Mátyás Kiss | Semmelweis University (original) (raw)
Papers by Mátyás Kiss
European Journal of Surgical Oncology, 2019
European Journal of Surgical Oncology, 2019
![Research paper thumbnail of Erratum to "Human liver regeneration in advanced cirrhosis is organized by the portal tree" [J Hepatol 66 (2017) 778-786]](https://attachments.academia-assets.com/113447808/thumbnails/1.jpg)
](Journal of hepatology, Aug 1, 2017
Journal of hepatology, Apr 29, 2016
In advanced cirrhosis new hepatocytic nodules are generated by budding of ductules in areas of pa... more In advanced cirrhosis new hepatocytic nodules are generated by budding of ductules in areas of parenchymal extinction. However, the vascular alterations in the areas of parenchymal extinction, the blood supply and the structure of the new hepatocytic nodules have not been analyzed in detail. Explanted human cirrhotic livers of three different etiologies and two experimental models of cirrhosis in rats were examined thoroughly. 3D reconstruction of the immunohistochemically stained serial sections and casting of human and experimental cirrhotic livers have been used to reveal the structural organization of the regenerative buds. In areas of parenchymal extinction the skeleton of the liver, the portal tree is preserved. The developing regenerative nodules are positioned along the portal tree and are supplied directly by terminal portal venules. The expanding nodules grow along the trunks of the portal vein. Casting of human and experimental cirrhotic livers by colored resin confirms t...
HPB, 2016
arterial branch thrombosis (1 early, 1 late) requiring anticoagulation. Other morbidity included ... more arterial branch thrombosis (1 early, 1 late) requiring anticoagulation. Other morbidity included collection (n = 2) and graft pancreatitis (n = 1). All grafts were functioning at a median follow up of 15 months (range 10e21) and all patients were insulin independent. Conclusions: Our data suggests luminal narrowing of all arteries associated with the pancreatic allograft without any corresponding changes in the renal arteries. This does not appear to impact on short term graft function. It is difficult to determine whether this remodelling process directly contributes to the development of vascular pathology. Therefore further studies should be performed to discover whether this phenomenon is detrimental in the long-term, and to determine if therapeutic intervention is required.
HPB, 2016
to the individual risk. Results: Between 2008 and 2014, 98 patients were candidates to IAT. 54 pa... more to the individual risk. Results: Between 2008 and 2014, 98 patients were candidates to IAT. 54 patients finally received IAT, while the remaining patients did not for a variety of factors (unmet intraoperative requirements, isolation failure/contamination, unstable patients, refusal or other). Control group was made of the remaining patients + further 17 patients with predicted high-risk anastomosis who entered a randomized study but were not randomized to IAT. Early IAT-related complications occurred in 8 patients (14.8%), four of these in case of completion pancreatectomy for POPF. 26/54 patients receiving IAT and 35/61 patients of the control group had malignancy. At a median follow-up of 557d, in the IAT group, relapse was observed in 4/22 patients that were disease-free after surgery (18.2%), and only 2 patients developed new liver metastases (9.1%). In the control group, relapse was observed in 13 patients (40.6%) of whom 7 developed new liver metastases (21.9%). At last follow-up, insulin independency was present in 45% of patients undergoing IAT and further 35% showed partial graft function. Conclusions: IAT can be performed with acceptable safety profile in selected patients with malignancy.
Transplant International, 2015
Pediatric transplantation, Jan 23, 2015
Multiple duct anastomoses during LLS transplantation increase the incidence of biliary complicati... more Multiple duct anastomoses during LLS transplantation increase the incidence of biliary complications. The optimal plane of hepatotomy that results in the least number of bile ducts at the surface was investigated according to LHD variations. Ducts of 30 human livers were injected with resin and LHD branching on 3D-CT reconstructions were analyzed. Ducts on the virtual hepatotomy surface were estimated in three splitting lines. Variations with subtypes were described. Ia (66.7%): ducts from segments (S.) II-III form a common trunk and S.IV duct joins it. Ib (10%): common trunk formed by ducts from S.II-S.III while S.IV duct joins the common hepatic duct. IIa (16.67%): S.IV duct drains into S.III duct. IIc (3.33%): S.IV duct drains into both S.II and S.III ducts. III (3.33%): trifurcation of S.II, S.III and S.IV ducts. When the virtual hepatotomy line was on the FL, there was a single duct for the anastomosis in 30% of cases but two, three, or four ducts in 53.3%, 10%, and 3.3%, respe...
Interventional Medicine and Applied Science, 2009
In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for f... more In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for forensic and pathologic examination. However, classical dissection remains dominant in everyday practice. Lack of quantifiable data on the coronary system has become a disadvantageous attribute of traditional autopsy. Therefore, post mortem MSCT angiography was performed in 80 ex corpo hearts with the aim of improving the accuracy and quantitative documentation of pathologic and forensic diagnoses of coronary artery disease (CAD). Hearts were perfused by introducing a new oily or synthetic resin, or using both contrast materials successively. Then the perfused organs were processed for imaging. Detailed angiographic analysis enabled us to localize, map and quantify coronary calcifications, stenoses, and to characterize the types of atherosclerotic plaques. Significant early or late complications of widely used percutaneous coronary interventions (PCI) and coronary bypass surgery (CABS) co...
Orvosi Hetilap, 2008
Because of the long waiting time for pediatric liver transplantation, new techniques of liver tra... more Because of the long waiting time for pediatric liver transplantation, new techniques of liver transplantion were invented. Split and living-donor related liver transplantation are common today and the Kaplan–Meier (3 years) overall survival is over 80%. By splitting the liver, two recipients can be transplanted. In general, the left lobe is used for the pediatric, the right lobe for the adult recipient. There are a lot of combinations depending on the donor and recipient weight. The accepted liver volume is approx. 1% of the recipient body weight. The results of the Hungarian pediatric program improve, 27 transplantations were done using 14 partial liver grafts and living donor program was started. Using strict protocols and improving surgical skills, the overall pediatric survival was over 80% in the last 5 years.
Forensic Science International, 2007
We have firstly presented a case using post mortem corrosive method in forensic medical practice ... more We have firstly presented a case using post mortem corrosive method in forensic medical practice after coronary stent implantation. Occlusions, fate of side branches could be detected during the clinical diagnostic angiography, intravascular ultrasound, computed tomography; however, the forensic medical determination of cause of death, identification of complications needs a careful post-mortem investigation. The injection-corrosive method seems to be a useful assistance in the characterisation of pathomorphological changes after stent implantation. Besides the classical techniques of histology, immunohistochemistry, electron microscopic investigation we have introduced a new synthetic resin corrosion cast method. This three-dimensional corrosion cast preparation may provide new data about the actual morphological condition of the coronary vessels and a better understanding of the pathomechanisms of sudden cardiac death after percutaneous coronary intervention.
Legal medicine (Tokyo, Japan), 2014
A careful post-mortem investigation is needed to determine the cause of death of patients bearing... more A careful post-mortem investigation is needed to determine the cause of death of patients bearing coronary stents and to describe complications of stent implantation. The main purpose of this study was to combine post mortem methods of CT angiography and corrosion cast preparation for the visualization of coronary stenoses, coronary stents, instent restenosis, and stent occlusion. Injection-corrosion method was combined with post-mortem MSCT angiography to characterize the pathomorphological changes after stent implantation in 6 male cadaver hearts. Multi-slice computed tomography was employed to visualize the coronary artery system. For image post processing, multiplanar reconstructions, maximal intensity projections and three dimensional reconstructions were used. This study was assessing the feasibility of post mortem MSCT for intracoronary stent evaluation. We described a method for characterization of the coronary side branch stenosis caused by stent implantation. Post mortem C...
Surgery Today, 2013
Rats are the most commonly used animal model for studies of acute lower limb ischemia-reperfusion... more Rats are the most commonly used animal model for studies of acute lower limb ischemia-reperfusion. The ischemia induced by arterial clamping may cause milder damage than the application of a tourniquet if the presence of a possible collateral system is considered. Male Wistar rats were randomized into three groups: in group A, the muscle weight affected by ischemia was measured; in group B, the severity of muscle damage caused by the application of a tourniquet and by infrarenal aortic occlusion was examined. Blood and muscle samples were taken from group B to assess the serum necroenzyme, potassium and TNF-α levels, as well as the muscle fiber viability and for histological examinations. In group C, the identification of the lower limb collateral system was performed using corrosion casting. Tourniquet application affected the lower muscle mass and resulted in significantly more severe injury compared to infrarenal aortic occlusion. This difference was reflected in the serum necroenzyme, potassium and TNF-α levels. The histological examination and viability assay confirmed these findings. The corrosion casts showed several anastomoses capable of supplying the lower limb. Tourniquet application proved to be capable of inducing absolute lower limb ischemia, in contrast to infrarenal aortic ligation, where a rich collateral system is considered to help mitigate the injury.
Orvosi Hetilap, 2008
Because of the long waiting time for pediatric liver transplantation, new techniques of liver tra... more Because of the long waiting time for pediatric liver transplantation, new techniques of liver transplantation were invented. Split and living-donor related liver transplantation are common today and the Kaplan-Meier (3 years) overall survival is over 80%. By splitting the liver, two recipients can be transplanted. In general, the left lobe is used for the pediatric, the right lobe for the adult recipient. There are a lot of combinations depending on the donor and recipient weight. The accepted liver volume is approx. 1% of the recipient body weight. The results of the Hungarian pediatric program improve, 27 transplantations were done using 14 partial liver grafts and living donor program was started. Using strict protocols and improving surgical skills, the overall pediatric survival was over 80% in the last 5 years.
European Journal of Surgical Oncology, 2019
European Journal of Surgical Oncology, 2019
Journal of hepatology, Aug 1, 2017
Journal of hepatology, Apr 29, 2016
In advanced cirrhosis new hepatocytic nodules are generated by budding of ductules in areas of pa... more In advanced cirrhosis new hepatocytic nodules are generated by budding of ductules in areas of parenchymal extinction. However, the vascular alterations in the areas of parenchymal extinction, the blood supply and the structure of the new hepatocytic nodules have not been analyzed in detail. Explanted human cirrhotic livers of three different etiologies and two experimental models of cirrhosis in rats were examined thoroughly. 3D reconstruction of the immunohistochemically stained serial sections and casting of human and experimental cirrhotic livers have been used to reveal the structural organization of the regenerative buds. In areas of parenchymal extinction the skeleton of the liver, the portal tree is preserved. The developing regenerative nodules are positioned along the portal tree and are supplied directly by terminal portal venules. The expanding nodules grow along the trunks of the portal vein. Casting of human and experimental cirrhotic livers by colored resin confirms t...
HPB, 2016
arterial branch thrombosis (1 early, 1 late) requiring anticoagulation. Other morbidity included ... more arterial branch thrombosis (1 early, 1 late) requiring anticoagulation. Other morbidity included collection (n = 2) and graft pancreatitis (n = 1). All grafts were functioning at a median follow up of 15 months (range 10e21) and all patients were insulin independent. Conclusions: Our data suggests luminal narrowing of all arteries associated with the pancreatic allograft without any corresponding changes in the renal arteries. This does not appear to impact on short term graft function. It is difficult to determine whether this remodelling process directly contributes to the development of vascular pathology. Therefore further studies should be performed to discover whether this phenomenon is detrimental in the long-term, and to determine if therapeutic intervention is required.
HPB, 2016
to the individual risk. Results: Between 2008 and 2014, 98 patients were candidates to IAT. 54 pa... more to the individual risk. Results: Between 2008 and 2014, 98 patients were candidates to IAT. 54 patients finally received IAT, while the remaining patients did not for a variety of factors (unmet intraoperative requirements, isolation failure/contamination, unstable patients, refusal or other). Control group was made of the remaining patients + further 17 patients with predicted high-risk anastomosis who entered a randomized study but were not randomized to IAT. Early IAT-related complications occurred in 8 patients (14.8%), four of these in case of completion pancreatectomy for POPF. 26/54 patients receiving IAT and 35/61 patients of the control group had malignancy. At a median follow-up of 557d, in the IAT group, relapse was observed in 4/22 patients that were disease-free after surgery (18.2%), and only 2 patients developed new liver metastases (9.1%). In the control group, relapse was observed in 13 patients (40.6%) of whom 7 developed new liver metastases (21.9%). At last follow-up, insulin independency was present in 45% of patients undergoing IAT and further 35% showed partial graft function. Conclusions: IAT can be performed with acceptable safety profile in selected patients with malignancy.
Transplant International, 2015
Pediatric transplantation, Jan 23, 2015
Multiple duct anastomoses during LLS transplantation increase the incidence of biliary complicati... more Multiple duct anastomoses during LLS transplantation increase the incidence of biliary complications. The optimal plane of hepatotomy that results in the least number of bile ducts at the surface was investigated according to LHD variations. Ducts of 30 human livers were injected with resin and LHD branching on 3D-CT reconstructions were analyzed. Ducts on the virtual hepatotomy surface were estimated in three splitting lines. Variations with subtypes were described. Ia (66.7%): ducts from segments (S.) II-III form a common trunk and S.IV duct joins it. Ib (10%): common trunk formed by ducts from S.II-S.III while S.IV duct joins the common hepatic duct. IIa (16.67%): S.IV duct drains into S.III duct. IIc (3.33%): S.IV duct drains into both S.II and S.III ducts. III (3.33%): trifurcation of S.II, S.III and S.IV ducts. When the virtual hepatotomy line was on the FL, there was a single duct for the anastomosis in 30% of cases but two, three, or four ducts in 53.3%, 10%, and 3.3%, respe...
Interventional Medicine and Applied Science, 2009
In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for f... more In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for forensic and pathologic examination. However, classical dissection remains dominant in everyday practice. Lack of quantifiable data on the coronary system has become a disadvantageous attribute of traditional autopsy. Therefore, post mortem MSCT angiography was performed in 80 ex corpo hearts with the aim of improving the accuracy and quantitative documentation of pathologic and forensic diagnoses of coronary artery disease (CAD). Hearts were perfused by introducing a new oily or synthetic resin, or using both contrast materials successively. Then the perfused organs were processed for imaging. Detailed angiographic analysis enabled us to localize, map and quantify coronary calcifications, stenoses, and to characterize the types of atherosclerotic plaques. Significant early or late complications of widely used percutaneous coronary interventions (PCI) and coronary bypass surgery (CABS) co...
Orvosi Hetilap, 2008
Because of the long waiting time for pediatric liver transplantation, new techniques of liver tra... more Because of the long waiting time for pediatric liver transplantation, new techniques of liver transplantion were invented. Split and living-donor related liver transplantation are common today and the Kaplan–Meier (3 years) overall survival is over 80%. By splitting the liver, two recipients can be transplanted. In general, the left lobe is used for the pediatric, the right lobe for the adult recipient. There are a lot of combinations depending on the donor and recipient weight. The accepted liver volume is approx. 1% of the recipient body weight. The results of the Hungarian pediatric program improve, 27 transplantations were done using 14 partial liver grafts and living donor program was started. Using strict protocols and improving surgical skills, the overall pediatric survival was over 80% in the last 5 years.
Forensic Science International, 2007
We have firstly presented a case using post mortem corrosive method in forensic medical practice ... more We have firstly presented a case using post mortem corrosive method in forensic medical practice after coronary stent implantation. Occlusions, fate of side branches could be detected during the clinical diagnostic angiography, intravascular ultrasound, computed tomography; however, the forensic medical determination of cause of death, identification of complications needs a careful post-mortem investigation. The injection-corrosive method seems to be a useful assistance in the characterisation of pathomorphological changes after stent implantation. Besides the classical techniques of histology, immunohistochemistry, electron microscopic investigation we have introduced a new synthetic resin corrosion cast method. This three-dimensional corrosion cast preparation may provide new data about the actual morphological condition of the coronary vessels and a better understanding of the pathomechanisms of sudden cardiac death after percutaneous coronary intervention.
Legal medicine (Tokyo, Japan), 2014
A careful post-mortem investigation is needed to determine the cause of death of patients bearing... more A careful post-mortem investigation is needed to determine the cause of death of patients bearing coronary stents and to describe complications of stent implantation. The main purpose of this study was to combine post mortem methods of CT angiography and corrosion cast preparation for the visualization of coronary stenoses, coronary stents, instent restenosis, and stent occlusion. Injection-corrosion method was combined with post-mortem MSCT angiography to characterize the pathomorphological changes after stent implantation in 6 male cadaver hearts. Multi-slice computed tomography was employed to visualize the coronary artery system. For image post processing, multiplanar reconstructions, maximal intensity projections and three dimensional reconstructions were used. This study was assessing the feasibility of post mortem MSCT for intracoronary stent evaluation. We described a method for characterization of the coronary side branch stenosis caused by stent implantation. Post mortem C...
Surgery Today, 2013
Rats are the most commonly used animal model for studies of acute lower limb ischemia-reperfusion... more Rats are the most commonly used animal model for studies of acute lower limb ischemia-reperfusion. The ischemia induced by arterial clamping may cause milder damage than the application of a tourniquet if the presence of a possible collateral system is considered. Male Wistar rats were randomized into three groups: in group A, the muscle weight affected by ischemia was measured; in group B, the severity of muscle damage caused by the application of a tourniquet and by infrarenal aortic occlusion was examined. Blood and muscle samples were taken from group B to assess the serum necroenzyme, potassium and TNF-α levels, as well as the muscle fiber viability and for histological examinations. In group C, the identification of the lower limb collateral system was performed using corrosion casting. Tourniquet application affected the lower muscle mass and resulted in significantly more severe injury compared to infrarenal aortic occlusion. This difference was reflected in the serum necroenzyme, potassium and TNF-α levels. The histological examination and viability assay confirmed these findings. The corrosion casts showed several anastomoses capable of supplying the lower limb. Tourniquet application proved to be capable of inducing absolute lower limb ischemia, in contrast to infrarenal aortic ligation, where a rich collateral system is considered to help mitigate the injury.
Orvosi Hetilap, 2008
Because of the long waiting time for pediatric liver transplantation, new techniques of liver tra... more Because of the long waiting time for pediatric liver transplantation, new techniques of liver transplantation were invented. Split and living-donor related liver transplantation are common today and the Kaplan-Meier (3 years) overall survival is over 80%. By splitting the liver, two recipients can be transplanted. In general, the left lobe is used for the pediatric, the right lobe for the adult recipient. There are a lot of combinations depending on the donor and recipient weight. The accepted liver volume is approx. 1% of the recipient body weight. The results of the Hungarian pediatric program improve, 27 transplantations were done using 14 partial liver grafts and living donor program was started. Using strict protocols and improving surgical skills, the overall pediatric survival was over 80% in the last 5 years.