Joseph Susa | UT Southwestern Medical Center at Dallas (original) (raw)

Papers by Joseph Susa

Diagnostic Pathology: Nonneoplastic Dermatopathology, 2017

Although some dermatologic diseases have decreased markedly in frequency in the potent antiretrov... more Although some dermatologic diseases have decreased markedly in frequency in the potent antiretroviral therapy era, other conditions remain common. Among patients with low CD4(+) cell counts who are not on or not adherent to antiretroviral therapy, notable conditions include psoriasis, photodermatitis, prurigo nodularis, molluscum, and adverse drug reactions. Conditions that remain relatively common despite adequate antiretroviral therapy include eczema, xerosis, warts, and Kaposi's sarcoma. Disorders that are associated with immune reconstitution under potent antiretroviral therapy include acne, staphylococcal infections, and erythema nodosum. In addition, HIV and hepatitis C virus (HCV) coinfection is associated with a number of skin disorders.

Case reports in dermatological medicine, 2017

Comedones occur when an overproliferation of keratinocytes blocks sebum secretion in a pilosebace... more Comedones occur when an overproliferation of keratinocytes blocks sebum secretion in a pilosebaceous duct. Comedones have multiple possible etiologies and contributing factors. While comedones are common to acne, they are also seen in occupational exposures and are associated with certain syndromes. We describe a particularly rare case of comedones at the perianus that is not associated with any known exposure or disease and is a rare incidental finding.

Journal of clinical pathology, Jan 31, 2018

The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and c... more The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and clinical stage in mycosis fungoides (MF) has not been studied. We analysed a cohort of patients with a diagnosis of MF to determine the different types of specific TCR gene rearrangements present and their relationship to disease stage. A retrospective chart review was used to select patients with a diagnosis of MF who had a skin biopsy and a positive TCR gene rearrangement study in either blood or tissue and at least 2 years of clinical follow-up. 43 patients were identified and divided into two groups. The first group consisted of 23 patients with early stage disease (IA-IIA) that was either stable or went into partial or complete remission with minimal intervention. None of these patients advanced to late stage disease. The second group consisted of 20 patients who had either late stage disease at diagnosis or progressed to late stage disease at some point in time. In the first group, ...

Case reports in dermatology

Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Su... more Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Suggested causes include fluorinated corticosteroids, , and irritant contact dermatitis. We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. As each recurrence correlated with a relapse of overflow incontinence, in this case the cause was irritant contact dermatitis from the liquid stool. This is the first reported case of recurrent granuloma gluteale infantum.

The American Journal of Dermatopathology

The American Journal of Dermatopathology

Journal of the American Academy of Dermatology, Jan 9, 2017

Histopathological features in morphea (localized scleroderma) and their clinical correlates are p... more Histopathological features in morphea (localized scleroderma) and their clinical correlates are poorly described. We sought to systematically describe histologic changes of morphea in a large, well-annotated cohort and determine the association between histopathology and clinical features. This was a cross-sectional study of 83 patients enrolled in the Morphea in Adults and Children cohort. The main outcome measure was the association of microanatomical location and degree of sclerosis and inflammation seen on histologic samples with patient-reported symptoms and physician-based measures of severity. Pattern of sclerosis was associated with morphea subtype, the presence of patient-reported symptoms, and functional limitation. A bottom-heavy pattern of sclerosis was associated with pain and tightness (P = .0039 and .001, respectively). These symptoms were not associated with a top-heavy pattern. Severe inflammation may be associated with pain and functional limitation (P = .073 for b...

The American Journal of Dermatopathology, 2015

Dermatologic Surgery, 2015

Laboratory Medicine, 2003

The American Journal of dermatopathology, Jan 5, 2015

Journal of Cutaneous Pathology, 2014

Laboratory Medicine, 2005

Journal of Cutaneous Pathology, 2008

Diseases of the Colon & Rectum, 2012

Diseases of the Colon & Rectum, 2011

Journal of Cutaneous Pathology, 2014

Diagnostic Pathology: Nonneoplastic Dermatopathology, 2017

Although some dermatologic diseases have decreased markedly in frequency in the potent antiretrov... more Although some dermatologic diseases have decreased markedly in frequency in the potent antiretroviral therapy era, other conditions remain common. Among patients with low CD4(+) cell counts who are not on or not adherent to antiretroviral therapy, notable conditions include psoriasis, photodermatitis, prurigo nodularis, molluscum, and adverse drug reactions. Conditions that remain relatively common despite adequate antiretroviral therapy include eczema, xerosis, warts, and Kaposi's sarcoma. Disorders that are associated with immune reconstitution under potent antiretroviral therapy include acne, staphylococcal infections, and erythema nodosum. In addition, HIV and hepatitis C virus (HCV) coinfection is associated with a number of skin disorders.

Case reports in dermatological medicine, 2017

Comedones occur when an overproliferation of keratinocytes blocks sebum secretion in a pilosebace... more Comedones occur when an overproliferation of keratinocytes blocks sebum secretion in a pilosebaceous duct. Comedones have multiple possible etiologies and contributing factors. While comedones are common to acne, they are also seen in occupational exposures and are associated with certain syndromes. We describe a particularly rare case of comedones at the perianus that is not associated with any known exposure or disease and is a rare incidental finding.

Journal of clinical pathology, Jan 31, 2018

The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and c... more The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and clinical stage in mycosis fungoides (MF) has not been studied. We analysed a cohort of patients with a diagnosis of MF to determine the different types of specific TCR gene rearrangements present and their relationship to disease stage. A retrospective chart review was used to select patients with a diagnosis of MF who had a skin biopsy and a positive TCR gene rearrangement study in either blood or tissue and at least 2 years of clinical follow-up. 43 patients were identified and divided into two groups. The first group consisted of 23 patients with early stage disease (IA-IIA) that was either stable or went into partial or complete remission with minimal intervention. None of these patients advanced to late stage disease. The second group consisted of 20 patients who had either late stage disease at diagnosis or progressed to late stage disease at some point in time. In the first group, ...

Case reports in dermatology

Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Su... more Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Suggested causes include fluorinated corticosteroids, , and irritant contact dermatitis. We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. As each recurrence correlated with a relapse of overflow incontinence, in this case the cause was irritant contact dermatitis from the liquid stool. This is the first reported case of recurrent granuloma gluteale infantum.

The American Journal of Dermatopathology

The American Journal of Dermatopathology

Journal of the American Academy of Dermatology, Jan 9, 2017

Histopathological features in morphea (localized scleroderma) and their clinical correlates are p... more Histopathological features in morphea (localized scleroderma) and their clinical correlates are poorly described. We sought to systematically describe histologic changes of morphea in a large, well-annotated cohort and determine the association between histopathology and clinical features. This was a cross-sectional study of 83 patients enrolled in the Morphea in Adults and Children cohort. The main outcome measure was the association of microanatomical location and degree of sclerosis and inflammation seen on histologic samples with patient-reported symptoms and physician-based measures of severity. Pattern of sclerosis was associated with morphea subtype, the presence of patient-reported symptoms, and functional limitation. A bottom-heavy pattern of sclerosis was associated with pain and tightness (P = .0039 and .001, respectively). These symptoms were not associated with a top-heavy pattern. Severe inflammation may be associated with pain and functional limitation (P = .073 for b...

The American Journal of Dermatopathology, 2015

Dermatologic Surgery, 2015

Laboratory Medicine, 2003

The American Journal of dermatopathology, Jan 5, 2015

Journal of Cutaneous Pathology, 2014

Laboratory Medicine, 2005

Journal of Cutaneous Pathology, 2008

Diseases of the Colon & Rectum, 2012

Diseases of the Colon & Rectum, 2011

Journal of Cutaneous Pathology, 2014