Hwa-Lung Yu | National Taiwan University (original) (raw)

Papers by Hwa-Lung Yu

Stochastic Environmental Research and Risk Assessment, 2010

Abstract Dengue Fever (DF) has been identified by the World Health organization (WHO) as one of t... more Abstract Dengue Fever (DF) has been identified by the World Health organization (WHO) as one of the most serious vector-borne infectious diseases in tropical and sub-tropical areas. During 2007, in particular, there were over 2,000 DF cases in Taiwan, which was the ...

EGU General Assembly Conference Abstracts, Apr 1, 2015

Alzheimer's & Dementia, 2021

Elders’ mobility and social activities are closely related to their living environments and cogni... more Elders’ mobility and social activities are closely related to their living environments and cognitive function. Built environments and social activities tend to vary across populations and geographic regions. Therefore, this study aims to explore the association between late‐life neighborhood built environment and cognitive function in community‐dwelling older adults.

Interdisciplinary Public Health Reasoning and Epidemic Modelling: The Case of Black Death

Environment International, 2019

The rapid growth of Internet of Things has provided a new aspect to air quality monitoring system... more The rapid growth of Internet of Things has provided a new aspect to air quality monitoring system. In Taiwan, over 5000 PM 2.5 sensors have been installed in the last two years. The greatest asset of low-cost sensors is possibly mapping spatiotemporal air pollution with finer resolution. But the data quality of low-cost sensors is the most common question that how to take proper interpretation of the measurements. This study proposes an efficient calibration approach based on generalized additive model which is further applied to a particular lowcost PM 2.5 sensor in Taiwan. The study carried out a field calibration that collecting both measurements of lowcost sensors and the regulatory stations, and investigated the space/time bias between the low-cost sensors and regulatory stations. Results show that the proposed approach can explain the variability of the biases from the low-cost sensors with R-square of 0.76. In addition, the present calibration model can quantify the uncertainty of the low-cost sensors observations and the average standard deviation is about 13.85% with respect to its adjusted levels. This operational spatiotemporal data calibration approach provides an useful information for local communities and governmental agency to face the new era of IoT sensor for air quality monitoring.

Alzheimer's & Dementia, 2017

Journal of the American Society of Nephrology : JASN, Jan 30, 2016

The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We es... more The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-term exposure to fine particulate matter of <2.5 μm (PM2.5) with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed by membranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM2.5 exposure varied among the 282 cities, ranging from 6 to 114 μg/m(3) (mean, 52.6 μg/m(3)). Each 10 μg/m(3) increase in PM2.5 concentration associated with 14% higher odds fo...

ABSTRACT Taiwan is located in subtropical and tropical regions with high temperature and high hum... more ABSTRACT Taiwan is located in subtropical and tropical regions with high temperature and high humidity in the summer. This kind of climatic condition is the hotbed for the propagation and spread of the dengue vector mosquito. Kaohsiung City has been the worst dengue fever epidemic city in Taiwan. During the study period, from January 1998 to December 2011, Taiwan CDC recorded 7071 locally dengue epidemic cases in Kaohsiung City, and the number of imported case is 118. Our research uses Quantile Regression, a spatial infection disease distribution, to analyze the correlation between dengue epidemic and geographic environmental factors and human society factors in Kaohsiung. According to our experiment statistics, agriculture and natural forest have a positive relation to dengue fever(5.5~34.39 and 3.91~15.52). The epidemic will rise when the ratio for agriculture and natural forest increases. Residential ratio has a negative relation for quantile 0.1 to 0.4(-0.005~-0.78), and a positive relation for quantile 0.5 to0.9(0.01~18.0) . The mean income is also a significant factor in social economy field, and it has a negative relation to dengue fever(-0.01~-0.04). Conclusion from our research is that the main factor affecting the degree of dengue fever in predilection area is the residential proportion and the ratio of agriculture and natural forest plays an important role affecting the degree of dengue fever in non predilection area. Moreover, the serious epidemic area located by regression model is the same as the actual condition in Kaohsiung. This model can be used to predict the serious epidemic area of dengue fever and provide some references for the Health Agencies

Public Health, 2007

This work demonstrates the importance of spatiotemporal stochastic modelling in constructing maps... more This work demonstrates the importance of spatiotemporal stochastic modelling in constructing maps of major epidemics from fragmentary information, assessing population impacts, searching for possible etiologies, and performing comparative analysis of epidemics. Based on the theory previously published by the authors and incorporating new knowledge bases, informative maps of the composite space-time distributions were generated for important characteristics of two major epidemics: Black Death (14th century Western Europe) and bubonic plague (19th-20th century Indian subcontinent). The comparative spatiotemporal analysis of the epidemics led to a number of interesting findings: (1) the two epidemics exhibited certain differences in their spatiotemporal characteristics (correlation structures, trends, occurrence patterns and propagation speeds) that need to be explained by means of an interdisciplinary effort; (2) geographical epidemic indicators confirmed in a rigorous quantitative manner the partial findings of isolated reports and time series that Black Death mortality was two orders of magnitude higher than that of bubonic plague; (3) modern bubonic plague is a rural disease hitting harder the small villages in the countryside whereas Black Death was a devastating epidemic that indiscriminately attacked large urban centres and the countryside, and while the epidemic in India lasted uninterruptedly for five decades, in Western Europe it lasted three and a half years; (4) the epidemics had reverse areal extension features in response to annual seasonal variations. Temperature increase at the end of winter led to an expansion of infected geographical area for Black Death and a reduction for bubonic plague, reaching a climax at the end of spring when the infected area in Western Europe was always larger than in India. Conversely, without exception, the infected area during winter was larger for the Indian bubonic plague; (5) during the Indian epidemic, the disease disappeared and reappeared several times at most locations; in Western Europe, once the disease entered a place, it lasted a time proportional to the population and then disappeared for several years (this on-and-off situation lasted more than three centuries); and (6) on average, Black Death moved much faster than bubonic plague to reach virgin territories, despite the fact that India is only slightly larger in area than Western Europe and had a railroad network almost instantly moving infected rats, fleas, and people from one end of the subcontinent to the other. These findings throw new light on the spatiotemporal characteristics of the epidemics and need to be taken into consideration in the scientific discussion concerning the two devastating diseases and the lessons learned from them.

Stochastic Environmental Research and Risk Assessment

Stochastic Environmental Research and Risk Assessment, 2010

Abstract Dengue Fever (DF) has been identified by the World Health organization (WHO) as one of t... more Abstract Dengue Fever (DF) has been identified by the World Health organization (WHO) as one of the most serious vector-borne infectious diseases in tropical and sub-tropical areas. During 2007, in particular, there were over 2,000 DF cases in Taiwan, which was the ...

EGU General Assembly Conference Abstracts, Apr 1, 2015

Alzheimer's & Dementia, 2021

Elders’ mobility and social activities are closely related to their living environments and cogni... more Elders’ mobility and social activities are closely related to their living environments and cognitive function. Built environments and social activities tend to vary across populations and geographic regions. Therefore, this study aims to explore the association between late‐life neighborhood built environment and cognitive function in community‐dwelling older adults.

Interdisciplinary Public Health Reasoning and Epidemic Modelling: The Case of Black Death

Environment International, 2019

The rapid growth of Internet of Things has provided a new aspect to air quality monitoring system... more The rapid growth of Internet of Things has provided a new aspect to air quality monitoring system. In Taiwan, over 5000 PM 2.5 sensors have been installed in the last two years. The greatest asset of low-cost sensors is possibly mapping spatiotemporal air pollution with finer resolution. But the data quality of low-cost sensors is the most common question that how to take proper interpretation of the measurements. This study proposes an efficient calibration approach based on generalized additive model which is further applied to a particular lowcost PM 2.5 sensor in Taiwan. The study carried out a field calibration that collecting both measurements of lowcost sensors and the regulatory stations, and investigated the space/time bias between the low-cost sensors and regulatory stations. Results show that the proposed approach can explain the variability of the biases from the low-cost sensors with R-square of 0.76. In addition, the present calibration model can quantify the uncertainty of the low-cost sensors observations and the average standard deviation is about 13.85% with respect to its adjusted levels. This operational spatiotemporal data calibration approach provides an useful information for local communities and governmental agency to face the new era of IoT sensor for air quality monitoring.

Alzheimer's & Dementia, 2017

Journal of the American Society of Nephrology : JASN, Jan 30, 2016

The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We es... more The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-term exposure to fine particulate matter of <2.5 μm (PM2.5) with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed by membranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM2.5 exposure varied among the 282 cities, ranging from 6 to 114 μg/m(3) (mean, 52.6 μg/m(3)). Each 10 μg/m(3) increase in PM2.5 concentration associated with 14% higher odds fo...

ABSTRACT Taiwan is located in subtropical and tropical regions with high temperature and high hum... more ABSTRACT Taiwan is located in subtropical and tropical regions with high temperature and high humidity in the summer. This kind of climatic condition is the hotbed for the propagation and spread of the dengue vector mosquito. Kaohsiung City has been the worst dengue fever epidemic city in Taiwan. During the study period, from January 1998 to December 2011, Taiwan CDC recorded 7071 locally dengue epidemic cases in Kaohsiung City, and the number of imported case is 118. Our research uses Quantile Regression, a spatial infection disease distribution, to analyze the correlation between dengue epidemic and geographic environmental factors and human society factors in Kaohsiung. According to our experiment statistics, agriculture and natural forest have a positive relation to dengue fever(5.5~34.39 and 3.91~15.52). The epidemic will rise when the ratio for agriculture and natural forest increases. Residential ratio has a negative relation for quantile 0.1 to 0.4(-0.005~-0.78), and a positive relation for quantile 0.5 to0.9(0.01~18.0) . The mean income is also a significant factor in social economy field, and it has a negative relation to dengue fever(-0.01~-0.04). Conclusion from our research is that the main factor affecting the degree of dengue fever in predilection area is the residential proportion and the ratio of agriculture and natural forest plays an important role affecting the degree of dengue fever in non predilection area. Moreover, the serious epidemic area located by regression model is the same as the actual condition in Kaohsiung. This model can be used to predict the serious epidemic area of dengue fever and provide some references for the Health Agencies

Public Health, 2007

This work demonstrates the importance of spatiotemporal stochastic modelling in constructing maps... more This work demonstrates the importance of spatiotemporal stochastic modelling in constructing maps of major epidemics from fragmentary information, assessing population impacts, searching for possible etiologies, and performing comparative analysis of epidemics. Based on the theory previously published by the authors and incorporating new knowledge bases, informative maps of the composite space-time distributions were generated for important characteristics of two major epidemics: Black Death (14th century Western Europe) and bubonic plague (19th-20th century Indian subcontinent). The comparative spatiotemporal analysis of the epidemics led to a number of interesting findings: (1) the two epidemics exhibited certain differences in their spatiotemporal characteristics (correlation structures, trends, occurrence patterns and propagation speeds) that need to be explained by means of an interdisciplinary effort; (2) geographical epidemic indicators confirmed in a rigorous quantitative manner the partial findings of isolated reports and time series that Black Death mortality was two orders of magnitude higher than that of bubonic plague; (3) modern bubonic plague is a rural disease hitting harder the small villages in the countryside whereas Black Death was a devastating epidemic that indiscriminately attacked large urban centres and the countryside, and while the epidemic in India lasted uninterruptedly for five decades, in Western Europe it lasted three and a half years; (4) the epidemics had reverse areal extension features in response to annual seasonal variations. Temperature increase at the end of winter led to an expansion of infected geographical area for Black Death and a reduction for bubonic plague, reaching a climax at the end of spring when the infected area in Western Europe was always larger than in India. Conversely, without exception, the infected area during winter was larger for the Indian bubonic plague; (5) during the Indian epidemic, the disease disappeared and reappeared several times at most locations; in Western Europe, once the disease entered a place, it lasted a time proportional to the population and then disappeared for several years (this on-and-off situation lasted more than three centuries); and (6) on average, Black Death moved much faster than bubonic plague to reach virgin territories, despite the fact that India is only slightly larger in area than Western Europe and had a railroad network almost instantly moving infected rats, fleas, and people from one end of the subcontinent to the other. These findings throw new light on the spatiotemporal characteristics of the epidemics and need to be taken into consideration in the scientific discussion concerning the two devastating diseases and the lessons learned from them.

Stochastic Environmental Research and Risk Assessment