Nicholas Bruno | Saint Louis University (original) (raw)

Papers by Nicholas Bruno

這是關於成功的海外財務中心的決定因素This is a thesis about The Determinants of a Successful Offshore Finance Cente

Texas Law Review, 2015

IntroductionIn 2013, the Supreme Court struck down a requirement that nongovernmental organizatio... more IntroductionIn 2013, the Supreme Court struck down a requirement that nongovernmental organizations combating HIV/AIDS must explicitly oppose prostitution to be eligible for government funding through a HIV/ AIDS program created in 2003,1 a program commonly referred to as the Leadership Act. Congress imposed this restriction as part of this "comprehensive" program to address HIV/AIDS, in part, by eradicating prostitution throughout the world.2 The Court found that the requirement violated the right to free speech because an organization could be ineligible for certain funding due to its beliefs regarding the legalization of prostitution.3This Note proposes a new approach to analyzing speech requirements imposed for potential recipients to be eligible for federal funding: the government should be allowed to enforce any such speech requirements as a condition for federal funding as long as the potential recipient has other opportunities to engage in that speech. This view pr...

Journal of Algebra and Its Applications, 2021

The work of Helmer [Divisibility properties of integral functions, Duke Math. J. 6(2) (1940) 345–... more The work of Helmer [Divisibility properties of integral functions, Duke Math. J. 6(2) (1940) 345–356] applied algebraic methods to the field of complex analysis when he proved the ring of entire functions on the complex plane is a Bezout domain (i.e. all finitely generated ideals are principal). This inspired the work of Henriksen [On the ideal structure of the ring of entire functions, Pacific J. Math. 2(2) (1952) 179–184. On the prime ideals of the ring of entire functions, Pacific J. Math. 3(4) (1953) 711–720] who proved a correspondence between the maximal ideals within the ring of entire functions and ultrafilters on sets of zeroes as well as a correspondence between the prime ideals and growth rates on the multiplicities of zeroes. We prove analogous results on rings of analytic functions in the non-Archimedean context: all finitely generated ideals in the ring of analytic functions on an annulus of a characteristic zero non-Archimedean field are two-generated but not guarante...

Journal of the American Chemical Society, 2015

The enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieve... more The enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N-and Oheterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (−)-paroxetine.

Cancer research, Jan 15, 1989

Interleukin 1 alpha and interleukin 1 beta induce peripheral neutrophilia with stimulation of gra... more Interleukin 1 alpha and interleukin 1 beta induce peripheral neutrophilia with stimulation of granulopoiesis in bone marrow. The continuous administration of interleukin 1 (100 ng/day) to mice for 7 days by s.c.-implanted Alzet osmotic minipumps induced marked stimulation of granulopoiesis in marrow and spleen in normal mice, and protected against the marked depletion of myeloid and erythroid cells in bone marrow of mice treated with single injections of either 20 or 30 mg/kg doxorubicin (DXN). Interleukin 1 beta infusion also protected against DXN-induced atrophy of thymus and secondary lymphoid organs. Single i.p. injection of either interleukin 1 alpha or interleukin 1 beta at doses up to 1000 ng 24 h prior to treatment with DXN did not protect against the hematopoietic and lymphoid toxicities of DXN.

Journal of Interferon Research, 1988

The combination of the immunomodulator interferon-(IFN-7) with the chemothera¬ peutic drug adriam... more The combination of the immunomodulator interferon-(IFN-7) with the chemothera¬ peutic drug adriamycin (ADM) was assessed in vitro and in vivo in murine tumor mod¬ els. When tested in vivo against the murine Lewis lung carcinoma, significantly greater reduction of spontaneous pulmonary métastases was obtained by combination treatment with IFN-7, followed 1 day later by ADM. Intraperitoneal ADM treatment also resulted in an increased recruitment of peritoneal mononuclear cells. It is noteworthy that, al¬ though the antitumor efficacy was significantly increased by the IFN-7/ADM combina¬ tion treatment, gross toxicity of ADM was not increased. Thus, a net increase in the therapeutic index of ADM was achieved. In vitro, the effects of-ADM on the ability of murine peritoneal macrophages, with or without the addition of immunological macro¬ phage activators, to kill tumor cells was studied. Resident macrophages were able to se¬ quester ADM (when present at 10 /ig/ml) from the medium, and could subsequently me¬ diate killing of target tumor cells. However, incubation of macrophages with low (inef¬ fective by themselves) doses of ADM (1 /ig/ml) prevented their simultaneous or subse¬ quent activation to the tumoricidal state after incubation with the normal macrophageactivating mixture of IFN-7 plus a muramyl dipeptide (MDP) analog. When the order of addition of reagents was reversed such that the macrophages were preincubated for 24 hr with IFN-7 (100 U/ml) plus the MDP analog (0.1-10 /ig/ml), no antagonism of tumorici¬ dal activity was obtained upon subsequent incubation with ADM. There were no interac¬ tions between IFN-7 and ADM on the direct proliferation of tumor cells. Taken to¬ gether, these results suggest that the enhanced antitumor efficacy of IFN-7/ADM combi¬ nations in vivo was not due to direct antiproliferative effects on the tumor cells, but rather may be mediated by direct cytotoxicity of ADM on tumor cells enhanced by phagocytic mononuclear cells. Syntex Research, Department of Tumor Biology Rl-215, 3401 Hillview Avenue, Palo Alto, CA 94304. This is Contribution No. 252 from the Institute of Bio-Organic Chemistry.

Plasma Chemistry and Plasma Processing, 2007

This study examined processes of decomposing phenol and its derivatives (resorcin, pyrocatechol a... more This study examined processes of decomposing phenol and its derivatives (resorcin, pyrocatechol and hydroquinone) in aqueous solutions under the action of an atmospheric pressure oxygen dielectric barrier discharge in the presence or absence of catalysts in the plasma zone. Two types of catalysts were tested, NiO and TiO 2. It was found that both materials exhibited catalytic properties. The action of NiO accelerated the step of phenol destruction while the action of TiO 2 catalyst resulted in a more preferable composition of decomposition products and provided a higher degree of carboxylic acid conversion into carbon dioxide than the NiO catalyst.

North American Journal of Fisheries Management, 1985

... NICHOLAS A. BRUNO Cooperative Fish and Wildlife Research Unit School of Forest Resources and ... more ... NICHOLAS A. BRUNO Cooperative Fish and Wildlife Research Unit School of Forest Resources and Conservation University of Florida Gainesville, Florida ... Results from creel surveys conducted on Orange Lake during spring and fall in 1974, 1977-1979, and 1982 indicated the ...

Cutis, 2002

Cryoglobulins (CGs) are serum proteins that reversibly precipitate when the serum is cooled below... more Cryoglobulins (CGs) are serum proteins that reversibly precipitate when the serum is cooled below 37 degrees C. Cryoglobulinemias are associated with a variety of diseases, including hematologic, autoimmune, and infectious. Isolation of CGs requires handling the specimen with extreme care. We describe a 70-year-old man, recently diagnosed with chronic lymphocytic leukemia, who developed hemorrhagic crusted skin ulcers on his legs that were pruritic and painful. Results of skin biopsies showed dilated superficial, mid-dermal and deep-dermal blood vessels containing pink amorphous material and red blood cells. Cryoglobulinemia was suspected; however, an initial search for CGs was negative. There was concern about suboptimal handling of the specimen, and the test was repeated. Two percent CGs with IgM kappa specificity were detected. This case illustrates the importance of the proper handling of specimens for evaluation of cryoglobulinemia.