Hamid Reza Niazkar | Shiraz University Of Medical Sciences (original) (raw)

Papers by Hamid Reza Niazkar

Reviews in Clinical Medicine, Mar 1, 2020

Introduction: Diabetes mellitus (DM) is a metabolic disorder with a high prevalence, which affect... more Introduction: Diabetes mellitus (DM) is a metabolic disorder with a high prevalence, which affects approximately 25% of the world's population. This systematic review aimed to assess the Iranian research regarding the effects of medicinal plants on pancreatic beta cells in diabetes. Methods: This systematic review was conducted via searching in databases such as Medline, PubMed, Google Scholar, and ScienceDirect until April 2018. The studied that were published in Iran, peer-reviewed, and designed as a randomized control trial on type I diabetes were retrieved and screened. Result: The initial search results of the electronic databases yielded 822 relevant articles. After two stages of screening, checking the references, and removing the duplicate articles in various databases, 18 articles were finally selected for the review. Conclusion: According to the results, medicinal plants have a positive impact on the performance of pancreatic beta cells in animal models through various mechanisms, such as increasing the number, size, regeneration, and reduction of the inflammation of beta cells.

International Journal of Gynecological Cancer, 2021

Methodology In our randomized pilot study, ten patients were tested using FRD staining solution. ... more Methodology In our randomized pilot study, ten patients were tested using FRD staining solution. In all 10 patients HPV Test, Pap Smear, and Colposcopy were also performed. These four methods were evaluated in regard to the histopathological findings of the targeted biopsy. Results The sensitivity and specificity of FRD staining solution were 100% and 50%, respectively. Conclusion The advantage of the FRD method is that the results are immediate. Another benefit of this test is that it can predict the location of cervical dysplasia both on the cervix and in the canal itself. Further study could be useful to check if overall accuracy for screening is improved when FRD is used as a co-test with HPV testing. Disclosures None.

PubMed, 2019

Acanthamoeba spp. are free-living amoeba commonly found in environmental sources such as soil, wa... more Acanthamoeba spp. are free-living amoeba commonly found in environmental sources such as soil, water, and dust. This ubiquitous amoeba is the causative agent of amoebic keratitis (AK) and encephalitis. The present study aimed to investigate the presence of Acanthamoeba spp. in the water sources of Kermanshah city, Iran. Sixty water samples were taken from different localities of Kermanshah including agricultural canals, rivers, and swimming pools. Filtration and cultivation were carried out on non-nutrient agar medium (NNA). The axenic cultivation was performed for all of the positive isolates. PCR analysis was performed on positive samples. Sequencing was done for 12 PCR products. Genotypes were identified by blast search and homology analysis. The obtained data were analyzed using Statistical Package for the Social Sciences (SPSS 16) software. Acanthamoeba spp. was found in 46 (76.66%) water samples and amoebae were grown in the TYI-S-33 medium. Sequencing of 12 samples proved that Acanthamoeba belonged to T4 (75%), T2 (8.34%), T5 (8.33%) and T11 (8.33%) genotypes. In this study, Acanthamoeba T4 (75%), T2 (8.34%), T5 (8.33%) and T11 (8.33%) genotypes were isolated from the water of Kermanshah city. Thus, hygiene consideration is recommended to prevent the contamination.

Eosinophilic gastroenteritis is a rare disease with unknown etiology. It is characterized by the ... more Eosinophilic gastroenteritis is a rare disease with unknown etiology. It is characterized by the eosinophilic infiltration of one or more layers of the gastrointestinal tract. Recently, the authors visited a rare case of eosinophilic gastroenteritis. A 30-year-old woman was admitted to our hospital complaining of acute-onset excessive abdominal pain in the periumbilical region and chronic diarrhea. Physical examination revealed a distended abdomen with tenderness. Complete blood count showed moderate eosinophilia with elevated IgA serum levels. Computed tomography of the abdomen and pelvis was normal. Upper endoscopy (with taking biopsy samples from the stomach and duodenum) and total colonoscopy (with taking biopsy sample from the rectum and ascending colon) were performed. The pathological examination showed a non-destructive colitis with increased mucosal eosinophilia throughout the entire thickness of the ascending colon and duodenum. Rectal and gastric biopsy samples did not show any signs of eosinophilic infiltration. After ruling out of other causes of eosinophilia, eosinophilic gastroenteritis was diagnosed. The patient recovered well after treatment with prednisone (40 mg/day) over two weeks and was free from gastrointestinal symptoms at the time we reported her disease.

Evidence-based Complementary and Alternative Medicine, Oct 6, 2022

Nonalcoholic fatty liver disease (NAFLD) is globally the leading cause of hepatic dysfunction. Ga... more Nonalcoholic fatty liver disease (NAFLD) is globally the leading cause of hepatic dysfunction. Garlic has many physiological benefts, including anti-infammatory, antioxidant, anticancer, lipid-lowering, and antidiabetes efects. Te present study aimed to systematically review the efects of garlic (Allium sativum) and its mechanisms of function in managing NAFLD and its associated complications. Te guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements were applied to perform the study (CRD42021289348). Te Scopus, Embase, Web of Science, Cochrane PubMed, and Google Scholar databases were searched until February 2022. According to the inclusion criteria, fnally, 12 studies were entered into the study. Te evidence provided in the study revealed that garlic could regulate the development of NAFLD via several mechanisms of action, such as lowering body weight, modulating lipid and glucose metabolism, and reducing infammation and oxidative stress (OS). Overall, the benefcial efects of garlic in the treatment of NAFLD make it a potential therapeutic and efcient agent in managing NAFLD and its related risk factors. Tere is an insufcient number of clinical trials addressing the efects of garlic in humans; therefore, conducting more human research in the future is recommended.

Food & Function, 2022

Sepsis is a severe reaction and an excessive immune response to infection, which can lead to orga... more Sepsis is a severe reaction and an excessive immune response to infection, which can lead to organ dysfunction and death.

Health science reports, Jun 1, 2023

Annals of Pediatric Surgery, Jan 10, 2023

Background Transanal endorectal pull-through (TEPT) surgery is a new trend in the treatment of Hi... more Background Transanal endorectal pull-through (TEPT) surgery is a new trend in the treatment of Hirschsprung disease, and evaluating its functional outcome is difficult. The purpose of this study is to evaluate the defecation pattern after TEPT surgery in pediatrics. Material and methods In this cross-sectional survey, 40 patients with Hirschsprung disease were studied. They underwent a one-stage transanal pull-through procedure from May 2007 till April 2015 in Namazi hospital by the same surgeon. All the patients had the aganglionic segment in the rectosigmoid, confirmed by pre-operation barium enema and post-operation histopathology. The patients were 40 children with mean operation age of 36.6 months old. The success rate of surgery was evaluated by following the questionnaire form. Clinical evaluation with bowel function score and anorectomanometry were carried out. Result One hundred percent of them had a daily stool. Eighty-five percent of patients never experienced pain during defecation, 10% experienced occasional pain, and the rest felt pain with every defecation. Just one case (5%) reported using a laxative. Regarding improvements after the operation, 75% were completely okay, 20% felt much better, and 5% reported some improvements. The average National Health Service score was 8.375, which seems satisfactory. The mean average anal sphincter in the group with soiling was 39.67 and in the group without soiling was 34.83, which is in the normal range in both groups, and there was no significant difference between these groups (P > 0.05). Conclusion The defecation pattern after TEPT surgery were satisfactory in almost all cases, even in infancy. Most patients had satisfactory manometry and clinical result.

Hemoglobin, Mar 3, 2020

Abstract Hb S (HBB: c.20A>T) and α- and/or β-thalassemia (α- and/or β-thal) coinheritance is a... more Abstract Hb S (HBB: c.20A>T) and α- and/or β-thalassemia (α- and/or β-thal) coinheritance is a common genetic disorder in regions with a high prevalence of thalassemia and sickle cell disease. The clinical manifestations of this coinheritance vary from mild to severe complications. Iran is a country with a high incidence of thalassemia and sickle cell disease. This study aimed to evaluate the coinheritance of sickle cell disease with α- and/or β-thal in Iranian patients. In this cross-sectional study from 2018–2019, a total of 47 participants with the Hb S abnormality, who were referred to the Zafar Thalassemia Clinic (Tehran, Iran), were selected as a study group. Molecular analysis for the evaluation of α and β gene mutations was performed in all participants. Hb SS, Hb S/β-thal and Hb S/Hb D-Punjab (also known as Hb D-Los Angeles, Hb D-Chicago, Hb D-North Carolina, Hb D-Portugal and Hb Oak Ridge) (HBB: c.364G>C) were detected in 21 (44.7%), 23 (48.9%) and three (6.4%) patients, respectively. α Gene mutations were also detected in five patients with Hb S/β-thal, four patients with sickle cell disease and one patient with Hb S/Hb D-Punjab. In the current study, –α3.7/αα with β gene abnormalities was the most common genotype. Our study showed that the coinheritance of sickle cell disease with α- and β-thal is common and evaluation of these disorders, especially in pre marriage screening is important for diagnosis and management strategies.

Turkish journal of hematology, Sep 2, 2019

First-time blood donors are the most common group of blood donors. They usually have different mo... more First-time blood donors are the most common group of blood donors. They usually have different motivations for blood donation, some of which provoke the donors to hide risk factors of transfusion-transmissible infections (TTIs). Therefore, detection of TTIs among first-time donors is crucial and can decrease the rate of TTIs among blood recipients. This study aimed to evaluate the prevalence of TTIs among first-time donors in the transfusion center of Kohgiluyeh and Boyer-Ahmad Province (KBTC), Iran. Materials and Methods: This retrospective study was conducted with volunteer blood donors in 2004-2014 in the KBTC. Various data, including sex, confidential unit exclusion (CUE), previous donation history, and the laboratory findings of confirmatory tests, were extracted from blood donor software. Data were analyzed by SPSS using the chi-square test. Results: Among 198,501 blood donors, 52,527 (26.46%) were firsttime donors, while 145,974 donors (73.54%) were repeat and regular donors. Most of the donors (94.5%) were male, while a minority (5.5%) were female. The CUE option was chosen by 2,237 (1.13%) donors. The incidence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) was 247 (0.13%) and 134 (0.07%) among the entire study population, respectively. Three donors (0.002%) had confirmed human immunodeficiency virus (HIV), while none of the blood donors were positive for syphilis. Most of the donors with positive HBsAg (95.8%), HCV (86.6%), and HIV (100%) infection were first-time donors. Conclusion: Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.

Nutrition & Food Science, May 18, 2021

<jats:sec> <jats:title content-type="abstract-subheading">Purpose</jats:... more <jats:sec> <jats:title content-type="abstract-subheading">Purpose</jats:title> <jats:p>Herbal medicine has been used for the management of complications of diabetes. The purpose of this paper is to examine the anti-diabetic effects of <jats:italic>Achillea millefolium</jats:italic> extract on diabetic rats.</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Design/methodology/approach</jats:title> <jats:p>To this aim, 32 male Wistar rats were randomly assigned into four groups in which each group comprised eight rats. The four experimental groups were as follows: control group, diabetic control (DC) group (STZ; 50 mg/kg), diabetic rats, receiving 250 mg/kg hydro-alcoholic extract of the <jats:italic>A. millefolium</jats:italic> (DAM) and diabetic rats, receiving 5 mg/kg glibenclamide (DG). After 21 days of the treatment course, tissues of the kidney and blood samples were collected for histopathological, biochemical and molecular analysis.</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Findings</jats:title> <jats:p>The concentration of malondialdehyde (MDA) and glucose serum were markedly reduced in the DC group while significantly increased in DG and DAM groups (1.11 ± 0.57 to 19.4 ± 3.5 and 17.8 ± 1.2 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.002 and 325 ± 0.18 to 223 ± 0.11 and 211 ± 0.32 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.02, respectively). Also, the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were markedly reduced in the DC group while significantly increased in DAM and DG groups (9.1 ± 2.21 to 18.7 ± 3.81 and 14.9 ± 3.1 <jats:italic>p</jats:italic> = 0.03 and <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.02, respectively). The concentrations of creatinine, blood urea nitrogen (BUN) and urea were substantially decreased in DAM and DG groups as compared with the DC group (0.49 ± 0.02 to 0.27 ± 0.01 and 0.25 ± 0.01 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.01, 15.6 ± 2.1 to 7.2 ± 0.68 and 8.6 ± 1.2 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.02 and 114 ± 9.4 to 59.8 ± 5.2 and 64 ± 5.2 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.03, respectively). Also, Bcl-2-associated X protein (BAX) expression was significantly decreased in DAM and DG groups as compared with the DC group (1.3 ± 0.32 to 0.91 ± 0.03 and 0.93 ± 0.02 <jats:italic>p</jats:italic> = <0.01) and Bcl-2 expression were significantly increased in DAM and DG groups as compared with the DC group (0.42 ± 0.05 to 0.88 ± 0.07 and 0.85 ± 0.06 <jats:italic>p </jats:italic>=<jats:italic> </jats:italic>0.01).</jats:p> </jats:sec> <jats:sec> <jats:title content-type="abstract-subheading">Originality/value</jats:title> <jats:p>Diabetes led to degenerative damages in the kidney of rats and increased the mRNA level of Bax, while treatment with <jats:italic>A. millefolium</jats:italic> could protect the kidney tissue against diabetes complications and increased the mRNA expression of Bcl-2. This study indicated that <jats:italic>A. millefolium</jats:italic> extracts not only improves renal function as a result of anti-oxidant activity but also modulates some biochemical factors in diabetic rats.</jats:p> </jats:sec>

Physiology and pharmacology, Sep 1, 2020

Diabetes Mellitus (DM) is one of the most important diseases among metabolic disorders (American ... more Diabetes Mellitus (DM) is one of the most important diseases among metabolic disorders (American diabetic association, 2017). Both types of diabetes (type 1 and type 2) are caused by the lack of insulin production, insulin resistance and the gradual

Phytomedicine, Jun 1, 2021

BACKGROUND Sepsis is a life-threatening condition caused by a dysregulated host response to infec... more BACKGROUND Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed flavonoids in the vegetables and fruits, presents various biological activities including modulation of oxidative stress, anti-infectious, anti-inflammatory, and neuroprotective activities. METHODS The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. We searched Web of Sciences, Google Scholar, PubMed, Scopus, and Embase databases up to February 2021 by using the relevant keywords. RESULTS Out of 672 records screened, 35 articles met the study criteria. The evidence reviewed here indicates that quercetin supplementation may exert beneficial effects on sepsis by attenuating inflammation and oxidative stress, downregulating the mRNA expression of toll-like receptors (TLRs), modulating the immune response, and alleviating sepsis-related organ dysfunctions. CONCLUSION Due to the promising therapeutic effects of quercetin on sepsis complications and the lack of clinical trials in this regard, future human randomized clinical trials are warranted.

International Journal of Laboratory Hematology, Dec 2, 2020

In December 2019, a new type of coronavirus was detected for the first time in Wuhan, Hubei Provi... more In December 2019, a new type of coronavirus was detected for the first time in Wuhan, Hubei Province, China. According to the reported data, the emerging coronavirus has spread worldwide, infecting more than fifty‐seven million individuals, leading to more than one million deaths. The current study aimed to review and discuss the hematological findings of COVID‐19. Laboratory changes and hematologic abnormalities have been reported repeatedly in COVID‐19 patients. WBC count and peripheral blood lymphocytes are normal or slightly reduced while these indicators may change with the progression of the disease. In addition, several studies demonstrated that decreased hemoglobin levels in COVID‐19 patients were associated with the severity of the disease. Moreover, thrombocytopenia, which is reported in 5%‐40% of patients, is known to be associated with poor prognosis of the disease. COVID‐19 can present with various hematologic manifestations. In this regard, accurate evaluation of laboratory indicators at the beginning and during COVID‐19 can help physicians to adjust appropriate treatment and provide special and prompt care for those in need.

DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2021

The Egyptian Journal of Internal Medicine, Jun 2, 2022

The COVID-19 pandemic affected millions of people worldwide, becoming a challenge of every nation... more The COVID-19 pandemic affected millions of people worldwide, becoming a challenge of every nation. Since the COVID-19 can present wide spectrum of clinical signs and symptoms, patients with symptoms similar to that of COVID-19 may be misdiagnosed during the context of COVID-19 pandemic. In this regard, various co-infections may affect the outcome of COVID-19 patients if it lefts undiagnosed, especially during the administration of immunosuppressive drugs. Similar to COVID-19, TB affect the lungs and respiratory airways primarily. These two diseases have resembling symptoms, including dry cough, fever, and dyspnea. Due to the importance of early COVID-19 diagnosis, many other respiratory infectious diseases such as tuberculosis (TB) may be missed. Herein, a case of COVID-19 and tuberculosis co-infection is presented.

Clinical Case Reports, Apr 1, 2022

We report herein a case of a 58‐year‐old woman with COVID‐19. During the hospitalization, the pat... more We report herein a case of a 58‐year‐old woman with COVID‐19. During the hospitalization, the patient complained of acute abdominal pain, and abdominal CT revealed the rectus sheath hematoma (RSH). Since corticosteroids and anti‐coagulation are commonly administered in COVID‐19 patients, physicians should consider RSH as a possible diagnosis for acute abdominal pain.

European Journal of Medical Research, Dec 3, 2022

Objective: Breast cancer is a worldwide health concern, and surgical removal has remained the pre... more Objective: Breast cancer is a worldwide health concern, and surgical removal has remained the preferred therapeutic option in most patients. Furthermore, the current study was designed to investigate the disease-free survival and overall survival in breast cancer patients, who receive either propofol or isoflurane during operation. Method: This retrospective study was conducted on 994 patients (IV group, n = 530; volatile/inhalational group, n = 464) who underwent breast cancer operation from January 2006 to December 2016 at Faghihi Hospital, Shiraz, Iran. All studied patients were followed up till 2020. Patients are classified into two groups, IV and volatile/inhalational, according to the received anesthesia. For statistical analysis, The Cox regression test was conducted to investigate the association between factors affecting the recurrence of the disease and the Log Rank test was utilized to assess the patients' survival. Finally, to reduce the effect of confounding factors, all patients were matched according to age, tumor size and tumor grade. Results: Based on results from the log-rank test, the volatile/inhalational group had a better recurrence-free survival (P = 0.039) compared to the total IV group. However, the overall survival was not considerably different (P = 0.520). Conclusion: The current study showed that although 2-year disease-free survival is higher in the volatile/inhalational group, there is no meaningful association between the 5-year overall survival and anesthesia technique.

International electronic journal of medicine, Dec 15, 2019

Background: Parasitology is a course filled with many complicated terminologies. In this study, a... more Background: Parasitology is a course filled with many complicated terminologies. In this study, a guide was designed to facilitate the learning of parasitology. More precisely, an annual educational calendar of medical parasitology was designed based on the weeks of education and its effectiveness was assessed in university students of medical sciences. Materials and Methods: This cross-sectional study included 174 students who were randomly divided into two intervention and control groups. At the baseline, the students were tested with a questionnaire at the beginning of each teaching session and the end of the intervention. In addition, another questionnaire was used to compare the attitude and satisfaction of students in two groups. Finally, the scores of the students were entered in SPSS 16 for analysis. Results: The results of parametric tests showed that the mean scores of laboratory and medical students during several tests in different sessions were significantly different in the two groups. Conclusion: The educational calendar is a new method in medical education, especially in the field of medical parasitology. This calendar as an educational supplement, emphasizes on students' active learning and contributes to improving the quality of teaching the parasitology course in addition to meeting their educational needs.

Iranian Journal of Blood and Cancer, Dec 10, 2018

Idiopathic thrombocytopenia purpura (ITP) is an autoimmune disorder characterized by isolated thr... more Idiopathic thrombocytopenia purpura (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia and mucocutaneous bleeding. The former has a primary role in the diagnosis and treatment of ITP. One of the leading causes of miscounted platelets in patients who suffer from ITP is giant platelets which may indicate factitiously a severe false thrombocytopenia. Here, a case of macrothrombocytopenia is presented in an ITP patient. Giant platelets of this patient not only resulted in miscounting platelets but also falsely increased reading of RBC counts. By counting platelets through peripheral blood smear and hemocytometer, the patient was saved from an unnecessary splenectomy.