Soran omed سۆران ئومێد | University of Sulaimani (original) (raw)

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Papers by Soran omed سۆران ئومێد

Inorganic Chemistry Communication , 2023

In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via ... more In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via a sequence of stepwise and one-pot three-component reactions. The synthetic process commenced with the diazotization of 3chloro-4-methyl aniline, followed bycoupling reaction with 4-hydroxy acetophenone, yielding the azo molecule denoted as 1-(3-((3-chloro-4-methylphenyl)diazenyl)-4-hydroxyphenyl)ethan-1-one. Subsequently, this compound underwent benzylation with benzyl bromide by Williamson ether synthesis, leading to the formation of 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl)diazenyl)phenyl)ethan-1-one. The resultant azo-benzyloxy compound was then subjected to both classical and one-pot methodologies to synthesize pyrimidine derivatives, from results obtained from one pot reaction were in good yield. Structural elucidation of the newly synthesized compounds was characterized by spectral analysis, including FT-IR, 1 H NMR, 13 C NMR, and 13 C-DEPT-135-NMR. The spectroscopic data confirmed the integrity of the molecular structures. Lastly, certain pyrimidine derivatives were evaluated for their antimicrobial activity against two strains of bacteria, namely Staphylococcus aureus and Escherichia coli. The results revealed that as the increasing of concentration, the sensitivity increased as reached 800 µg /mL no growth of bacterial was seen, It is also notable that the synthesized compounds have antimicrobial efficacy against both bacterial types.

Egyptian Journal of Chemistry

Egyptian Journal of Chemistry, 2022

This work synthesized a new series of pyrazoline compounds containing azo linkages via classical ... more This work synthesized a new series of pyrazoline compounds containing azo linkages via classical and one-pot three-component reactions. The progress started with 3-chloro,4-methyl aniline, which has been diazotized and coupled with 4-hydroxy acetophenone to form azo compound 1-(3-((3-chloro-4-methyl phenyl) diazenyl)-4-hydroxyphenyl) ethan-1-one (1) and converted to 1-(4-(benzyloxy)-3-((3-chloro-4-methyl phenyl) diazenyl) phenyl) ethan-1-one (2). The later azo compound was subjected to both classical and one-pot methods to give target pyrazoline derivatives. The structure of all newly obtained compounds was supported by spectral data (1 H-NMR, 13 CNMR, Dept.135, and FT-IR). Finally, some pyrazoline derivatives were estimated for their antibacterial activity against Escherichia coli as gram-negative and Staphylococcus aureus as grampositive. The results showed significant activity against both types of bacteria.

Inorganic Chemistry Communication , 2023

In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via ... more In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via a sequence of stepwise and one-pot three-component reactions. The synthetic process commenced with the diazotization of 3chloro-4-methyl aniline, followed bycoupling reaction with 4-hydroxy acetophenone, yielding the azo molecule denoted as 1-(3-((3-chloro-4-methylphenyl)diazenyl)-4-hydroxyphenyl)ethan-1-one. Subsequently, this compound underwent benzylation with benzyl bromide by Williamson ether synthesis, leading to the formation of 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl)diazenyl)phenyl)ethan-1-one. The resultant azo-benzyloxy compound was then subjected to both classical and one-pot methodologies to synthesize pyrimidine derivatives, from results obtained from one pot reaction were in good yield. Structural elucidation of the newly synthesized compounds was characterized by spectral analysis, including FT-IR, 1 H NMR, 13 C NMR, and 13 C-DEPT-135-NMR. The spectroscopic data confirmed the integrity of the molecular structures. Lastly, certain pyrimidine derivatives were evaluated for their antimicrobial activity against two strains of bacteria, namely Staphylococcus aureus and Escherichia coli. The results revealed that as the increasing of concentration, the sensitivity increased as reached 800 µg /mL no growth of bacterial was seen, It is also notable that the synthesized compounds have antimicrobial efficacy against both bacterial types.

Egyptian Journal of Chemistry

Egyptian Journal of Chemistry, 2022

This work synthesized a new series of pyrazoline compounds containing azo linkages via classical ... more This work synthesized a new series of pyrazoline compounds containing azo linkages via classical and one-pot three-component reactions. The progress started with 3-chloro,4-methyl aniline, which has been diazotized and coupled with 4-hydroxy acetophenone to form azo compound 1-(3-((3-chloro-4-methyl phenyl) diazenyl)-4-hydroxyphenyl) ethan-1-one (1) and converted to 1-(4-(benzyloxy)-3-((3-chloro-4-methyl phenyl) diazenyl) phenyl) ethan-1-one (2). The later azo compound was subjected to both classical and one-pot methods to give target pyrazoline derivatives. The structure of all newly obtained compounds was supported by spectral data (1 H-NMR, 13 CNMR, Dept.135, and FT-IR). Finally, some pyrazoline derivatives were estimated for their antibacterial activity against Escherichia coli as gram-negative and Staphylococcus aureus as grampositive. The results showed significant activity against both types of bacteria.