Paul Hatton | The University of Sheffield (original) (raw)

Papers by Paul Hatton

Abstract Aggrecan is one of the two major constituents of articular cartilage, and during disease... more Abstract Aggrecan is one of the two major constituents of articular cartilage, and during diseases such as osteoarthritis (OA) it is subject to degradation by proteolytic enzymes. The primary proteases responsible for aggrecan cleavage are the aggrecanases, identified as members of the ADAMTS family of proteases, which are upregulated in response to inflammatory stimuli.

Hydroxyapatite (HA) has been used in orthopedic, dental, and maxillofacial surgery as a bone subs... more Hydroxyapatite (HA) has been used in orthopedic, dental, and maxillofacial surgery as a bone substitute. The aim of this investigation was to study the effect of surface topography produced by the presence of microporosity on cell response, evaluating: cell attachment, cell morphology, cell proliferation, total protein content, and alkaline phosphatase (ALP) activity.

OBJECTIVES: There is concern that hydrogen peroxide generated by tooth bleaching agents may cause... more OBJECTIVES: There is concern that hydrogen peroxide generated by tooth bleaching agents may cause enhanced metal ion release (including mercury) from dental amalgam following contact. The aim of this in vitro study was therefore to investigate the effect of a carbamide peroxide (CP) based tooth bleaching gel on metal ion release from dental amalgam. METHODS: Dental amalgam discs were prepared according to the manufacturers' instructions.

The aim of this study was to determine the biocompatibility and osteoconductive potential of a hi... more The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light and electron microscopy. Hydroxyapatite was used as a control material. Hydroxyapatite implants were surrounded by new mineralised bone tissue after 4 weeks of implantation.

summary There are concerns that tooth bleaching agents may adversely affect dental materials. The... more summary There are concerns that tooth bleaching agents may adversely affect dental materials. The aim of this study was to test the hypothesis that increasing concentrations of hydrogen peroxide (HP) are more effective than water at increasing metal ion release from two typical dental casting alloys during bleaching. Discs (n= 28 for each alloy) were prepared by casting and heat treated to simulate a typical porcelain-firing cycle.

The effects of devitrification of an ionomer glass with a molar composition 4.5 SiO2· 3Al2O3· 1.5... more The effects of devitrification of an ionomer glass with a molar composition 4.5 SiO2· 3Al2O3· 1.5 P2O5· 3CaO· 2CaF2 on cement formation and in vitro biocompatibility were investigated. Differential thermal analysis was used to study the phase evolution in the glass, and to determine the heat treatments for production of glass-ceramics.

Summary S ilks are fibrous proteins, which are spun by a variety of species including silkworms a... more Summary S ilks are fibrous proteins, which are spun by a variety of species including silkworms and spiders. Silks have common structural components and have a hierarchical structure. Silkworm silk must be degummed for biomedical applications in order to remove the immunogenic sericin coating. It may subsequently be processed into a variety of forms, often via the formation of a fibroin solution, including films, fibres and sponges, and used in combination with other materials such as gelatine and hydroxyapatite.

Abstract Potassium fluorrichterite (KNaCaMg 5 Si 8 O 22 F 2) glass–ceramics were modified by eith... more Abstract Potassium fluorrichterite (KNaCaMg 5 Si 8 O 22 F 2) glass–ceramics were modified by either increasing the concentration of calcium (GC5) or by the addition of P 2 O 5 (GP2). Rods (2× 4 mm) of stoichiometric fluorrichterite (GST), modified compositions (GC5 and GP2) and 45S5 bioglass, which was used as the reference material, were prepared using a conventional lost-wax technique. Osteoconductivity was investigated by implantation into healing defects in the midshaft of rabbit femora.

Abstract In the present work we originally tested the suitability of corn starch-polycaprolactone... more Abstract In the present work we originally tested the suitability of corn starch-polycaprolactone (SPCL) scaffolds for pursuing a cartilage tissue engineering approach. Bovine articular chondrocytes were seeded on SPCL scaffolds under dynamic conditions using spinner flasks (total of 4 scaffolds per spinner flask using cell suspensions of 0.5× 10 6 cells/ml) and cultured under orbital agitation for a total of 6 weeks.

Dental Materials, Jan 1, 1998

Journal of the …, Jan 1, 2004

Journal of the …, Jan 1, 2005

Journal of Materials …, Jan 1, 2007

Journal of the …, Jan 1, 2007

Journal of the …, Jan 1, 2006

Summary The aim of this study was to evaluate the potential of ionomer glasses for the manufactur... more Summary The aim of this study was to evaluate the potential of ionomer glasses for the manufacture of dental restorations and small bone prostheses using the lost wax casting technique. Casting machines were tested regarding their suitability to melt and cast ionomer glasses to form test pieces. A method to assess relative castability of different glass formulations was also developed.

Journal of Materials …, Jan 1, 2008

methodology

Page 1. TEM of Tissue-Polymer Constructs 197 197 From: Methods in Molecular Biology, vol. 238: Bi... more Page 1. TEM of Tissue-Polymer Constructs 197 197 From: Methods in Molecular Biology, vol. 238: Biopolymer Methods in Tissue Engineering Edited by: AP Hollander and PV Hatton © Humana Press Inc., Totowa, NJ 15 Transmission ...