Alan Lin | National Taiwan University (original) (raw)

Papers by Alan Lin

Research paper thumbnail of Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells

Journal of Biological Chemistry, 1980

Research paper thumbnail of The participation of 5S rRNA in the co-translational formation of a eukaryotic 5S ribonucleoprotein complex

Nucleic Acids Research, 2001

The eukaryotic ribosomal 5S RNA–protein complex (5S rRNP) is formed by a co-translational event t... more The eukaryotic ribosomal 5S RNA–protein complex (5S rRNP) is formed by a co-translational event that requires 5S rRNA binding to the nascent peptide chain of eukaryotic ribosomal protein L5. Binding between 5S rRNA and the nascent chain is specific: neither the 5S rRNA nor ...

Research paper thumbnail of Automatic generation of NC cutter path from massive data points

Computer-aided design, 1998

This paper proposes methodologies and algorithms through which a three-axis NC cutter path can be... more This paper proposes methodologies and algorithms through which a three-axis NC cutter path can be directly generated from massive data points obtained with contact or non-contact measuring devices. At the beginning, a Z-map model is employed to set up mesh points in order to economize on the use of computer memory. Rough-cut paths are produced by machining volumes of material in a slice-by-slice manner: firstly cutting the raw material into several slices on the basis of depth of cut, next judging from intersection information the cut and non-cut areas, and then generating roughcut paths of slices. Fine-cut paths are achieved by the height correction method, which by degrees examines mesh points within the cutters' projection areas. Any interference between the cutting tool and the data points is taken into account during the correction of the cutter height. Aside from a theoretical discussion, this research develops a computer-aided engraving system to prove the applicability of the proposed methods. In contrast to traditional copy milling, computer-aided engraving provides users with much more flexibility, reduces machining time, and adapts the workpiece forms to different circumstances so as to manufacture male or female dies.

Research paper thumbnail of P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice

… of Pharmacology and …, 2008

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid β (Aβ) peptides... more Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid β (Aβ) peptides are hypothesized to cause the initiation and progression of AD based on pathologic data from AD patients, genetic analysis of mutations that cause early onset forms of AD, and ...

Research paper thumbnail of A volume decomposition approach to process planning for prismatic parts with depression and protrusion design features

International Journal of Computer Integrated …, 1998

Abstract. This paper proposes a volume decomposition approach to building an interface which brid... more Abstract. This paper proposes a volume decomposition approach to building an interface which bridges the gap between a 3D CAD model and an automated process planning system. The volume decomposition approach partitions the whole machining volume, which needs to ...

Research paper thumbnail of The primary structure of rat ribosomal protein S8

Nucleic acids research, 1987

Research paper thumbnail of Nano-bio-chip sensor platform for examination of oral exfoliative cytology

Cancer Prevention …, 2010

Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic ap... more Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic approaches enabling early detection. In this pilot study, we describe a nano-bio-chip (NBC) sensor technique for analysis of oral cancer biomarkers in exfoliative cytology specimens, ...

Research paper thumbnail of Automatic 3D measuring system for optical scanning of axial fan blades

The International Journal of Advanced Manufacturing …

Consumer electronics are ever more sophisti-cated in terms of esthetics and design. Due to mass p... more Consumer electronics are ever more sophisti-cated in terms of esthetics and design. Due to mass production, the required sampling quantity for quality inspection of products has surged considerably. As such, learning how to utilize the appropriate device and ...

Research paper thumbnail of The in Vitro Secretion of Growth Regulators by Isolated Callus Tissues

American Journal of Botany, 1973

The inhibition of the growth of Bacillus subtilis by isolated callus tissues ........ 21 3. The i... more The inhibition of the growth of Bacillus subtilis by isolated callus tissues ........ 21 3. The influence of isolated callus growth on the growth of Lemna minor ......... 25 4. The influence of isolated callus growth on the germination and growth of tomato s e e d s. 31 5. The influence of juice expressed from isolated callus tissues on the growth of Lemna minor .

Research paper thumbnail of Raman spectroscopy monitoring of the cellular activities of a tissue-engineered ex vivo produced oral mucosal equivalent

Journal of Raman Spectroscopy, 2011

To ensure quality control and assurance in tissue engineering, noninvasive, real-time and aseptic... more To ensure quality control and assurance in tissue engineering, noninvasive, real-time and aseptic evaluation of cell-based devices is required before product release. In this study, Raman spectroscopy was applied to monitor the cellular activities of an oral mucosa equivalent (EVPOME) produced ex vivo from cultured autogenous oral keratinocytes and acellular dermis-AlloDerm. Raman spectra showed a positive correlation of the peak area ratio of amide I (1655 cm −1)/phenylalanine (1004 cm −1) with a negative linear regression (R 2 > 0.95) according to the number of cultured days, especially on the 14thand 21st day. This work demonstrates the successful application of Raman spectroscopy for quantitatively monitoring and evaluating the maturity of EVPOME.

Research paper thumbnail of Procase - a Case-Based Process Planning System for Machining of Rotational Parts

Page 1. Journal of Intelligent Manufacturing (1994) 5, 411-430 PROCASE: a case-based process plan... more Page 1. Journal of Intelligent Manufacturing (1994) 5, 411-430 PROCASE: a case-based process planning system for machining of rotational parts HA0 YANG,l WEN F. LU1 and ALAN C. LIN2 'Department of Mechanical Engineering ...

Research paper thumbnail of The action mode of the ribosome-inactivating protein α-sarcin

Journal of biomedical science, 2000

Based on the tertiary structure of the ribosome-inactivat-ing protein ~-sarein, domains that are ... more Based on the tertiary structure of the ribosome-inactivat-ing protein ~-sarein, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dis-sected. In this study, we found that the head-to-tail inter-action between the first amino 13-strand and ...

Research paper thumbnail of Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells

Journal of Biological Chemistry, 1980

Research paper thumbnail of The participation of 5S rRNA in the co-translational formation of a eukaryotic 5S ribonucleoprotein complex

Nucleic Acids Research, 2001

The eukaryotic ribosomal 5S RNA–protein complex (5S rRNP) is formed by a co-translational event t... more The eukaryotic ribosomal 5S RNA–protein complex (5S rRNP) is formed by a co-translational event that requires 5S rRNA binding to the nascent peptide chain of eukaryotic ribosomal protein L5. Binding between 5S rRNA and the nascent chain is specific: neither the 5S rRNA nor ...

Research paper thumbnail of Automatic generation of NC cutter path from massive data points

Computer-aided design, 1998

This paper proposes methodologies and algorithms through which a three-axis NC cutter path can be... more This paper proposes methodologies and algorithms through which a three-axis NC cutter path can be directly generated from massive data points obtained with contact or non-contact measuring devices. At the beginning, a Z-map model is employed to set up mesh points in order to economize on the use of computer memory. Rough-cut paths are produced by machining volumes of material in a slice-by-slice manner: firstly cutting the raw material into several slices on the basis of depth of cut, next judging from intersection information the cut and non-cut areas, and then generating roughcut paths of slices. Fine-cut paths are achieved by the height correction method, which by degrees examines mesh points within the cutters' projection areas. Any interference between the cutting tool and the data points is taken into account during the correction of the cutter height. Aside from a theoretical discussion, this research develops a computer-aided engraving system to prove the applicability of the proposed methods. In contrast to traditional copy milling, computer-aided engraving provides users with much more flexibility, reduces machining time, and adapts the workpiece forms to different circumstances so as to manufacture male or female dies.

Research paper thumbnail of P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice

… of Pharmacology and …, 2008

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid β (Aβ) peptides... more Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid β (Aβ) peptides are hypothesized to cause the initiation and progression of AD based on pathologic data from AD patients, genetic analysis of mutations that cause early onset forms of AD, and ...

Research paper thumbnail of A volume decomposition approach to process planning for prismatic parts with depression and protrusion design features

International Journal of Computer Integrated …, 1998

Abstract. This paper proposes a volume decomposition approach to building an interface which brid... more Abstract. This paper proposes a volume decomposition approach to building an interface which bridges the gap between a 3D CAD model and an automated process planning system. The volume decomposition approach partitions the whole machining volume, which needs to ...

Research paper thumbnail of The primary structure of rat ribosomal protein S8

Nucleic acids research, 1987

Research paper thumbnail of Nano-bio-chip sensor platform for examination of oral exfoliative cytology

Cancer Prevention …, 2010

Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic ap... more Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic approaches enabling early detection. In this pilot study, we describe a nano-bio-chip (NBC) sensor technique for analysis of oral cancer biomarkers in exfoliative cytology specimens, ...

Research paper thumbnail of Automatic 3D measuring system for optical scanning of axial fan blades

The International Journal of Advanced Manufacturing …

Consumer electronics are ever more sophisti-cated in terms of esthetics and design. Due to mass p... more Consumer electronics are ever more sophisti-cated in terms of esthetics and design. Due to mass production, the required sampling quantity for quality inspection of products has surged considerably. As such, learning how to utilize the appropriate device and ...

Research paper thumbnail of The in Vitro Secretion of Growth Regulators by Isolated Callus Tissues

American Journal of Botany, 1973

The inhibition of the growth of Bacillus subtilis by isolated callus tissues ........ 21 3. The i... more The inhibition of the growth of Bacillus subtilis by isolated callus tissues ........ 21 3. The influence of isolated callus growth on the growth of Lemna minor ......... 25 4. The influence of isolated callus growth on the germination and growth of tomato s e e d s. 31 5. The influence of juice expressed from isolated callus tissues on the growth of Lemna minor .

Research paper thumbnail of Raman spectroscopy monitoring of the cellular activities of a tissue-engineered ex vivo produced oral mucosal equivalent

Journal of Raman Spectroscopy, 2011

To ensure quality control and assurance in tissue engineering, noninvasive, real-time and aseptic... more To ensure quality control and assurance in tissue engineering, noninvasive, real-time and aseptic evaluation of cell-based devices is required before product release. In this study, Raman spectroscopy was applied to monitor the cellular activities of an oral mucosa equivalent (EVPOME) produced ex vivo from cultured autogenous oral keratinocytes and acellular dermis-AlloDerm. Raman spectra showed a positive correlation of the peak area ratio of amide I (1655 cm −1)/phenylalanine (1004 cm −1) with a negative linear regression (R 2 > 0.95) according to the number of cultured days, especially on the 14thand 21st day. This work demonstrates the successful application of Raman spectroscopy for quantitatively monitoring and evaluating the maturity of EVPOME.

Research paper thumbnail of Procase - a Case-Based Process Planning System for Machining of Rotational Parts

Page 1. Journal of Intelligent Manufacturing (1994) 5, 411-430 PROCASE: a case-based process plan... more Page 1. Journal of Intelligent Manufacturing (1994) 5, 411-430 PROCASE: a case-based process planning system for machining of rotational parts HA0 YANG,l WEN F. LU1 and ALAN C. LIN2 'Department of Mechanical Engineering ...

Research paper thumbnail of The action mode of the ribosome-inactivating protein α-sarcin

Journal of biomedical science, 2000

Based on the tertiary structure of the ribosome-inactivat-ing protein ~-sarein, domains that are ... more Based on the tertiary structure of the ribosome-inactivat-ing protein ~-sarein, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dis-sected. In this study, we found that the head-to-tail inter-action between the first amino 13-strand and ...