Sedigheh Dehbashi | Shiraz University Of Medical Sciences (original) (raw)

Papers by Sedigheh Dehbashi

Research paper thumbnail of Laparoscopic Ovarian Drilling in Clomiphene Resistant Pco Patients: A Preferred Method of Treatment

The Medical Journal of The Islamic Republic of Iran, 2005

Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pr... more Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis ofPCO of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomi­ phene resistant. The other methods like bromocriptin, gonadotropins, GnRH -a and metformin had been given to these patients for infertility treatment without benefit. After ovarian drilling, pregnancy was achieved in 41 patients (54.6%), 30(40%) in group I (primary infertile group) and 11 (14.6%) in group II (secondary infertile group). During the operation adhesiolysis was necessary in 14( 18.6%) and removal of endometriotic lesions was indicated in 5(6.6%) in both groups. Conclusion: Ovarian drilling is an ideal technique in PCO patients with failure of medical treatment, considering the benefit of also performing other necessary surgical interventions. MJIRl, Vol. 19, No.3, 237-240, 2005.

Research paper thumbnail of Comparison of the Effects of Letrozole and Clomiphene Citrate on Ovulation and Pregnancy Rate in Patients with Polycystic Ovary Syndrome P P

Background: For more than four decades clomiphene citrate has been the first line of the treatmen... more Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intra-muscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letro-zole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administr...

Research paper thumbnail of Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with... more Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. Objective: The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Materials and Methods: Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. Results: The incubation of the sperm samples in sera with URSA lead...

Research paper thumbnail of The Relationship Between Domestic Violence During Pregnancy and Complications of Pregnancy, Type of Delivery and Birth Weight on Delivered Women in Hospital Affiliated to Shiraz University of Medical Sciences

The Horizon of Medical Sciences, 2008

Research paper thumbnail of The Relationship between Random Urinary Protein-to-Creatinine Ratio and 24-hours Urine Protein in Diagnosis of Proteinuria in Mild Preeclampsia

Journal of Research in Medical Sciences, 2006

Background: The purpose of this study was to evaluate whether a random urinary protein / creatini... more Background: The purpose of this study was to evaluate whether a random urinary protein / creatinine ratio is a clinically useful predictor of significant proteinuria (≥300 mg/24 hr) instead of 24- hours urine protein, among women with suspected preeclampsia. Methods: Women with suspected preeclampsia and gestational age of ≥20 weeks were included in a prospective study. Patients with chronic hypertension, diabetes mellitus, or preexisting renal disease were excluded. Protein/creatinine ratio was obtained before 24-hours urine collection. Positive and negative predictive values and sensitivity and specificity of the protein/creatinine ratio for significant proteinuria (≥ 300 mg) were calculated, based on 24hours urine total protein. Results: 100 women were evaluated totally. Mean maternal and gestational ages were 27.3 years and 33.26 weeks, respectively.73% of cases had significant proteinuria based on 24-hours urine collection. Good correlations were found between the protein/creat...

Research paper thumbnail of Prospective , Randomized Study Omparing Laparoscopic Ovarian Ystectomy Versus Fenestration and Oagulation in Patients with Ndometriomas

bjective: To determine the difference between two laparoscopic methods for the management of endo... more bjective: To determine the difference between two laparoscopic methods for the management of endoetriomas with regard to recurrence of signs and symptoms and pregnancy rate. esign: Prospective, randomized clinical trial. etting: Infertility and gynecologic endoscopy units of two medical university hospitals. atient(s): One hundred patients with endometriomas who had either infertility or pelvic pain. ntervention(s): Patients were randomly divided into two groups; one group underwent cystectomy (group 1), nd fenestration and coagulation were performed for the other (group 2). ain Outcome Measure(s): A comparison of recurrence of signs and symptoms of endometriomas and regnancy rates in two groups. esult(s): Fifty-two patients were studied in group 1 and 48 in group 2. The recurrence of symptoms, such s pelvic pain and dysmenorrhea, was 15.8% in group 1 and 56.7% in group 2 after 2 years. The rate of eoperation was 5.8% in group 1 and 22.9% in group 2 and these differences were statis...

Research paper thumbnail of Comparison of the Effects of Letrozole and Clomiphene Citrate on Ovulation and Pregnancy Rate in Patients with Polycystic Ovary Syndrome

Background: For more than four decades clomiphene citrate has been the first line of the treatmen... more Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intramuscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letrozole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administrat...

Research paper thumbnail of Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

Iranian Journal of …, 2011

Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained... more Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. The incubation of the sperm samples in sera with URSA lead to a decrease in the percentage of the motile sperm from 55% in control to 41% in the treated group, significantly (p=0.038). The percentage of the sperm with abnormal fragmented DNA increased after incubation with URSA (26.6%) compare to the control (21.2%); however, it was not significant. It seems that sera from URSA patients could not induce a significant increase in the percentage of the sperms with nuclei contain DNA fragmentation. However, the sera of women with URSA could affect the fertility rate by reduction of the sperm motility.

Research paper thumbnail of Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome

International Journal of Gynecology & Obstetrics, 2008

Objective: To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin r... more Objective: To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin resistance and polycystic ovary syndrome (PCOS) in a prospective clinical trial. Method: Of 210 women with PCOS, 70 were hyperhomocysteinemic; and of these, 32 were insulin resistant and 38 were not. The 70 women were treated with folic acid for 3 months. Baseline and serum levels of Hcy and insulin were measured in both groups. Results: In both groups Hcy concentrations were significantly decreased following folic acid supplementation. The mean ± SD levels before and after treatment were 14.03 ± 1.5 µmol/L and 12.53 ± 1.72 µmol/L in group 1 (P b 0.001), and they were 12.07 ± 0.87 µmol/L and 8.83 ± 0.78 µmol/L in group 2 (P b 0.001). Conclusion: The Hcy levels of hyperhomocysteinemic women with PCOS were reduced after 3 months of folic acid supplementation, and the rate of reduction was higher among women without insulin resistance. No change was found in fasting insulin levels.

Research paper thumbnail of A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas

Fertility and Sterility, 2004

Objective: To determine the difference between two laparoscopic methods for the management of end... more Objective: To determine the difference between two laparoscopic methods for the management of endometriomas with regard to recurrence of signs and symptoms and pregnancy rate. Design: Prospective, randomized clinical trial. Setting: Infertility and gynecologic endoscopy units of two medical university hospitals. Patient(s): One hundred patients with endometriomas who had either infertility or pelvic pain. Intervention(s): Patients were randomly divided into two groups; one group underwent cystectomy (group 1), and fenestration and coagulation were performed for the other (group 2). Main Outcome Measure(s): A comparison of recurrence of signs and symptoms of endometriomas and pregnancy rates in two groups. Result(s): Fifty-two patients were studied in group 1 and 48 in group 2. The recurrence of symptoms, such as pelvic pain and dysmenorrhea, was 15.8% in group 1 and 56.7% in group 2 after 2 years. The rate of reoperation was 5.8% in group 1 and 22.9% in group 2 and these differences were statistically significant. The cumulative pregnancy rate was significantly higher in group 1 (59.4%) than in group 2 (23.3%) at 1-year follow-up. Conclusion(s): Laparoscopic cystectomy of endometriomas is a better choice than fenestration and coagulation because the former technique leads to a lower recurrence of signs and symptoms and a lower rate of reoperation and a higher cumulative pregnancy rate than the latter. (Fertil Steril 2004;82:1633-7.

Research paper thumbnail of A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma

Fertility and Sterility, 2007

In a comparison of follicular responses to controlled ovarian hyperstimulation (COH) between norm... more In a comparison of follicular responses to controlled ovarian hyperstimulation (COH) between normal ovaries and ovaries previously treated by different laparoscopic techniques for ovarian endometrioma in 65 patients with unilateral endometrioma, laparoscopic ovarian fenestration and coagulation was performed in 24 cases (group 1) and laparoscopic ovarian cystectomy in the other 41 (group 2). In 16 patients with bilateral endometrioma (group 3), cystectomy was done in one ovary and fenestration and coagulation in the contralateral side. The results indicate that the response of ovaries to COH after laparoscopic ovarian cystectomy or fenestration and coagulation was the same and that there was no difference in response to COH between normal ovaries and those operated on by the laparoscopic techniques mentioned above. (Fertil Steril 2007;88:507-9.

Research paper thumbnail of A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis

Archives of Gynecology and Obstetrics, 2011

Purpose To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptoreli... more Purpose To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptorelin) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis. Methods In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication. We followed up each group at least for 12 months after their restoration of regular cycle. Results Pregnancy rate was 23.4% in group 1, 27.5% in group 2, and 28.1% in group 3. The results did not show significant differences among the 3 groups. Recurrence rate of endometriosis was 6.4% in group 1, 5% group 2 and 5.3% in group 3, which was not statistically significantly different as well. Conclusion Pregnancy rate and endometriosis recurrence rate are comparable among the 3 groups.

Research paper thumbnail of Comparison of four diagnostic methods for detection of methicillin resistant Staphylococcus aureus

Iranian journal of microbiology, 2014

Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide dist... more Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide distribution. Given the increasing rate of MRSA infections, implementing of reliable, accurate and rapid testing for diagnosis of MRSA is necessary. The aim of this study was to compare four diagnostic methods for detection of MRSA isolates. From December 2012 to April 2014, 120 S. aureus isolates were collected from three hospitals affiliated with Tehran University of Medical Sciences. MRSA isolates were detected by four different methods including cefoxitin disc diffusion test, oxacillin disc diffusion test, minimum inhibitory concentration (MIC) of oxacillin as determined by MIC test strip, and mecA detection by PCR. Out of 120 S. aureus isolates, cefoxitin disc diffusion test, oxacillin disc diffusion test and MIC test strip identified 60 (50%), 48 (40%), 55 (45.83%) isolates as MRSA, respectively. The sensitivity and specificity for oxacillin disc diffusion, cefoxitin disc diffusion and...

Research paper thumbnail of Paper: THE RELATIONSHIP BETWEEN DOMESTIC VIOLENCE DURING PREGNANCY AND COMPLICATIONS OF PREGNANCY, TYPE OF DELIVERY AND BIRTH WEIGHT ON DELIVERED WOMEN IN HOSPITAL AFFILIATED TO SHIRAZ UNIVERSITY OF MEDICAL SCIENCES

Research paper thumbnail of Demographic characteristics of women with domestic violence during pregnancy

Research paper thumbnail of Paper: COMPARISON OF THE EFFECTS OF LETROZOLE AND CLOMIPHENE CITRATE ON OVULATION AND PREGNANCY RATE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Research paper thumbnail of Relationship between Domestic Violence during pregnancy and Complications of Pregnancy, type of delivery and birth weight on delivered women in hospital affiliated to Shiraz university of Medical Sciences

Research paper thumbnail of Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: A prospective, double-blind, randomized, placebo-controlled study

Journal of Minimally Invasive Gynecology, 2007

STUDY OBJECTIVE: To evaluate the effects of pentoxifylline administration on patients with differ... more STUDY OBJECTIVE: To evaluate the effects of pentoxifylline administration on patients with different stages of endometriosis on whom laparoscopy was performed.

Research paper thumbnail of Time of initiation of clomiphene citrate and pregnancy rate in polycystic ovarian syndrome

International Journal of Gynecology & Obstetrics, 2006

Objective: To investigate whether the timing of clomiphene citrate (CC) administration affects ho... more Objective: To investigate whether the timing of clomiphene citrate (CC) administration affects hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates in women with polycystic ovarian syndrome (PCOS). Methods: Of the 78 infertile women with PCOS who participated in this prospective, double-blind, randomized clinical trial, 37 collectively underwent 71 cycles of CC (100 mg/day) on days 1 through 5 of the menstrual cycle (group 1) and 41 collectively underwent 73 cycles of CC at the same concentration on days 5 through 9 (group 2). Hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates were compared. Results: The mean number of follicles and the maximum follicular size were greater in group 2. However, ovulation rates were 72.8% in group 1 and 70.8% in group 2 ( P = .78), and pregnancy rates were 40.5% in group 1 and 19.5% in group 2 ( P = .04). Conclusion: Treatment with CC is associated with higher rates of pregnancy if started early (days 1-5) in the menstrual cycle.

Research paper thumbnail of A simple estimated fetal weight equation for fetuses between 24 and 34 weeks of gestation

International Journal of Gynecology & Obstetrics, 1999

Objecti¨e. To develop a mathematical equation that is simple, accurate and easy to use when appli... more Objecti¨e. To develop a mathematical equation that is simple, accurate and easy to use when applied to low-birth Ž . weight or preterm fetuses -35 weeks and to assess previous normal ultrasonic fetal weight curves and make a comparison with normal fetal delivery weight curves. Method. In a large teaching hospital, 269 pregnant mothers were identified by the criteria of normalities, such as: well known LMP, regular menstrual cycles, no use of OCP for Ž the last 3 months, no smoking and no history of diabetes. Birth-weight measurements adjusted for maternal age, . baby's sex, parity and week of gestation were taken immediately after birth. Results. Mean gestational age and mean birth weight " S.D. were 29.5" 3.02 weeks and 1530.238" 237.856 g, respectively. With the aid of a scientific Ž . Ž . calculator the data were analyzed and a simple regression equation has been derived: EFW kg s 0.17 G.A.y20 , Ž . S.D.; 235 g Honarvar's Formula 1 . Conclusion. For estimating weights of preterm or low-birth weight fetuses of less than 2500 g, this simple equation appears to be clinically reliable and easy to use and suggests that previous normal ultrasonic fetal weight curves may underestimate or overestimate normal fetal delivery weight between the 24th and 34th week of gestation. Our formula approximates actual birth weight better and recommends Ott's ultrasonic weight curve for Iranian population. ᮊ 1999 International Federation of Gynecology and Obstetrics.

Research paper thumbnail of Laparoscopic Ovarian Drilling in Clomiphene Resistant Pco Patients: A Preferred Method of Treatment

The Medical Journal of The Islamic Republic of Iran, 2005

Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pr... more Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis ofPCO of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomi­ phene resistant. The other methods like bromocriptin, gonadotropins, GnRH -a and metformin had been given to these patients for infertility treatment without benefit. After ovarian drilling, pregnancy was achieved in 41 patients (54.6%), 30(40%) in group I (primary infertile group) and 11 (14.6%) in group II (secondary infertile group). During the operation adhesiolysis was necessary in 14( 18.6%) and removal of endometriotic lesions was indicated in 5(6.6%) in both groups. Conclusion: Ovarian drilling is an ideal technique in PCO patients with failure of medical treatment, considering the benefit of also performing other necessary surgical interventions. MJIRl, Vol. 19, No.3, 237-240, 2005.

Research paper thumbnail of Comparison of the Effects of Letrozole and Clomiphene Citrate on Ovulation and Pregnancy Rate in Patients with Polycystic Ovary Syndrome P P

Background: For more than four decades clomiphene citrate has been the first line of the treatmen... more Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intra-muscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letro-zole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administr...

Research paper thumbnail of Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with... more Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. Objective: The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Materials and Methods: Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. Results: The incubation of the sperm samples in sera with URSA lead...

Research paper thumbnail of The Relationship Between Domestic Violence During Pregnancy and Complications of Pregnancy, Type of Delivery and Birth Weight on Delivered Women in Hospital Affiliated to Shiraz University of Medical Sciences

The Horizon of Medical Sciences, 2008

Research paper thumbnail of The Relationship between Random Urinary Protein-to-Creatinine Ratio and 24-hours Urine Protein in Diagnosis of Proteinuria in Mild Preeclampsia

Journal of Research in Medical Sciences, 2006

Background: The purpose of this study was to evaluate whether a random urinary protein / creatini... more Background: The purpose of this study was to evaluate whether a random urinary protein / creatinine ratio is a clinically useful predictor of significant proteinuria (≥300 mg/24 hr) instead of 24- hours urine protein, among women with suspected preeclampsia. Methods: Women with suspected preeclampsia and gestational age of ≥20 weeks were included in a prospective study. Patients with chronic hypertension, diabetes mellitus, or preexisting renal disease were excluded. Protein/creatinine ratio was obtained before 24-hours urine collection. Positive and negative predictive values and sensitivity and specificity of the protein/creatinine ratio for significant proteinuria (≥ 300 mg) were calculated, based on 24hours urine total protein. Results: 100 women were evaluated totally. Mean maternal and gestational ages were 27.3 years and 33.26 weeks, respectively.73% of cases had significant proteinuria based on 24-hours urine collection. Good correlations were found between the protein/creat...

Research paper thumbnail of Prospective , Randomized Study Omparing Laparoscopic Ovarian Ystectomy Versus Fenestration and Oagulation in Patients with Ndometriomas

bjective: To determine the difference between two laparoscopic methods for the management of endo... more bjective: To determine the difference between two laparoscopic methods for the management of endoetriomas with regard to recurrence of signs and symptoms and pregnancy rate. esign: Prospective, randomized clinical trial. etting: Infertility and gynecologic endoscopy units of two medical university hospitals. atient(s): One hundred patients with endometriomas who had either infertility or pelvic pain. ntervention(s): Patients were randomly divided into two groups; one group underwent cystectomy (group 1), nd fenestration and coagulation were performed for the other (group 2). ain Outcome Measure(s): A comparison of recurrence of signs and symptoms of endometriomas and regnancy rates in two groups. esult(s): Fifty-two patients were studied in group 1 and 48 in group 2. The recurrence of symptoms, such s pelvic pain and dysmenorrhea, was 15.8% in group 1 and 56.7% in group 2 after 2 years. The rate of eoperation was 5.8% in group 1 and 22.9% in group 2 and these differences were statis...

Research paper thumbnail of Comparison of the Effects of Letrozole and Clomiphene Citrate on Ovulation and Pregnancy Rate in Patients with Polycystic Ovary Syndrome

Background: For more than four decades clomiphene citrate has been the first line of the treatmen... more Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intramuscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letrozole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administrat...

Research paper thumbnail of Effects of sera taken from women with recurrent spontaneous abortion on sperm motility and apoptosis

Iranian Journal of …, 2011

Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained... more Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. The incubation of the sperm samples in sera with URSA lead to a decrease in the percentage of the motile sperm from 55% in control to 41% in the treated group, significantly (p=0.038). The percentage of the sperm with abnormal fragmented DNA increased after incubation with URSA (26.6%) compare to the control (21.2%); however, it was not significant. It seems that sera from URSA patients could not induce a significant increase in the percentage of the sperms with nuclei contain DNA fragmentation. However, the sera of women with URSA could affect the fertility rate by reduction of the sperm motility.

Research paper thumbnail of Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome

International Journal of Gynecology & Obstetrics, 2008

Objective: To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin r... more Objective: To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin resistance and polycystic ovary syndrome (PCOS) in a prospective clinical trial. Method: Of 210 women with PCOS, 70 were hyperhomocysteinemic; and of these, 32 were insulin resistant and 38 were not. The 70 women were treated with folic acid for 3 months. Baseline and serum levels of Hcy and insulin were measured in both groups. Results: In both groups Hcy concentrations were significantly decreased following folic acid supplementation. The mean ± SD levels before and after treatment were 14.03 ± 1.5 µmol/L and 12.53 ± 1.72 µmol/L in group 1 (P b 0.001), and they were 12.07 ± 0.87 µmol/L and 8.83 ± 0.78 µmol/L in group 2 (P b 0.001). Conclusion: The Hcy levels of hyperhomocysteinemic women with PCOS were reduced after 3 months of folic acid supplementation, and the rate of reduction was higher among women without insulin resistance. No change was found in fasting insulin levels.

Research paper thumbnail of A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas

Fertility and Sterility, 2004

Objective: To determine the difference between two laparoscopic methods for the management of end... more Objective: To determine the difference between two laparoscopic methods for the management of endometriomas with regard to recurrence of signs and symptoms and pregnancy rate. Design: Prospective, randomized clinical trial. Setting: Infertility and gynecologic endoscopy units of two medical university hospitals. Patient(s): One hundred patients with endometriomas who had either infertility or pelvic pain. Intervention(s): Patients were randomly divided into two groups; one group underwent cystectomy (group 1), and fenestration and coagulation were performed for the other (group 2). Main Outcome Measure(s): A comparison of recurrence of signs and symptoms of endometriomas and pregnancy rates in two groups. Result(s): Fifty-two patients were studied in group 1 and 48 in group 2. The recurrence of symptoms, such as pelvic pain and dysmenorrhea, was 15.8% in group 1 and 56.7% in group 2 after 2 years. The rate of reoperation was 5.8% in group 1 and 22.9% in group 2 and these differences were statistically significant. The cumulative pregnancy rate was significantly higher in group 1 (59.4%) than in group 2 (23.3%) at 1-year follow-up. Conclusion(s): Laparoscopic cystectomy of endometriomas is a better choice than fenestration and coagulation because the former technique leads to a lower recurrence of signs and symptoms and a lower rate of reoperation and a higher cumulative pregnancy rate than the latter. (Fertil Steril 2004;82:1633-7.

Research paper thumbnail of A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma

Fertility and Sterility, 2007

In a comparison of follicular responses to controlled ovarian hyperstimulation (COH) between norm... more In a comparison of follicular responses to controlled ovarian hyperstimulation (COH) between normal ovaries and ovaries previously treated by different laparoscopic techniques for ovarian endometrioma in 65 patients with unilateral endometrioma, laparoscopic ovarian fenestration and coagulation was performed in 24 cases (group 1) and laparoscopic ovarian cystectomy in the other 41 (group 2). In 16 patients with bilateral endometrioma (group 3), cystectomy was done in one ovary and fenestration and coagulation in the contralateral side. The results indicate that the response of ovaries to COH after laparoscopic ovarian cystectomy or fenestration and coagulation was the same and that there was no difference in response to COH between normal ovaries and those operated on by the laparoscopic techniques mentioned above. (Fertil Steril 2007;88:507-9.

Research paper thumbnail of A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis

Archives of Gynecology and Obstetrics, 2011

Purpose To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptoreli... more Purpose To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptorelin) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis. Methods In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication. We followed up each group at least for 12 months after their restoration of regular cycle. Results Pregnancy rate was 23.4% in group 1, 27.5% in group 2, and 28.1% in group 3. The results did not show significant differences among the 3 groups. Recurrence rate of endometriosis was 6.4% in group 1, 5% group 2 and 5.3% in group 3, which was not statistically significantly different as well. Conclusion Pregnancy rate and endometriosis recurrence rate are comparable among the 3 groups.

Research paper thumbnail of Comparison of four diagnostic methods for detection of methicillin resistant Staphylococcus aureus

Iranian journal of microbiology, 2014

Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide dist... more Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide distribution. Given the increasing rate of MRSA infections, implementing of reliable, accurate and rapid testing for diagnosis of MRSA is necessary. The aim of this study was to compare four diagnostic methods for detection of MRSA isolates. From December 2012 to April 2014, 120 S. aureus isolates were collected from three hospitals affiliated with Tehran University of Medical Sciences. MRSA isolates were detected by four different methods including cefoxitin disc diffusion test, oxacillin disc diffusion test, minimum inhibitory concentration (MIC) of oxacillin as determined by MIC test strip, and mecA detection by PCR. Out of 120 S. aureus isolates, cefoxitin disc diffusion test, oxacillin disc diffusion test and MIC test strip identified 60 (50%), 48 (40%), 55 (45.83%) isolates as MRSA, respectively. The sensitivity and specificity for oxacillin disc diffusion, cefoxitin disc diffusion and...

Research paper thumbnail of Paper: THE RELATIONSHIP BETWEEN DOMESTIC VIOLENCE DURING PREGNANCY AND COMPLICATIONS OF PREGNANCY, TYPE OF DELIVERY AND BIRTH WEIGHT ON DELIVERED WOMEN IN HOSPITAL AFFILIATED TO SHIRAZ UNIVERSITY OF MEDICAL SCIENCES

Research paper thumbnail of Demographic characteristics of women with domestic violence during pregnancy

Research paper thumbnail of Paper: COMPARISON OF THE EFFECTS OF LETROZOLE AND CLOMIPHENE CITRATE ON OVULATION AND PREGNANCY RATE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Research paper thumbnail of Relationship between Domestic Violence during pregnancy and Complications of Pregnancy, type of delivery and birth weight on delivered women in hospital affiliated to Shiraz university of Medical Sciences

Research paper thumbnail of Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: A prospective, double-blind, randomized, placebo-controlled study

Journal of Minimally Invasive Gynecology, 2007

STUDY OBJECTIVE: To evaluate the effects of pentoxifylline administration on patients with differ... more STUDY OBJECTIVE: To evaluate the effects of pentoxifylline administration on patients with different stages of endometriosis on whom laparoscopy was performed.

Research paper thumbnail of Time of initiation of clomiphene citrate and pregnancy rate in polycystic ovarian syndrome

International Journal of Gynecology & Obstetrics, 2006

Objective: To investigate whether the timing of clomiphene citrate (CC) administration affects ho... more Objective: To investigate whether the timing of clomiphene citrate (CC) administration affects hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates in women with polycystic ovarian syndrome (PCOS). Methods: Of the 78 infertile women with PCOS who participated in this prospective, double-blind, randomized clinical trial, 37 collectively underwent 71 cycles of CC (100 mg/day) on days 1 through 5 of the menstrual cycle (group 1) and 41 collectively underwent 73 cycles of CC at the same concentration on days 5 through 9 (group 2). Hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates were compared. Results: The mean number of follicles and the maximum follicular size were greater in group 2. However, ovulation rates were 72.8% in group 1 and 70.8% in group 2 ( P = .78), and pregnancy rates were 40.5% in group 1 and 19.5% in group 2 ( P = .04). Conclusion: Treatment with CC is associated with higher rates of pregnancy if started early (days 1-5) in the menstrual cycle.

Research paper thumbnail of A simple estimated fetal weight equation for fetuses between 24 and 34 weeks of gestation

International Journal of Gynecology & Obstetrics, 1999

Objecti¨e. To develop a mathematical equation that is simple, accurate and easy to use when appli... more Objecti¨e. To develop a mathematical equation that is simple, accurate and easy to use when applied to low-birth Ž . weight or preterm fetuses -35 weeks and to assess previous normal ultrasonic fetal weight curves and make a comparison with normal fetal delivery weight curves. Method. In a large teaching hospital, 269 pregnant mothers were identified by the criteria of normalities, such as: well known LMP, regular menstrual cycles, no use of OCP for Ž the last 3 months, no smoking and no history of diabetes. Birth-weight measurements adjusted for maternal age, . baby's sex, parity and week of gestation were taken immediately after birth. Results. Mean gestational age and mean birth weight " S.D. were 29.5" 3.02 weeks and 1530.238" 237.856 g, respectively. With the aid of a scientific Ž . Ž . calculator the data were analyzed and a simple regression equation has been derived: EFW kg s 0.17 G.A.y20 , Ž . S.D.; 235 g Honarvar's Formula 1 . Conclusion. For estimating weights of preterm or low-birth weight fetuses of less than 2500 g, this simple equation appears to be clinically reliable and easy to use and suggests that previous normal ultrasonic fetal weight curves may underestimate or overestimate normal fetal delivery weight between the 24th and 34th week of gestation. Our formula approximates actual birth weight better and recommends Ott's ultrasonic weight curve for Iranian population. ᮊ 1999 International Federation of Gynecology and Obstetrics.