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Research paper thumbnail of A Review on Granulation of Trikuta Churna

Research Journal of Pharmacognosy and Phytochemistry

The objective of this work is the conversion of trikutachurna into stable, palatable and patient ... more The objective of this work is the conversion of trikutachurna into stable, palatable and patient acceptable granules to swallow conveniently by wet granulation method, using suitable binding agents. In Trikuta as essential ingredients of numerous prescription and formulations used for wide range of disorders. Ayurvedic system of medicine prescribes Trikatu for the management of tastelessness (Arocaka) disturbed digestion (Agnimandya and Amadosa), diseases of nose (Pinasa) and upper respiratory tract (Gala and swasaroga, Kasa), excess and frequent urination (Meha), edema (Gulma), obesity (Sthaulya), Filariasis (Slipada), and skin diseases (Tvakroga). Trikatu acts primarily by its effect on stomach, liver, and pancreas. In stomach, it increases production of digestive juices thereby stimulating digestion. In liver, it acts as Cholagogue and increases production of bile salts by stimulating gallbladder functioning. Trikatu also has its influence on pancreatic functioning.

Research paper thumbnail of Formulation and Evaluation of Nano Particulate Drug Delivery System for an Effective Treatment of Acne

International Journal of Pharmacy Research & Technology, 2019

The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (N... more The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (Nanostructured Lipid Carrier) for the treatment of Acne. The nanostructured lipid carrier was prepared by high speed and high pressure homogenizer by using different types of solid lipid, liquid lipid and concentration of surfactants. The NLC was characterized by particle size, zeta potential, polydispersity index. Stearic acid and oleic acid were used as solid lipid and liquid lipid and Pluronic F-68 was used as surfactant. The drug excipient compatibility study was performed by Fourier transform infrared spectrophotometer and the result revealed that all the excipients and drugs were compatible with each other. For the drug estimation HPLC method was developed for the combined drug Clindamycin phosphate and Nicotinamide. Formulation of nanoemulsion was prepared by high speed and high pressure homogenization technique. This emulsion was incorporated into the gel which was prepared by using Carbopol 934P as gel base and evaluated for the In-vitro release. Factorial design was used for the evaluation and optimization of the nanoparticles. Short term stability study was performed for 30 days and there was no significant change in consistency, pH and viscosity

Research paper thumbnail of Correspondence to Author

www.ijpsr.com Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitac... more www.ijpsr.com Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice and to cure certain liver disorders. Antioxidants are well known for their hepatoprotective effect and in curing liver disorders. In this study, hepatoprotective and antioxidant effects of fruits were investigated. Materials and Methods: The coarsely powdered plant material was extracted successively with petroleum ether (PE) and ethanol (ETH) using soxhlet. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively. Hepatoprotective activity was evaluated at three oral dose levels of 250, 500 and 1000 mg/kg. Results: Both extracts, PE and ETH exhibited a significant hepatoprotective and antioxidant activity. The ETH (1000 mg/kg) showed maximum hepatoprotection.

Research paper thumbnail of PHYTOCHEMICAL STUDY ON SESBANIA SESBAN ISOLATED PHYTOCONSTITUENTS FOR IN-VIVO ANTI-INFLAMMATORY AND IN-VITRO ANTIOXIDANT and ANTICANCER ACTIVITY

Journal of Complementary Medicine Research

Research paper thumbnail of Identification of Parasitic Cysteine Protease Inhibitors using Analog Design , Molecular Docking and Molecular Dynamics Studies

In this study, de novo analogue design approach was adopted to find out novel chemical entities f... more In this study, de novo analogue design approach was adopted to find out novel chemical entities for the inhibition of cysteine protease falcipain-2 protein for Plasmodium falciparum. In this purpose a set 34 cysteine protease falcipain-2 protein inhibitors were collected from the literature and molecular docking performed. High binding energy complexes were used for analogue design in e-LEA3D: Chem Informatic Tools and Databases (http://chemoinfo.ipmc.cnrs.fr/eDESIGN/index.html). Best twelve analogues were selected from a number designed analogues based on dock score and binding interactions. Further, the drug likeness properties were analyzed and found that all selected analogues have potential being antimalarial drug against cysteine protease falcipain-2. The root means square deviation (RMSD) and root means square fluctuation (RMSF) from the molecular dynamics simulation clearly indicated that selected analogues were formed stable complex with the cysteine protease falcipain2. Th...

Research paper thumbnail of Stability Indicating Method Development and Validation for Valacyclovir in Bulk and Tablet Dosage Form by Rp-Hplc

Journal of Complementary Medicine Research

Research paper thumbnail of In Vitro Anthelmintic Activity of Bark Extract of Ficus Glomerata Roxb. Against Eudrilus Eugeniae

INDIAN DRUGS

The present study was undertaken to evaluate anthelmintic activity of ethanolic and aqueous bark ... more The present study was undertaken to evaluate anthelmintic activity of ethanolic and aqueous bark extracts of Ficus glomerata against Eudrilus eugeniae. For this study, we used various concentrations (25-100 mg/mL) of aqueous and ethanolic extracts and these were evaluated in the bioassay involving determination of time of paralysis (P) and time of death (D) of the worms. Albendazole was used as standard anthelmintic drug and distilled water was used as control. The results of present study indicate that the ethanolic and aqueous extracts significantly exhibited paralysis (P<0.01) in worms in lower doses (25, 50 and 100 mg/mL) and also caused death of worms, especially at higher concentration of 100 mg/mL, as compared to standard drug.

Research paper thumbnail of In Vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal

Archives of Pharmacal Research, 2008

... possess anti-diabetic and antiallergic activities (Jung et al., 2007; Lee et al., 2006). Vari... more ... possess anti-diabetic and antiallergic activities (Jung et al., 2007; Lee et al., 2006). Various flavonoids, sterols, and a lot of volatile chemicals were isolated from the aerial parts of A. princeps Pamp. (Bang et al., 2005, 2006; Umano et al., 2000). ... cv. Sajabal (Bang et al., 2005). ...

Research paper thumbnail of Pharmacognostic studies of Lagenaria siceraria (Molina) standley fruits

Pharmacognosy Journal, 2014

Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in I... more Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in Indian traditional medicine for its various medicinal values. As per best of our knowledge there were no pharmacognostical reports, specifically to determine anatomical and other physicochemical standards required for its standardization. Material and Methods: In this study various standardization parameters like macroscopic and microscopic studies, physicochemical constants, extractive values and preliminary phytochemical screening were studied and reported. Results: Different standardization parameters were reported, which would be of immense use to identify and establish the authenticity of the plant. Conclusion: Preliminary pharmacognostic evaluation of Lagenaria siceraria fruits can give some useful information, which will be further used for standardization.

Research paper thumbnail of Pharmacognostic studies of the Lagenaria siceraria (Molina) standley

International Journal of PharmTech Research, 2010

Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in I... more Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in Indian traditional medicine for its various medicinal values. As per best of our knowledge there were no pharmacognostical reports, specifically to determine anatomical and other physicochemical standards required for its standardization. Material and Methods: In this study various standardization parameters like macroscopic and microscopic studies, physicochemical constants, extractive values and preliminary phytochemical screening were studied and reported. Results: Different standardization parameters were reported, which would be of immense use to identify and establish the authenticity of the plant. Conclusion: Preliminary pharmacognostic evaluation of Lagenaria siceraria fruits can give some useful information, which will be further used for standardization.

Research paper thumbnail of A Review on Granulation of Trikuta Churna

Research Journal of Pharmacognosy and Phytochemistry

The objective of this work is the conversion of trikutachurna into stable, palatable and patient ... more The objective of this work is the conversion of trikutachurna into stable, palatable and patient acceptable granules to swallow conveniently by wet granulation method, using suitable binding agents. In Trikuta as essential ingredients of numerous prescription and formulations used for wide range of disorders. Ayurvedic system of medicine prescribes Trikatu for the management of tastelessness (Arocaka) disturbed digestion (Agnimandya and Amadosa), diseases of nose (Pinasa) and upper respiratory tract (Gala and swasaroga, Kasa), excess and frequent urination (Meha), edema (Gulma), obesity (Sthaulya), Filariasis (Slipada), and skin diseases (Tvakroga). Trikatu acts primarily by its effect on stomach, liver, and pancreas. In stomach, it increases production of digestive juices thereby stimulating digestion. In liver, it acts as Cholagogue and increases production of bile salts by stimulating gallbladder functioning. Trikatu also has its influence on pancreatic functioning.

Research paper thumbnail of Formulation and Evaluation of Nano Particulate Drug Delivery System for an Effective Treatment of Acne

International Journal of Pharmacy Research & Technology, 2019

The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (N... more The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (Nanostructured Lipid Carrier) for the treatment of Acne. The nanostructured lipid carrier was prepared by high speed and high pressure homogenizer by using different types of solid lipid, liquid lipid and concentration of surfactants. The NLC was characterized by particle size, zeta potential, polydispersity index. Stearic acid and oleic acid were used as solid lipid and liquid lipid and Pluronic F-68 was used as surfactant. The drug excipient compatibility study was performed by Fourier transform infrared spectrophotometer and the result revealed that all the excipients and drugs were compatible with each other. For the drug estimation HPLC method was developed for the combined drug Clindamycin phosphate and Nicotinamide. Formulation of nanoemulsion was prepared by high speed and high pressure homogenization technique. This emulsion was incorporated into the gel which was prepared by using Carbopol 934P as gel base and evaluated for the In-vitro release. Factorial design was used for the evaluation and optimization of the nanoparticles. Short term stability study was performed for 30 days and there was no significant change in consistency, pH and viscosity

Research paper thumbnail of Correspondence to Author

www.ijpsr.com Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitac... more www.ijpsr.com Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice and to cure certain liver disorders. Antioxidants are well known for their hepatoprotective effect and in curing liver disorders. In this study, hepatoprotective and antioxidant effects of fruits were investigated. Materials and Methods: The coarsely powdered plant material was extracted successively with petroleum ether (PE) and ethanol (ETH) using soxhlet. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively. Hepatoprotective activity was evaluated at three oral dose levels of 250, 500 and 1000 mg/kg. Results: Both extracts, PE and ETH exhibited a significant hepatoprotective and antioxidant activity. The ETH (1000 mg/kg) showed maximum hepatoprotection.

Research paper thumbnail of PHYTOCHEMICAL STUDY ON SESBANIA SESBAN ISOLATED PHYTOCONSTITUENTS FOR IN-VIVO ANTI-INFLAMMATORY AND IN-VITRO ANTIOXIDANT and ANTICANCER ACTIVITY

Journal of Complementary Medicine Research

Research paper thumbnail of Identification of Parasitic Cysteine Protease Inhibitors using Analog Design , Molecular Docking and Molecular Dynamics Studies

In this study, de novo analogue design approach was adopted to find out novel chemical entities f... more In this study, de novo analogue design approach was adopted to find out novel chemical entities for the inhibition of cysteine protease falcipain-2 protein for Plasmodium falciparum. In this purpose a set 34 cysteine protease falcipain-2 protein inhibitors were collected from the literature and molecular docking performed. High binding energy complexes were used for analogue design in e-LEA3D: Chem Informatic Tools and Databases (http://chemoinfo.ipmc.cnrs.fr/eDESIGN/index.html). Best twelve analogues were selected from a number designed analogues based on dock score and binding interactions. Further, the drug likeness properties were analyzed and found that all selected analogues have potential being antimalarial drug against cysteine protease falcipain-2. The root means square deviation (RMSD) and root means square fluctuation (RMSF) from the molecular dynamics simulation clearly indicated that selected analogues were formed stable complex with the cysteine protease falcipain2. Th...

Research paper thumbnail of Stability Indicating Method Development and Validation for Valacyclovir in Bulk and Tablet Dosage Form by Rp-Hplc

Journal of Complementary Medicine Research

Research paper thumbnail of In Vitro Anthelmintic Activity of Bark Extract of Ficus Glomerata Roxb. Against Eudrilus Eugeniae

INDIAN DRUGS

The present study was undertaken to evaluate anthelmintic activity of ethanolic and aqueous bark ... more The present study was undertaken to evaluate anthelmintic activity of ethanolic and aqueous bark extracts of Ficus glomerata against Eudrilus eugeniae. For this study, we used various concentrations (25-100 mg/mL) of aqueous and ethanolic extracts and these were evaluated in the bioassay involving determination of time of paralysis (P) and time of death (D) of the worms. Albendazole was used as standard anthelmintic drug and distilled water was used as control. The results of present study indicate that the ethanolic and aqueous extracts significantly exhibited paralysis (P<0.01) in worms in lower doses (25, 50 and 100 mg/mL) and also caused death of worms, especially at higher concentration of 100 mg/mL, as compared to standard drug.

Research paper thumbnail of In Vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal

Archives of Pharmacal Research, 2008

... possess anti-diabetic and antiallergic activities (Jung et al., 2007; Lee et al., 2006). Vari... more ... possess anti-diabetic and antiallergic activities (Jung et al., 2007; Lee et al., 2006). Various flavonoids, sterols, and a lot of volatile chemicals were isolated from the aerial parts of A. princeps Pamp. (Bang et al., 2005, 2006; Umano et al., 2000). ... cv. Sajabal (Bang et al., 2005). ...

Research paper thumbnail of Pharmacognostic studies of Lagenaria siceraria (Molina) standley fruits

Pharmacognosy Journal, 2014

Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in I... more Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in Indian traditional medicine for its various medicinal values. As per best of our knowledge there were no pharmacognostical reports, specifically to determine anatomical and other physicochemical standards required for its standardization. Material and Methods: In this study various standardization parameters like macroscopic and microscopic studies, physicochemical constants, extractive values and preliminary phytochemical screening were studied and reported. Results: Different standardization parameters were reported, which would be of immense use to identify and establish the authenticity of the plant. Conclusion: Preliminary pharmacognostic evaluation of Lagenaria siceraria fruits can give some useful information, which will be further used for standardization.

Research paper thumbnail of Pharmacognostic studies of the Lagenaria siceraria (Molina) standley

International Journal of PharmTech Research, 2010

Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in I... more Background: Lagenaria siceraria (LS) fruits belonging to Cucurbitaceae family is widely used in Indian traditional medicine for its various medicinal values. As per best of our knowledge there were no pharmacognostical reports, specifically to determine anatomical and other physicochemical standards required for its standardization. Material and Methods: In this study various standardization parameters like macroscopic and microscopic studies, physicochemical constants, extractive values and preliminary phytochemical screening were studied and reported. Results: Different standardization parameters were reported, which would be of immense use to identify and establish the authenticity of the plant. Conclusion: Preliminary pharmacognostic evaluation of Lagenaria siceraria fruits can give some useful information, which will be further used for standardization.