Hanaa El-Desoky | Tanta University (original) (raw)

Hanaa El-Desoky

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Papers by Hanaa El-Desoky

Research paper thumbnail of Electrochemical stripping voltammetrical sensor based on polypyrrole exfoliated polyetheramine–montmorillonite nanocomposite for nanomolar detection of nifuroxazide

Research paper thumbnail of The first utilization of graphene nano-sheets and synthesized Fe3O4 nanoparticles as a synergistic electrodeposition platform for simultaneous voltammetric determination of some toxic heavy metal ions in various real environmental water samples

Microchemical Journal, 2021

Research paper thumbnail of An advanced and Facile Synthesized Graphene/Magnetic Fe3O4 Nanoparticles Platform for Subnanomolar Voltammetric Determination of Antipsychotic Olanzapine Drug in Human Plasma

Journal of The Electrochemical Society, 2020

Research paper thumbnail of A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

Journal of The Electrochemical Society, 2020

Research paper thumbnail of Utilizing the Synergetic Benefit of Synthesized NiO Nano Flakes and Natural Activated Charcoal (an Alternative of Graphene) as a Novel Platform for Voltammetric Determination of Chronic Hepatitis C Virus Inhibitor Ledipasvir

Journal of The Electrochemical Society, 2020

Research paper thumbnail of Electrochemical Sensor Based on Functionalized Multiwalled Carbon Nanotubes, Domperidone Determination, DNA Binding and Molecular Docking

Journal of The Electrochemical Society, 2017

An electrochemical sensor based on modification of carbon paste electrode by the functionlized MW... more An electrochemical sensor based on modification of carbon paste electrode by the functionlized MWCNT (f-MWCNT/CPE) was prepared for determination of Domperidone in formulation and in human serum. f-MWCNTs were prepared by a simple surface oxidization of the pristine MWCNTs using a famous, less expensive and less vigorous KMnO 4. The f-MWCNTs were characterized using FTIR spectra, TEM, BET N 2 sorption isotherms and TGA. Point of zero charge of pristine and oxidized MWCNTs was also determined. The surface morphology and charge transfer resistance of the bare and f-MWCNT/CPEs were investigated using SEM and EIS. The detection limit (4.68 × 10 −11 M) indicates the sensitivity of the developed electrode for trace assay of Domperidone in biological fluids. The binding interactions of Domperidone with DNA and the mode of this binding have been investigated using cyclic voltammetry, UV-vis spectrophotometry and molecular docking studies. The estimated binding free energy (–20.47 KJmol −1) by Autodock was comparable to the experimental free energy (–25.82 KJmol −1) in the cyclic voltammetric analysis. The minor groove-binding mode of interaction was also supported by docking simulation studies. The higher binding constant value (8.77 × 10 4 M −1) might be sufficient to interfere with DNA replication and thus, Domperidone can be used as an anticancer therapy.

Research paper thumbnail of Application of Montmorillonite Clay and Mesoporous Carbon as Modifiers to Carbon Paste Electrode for Determination of Amoxicillin Drug

Journal of The Electrochemical Society, 2017

Research paper thumbnail of High Sensitive Analysis Method for Determination of Carbosulfan Pesticide in Bulk Form, in Soil and in Orange Matrix

The International Conference on Chemical and Environmental Engineering, 2016

Research paper thumbnail of Graphene-Based Sensor for Voltammetric Quantification of Dapoxetine Hydrochloride: A Drug for Premature Ejaculation in Formulation and Human Plasma

Journal of The Electrochemical Society, 2018

Research paper thumbnail of Mesoporous SiO2 (SBA-15) modified graphite electrode as highly sensitive sensor for ultra trace level determination of Dapoxetine hydrochloride drug in human plasma

Journal of Electroanalytical Chemistry, 2019

Research paper thumbnail of A First Efficient Voltammetric Approach for Detection of Octreotide, an Octapeptide Analogue of Somatostatin Natural Hormone, in Sandostatin Intramuscular Injection and Human Plasma Based on Modification Free Electrochemical Sensor

Journal of The Electrochemical Society, 2019

Research paper thumbnail of Quantification of Chloroxylenol, a Potent Antimicrobial Agent in Various Formulations and Water Samples: Environmental Friendly Electrochemical Sensor Based on Microwave Synthesis of Graphene

Journal of The Electrochemical Society, 2018

Research paper thumbnail of Simple Voltammetric Method for Nano Estimation of Etilefrine Hydrochloride Based on Environmentally Friendly Montmorillonite Natural Clay

Journal of The Electrochemical Society, 2017

Research paper thumbnail of Magnetic cobalt ferrite nanoparticles CoFe2O4platform as an efficient sensor for trace determination of Cu(ii) in water samples and different food products

New Journal of Chemistry, 2017

A novel electrochemical sensing platform using mesoporous nanoparticles for precise Cu determinat... more A novel electrochemical sensing platform using mesoporous nanoparticles for precise Cu determination is described.

Research paper thumbnail of Voltammetric Ciprofloxacin Sensor Based on Carbon Paste Electrodes Modified with Mesoporous Carbon with Enhancement Effect Using CTAB

Journal of The Electrochemical Society, 2015

Research paper thumbnail of Carbon Nanotubes Modified Electrode for Enhanced Voltammetric Sensing of Mebeverine Hydrochloride in Formulations and Human Serum Samples

Journal of The Electrochemical Society, 2017

Research paper thumbnail of Electrochemistry of the COMT Enzyme Inhibitor Entacapone and Its Determination in Pharmaceutical Formulation and Human Blood-Pharmacokinetic Study

Journal of The Electrochemical Society, 2015

Research paper thumbnail of A Direct Spectrophotometric Method for Determination of Antiparasitic Drug Nitazoxanide in a Bulk Form and Pharmaceutical Formulation

Nitazoxanide is a broad-spectrum drug efficacious in the treatment of infections caused by amitoc... more Nitazoxanide is a broad-spectrum drug efficacious in the treatment of infections caused by amitochondriate luminal parasites and helminthes. A simple and direct UV-VIS spectrophotometric method for determination of nitazoxanide in a bulk form and pharmaceutical formulation "Cryptonaz powder" was elaborated and validated. The method did not require sample pretreatment, extraction, or formation of colored chromogens prior to the analysis. The analysis was carried out in a B-R universal buffer ofpH 7 containing 20% (v/v) of acetonitrile. Absorbance of nitazoxanide was measured at λ max = 420 nm. Beer's law was obeyed over the nitazoxanide concentration range 1.0 x 10 -6 -1.0 x 10 -4 mol L -1 (0.293-29.30 μg mL -1 ); detection limit was 3.0 × 10 -7 mol L-' (0.088 μg mL -1 ). Insignificant interferences from the excipients present in "Cryptonaz powder" or degradation products of nitazoxanide were detected. The described method is direct, simple, precise, less time-consuming, and offers economical assay of nitazoxanide with sensitivity better than or at least comparable to that of the reported spectrophotometric methods. The ionization constant (pk a ) ofnitazoxanide was also determined.

Research paper thumbnail of Voltammetric analysis of nitroxoline in tablets and human serum using modified carbon paste electrodes incorporating mesoporous carbon or multiwalled carbon nanotubes

RSC Advances, 2015

Mesoporous carbon (MC) was synthesized using mesoporous SiO2 template material (SBA-15) and sucro... more Mesoporous carbon (MC) was synthesized using mesoporous SiO2 template material (SBA-15) and sucrose as the carbon source. SBA-15, MC and multi-walled carbon nanotubes (MWCNTs) were used as sensors for determination of nitroxoline drug.

Research paper thumbnail of Electrochemical determination of pipazethate hydrochloride on Na-montmorillonite modified carbon paste electrode in formulation and human blood

Journal of Solid State Electrochemistry, 2014

The electrochemical and interfacial adsorptive behavior of pipazethate HCl (PZ.HCl) onto the deve... more The electrochemical and interfacial adsorptive behavior of pipazethate HCl (PZ.HCl) onto the developed carbon paste electrode surface modified with sodium-montmorillonite clay (Na-MMT CPE) were investigated using cyclic voltammetry. Two validated adsorptive anodic stripping voltammetry methods have also been developed for its determination using 7 % (w/w) Na-MMT-modified CPE. Langmuir isotherm can describe the experimental data well, indicating monolayer adsorption. Limits of detection of 2.4 × 10−7 and 3.0 × 10−8 mol L−1 PZ.HCl were achieved in the bulk form using linear-sweep and square-wave adsorptive anodic stripping voltammetric methods, respectively. The developed methods were also successfully applied for determination of PZ.HCl in pharmaceutical formulation and in spiked human serum without time-consuming extraction steps prior to the analysis. Statistical comparison of the results of the proposed methods with that of official and reported spectrophotometric methods indicates no significant difference in precision and accuracy between the proposed and reference methods.

Research paper thumbnail of Electrochemical stripping voltammetrical sensor based on polypyrrole exfoliated polyetheramine–montmorillonite nanocomposite for nanomolar detection of nifuroxazide

Research paper thumbnail of The first utilization of graphene nano-sheets and synthesized Fe3O4 nanoparticles as a synergistic electrodeposition platform for simultaneous voltammetric determination of some toxic heavy metal ions in various real environmental water samples

Microchemical Journal, 2021

Research paper thumbnail of An advanced and Facile Synthesized Graphene/Magnetic Fe3O4 Nanoparticles Platform for Subnanomolar Voltammetric Determination of Antipsychotic Olanzapine Drug in Human Plasma

Journal of The Electrochemical Society, 2020

Research paper thumbnail of A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

Journal of The Electrochemical Society, 2020

Research paper thumbnail of Utilizing the Synergetic Benefit of Synthesized NiO Nano Flakes and Natural Activated Charcoal (an Alternative of Graphene) as a Novel Platform for Voltammetric Determination of Chronic Hepatitis C Virus Inhibitor Ledipasvir

Journal of The Electrochemical Society, 2020

Research paper thumbnail of Electrochemical Sensor Based on Functionalized Multiwalled Carbon Nanotubes, Domperidone Determination, DNA Binding and Molecular Docking

Journal of The Electrochemical Society, 2017

An electrochemical sensor based on modification of carbon paste electrode by the functionlized MW... more An electrochemical sensor based on modification of carbon paste electrode by the functionlized MWCNT (f-MWCNT/CPE) was prepared for determination of Domperidone in formulation and in human serum. f-MWCNTs were prepared by a simple surface oxidization of the pristine MWCNTs using a famous, less expensive and less vigorous KMnO 4. The f-MWCNTs were characterized using FTIR spectra, TEM, BET N 2 sorption isotherms and TGA. Point of zero charge of pristine and oxidized MWCNTs was also determined. The surface morphology and charge transfer resistance of the bare and f-MWCNT/CPEs were investigated using SEM and EIS. The detection limit (4.68 × 10 −11 M) indicates the sensitivity of the developed electrode for trace assay of Domperidone in biological fluids. The binding interactions of Domperidone with DNA and the mode of this binding have been investigated using cyclic voltammetry, UV-vis spectrophotometry and molecular docking studies. The estimated binding free energy (–20.47 KJmol −1) by Autodock was comparable to the experimental free energy (–25.82 KJmol −1) in the cyclic voltammetric analysis. The minor groove-binding mode of interaction was also supported by docking simulation studies. The higher binding constant value (8.77 × 10 4 M −1) might be sufficient to interfere with DNA replication and thus, Domperidone can be used as an anticancer therapy.

Research paper thumbnail of Application of Montmorillonite Clay and Mesoporous Carbon as Modifiers to Carbon Paste Electrode for Determination of Amoxicillin Drug

Journal of The Electrochemical Society, 2017

Research paper thumbnail of High Sensitive Analysis Method for Determination of Carbosulfan Pesticide in Bulk Form, in Soil and in Orange Matrix

The International Conference on Chemical and Environmental Engineering, 2016

Research paper thumbnail of Graphene-Based Sensor for Voltammetric Quantification of Dapoxetine Hydrochloride: A Drug for Premature Ejaculation in Formulation and Human Plasma

Journal of The Electrochemical Society, 2018

Research paper thumbnail of Mesoporous SiO2 (SBA-15) modified graphite electrode as highly sensitive sensor for ultra trace level determination of Dapoxetine hydrochloride drug in human plasma

Journal of Electroanalytical Chemistry, 2019

Research paper thumbnail of A First Efficient Voltammetric Approach for Detection of Octreotide, an Octapeptide Analogue of Somatostatin Natural Hormone, in Sandostatin Intramuscular Injection and Human Plasma Based on Modification Free Electrochemical Sensor

Journal of The Electrochemical Society, 2019

Research paper thumbnail of Quantification of Chloroxylenol, a Potent Antimicrobial Agent in Various Formulations and Water Samples: Environmental Friendly Electrochemical Sensor Based on Microwave Synthesis of Graphene

Journal of The Electrochemical Society, 2018

Research paper thumbnail of Simple Voltammetric Method for Nano Estimation of Etilefrine Hydrochloride Based on Environmentally Friendly Montmorillonite Natural Clay

Journal of The Electrochemical Society, 2017

Research paper thumbnail of Magnetic cobalt ferrite nanoparticles CoFe2O4platform as an efficient sensor for trace determination of Cu(ii) in water samples and different food products

New Journal of Chemistry, 2017

A novel electrochemical sensing platform using mesoporous nanoparticles for precise Cu determinat... more A novel electrochemical sensing platform using mesoporous nanoparticles for precise Cu determination is described.

Research paper thumbnail of Voltammetric Ciprofloxacin Sensor Based on Carbon Paste Electrodes Modified with Mesoporous Carbon with Enhancement Effect Using CTAB

Journal of The Electrochemical Society, 2015

Research paper thumbnail of Carbon Nanotubes Modified Electrode for Enhanced Voltammetric Sensing of Mebeverine Hydrochloride in Formulations and Human Serum Samples

Journal of The Electrochemical Society, 2017

Research paper thumbnail of Electrochemistry of the COMT Enzyme Inhibitor Entacapone and Its Determination in Pharmaceutical Formulation and Human Blood-Pharmacokinetic Study

Journal of The Electrochemical Society, 2015

Research paper thumbnail of A Direct Spectrophotometric Method for Determination of Antiparasitic Drug Nitazoxanide in a Bulk Form and Pharmaceutical Formulation

Nitazoxanide is a broad-spectrum drug efficacious in the treatment of infections caused by amitoc... more Nitazoxanide is a broad-spectrum drug efficacious in the treatment of infections caused by amitochondriate luminal parasites and helminthes. A simple and direct UV-VIS spectrophotometric method for determination of nitazoxanide in a bulk form and pharmaceutical formulation "Cryptonaz powder" was elaborated and validated. The method did not require sample pretreatment, extraction, or formation of colored chromogens prior to the analysis. The analysis was carried out in a B-R universal buffer ofpH 7 containing 20% (v/v) of acetonitrile. Absorbance of nitazoxanide was measured at λ max = 420 nm. Beer's law was obeyed over the nitazoxanide concentration range 1.0 x 10 -6 -1.0 x 10 -4 mol L -1 (0.293-29.30 μg mL -1 ); detection limit was 3.0 × 10 -7 mol L-' (0.088 μg mL -1 ). Insignificant interferences from the excipients present in "Cryptonaz powder" or degradation products of nitazoxanide were detected. The described method is direct, simple, precise, less time-consuming, and offers economical assay of nitazoxanide with sensitivity better than or at least comparable to that of the reported spectrophotometric methods. The ionization constant (pk a ) ofnitazoxanide was also determined.

Research paper thumbnail of Voltammetric analysis of nitroxoline in tablets and human serum using modified carbon paste electrodes incorporating mesoporous carbon or multiwalled carbon nanotubes

RSC Advances, 2015

Mesoporous carbon (MC) was synthesized using mesoporous SiO2 template material (SBA-15) and sucro... more Mesoporous carbon (MC) was synthesized using mesoporous SiO2 template material (SBA-15) and sucrose as the carbon source. SBA-15, MC and multi-walled carbon nanotubes (MWCNTs) were used as sensors for determination of nitroxoline drug.

Research paper thumbnail of Electrochemical determination of pipazethate hydrochloride on Na-montmorillonite modified carbon paste electrode in formulation and human blood

Journal of Solid State Electrochemistry, 2014

The electrochemical and interfacial adsorptive behavior of pipazethate HCl (PZ.HCl) onto the deve... more The electrochemical and interfacial adsorptive behavior of pipazethate HCl (PZ.HCl) onto the developed carbon paste electrode surface modified with sodium-montmorillonite clay (Na-MMT CPE) were investigated using cyclic voltammetry. Two validated adsorptive anodic stripping voltammetry methods have also been developed for its determination using 7 % (w/w) Na-MMT-modified CPE. Langmuir isotherm can describe the experimental data well, indicating monolayer adsorption. Limits of detection of 2.4 × 10−7 and 3.0 × 10−8 mol L−1 PZ.HCl were achieved in the bulk form using linear-sweep and square-wave adsorptive anodic stripping voltammetric methods, respectively. The developed methods were also successfully applied for determination of PZ.HCl in pharmaceutical formulation and in spiked human serum without time-consuming extraction steps prior to the analysis. Statistical comparison of the results of the proposed methods with that of official and reported spectrophotometric methods indicates no significant difference in precision and accuracy between the proposed and reference methods.

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