Peter Reader-harris | University of St Andrews (original) (raw)

Papers by Peter Reader-harris

Research paper thumbnail of Advanced applications of flexible metamaterials at visible frequencies

Photonic and Phononic Properties of Engineered Nanostructures V, 2015

Research paper thumbnail of A mechanically flexible free standing optical filter

ABSTRACT A flexible filter based on the principle of guided mode resonances is demonstrated, oper... more ABSTRACT A flexible filter based on the principle of guided mode resonances is demonstrated, operating in the visible part of the spectrum. The filter consists of a subwavelength gold grating on top of a polymer waveguide which can be arranged to be free standing. We show the versatility of the approach by being able to produce different kinds of filter by changing the geometrical parameters. We then exploit the unique properties of our filter by wrapping it round the end of a collimated fibre output and show successful filtering.

Research paper thumbnail of SERS sensing of cancer biomarkers

ABSTRACT In this work, we establish the use a SERS biosensor based on gold fishnet as a label-fre... more ABSTRACT In this work, we establish the use a SERS biosensor based on gold fishnet as a label-free analytical technique for direct detection of glycerophosphoinositol (GroPIns). Here we demonstrate that with our approach we can quantitatively determine low concentration of GroPIns (200 nM) in multicomponent mixtures, with a high accuracy (up to 6%).

Research paper thumbnail of Functional Metamaterials for Lab-on-Fiber

Springer Series in Surface Sciences, 2014

Research paper thumbnail of Design and applications of flexible photonic membranes

Quantum Sensing and Nanophotonic Devices XI, 2013

Research paper thumbnail of Optical guided mode resonance filter on a flexible substrate

Optics Express, 2013

We demonstrate the operation of a flexible optical filter based on guided mode resonances that op... more We demonstrate the operation of a flexible optical filter based on guided mode resonances that operates in the visible regime. The filter is fabricated on a free standing polymeric membrane of 1.3 μm thickness and we show how the geometrical design parameters of the filter determine its optical properties, and how various types of filter can be made with this scheme. To highlight the versatility and robustness of the approach, we mount a filter onto a collimated fibre output and demonstrate successful wavelength filtering.

Research paper thumbnail of Reproducible Surface-Enhanced Raman Quantification of Biomarkers in Multicomponent Mixtures

ACS Nano, 2014

Direct and quantitative detection of unlabeled glycerophosphoinositol (GroPIns), an abundant cyto... more Direct and quantitative detection of unlabeled glycerophosphoinositol (GroPIns), an abundant cytosolic phosphoinositide derivative, would allow rapid evaluation of several malignant cell transformations. Here we report label-free analysis of GroPIns via surface-enhanced Raman spectroscopy (SERS) with a sensitivity of 200 nM, well below its apparent concentration in cells. Crucially, our SERS substrates, based on lithographically defined gold nanofeatures, can be used to predict accurately the GroPIns concentration even in multicomponent mixtures, avoiding the preliminary separation of individual compounds. Our results represent a critical step toward the creation of SERS-based biosensor for rapid, label-free, and reproducible detection of specific molecules, overcoming limits of current experimental methods.

Research paper thumbnail of Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Plasmonics in Biology and Medicine XI, 2014

ABSTRACT We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithogra... more ABSTRACT We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

Research paper thumbnail of Advanced applications of flexible metamaterials at visible frequencies

Photonic and Phononic Properties of Engineered Nanostructures V, 2015

Research paper thumbnail of A mechanically flexible free standing optical filter

ABSTRACT A flexible filter based on the principle of guided mode resonances is demonstrated, oper... more ABSTRACT A flexible filter based on the principle of guided mode resonances is demonstrated, operating in the visible part of the spectrum. The filter consists of a subwavelength gold grating on top of a polymer waveguide which can be arranged to be free standing. We show the versatility of the approach by being able to produce different kinds of filter by changing the geometrical parameters. We then exploit the unique properties of our filter by wrapping it round the end of a collimated fibre output and show successful filtering.

Research paper thumbnail of SERS sensing of cancer biomarkers

ABSTRACT In this work, we establish the use a SERS biosensor based on gold fishnet as a label-fre... more ABSTRACT In this work, we establish the use a SERS biosensor based on gold fishnet as a label-free analytical technique for direct detection of glycerophosphoinositol (GroPIns). Here we demonstrate that with our approach we can quantitatively determine low concentration of GroPIns (200 nM) in multicomponent mixtures, with a high accuracy (up to 6%).

Research paper thumbnail of Functional Metamaterials for Lab-on-Fiber

Springer Series in Surface Sciences, 2014

Research paper thumbnail of Design and applications of flexible photonic membranes

Quantum Sensing and Nanophotonic Devices XI, 2013

Research paper thumbnail of Optical guided mode resonance filter on a flexible substrate

Optics Express, 2013

We demonstrate the operation of a flexible optical filter based on guided mode resonances that op... more We demonstrate the operation of a flexible optical filter based on guided mode resonances that operates in the visible regime. The filter is fabricated on a free standing polymeric membrane of 1.3 μm thickness and we show how the geometrical design parameters of the filter determine its optical properties, and how various types of filter can be made with this scheme. To highlight the versatility and robustness of the approach, we mount a filter onto a collimated fibre output and demonstrate successful wavelength filtering.

Research paper thumbnail of Reproducible Surface-Enhanced Raman Quantification of Biomarkers in Multicomponent Mixtures

ACS Nano, 2014

Direct and quantitative detection of unlabeled glycerophosphoinositol (GroPIns), an abundant cyto... more Direct and quantitative detection of unlabeled glycerophosphoinositol (GroPIns), an abundant cytosolic phosphoinositide derivative, would allow rapid evaluation of several malignant cell transformations. Here we report label-free analysis of GroPIns via surface-enhanced Raman spectroscopy (SERS) with a sensitivity of 200 nM, well below its apparent concentration in cells. Crucially, our SERS substrates, based on lithographically defined gold nanofeatures, can be used to predict accurately the GroPIns concentration even in multicomponent mixtures, avoiding the preliminary separation of individual compounds. Our results represent a critical step toward the creation of SERS-based biosensor for rapid, label-free, and reproducible detection of specific molecules, overcoming limits of current experimental methods.

Research paper thumbnail of Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Plasmonics in Biology and Medicine XI, 2014

ABSTRACT We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithogra... more ABSTRACT We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.