transplantation consecutively at the

PubMed, 2010

A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms su... more A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms suggestive of pulmonary embolism. Transthoracic echocardiography revealed a free-floating large thrombus traversing the right atrial cavity. Transesophageal echocardiography confirmed the presence of an unattached thrombus that originated from the most proximal part of the inferior vena cava. Multi-slice computed tomography of the chest and abdomen revealed the thrombus to start from the intra-hepatic part of the inferior vena cava and extend through the right atrium. It also demonstrated multiple thrombi in the pulmonary vasculature, the largest being in the right main pulmonary artery and its lower lobe branch. The patient was triaged for surgical embolectomy under cardio-pulmonary bypass. Follow-up trans-thoracic and transesophageal echocardiography confirmed adequate removal of the thrombus. By genetic examination, she proved to have factor V 'Leiden' gene and two thrombophilia genes, all of which were positive in the heterozygous state. She had also a high serum homocysteine.

Bone Marrow Transplantation

Journal of Clinical Apheresis

Cureus

Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cance... more Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations.

Hematology/Oncology and Stem Cell Therapy

Background and objective: CAR T-cell therapy has significantly improved the outcomes of patients ... more Background and objective: CAR T-cell therapy has significantly improved the outcomes of patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL). However, most clinical trials excluded patients with central nervous system (CNS) involvement due to uncertain efficacy and safety. Material and methods: On January 1, 2022, we searched PubMed to identify all published literature associated with current commercial CAR T-cell therapies for B-NHL, including tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axicel), brexucabtagene autoleucel (brexu-cel), and lisocabtagene maraleucel (liso-cel). Studies that involved patients with either primary or secondary CNS lymphoma, and evaluated response rate, adverse events (AEs), or survival were included and summarized. Result: Herein, we summarize the results of 11 studies qualified for our inclusion criteria, reporting 58 lymphoma patients with CNS Involvement with 44 evaluable for clinical response, 25 for immune effector cell-associated neurotoxicity syndrome (ICANS) and 48 for Cytokine release syndrome (CRS). Objective response was achieved in 62% (16/26) of patients, and CR was achieved in 52% (23/44) of patients. Forty-four percent (11/25) developed ICANS, and 35% (17/48) developed severe ICANS (grade≥3). CRS was reported in 63% (15/24) of patients, while severe CRS (grade≥3) was reported in 7% (3/42) of patients. Conclusion: Based on our PubMed literature review, we conclude that CAR T-cell therapy may benefit patients with CNS lymphoma with promising response rates and acceptable AE. However, definite conclusions cannot be drawn until data with a larger sample size is available.

Leukemia Research, 2019

selected on the basis of the presence of HLA-A2, which is the HLA restriction molecule for miHA H... more selected on the basis of the presence of HLA-A2, which is the HLA restriction molecule for miHA HA-1. MiHA alleles were analysed using the PCR-SSP. Results: Among 200 healthy individuals, 45.7% had HA-1H allele and 54.2% the HA-1 R allele matching according to Hardy-Weinberg Equilibrium (HWE). Allelic variant genotype distribution in healthy population was as follows; RR with 26.5%, HH with 8% and HR with 55.5%. Among individuals with hematopoietic malignancies, the allelic frequency was for H 43.3%, and for R allele 56.6% which was not different in recipients/donor pairs. Allelic variant genotype distribution was for RR 35%, for HH 10% and for HR 55%. Ten patients were MiHA incompatibile and 50% of them developed aGVHD. Conclusion: MiHA distribution in Turkish population as a mixed ethnic Asian European population was found to be similar to the other populations. However, the study conducted by Kotzampasaki et al. from Greece, with 49 healthy bone marrow donors revealed the HA-1H, and HA-1R in a frequency of 29%, and 70%, respectively. Goulmy et al. found the HA-1H, and HA-1R as 47.6%, 52.4% in Asian/Pasific islanders, as 47.8%, and 52.2% in the black population, and as 35.9%, 64.1% in white population. This study included a large study cohort as 2262 individuals with 10 different MiHA genotyping from 16 countries, and in 6 different ethnic groups in 5 different continents. MiHA frequency n healthy Turkish population based on our study seemed to be not different from other countries. İn addition to MHAs, MiHA identification may determine the immune response type which may be predictive for the clinical outcome. As a target for posttransplant T-cell immunotherapy.

Saudi medical journal, 2008

To describe the experience in setting up a bone marrow transplant program at Ain Shams University... more To describe the experience in setting up a bone marrow transplant program at Ain Shams University, Cairo, Egypt. Sixteen patients were transplanted at Ain Shams University Bone Marrow Transplantation unit from March 2005 to January 2008. Sixteen patients were transplanted with a median age of 25 years. Indications for transplantation were chronic myeloid leukemia, acute myeloid leukemia, aplastic anemia, acute lymphoblastic leukemia, and aggressive lymphoma. Seven donors and 6 patients were positive for cytomegalovirus immunoglobulin G (IgG) antibody (Ab) pretransplant. Only one patient was positive for toxoplasma IgG Ab and another had a high titre for toxoplasma IgM Ab pretransplant. Two donors and 2 recipients were positive for hepatitis B antibody markers; however, none were positive for hepatitis B virus DNA by polymerase chain reaction (PCR). None of the patients or donors were positive for hepatitis C virus via PCR pre-transplant. Acute graft versus host disease (GVHD) was se...

PeerJ

Background Real-world evidence on factor Xa inhibitor (rivaroxaban) prescribing patterns, safety,... more Background Real-world evidence on factor Xa inhibitor (rivaroxaban) prescribing patterns, safety, and efficacy in patients with non-valvular atrial fibrillation (NVAF) and venous thromboembolism (VTE) is rare. Herein, we sought to examine the above outcomes in the largest academic center in the Kingdom of Saudi Arabia (KSA). Methods This is a retrospective observational study designed to examine the prescribing pattern, safety and real-world effectiveness of the factor Xa inhibitor rivaroxaban in patients with NVAF and VTE. Data on rivaroxaban prescriptions were collected and analyzed. Bleeding outcomes were defined as per the International Society on Thrombosis and Hemostasis (ISTH) definition. Results A total of 2,316 patients taking rivaroxaban recruited through several departments of King Saud University Medical City (KSUMC). The mean age was 61 years (±17.8) with 55% above the age of 60 and 58% were females. Deep vein thrombosis and pulmonary embolism (VTE) was the most prevale...

Medical and Clinical Research: Open Access, 2020

COVID-19 virology SARS-CoV-2, the virus causing COVID-19, is a novel betacoronavirus (large RNA v... more COVID-19 virology SARS-CoV-2, the virus causing COVID-19, is a novel betacoronavirus (large RNA virus) that shares 80% sequence homology with the earlier SARS-CoV virus that caused the SARS

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2018

Purpose To evaluate a single institution's experience with granulocyte colony-stimulating fac... more Purpose To evaluate a single institution's experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration. Methods Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm for two consecutive days or absolute neutrophil count > 1000/mm once. A subset analysis was performed on patients whose date of engraftment was known. Results In total, 216 individual patients were included in the ...

The Egyptian Journal of Haematology, 2014

Background Platelet concentrates (PCs) can be prepared by immediate processing of fresh whole blo... more Background Platelet concentrates (PCs) can be prepared by immediate processing of fresh whole blood (WB); alternatively, they can be prepared from WB stored overnight at room temperature. For blood centers, extension of WB storage time from 8 to 24 h would very useful because of significant operational and logistical benefits. This work was carried out to assess the quality of PCs prepared from WB that had been held overnight at ambient temperature compared with that of PCs prepared from fresh WB donations over a 5-day storage period. Study design and methods Thirty units of WB were collected; 15 U were kept at room temperature for 6-8 h before platelet preparation (fresh group) and 15 U were kept in a controlled environment of 20-24°C for 22-24 h before platelet preparation (overnight group). Results PCs prepared after an 8-h or a 24-h hold were comparable in platelet count per PC. CD62P expression and pH values were significantly lower in PCs prepared from 24-h hold donations. Conclusion The quality of PC may in fact improve because of the ambient overnight hold period as evidenced by lower CD62P expression throughout the storage period, which indicates a lower level of platelet activation. The lower pH values detected in overnight PCs remained within the international acceptable range. Egyptian J Haematol 39:-0 © 2014 The Egyptian Society of Haematology.