Dr.Fenil C Panwala | Siddaganga Institute of Technology (original) (raw)

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Papers by Dr.Fenil C Panwala

The Journal of Supercomputing, Dec 11, 2018

A peculiar method used for particle separation device in microfluidics is hydrodynamic filtration... more A peculiar method used for particle separation device in microfluidics is hydrodynamic filtration. To achieve the filtration of sample fluid with particle, this is the technique which concedes two-input (with buffer inlet) sheath fluid to conflow at distinct velocity rates in a sifter-shaped microchannel network demonstrated. The objective is to assure the separation of particles based on size and mass in microflow network with grooves or rectangular cross section by hydrodynamic filtration. However, simulation is done to examine the particle tracing with mass by sifter-shaped microchannel network using COMSOL Multiphysics software. The size, mass and density of the particle are related to the properties of K. pneumoniae \space and blood particles samples. During the experiments, different networks were designed and simulated to acquire a better filtration effect and particle separation based on size and mass. After the simulation done for the networks, it resulted that siftershaped microchannel network shows a precise separation of K. pneumoniae particle. Analysis of a microchannel having distinct angles (90°, 15°, 25°and 35°) with individual inflow velocity for sample with particle and buffer inflow velocity without particle at 3000 µl/s and with various other flow rates for blood and 50 µl/s and with various other flow rates for water was performed, where sifter-shaped microchannel device consisting of 90°and 25°sifter structure provides a preferable separation through the targeted outlet 4 and outlet 1 of microchannel for a larger bioparticles and smaller particles (blood cells) through the other outlets of device.

Measurement, Jul 1, 2019

In the development of the biological device separation of bioparticles plays a vital role in the ... more In the development of the biological device separation of bioparticles plays a vital role in the field of health care and diagnostics. One of the mechanism which satisfies the demands of precision, high throughput, less clogging problem and multiple bioparticle separation is Hydrodynamic Filtration (HDF) Technique uses fluid flow rates, arrays/grooves, streamlines and other related characteristics/parameters by utilizing a Colander/Strainer microchannel network. By using a commercial software COMSOL Multiphysics a proposed analysis and simulation for bioparticle separation through Colander/Strainer geometrical network were studied with a structure of slanted angles 15º, 25º, 35º and 90º in which a bioparticles were introduced via inlet systematically with definite fluid flow rates with addition of buffer. However the larger bioparticles (K.Pneumoniae/mammalian cells) and smaller bioparticles(Blood cells) were been formulated (injected) depending on the individual flowrates in a system of microfluidics and its streamlines due to which smaller bioparticles were towed(dragged) with the streamlines directions and larger bioparticles were robust towards the upper sidewalls of a microchannel as per the flow rates as well as other parameters applied and the separation of targeted bioparticles were achieved in a precise manner through a desired outlets. A successful performance for Colander/Strained microchannel network was achieved by simulation for separation of targeted bioparticles, specifically a design consisting of 25º and 90º Colander/Strained structure provided a precise targeted bioparticle separation through outlet-4 and outlet-1 for larger bioparticles dependent on size and mass and other bioparticles through the different outlets available according to the parameters registered.

International Journal of Vehicle Information and Communication Systems, 2022

2022 IEEE 3rd Global Conference for Advancement in Technology (GCAT), Oct 7, 2022

Complex & Intelligent Systems, Jun 21, 2020

Circulating tumor cells (CTCs) are extremely scarce cells which cut off from a primary tumor and ... more Circulating tumor cells (CTCs) are extremely scarce cells which cut off from a primary tumor and percolate into the circulation of blood flow and are, thus, critical for precise cancer detection and treatment. Deterministic lateral displacement (DLD) which exploits asymmetric splitting of laminar flow around the implanted microposts has displayed trustworthy capabilities in separating cells of varying sizes. In this research work, a microfluidic channel consisting of three symmetrically aligned inlets and outlets and embedded circular posts has been proposed which effectively separates the CTCs from lymphocytes utilizing the concept of DLD. Using a commercial software COMSOL Multiphysics 5.4, the design of the proposed microchannel has been simulated and analyzed considering an injected blood sample containing massive CTCs and slim WBCs of radii 13.5 µm and 6 µm, respectively. The proposed model of microchannel isolates the CTCs from WBCs at a comparatively higher sample mass flow rate of 4 × 10-6 kg/s and Reynolds number of 8.9 thereby operating efficiently at higher throughput, and offers excellent linearity in terms of velocity magnitude, pressure, shear rate and Reynolds number. The computational analysis of the proposed microchannel reveals that it can isolate CTCs from WBCs with better separation ratio, offers higher throughput, reduces possibilities of clogging and maintains better uniformity of pressure distribution and other flow parameters when compared with existing microchannel designs. The maximum separation ratio for CTCs and WBCs has been obtained as 84% and 96%, respectively.

2018 International Conference on Recent Trends in Electrical, Control and Communication (RTECC), 2018

Microelectromechanical system based silicon diaphragm pressure sensor using S-shaped piezoresisto... more Microelectromechanical system based silicon diaphragm pressure sensor using S-shaped piezoresistors with four grooves has been proposed for pressure measurement in the range of 0 to 1.02 kg.cm-2. Four voids are located between every two grooves where the piezoresistors are placed. These piezoresistors are electrically connected with aluminium wires to form a Wheatstone bridge. By introducing grooves around the diaphragm, more stress is concentrated in the void regions, resulting in high sensitivity. In addition, improvement in the performance of the sensor has been attained by modifying its geometrical dimensions. On the basis of simulation experiments, the proposed pressure sensor has achieved a high sensitivity in the range of 45.41 mV/V/Kg.cm-2 to 48.25 mV/V/kg.cm-2 by taking different lengths of piezoresistors varying from 300 μm to 120 μm. The pressure sensor has a very low nonlinearity compared to other pressure sensors within this range. The design and simulation of the propo...

2017 4th International Conference on Electronics and Communication Systems (ICECS), 2017

There are different types of Microfluidic particles sorting devices have been developed, but most... more There are different types of Microfluidic particles sorting devices have been developed, but most of those devices have limitation in terms of the relatively low throughput. In this which method has been used is Hydrodynamic Filtration through which sorting of Bacteria particles (Beads or cells) from given sample medium can be separated which are of different size. A new scheme has been describes in this paper for a continuous sorting of Bacteria particles that is Mammalian cells (K. Pneumoniea) using Lattice-Shaped and dual-depth microchannel network. Microchannels were sorted on the base of size and it is clearly showed that the angles dominate the separation efficiencies. The problem which occurs during a fluid flow is clogging due to which particles are not separated in proper way can be overcome. The Scheme presented here for a size based particle sorting can be applicable to various biological or industrial experiments for diagnosis to achieve length-dependent sorting of bisph...

International Journal of Vehicle Information and Communication Systems

MEMS Sensors - Design and Application, Jul 18, 2018

Biofluids remain a difficult issue in some drug delivery processes for separation of bioparticles... more Biofluids remain a difficult issue in some drug delivery processes for separation of bioparticles through microchannels. This chapter reviews the techniques which have been substantiated and proven helpful for the separation of particles depending on mass and size with some constraints of high throughput. In this study, a key focus will be on separation criterion by patterning of a microchannel and utilize sieve type channels based on spherical bioparticles. The first part focuses on the designing of the pattern for issues of the network like clogging and theoretical experiments by both hydrodynamic and other passive methods for sorting/separation. The second part focuses on the simulations for separation for small and larger bio particles depending on mass and size, samples of blood and other Klebsiella infected fluidic samples for the experiment. The theme provided for mass and size-based separation is simple and can accomplish operations in microfluidics for several biological experiments, diagnosis approaches and zoological researches.

Complex & Intelligent Systems