Naimin Jing | Temple University (original) (raw)
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Papers by Naimin Jing
Modern large data sets inevitably contain outliers that deviate from the model assumptions. Howev... more Modern large data sets inevitably contain outliers that deviate from the model assumptions. However, many widely used estimators, such as maximum likelihood estimators and least squared estimators, perform weakly with the existence of outliers. Alternatively, many statistical modeling approaches have matrices as the parameters. We consider penalized estimators for matrix-valued parameters with a focus on their robustness properties in the presence of outliers. We propose a general framework for robust modeling with matrix-valued parameters by minimizing robust loss functions with penalization. However, there are challenges to this approach in both computation and theoretical analysis. To tackle the computational challenges from the large size of the data, non-smoothness of robust loss functions, and the slow speed of matrix operations, we propose to apply the Frank-Wolfe algorithm, a first-order algorithm for optimization on a restricted region with low computation burden per iterat...
BackgroundMulti-system inflammatory syndrome in children (MIS-C) represents one of the most sever... more BackgroundMulti-system inflammatory syndrome in children (MIS-C) represents one of the most severe post-acute sequelae of SARS-CoV-2 infection in children, and there is a critical need to characterize its disease patterns for improved recognition and management. Our objective was to characterize subphenotypes of MIS-C based on presentation, demographics and laboratory parameters.MethodsWe conducted a retrospective cohort study of children with MIS-C from March 1, 2020 - April 30, 2022 and cared for in 8 pediatric medical centers that participate in PEDSnet. We included demographics, symptoms, conditions, laboratory values, medications and outcomes (ICU admission, death), and grouped variables into eight categories according to organ system involvement. We used a heterogeneity-adaptive latent class analysis model to identify three clinically-relevant subphenotypes. We further characterized the sociodemographic and clinical characteristics of each subphenotype, and evaluated their tem...
Contemporary Clinical Trials, 2022
Modern large data sets inevitably contain outliers that deviate from the model assumptions. Howev... more Modern large data sets inevitably contain outliers that deviate from the model assumptions. However, many widely used estimators, such as maximum likelihood estimators and least squared estimators, perform weakly with the existence of outliers. Alternatively, many statistical modeling approaches have matrices as the parameters. We consider penalized estimators for matrix-valued parameters with a focus on their robustness properties in the presence of outliers. We propose a general framework for robust modeling with matrix-valued parameters by minimizing robust loss functions with penalization. However, there are challenges to this approach in both computation and theoretical analysis. To tackle the computational challenges from the large size of the data, non-smoothness of robust loss functions, and the slow speed of matrix operations, we propose to apply the Frank-Wolfe algorithm, a first-order algorithm for optimization on a restricted region with low computation burden per iterat...
BackgroundMulti-system inflammatory syndrome in children (MIS-C) represents one of the most sever... more BackgroundMulti-system inflammatory syndrome in children (MIS-C) represents one of the most severe post-acute sequelae of SARS-CoV-2 infection in children, and there is a critical need to characterize its disease patterns for improved recognition and management. Our objective was to characterize subphenotypes of MIS-C based on presentation, demographics and laboratory parameters.MethodsWe conducted a retrospective cohort study of children with MIS-C from March 1, 2020 - April 30, 2022 and cared for in 8 pediatric medical centers that participate in PEDSnet. We included demographics, symptoms, conditions, laboratory values, medications and outcomes (ICU admission, death), and grouped variables into eight categories according to organ system involvement. We used a heterogeneity-adaptive latent class analysis model to identify three clinically-relevant subphenotypes. We further characterized the sociodemographic and clinical characteristics of each subphenotype, and evaluated their tem...
Contemporary Clinical Trials, 2022