Harshita Chatterjee | Texila American University (original) (raw)

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Papers by Harshita Chatterjee

Journal of the Neurological Sciences, Oct 1, 2019

The mean admission rate due to relapse was significantly reduced from 24.54 ± 7.48 to 2.92 ± 4.26... more The mean admission rate due to relapse was significantly reduced from 24.54 ± 7.48 to 2.92 ± 4.26, P b 0.004 after establishing the MS clinic. Most patients (61%) had escalated therapy (mean duration till escalation: 7.4 years). MS specialists prescribed second line DMT for 600 patients (50.1%). Escalation therapy was significantly higher in patients who were seen by an MS specialist versus those who were seen by a general neurologist (66.6% vs 33.4%, Pb0.0. Mean EDSS at latest visit to MS clinic was less than 3 in 1039 (83.3%), from 3-4 in 59 (4.7%) and more than 4 in in 148 (12.7%). Conclusion Optimal therapy decisions for MS patients via a specialised MS clinic are associated with a significant decrease in relapse rate, disability, and hence, the economic burden of multiple sclerosis.

Different aspects of spatial neglect, the disability to locate the position of the source of an e... more Different aspects of spatial neglect, the disability to locate the position of the source of an external stimulus, has been studied frequently especially with regards to lack of response to visual stimuli. A modicum of papers fails to elaborate on that of the auditory field and even less conducted on the extraction of spatial information from olfactory stimuli. In this study we attempted to find a structural connection between the Olfactory Cortex (OC) and Temporoparietal Junction (TPJ), in order to suggest that processed olfactory information is carried from OC to TPJ, where the spatial information of the odor maybe acquired. Positive results were attained in all subjects with a lateralization observed in the right hemisphere.

(HCP). In all the datasets from both the sexes, fibers were traced and the neural structural conn... more (HCP). In all the datasets from both the sexes, fibers were traced and the neural structural connectivity was confirmed. The hemispheric differences between male and female subjects were analysed using independent sample t-test. Thus, the study confirmed the structural existences of Olfactory-saccadic pathways that may be involved in influencing the movements of the neck and eyeball gaze (saccadic eye movement), towards the spatial orientation of olfactory stimulus.

Journal of the Neurological Sciences, Oct 1, 2019

An extract of Vicia faba (VF,broad beans) has been reported to be protective against experimental... more An extract of Vicia faba (VF,broad beans) has been reported to be protective against experimentally induced convulsions in mice, explaining the relatively low prevalence rate of epilepsy in communities where VF constitutes a major food item. To identify and characterize the active compound(s) in VF extract, the oil-free lyophilized powder was dissolved in an ethanol solvent and extracted for eight hours under reflux, and filtered. The volume of ethanol was reduced by a rotary evaporator, and a first off-white precipitate (Sample A-1) was collected, washed with ethanol, and dried at 80°C. The oil-free lyophilized powder was then extracted with ethanol, again using the above-mentioned procedure. The thin-layer chromatography (TLC) results indicated a mixture of components. Mass spectrometry showed a molecular weight of 200.16447 g mol-1 , and an empirical formula of C9H16N2O3 was assigned. Intraperitoneal injection of mice with 50 mg/kg of Sample A-1, twenty minutes prior to administration of strychnine, protected the mice from strychnine-induced convulsions to the same extent as phenobarbitone (phenobarbital). Further extraction of the remaining ethanol solvent by column chromatography with a mixture of ammonium hydroxide, methanol, and ethanol extraction solvents produced a second off-white precipitate (Sample A-2), which delays the onset of strychnine-induced convulsions, but is not as effective as Sample A-1. Further isolation of compounds from the mixture of extraction solvents by gas chromatography-mass spectrometry (GC-MS) or high-performance liquid chromatography-mass spectrometry (HPLC-MS), did not include any further anticonvulsants of interest. Compound A-1 (Sample A-1) constitutes an effective anticovulsant agent extracted from natural sources.

PLOS ONE

Background The emergence of the COVID-19 pandemic has affected the lives of many people, includin... more Background The emergence of the COVID-19 pandemic has affected the lives of many people, including medical students. The present study explored internet addiction and changes in sleep patterns among medical students during the pandemic and assessed the relationship between them. Methods A cross-sectional study was carried out in seven countries, the Dominican Republic, Egypt, Guyana, India, Mexico, Pakistan, and Sudan, using a convenience sampling technique, an online survey comprising demographic details, information regarding COVID-19, the Pittsburgh Sleep Quality Index (PSQI), and the Internet Addiction Test (IAT). Results In total, 2749 participants completed the questionnaire. Of the total, 67.6% scored above 30 in the IAT, suggesting the presence of an Internet addiction, and 73.5% scored equal and above 5 in the PSQI, suggesting poor sleep quality. Internet addiction was found to be significant predictors of poor sleep quality, causing 13.2% of the variance in poor sleep qual...

This confirmatory study aimed to unravel the neural structural connectivity of Olfactory-Saccadic... more This confirmatory study aimed to unravel the neural structural connectivity of Olfactory-Saccadic pathways extending between Piriform and Entorhinal Cortices to Frontal Eye Field (FEF), and to correlate its functional importance with possible clinical implications, using Diffusion Imaging fiber Tractography. The confirmatory observational analysis used thirty-two healthy adults, ultra-high b-value, diffusion imaging datasets from an Open access platform in Human Connectome Project (HCP). In all the datasets from both the sexes, fibers were traced and the neural structural connectivity was confirmed. The hemispheric differences between male and female subjects were analysed using independent sample t-test. Thus, the study confirmed the structural existences of Olfactory-saccadic pathways that may be involved in influencing the movements of the neck and eyeball gaze (saccadic eye movement), towards the spatial orientation of olfactory stimulus.

Journal of the Neurological Sciences, Oct 1, 2019

PLOS ONE