Yiwen Zhang | Texas A&M University (original) (raw)
Papers by Yiwen Zhang
Renal Failure, 2002
Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI do... more Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI domain). In this way, type IV collagen forms the main framework of basement membrane. We have developed sandwich Enzyme-Linked Immunosorbent Assay (ELISA) for human serum type IV collage peptide monoclonals for CO5 and CO6 recognizing two different determinants on the central triplex of human collagen molecules. Using this, we explored the possibility that serum levels of type IV collagen (Col IV) are an indicator of early diabetic nephropathy (DN). Serum type IV collagen levels were determined by ELISA in 36 patients with diabetic nephropathy. Serum hemoglobin A1c (HbA1c) and in twenty-four hour urinary albumin excretion rates (UAER) were measured at the same time. A relationship was found between serum levels of this collagen IV and the presence of diabetic nephropathy. That is, serum levels of type IV collagen in diabetic nephropathy were significantly higher than those found in non-insulin-dependent diabetic (NIDDM) patients without nephropathy and in healthy subjects (HS). It is possible that an elevated serum collagen type IV level reflects increased synthetic activity in basement membrane collagen type IV. Serum type IV collagen may be a useful marker for monitoring the dynamics of basement membrane metabolism and in this way serve as a clinical indicator of the progression or the activity of diabetic nephropathy and a marker for the assessment of therapeutic effects.
In job market, there's an increased demand for application-oriented t... more In job market, there's an increased demand for application-oriented talents. Computer Supported Collaborative Learning (CSCL) is an important model of practice teaching for the training of the application-oriented talents. The status of practice teaching is studied based on the characteristics of the Information Management and Information System (IMIS). Computer Supported Collaborative Learning is introduced to break the shackles of the
BMC Public Health, 2011
Background Several studies conducted during the past two decades suggested increasing trend of ch... more Background Several studies conducted during the past two decades suggested increasing trend of childhood allergic diseases in China. However, few studies have provided detailed description of geographic variation and explored risk factors of these diseases. This study investigated the pattern and risk factors of asthma, allergic rhinitis and eczema in eight metropolitan cities in China. Methods We conducted a cross-sectional survey during November-December 2005 in eight metropolitan cities in China. A total of 23791 children aged 6-13 years participated in this survey. Questions from the standard questionnaire of the International Study of Asthma and Allergies in Children (ISAAC) were used to examine the pattern of current asthma, allergic rhinitis and eczema. Logistic regression analyses were performed to assess the risk factors for childhood allergies. Results The average prevalence of childhood asthma, allergic rhinitis and eczema across the eight cities was 3∙3% (95% Confidence interval (CI): 3∙1%, 3∙6%), 9∙8% (95% CI: 9∙4%, 10∙2%) and 5∙5% (95% CI: 5∙2%, 5∙8%), respectively. Factors related to lifestyle, mental health and socio-economic status were found to be associated with the prevalence of childhood allergies. These risk factors were unevenly distributed across cities and disproportionately affected the local prevalence. Conclusions There was apparent geographic variation of childhood allergies in China. Socio-environmental factors had strong impacts on the prevalence of childhood allergies; but these impacts differed across regions. Thus public health policies should specifically target at the local risk factors for each individual area.
International Journal of Behavioral Development, 2008
Caregivers of 608 (331 boys and 277 girls) children in Shanghai, China reported on their children... more Caregivers of 608 (331 boys and 277 girls) children in Shanghai, China reported on their children's language development and on the language teaching practices used in the home. The children were between 24 and 47 months old. The relation of age-corrected language level to paternal education, child gender, and teaching practice use was examined. Children of more educated fathers were more advanced in language development than children of less educated fathers. Girls were more advanced than boys. Some language teaching practices were positively related to language development but one, the practice of eliciting imitation from children, was negatively related to language development. Vocabulary development showed a greater number of significant relations to environmental variables than did grammatical development. These results suggest the cross-linguistic and cross-cultural generalizability of previous findings from studies of North American samples with respect to correlates of children's early language development.
Environmental Toxicology and Pharmacology, 2009
Cancer risk is modulated by gene-environment interactions between toxic exposure and genetic vari... more Cancer risk is modulated by gene-environment interactions between toxic exposure and genetic variation in carcinogen metabolism. Our objective was to assess interactions between exposure to industrial pollutants and polymorphisms affecting cytochrome P450s (CYP1A1 and CYP2E1) and glutathione Stransferases (GSTP1 and GSTT) in childhood acute leukemia (AL). A case-only design was conducted in 123 Chinese children with sporadic AL. Industrial plants in the vicinity were recorded and, if present, their size and proximity to the usual place of residence of AL children was evaluated. Unconditional logistic regression analysis was performed across the AL study group adjusting for age, gender, parental education, occupation and smoking, indoor and outdoor pesticide use, presence of television sets, refrigerators, microwave ovens and furniture material in children's rooms, and electric transformers, power lines, and telecommunication transmitters within 500 m. This analysis revealed an interaction between the GSTT null allele and industrial plants within 500 m of the residences of childhood AL patients (interaction odds ratio, COR = 2.96, 95% CI: 1.09-8.01). Furthermore, the COR for the interaction between GSTT null and industrial plants within 50 m was 5.99 (95% CI: 1.41-25.45). Our results suggest an association between proximity to industrial plants and the GSTT null allele in patients with childhood AL.
Journal of University of Science and Technology Beijing, 2006
The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were i... more The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were investigated by means of the isothermal compression tests at a Gleeble-1500 thermal mechanical simulator. The results show that dynamic recovery acts as the main softening ...
Materials Science and Engineering A-structural Materials Properties Microstructure and Processing, 2010
The hot deformation behavior of hot isostatically pressed (HIPd) P/M superalloy FGH4096 has been ... more The hot deformation behavior of hot isostatically pressed (HIPd) P/M superalloy FGH4096 has been characterized by isothermal compression testing in the temperature range of 1050-1140 • C and strain rate range of 0.002-1.0 s −1 . The apparent activation energy of deformation was calculated to be 418 kJ/mol, and constitutive equation that described the flow stress as a function of the strain rate and deformation temperature was proposed for high temperature deformation of the alloy. The processing map was calculated to evaluate the efficiency of the forging process in the temperatures and strain rates investigated and to recognize the instability regimes. It was found that the strain has no significant effect on the processing maps. The optimum processing conditions were in the strain rates of around 0.01-0.2 s −1 and temperatures of 1080-1110 • C, the efficiencies are higher compared to other stable regimes. The DRX occurs at the temperatures of 1050-1130 • C and strain rate range 0.005-0.2 s −1 . At the processed temperature of 1080 • C, lower than dissolution temperature of ␥ phase about 30 • C, undissolved ␥ phase particles were contributed to restricting the coarsening of complete recrystallized grains. Plasticity instability was expected in the regime of strain rate higher than 0.4 s −1 and temperature range of 1090-1130 • C.
Materials & Design, 2011
The hot compressive deformation behavior of a new hot isostatically pressed Ni-Cr-Co based powder... more The hot compressive deformation behavior of a new hot isostatically pressed Ni-Cr-Co based powder metallurgy (P/M) superalloy was studied in the temperature range of 950-1150°C and strain rate range of 0.0003-1 s À1 using Gleeble-1500 thermal simulator. The dynamic recrystallization-time-temperature (RTT) curve was developed and the constitutive equation of flow stress during hot deformation was established. The results show that the flow stress decreases with increasing deformation temperature and decreasing strain rate. The flow stress represents as the characteristic of dynamic crystallization with the increasing of strain at the deformation temperatures lower than 1100°C and strain rates higher than 0.0003 s À1 . The beginning time of dynamic crystallization has no linear relationship with deformation temperature in the condition of strain rate lower than 0.01 s À1 . Besides, the experiments verify that the hyperbolic sine model including the variable of strain reflects the changing law of flow stress during the hot deformation process.
Materials Characterization, 2010
The hot deformation characteristics of Haynes230 has been investigated in the temperature range 1... more The hot deformation characteristics of Haynes230 has been investigated in the temperature range 1050-1250 • C and strain rate range 0.001-10 s −1 using hot compression tests. Power dissipation map for hot working are developed on the basis of the Dynamic Materials Model. The map exhibits two domains of dynamic recrystallization (DRX): one occurring in the temperature range of 1200-1250 • C and in the strain rate range of 0.001-0.03 s −1 , which associated with grain coarsening; the other occurring in the temperature range of 1100-1200 • C and strain rate range of 0.001-0.01 s −1 , which are the optimum condition for hot working of this material. The average apparent activation energy for hot deformation is calculated to be 449 kJ/mol. The material undergoes flow instabilities at temperatures of 1050-1100 • C and at strain rates of 1-10 s −1 , as predicted by the continuum instability criterion. The manifestations of the instabilities have been observed to be adiabatic shear bands which are confirmed by optical observation.
Renal Failure, 2002
Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI do... more Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI domain). In this way, type IV collagen forms the main framework of basement membrane. We have developed sandwich Enzyme-Linked Immunosorbent Assay (ELISA) for human serum type IV collage peptide monoclonals for CO5 and CO6 recognizing two different determinants on the central triplex of human collagen molecules. Using this, we explored the possibility that serum levels of type IV collagen (Col IV) are an indicator of early diabetic nephropathy (DN). Serum type IV collagen levels were determined by ELISA in 36 patients with diabetic nephropathy. Serum hemoglobin A1c (HbA1c) and in twenty-four hour urinary albumin excretion rates (UAER) were measured at the same time. A relationship was found between serum levels of this collagen IV and the presence of diabetic nephropathy. That is, serum levels of type IV collagen in diabetic nephropathy were significantly higher than those found in non-insulin-dependent diabetic (NIDDM) patients without nephropathy and in healthy subjects (HS). It is possible that an elevated serum collagen type IV level reflects increased synthetic activity in basement membrane collagen type IV. Serum type IV collagen may be a useful marker for monitoring the dynamics of basement membrane metabolism and in this way serve as a clinical indicator of the progression or the activity of diabetic nephropathy and a marker for the assessment of therapeutic effects.
In job market, there's an increased demand for application-oriented t... more In job market, there's an increased demand for application-oriented talents. Computer Supported Collaborative Learning (CSCL) is an important model of practice teaching for the training of the application-oriented talents. The status of practice teaching is studied based on the characteristics of the Information Management and Information System (IMIS). Computer Supported Collaborative Learning is introduced to break the shackles of the
BMC Public Health, 2011
Background Several studies conducted during the past two decades suggested increasing trend of ch... more Background Several studies conducted during the past two decades suggested increasing trend of childhood allergic diseases in China. However, few studies have provided detailed description of geographic variation and explored risk factors of these diseases. This study investigated the pattern and risk factors of asthma, allergic rhinitis and eczema in eight metropolitan cities in China. Methods We conducted a cross-sectional survey during November-December 2005 in eight metropolitan cities in China. A total of 23791 children aged 6-13 years participated in this survey. Questions from the standard questionnaire of the International Study of Asthma and Allergies in Children (ISAAC) were used to examine the pattern of current asthma, allergic rhinitis and eczema. Logistic regression analyses were performed to assess the risk factors for childhood allergies. Results The average prevalence of childhood asthma, allergic rhinitis and eczema across the eight cities was 3∙3% (95% Confidence interval (CI): 3∙1%, 3∙6%), 9∙8% (95% CI: 9∙4%, 10∙2%) and 5∙5% (95% CI: 5∙2%, 5∙8%), respectively. Factors related to lifestyle, mental health and socio-economic status were found to be associated with the prevalence of childhood allergies. These risk factors were unevenly distributed across cities and disproportionately affected the local prevalence. Conclusions There was apparent geographic variation of childhood allergies in China. Socio-environmental factors had strong impacts on the prevalence of childhood allergies; but these impacts differed across regions. Thus public health policies should specifically target at the local risk factors for each individual area.
International Journal of Behavioral Development, 2008
Caregivers of 608 (331 boys and 277 girls) children in Shanghai, China reported on their children... more Caregivers of 608 (331 boys and 277 girls) children in Shanghai, China reported on their children's language development and on the language teaching practices used in the home. The children were between 24 and 47 months old. The relation of age-corrected language level to paternal education, child gender, and teaching practice use was examined. Children of more educated fathers were more advanced in language development than children of less educated fathers. Girls were more advanced than boys. Some language teaching practices were positively related to language development but one, the practice of eliciting imitation from children, was negatively related to language development. Vocabulary development showed a greater number of significant relations to environmental variables than did grammatical development. These results suggest the cross-linguistic and cross-cultural generalizability of previous findings from studies of North American samples with respect to correlates of children's early language development.
Environmental Toxicology and Pharmacology, 2009
Cancer risk is modulated by gene-environment interactions between toxic exposure and genetic vari... more Cancer risk is modulated by gene-environment interactions between toxic exposure and genetic variation in carcinogen metabolism. Our objective was to assess interactions between exposure to industrial pollutants and polymorphisms affecting cytochrome P450s (CYP1A1 and CYP2E1) and glutathione Stransferases (GSTP1 and GSTT) in childhood acute leukemia (AL). A case-only design was conducted in 123 Chinese children with sporadic AL. Industrial plants in the vicinity were recorded and, if present, their size and proximity to the usual place of residence of AL children was evaluated. Unconditional logistic regression analysis was performed across the AL study group adjusting for age, gender, parental education, occupation and smoking, indoor and outdoor pesticide use, presence of television sets, refrigerators, microwave ovens and furniture material in children's rooms, and electric transformers, power lines, and telecommunication transmitters within 500 m. This analysis revealed an interaction between the GSTT null allele and industrial plants within 500 m of the residences of childhood AL patients (interaction odds ratio, COR = 2.96, 95% CI: 1.09-8.01). Furthermore, the COR for the interaction between GSTT null and industrial plants within 50 m was 5.99 (95% CI: 1.41-25.45). Our results suggest an association between proximity to industrial plants and the GSTT null allele in patients with childhood AL.
Journal of University of Science and Technology Beijing, 2006
The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were i... more The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were investigated by means of the isothermal compression tests at a Gleeble-1500 thermal mechanical simulator. The results show that dynamic recovery acts as the main softening ...
Materials Science and Engineering A-structural Materials Properties Microstructure and Processing, 2010
The hot deformation behavior of hot isostatically pressed (HIPd) P/M superalloy FGH4096 has been ... more The hot deformation behavior of hot isostatically pressed (HIPd) P/M superalloy FGH4096 has been characterized by isothermal compression testing in the temperature range of 1050-1140 • C and strain rate range of 0.002-1.0 s −1 . The apparent activation energy of deformation was calculated to be 418 kJ/mol, and constitutive equation that described the flow stress as a function of the strain rate and deformation temperature was proposed for high temperature deformation of the alloy. The processing map was calculated to evaluate the efficiency of the forging process in the temperatures and strain rates investigated and to recognize the instability regimes. It was found that the strain has no significant effect on the processing maps. The optimum processing conditions were in the strain rates of around 0.01-0.2 s −1 and temperatures of 1080-1110 • C, the efficiencies are higher compared to other stable regimes. The DRX occurs at the temperatures of 1050-1130 • C and strain rate range 0.005-0.2 s −1 . At the processed temperature of 1080 • C, lower than dissolution temperature of ␥ phase about 30 • C, undissolved ␥ phase particles were contributed to restricting the coarsening of complete recrystallized grains. Plasticity instability was expected in the regime of strain rate higher than 0.4 s −1 and temperature range of 1090-1130 • C.
Materials & Design, 2011
The hot compressive deformation behavior of a new hot isostatically pressed Ni-Cr-Co based powder... more The hot compressive deformation behavior of a new hot isostatically pressed Ni-Cr-Co based powder metallurgy (P/M) superalloy was studied in the temperature range of 950-1150°C and strain rate range of 0.0003-1 s À1 using Gleeble-1500 thermal simulator. The dynamic recrystallization-time-temperature (RTT) curve was developed and the constitutive equation of flow stress during hot deformation was established. The results show that the flow stress decreases with increasing deformation temperature and decreasing strain rate. The flow stress represents as the characteristic of dynamic crystallization with the increasing of strain at the deformation temperatures lower than 1100°C and strain rates higher than 0.0003 s À1 . The beginning time of dynamic crystallization has no linear relationship with deformation temperature in the condition of strain rate lower than 0.01 s À1 . Besides, the experiments verify that the hyperbolic sine model including the variable of strain reflects the changing law of flow stress during the hot deformation process.
Materials Characterization, 2010
The hot deformation characteristics of Haynes230 has been investigated in the temperature range 1... more The hot deformation characteristics of Haynes230 has been investigated in the temperature range 1050-1250 • C and strain rate range 0.001-10 s −1 using hot compression tests. Power dissipation map for hot working are developed on the basis of the Dynamic Materials Model. The map exhibits two domains of dynamic recrystallization (DRX): one occurring in the temperature range of 1200-1250 • C and in the strain rate range of 0.001-0.03 s −1 , which associated with grain coarsening; the other occurring in the temperature range of 1100-1200 • C and strain rate range of 0.001-0.01 s −1 , which are the optimum condition for hot working of this material. The average apparent activation energy for hot deformation is calculated to be 449 kJ/mol. The material undergoes flow instabilities at temperatures of 1050-1100 • C and at strain rates of 1-10 s −1 , as predicted by the continuum instability criterion. The manifestations of the instabilities have been observed to be adiabatic shear bands which are confirmed by optical observation.