Thuthi Mohan | Sri Ramachandra University (original) (raw)

Papers by Thuthi Mohan

Biomedical and Pharmacology Journal, 2021

Periodontitis is a common multifactorial inflammatory disease with gradual loss of supportive tis... more Periodontitis is a common multifactorial inflammatory disease with gradual loss of supportive tissues around the teeth which eventually leads to decrease in the quality of life. Blocking Interleukin-6 (IL-6), a multifunctional cytokine with pro-inflammatory properties has demonstrated therapeutic efficacy in inflammatory diseases like Rheumatoid arthritis, SLE and multiple sclerosis. Host immune response, the underlying cause for this progressive disease is targeted by Host modulatory therapy (HMT), an emerging treatment modality. Omega-3 polyunsaturated fatty acids (ώ 3 PUFAs), one of the relatively safe HMTs, reduces tissue destruction, stabilizes or even regenerates the periodontium through its anti-inflammatory & immunoregulatory properties. ώ 3 PUFAs are essential for the synthesis of eicosanoids which are involved in anti-inflammatory, antiplatelet aggregatory, vasodilation, vasoconstriction, immune response, cell growth and proliferation. The key factor examined and extrapola...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Background: There is a growing concern about the high prevalence of vitamin D deficiency and its ... more Background: There is a growing concern about the high prevalence of vitamin D deficiency and its relationship with variety of diseases worldwide. The objective of this study was to determine the prevalence of vitamin D deficiency and its association with pregnancy outcome.Methods: This was a cross sectional study conducted among 150 antenatal women from October 2014 to April 2015. Data containing socio-demographic details, vitamin D level, serum calcium, pregnancy complications and growth situation of newborns were collected and analyzed.Results: A total 150 pregnant women participated in the study, 75.3% were vitamin D deficient, 22.1% vitamin D insufficient and 2.6% normal. There was no significant adverse maternal outcome. NICU admission was required in 28.3 and 15.2% in the vitamin D deficient and insufficient groups respectively.Conclusions: Women from different socioeconomic status, irrespective of parity and educational levels had vitamin D deficiency and insufficiency. This ...

Indian journal of Medical Biochemistry

Introduction Measured total carbon dioxide (TCO2) from venous sample and calculated bicarbonate f... more Introduction Measured total carbon dioxide (TCO2) from venous sample and calculated bicarbonate from arterial blood gas (ABG) have shown good agreement in some studies, while conflicting results have been obtained in few other studies. The objective of this study is to compare and assess the degree of agreement between the measured TCO2 and calculated bicarbonate and also whether they can be used interchangeably in our laboratory. Materials and methods We prospectively analyzed 89 ABG samples requested for calculated bicarbonate and then measured TCO2 from venous blood samples drawn simultaneously from the same participants between November 2016 and April 2017. Results Measured TCO2 results ranged from 5.7 to 39.9 mmol/L (mean 23.45 mmol/L), while calculated bicarbonate ranged from 9 to 40 mmol/L (mean 24.36 mmol/L). The values of TCO2 and bicarbonate correlated well (r = 0.95, p < 0.001), with the correlation given by the equation, y = 0.884x + 3.605. The bias obtained was —0.9 ...

Journal of laboratory physicians

Six Sigma is one of the most popular quality management system tools employed for process improve... more Six Sigma is one of the most popular quality management system tools employed for process improvement. The Six Sigma methods are usually applied when the outcome of the process can be measured. This study was done to assess the performance of individual biochemical parameters on a Sigma Scale by calculating the sigma metrics for individual parameters and to follow the Westgard guidelines for appropriate Westgard rules and levels of internal quality control (IQC) that needs to be processed to improve target analyte performance based on the sigma metrics. This is a retrospective study, and data required for the study were extracted between July 2015 and June 2016 from a Secondary Care Government Hospital, Chennai. The data obtained for the study are IQC - coefficient of variation percentage and External Quality Assurance Scheme (EQAS) - Bias% for 16 biochemical parameters. For the level 1 IQC, four analytes (alkaline phosphatase, magnesium, triglyceride, and high-density lipoprotein-c...

International Journal of Contemporary Pediatrics

Background: Childhood asthma appears to be increasing in prevalence despite advancements in the c... more Background: Childhood asthma appears to be increasing in prevalence despite advancements in the care of asthma. In asthma, local as well as systemic inflammation contributes to the pathogenesis. Thus successful management depends on controlling this inflammation by appropriate doses of inhaled corticosteroids. High sensitivity C reactive protein (hsCRP) is an easily measurable marker of inflammation and its level can be used as a diagnostic tool in assessing control of asthma. The objective of this study was study the correlation of serum hsCRP levels with asthma control in childrenMethods: It is an observational study conducted in the Pediatric asthma clinic of a Government Medical College in south India. The study population consisted of 75 asthmatic children aged 5-15 years. Children with persistent asthma were classified into three groups based on GINA guidelines. Serum hsCRP levels were measured in all the three groups.Results: Among the 75 children 33% belonged to controlled g...

Journal of clinical and diagnostic research : JCDR, 2017

The assessment of Glomerular Filtration Rate (GFR) is essential for clinical practice in assessin... more The assessment of Glomerular Filtration Rate (GFR) is essential for clinical practice in assessing kidney function, drug dosing, detecting and estimating the prognosis of Chronic Kidney Disease (CKD). The most common practical method for assessing GFR is performed with a 24 hour/timed urine collection for creatinine clearance evaluation. The estimation of eGFR by creatinine based formulae is known to be a rapid and reliable means of approximation of creatinine clearance. To compare eGFR using three commonly used Formulae {Modification of Diet in Renal Disease Study Equation (MDRD 2006), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2009) and Cockcroft-Gault Formula} with 24 hour creatinine clearance and to identify which amongst the 3 formulae for eGFR closely correlates with 24 hour creatinine clearance in a secondary care hospital. We retrospectively collected laboratory data requested for 24 hour creatinine clearance in the period from January 2014 to August 2016. To...

Biomedical and Pharmacology Journal, 2021

Periodontitis is a common multifactorial inflammatory disease with gradual loss of supportive tis... more Periodontitis is a common multifactorial inflammatory disease with gradual loss of supportive tissues around the teeth which eventually leads to decrease in the quality of life. Blocking Interleukin-6 (IL-6), a multifunctional cytokine with pro-inflammatory properties has demonstrated therapeutic efficacy in inflammatory diseases like Rheumatoid arthritis, SLE and multiple sclerosis. Host immune response, the underlying cause for this progressive disease is targeted by Host modulatory therapy (HMT), an emerging treatment modality. Omega-3 polyunsaturated fatty acids (ώ 3 PUFAs), one of the relatively safe HMTs, reduces tissue destruction, stabilizes or even regenerates the periodontium through its anti-inflammatory & immunoregulatory properties. ώ 3 PUFAs are essential for the synthesis of eicosanoids which are involved in anti-inflammatory, antiplatelet aggregatory, vasodilation, vasoconstriction, immune response, cell growth and proliferation. The key factor examined and extrapola...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Background: There is a growing concern about the high prevalence of vitamin D deficiency and its ... more Background: There is a growing concern about the high prevalence of vitamin D deficiency and its relationship with variety of diseases worldwide. The objective of this study was to determine the prevalence of vitamin D deficiency and its association with pregnancy outcome.Methods: This was a cross sectional study conducted among 150 antenatal women from October 2014 to April 2015. Data containing socio-demographic details, vitamin D level, serum calcium, pregnancy complications and growth situation of newborns were collected and analyzed.Results: A total 150 pregnant women participated in the study, 75.3% were vitamin D deficient, 22.1% vitamin D insufficient and 2.6% normal. There was no significant adverse maternal outcome. NICU admission was required in 28.3 and 15.2% in the vitamin D deficient and insufficient groups respectively.Conclusions: Women from different socioeconomic status, irrespective of parity and educational levels had vitamin D deficiency and insufficiency. This ...

Indian journal of Medical Biochemistry

Introduction Measured total carbon dioxide (TCO2) from venous sample and calculated bicarbonate f... more Introduction Measured total carbon dioxide (TCO2) from venous sample and calculated bicarbonate from arterial blood gas (ABG) have shown good agreement in some studies, while conflicting results have been obtained in few other studies. The objective of this study is to compare and assess the degree of agreement between the measured TCO2 and calculated bicarbonate and also whether they can be used interchangeably in our laboratory. Materials and methods We prospectively analyzed 89 ABG samples requested for calculated bicarbonate and then measured TCO2 from venous blood samples drawn simultaneously from the same participants between November 2016 and April 2017. Results Measured TCO2 results ranged from 5.7 to 39.9 mmol/L (mean 23.45 mmol/L), while calculated bicarbonate ranged from 9 to 40 mmol/L (mean 24.36 mmol/L). The values of TCO2 and bicarbonate correlated well (r = 0.95, p < 0.001), with the correlation given by the equation, y = 0.884x + 3.605. The bias obtained was —0.9 ...

Journal of laboratory physicians

Six Sigma is one of the most popular quality management system tools employed for process improve... more Six Sigma is one of the most popular quality management system tools employed for process improvement. The Six Sigma methods are usually applied when the outcome of the process can be measured. This study was done to assess the performance of individual biochemical parameters on a Sigma Scale by calculating the sigma metrics for individual parameters and to follow the Westgard guidelines for appropriate Westgard rules and levels of internal quality control (IQC) that needs to be processed to improve target analyte performance based on the sigma metrics. This is a retrospective study, and data required for the study were extracted between July 2015 and June 2016 from a Secondary Care Government Hospital, Chennai. The data obtained for the study are IQC - coefficient of variation percentage and External Quality Assurance Scheme (EQAS) - Bias% for 16 biochemical parameters. For the level 1 IQC, four analytes (alkaline phosphatase, magnesium, triglyceride, and high-density lipoprotein-c...

International Journal of Contemporary Pediatrics

Background: Childhood asthma appears to be increasing in prevalence despite advancements in the c... more Background: Childhood asthma appears to be increasing in prevalence despite advancements in the care of asthma. In asthma, local as well as systemic inflammation contributes to the pathogenesis. Thus successful management depends on controlling this inflammation by appropriate doses of inhaled corticosteroids. High sensitivity C reactive protein (hsCRP) is an easily measurable marker of inflammation and its level can be used as a diagnostic tool in assessing control of asthma. The objective of this study was study the correlation of serum hsCRP levels with asthma control in childrenMethods: It is an observational study conducted in the Pediatric asthma clinic of a Government Medical College in south India. The study population consisted of 75 asthmatic children aged 5-15 years. Children with persistent asthma were classified into three groups based on GINA guidelines. Serum hsCRP levels were measured in all the three groups.Results: Among the 75 children 33% belonged to controlled g...

Journal of clinical and diagnostic research : JCDR, 2017

The assessment of Glomerular Filtration Rate (GFR) is essential for clinical practice in assessin... more The assessment of Glomerular Filtration Rate (GFR) is essential for clinical practice in assessing kidney function, drug dosing, detecting and estimating the prognosis of Chronic Kidney Disease (CKD). The most common practical method for assessing GFR is performed with a 24 hour/timed urine collection for creatinine clearance evaluation. The estimation of eGFR by creatinine based formulae is known to be a rapid and reliable means of approximation of creatinine clearance. To compare eGFR using three commonly used Formulae {Modification of Diet in Renal Disease Study Equation (MDRD 2006), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2009) and Cockcroft-Gault Formula} with 24 hour creatinine clearance and to identify which amongst the 3 formulae for eGFR closely correlates with 24 hour creatinine clearance in a secondary care hospital. We retrospectively collected laboratory data requested for 24 hour creatinine clearance in the period from January 2014 to August 2016. To...