Gaurav Pandey | Thapar University, Patiala (original) (raw)
Papers by Gaurav Pandey
The Journal of Association of Chest Physicians, 2016
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Tij S Research Journal of Economics Business Studies Rjebs, Jul 26, 2014
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Frontiers in bioengineering and biotechnology, 2015
A genetic interaction (GI) is a type of interaction where the effect of one gene is modified by t... more A genetic interaction (GI) is a type of interaction where the effect of one gene is modified by the effect of one or several other genes. These interactions are important for delineating functional relationships among genes and their corresponding proteins, as well as elucidating complex biological processes and diseases. An important type of GI - synthetic sickness or synthetic lethality - involves two or more genes, where the loss of either gene alone has little impact on cell viability, but the combined loss of all genes leads to a severe decrease in fitness (sickness) or cell death (lethality). The identification of GIs is an important problem for it can help delineate pathways, protein complexes, and regulatory dependencies. Synthetic lethal interactions have important clinical and biological significance, such as providing therapeutically exploitable weaknesses in tumors. While near systematic high-content screening for GIs is possible in single cell organisms such as yeast, t...
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Journal of Optical Communications, 2016
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IEEE Journal of Selected Topics in Quantum Electronics, 2016
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Optical and Quantum Electronics, 2015
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Journal of Cellular Biochemistry, 2016
Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic hum... more Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic humans and animals. We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. To elucidate the mechanism, we examined human proximal tubule cells (hPTC) and C57BL/6 mice fed with high-fat diet (HFD, 60% fat for 20 weeks). Immunoblotting revealed a significantly lower protein level of IR in HFD compare to normal chow diet (NCD). Furthermore, a blunted rise in p-AKT(308) levels in the kidney cortex of HFD mice was observed in response to acute insulin (0.75 IU/kg body weight, i.p) relative to NCD n = 8/group, P < 0.05). Moreover, we found significantly higher transcript levels of phosphoenolpyruvate carboxykinase (PEPCK, a key gluconeogenic enzyme) in the kidney cortex from HFD, relative to mice on NCD. The higher level of PEPCK in HFD was confirmed by immunoblotting. However, no significant differences were observed in cortical glucose-6-phosphatase (G6Pase) or fructose-1,6, bisphosphosphatase (FBPase) enzyme transcript levels. Furthermore, we demonstrated insulin inhibited glucose production in hPTC treated with cyclic AMP and dexamethasone (cAMP/DEXA) to stimulate gluconeogenesis. Transcript levels of the gluconeogenic enzyme PEPCK were significantly increased in cAMP/DEXA-stimulated hPTC cells (n = 3, P < 0.05), and insulin attenuated this upregulation Furthermore, the effect of insulin on cAMP/DEXA-induced gluconeogenesis and PEPCK induction was significantly attenuated in IR (siRNA) silenced hPTC (n = 3, P < 0.05). Overall the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis. J. Cell. Biochem. 9999: 1-10, 2016. © 2016 Wiley Periodicals, Inc.
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ABSTRACT A tri-band slot loaded microstrip antenna is proposed. The tri-band characteristics of a... more ABSTRACT A tri-band slot loaded microstrip antenna is proposed. The tri-band characteristics of antenna are achieved by incorporating a combination of symmetrical Y-shaped and asymmetrical U-shaped slot. The Y-shaped slot is placed symmetrically where as U-shaped slot is placed asymmetrically to the center of the patch to achieve the desired tri-band characteristics. Proposed antenna is able to achieve lower frequency ratio of 1.55 (second resonant frequency /first resonant frequency) and 1.37 (third resonant frequency/second resonant frequency), respectively. The return loss characteristics shows that the percentage impedance bandwidth achieved for global positioning system (GPS), wireless fidelity (Wi-Fi), and wireless metropolitan area networks (WiMAX) bands are 1.78%, 5.29%, and 10.37%, respectively. The parametric study of the antenna is presented. The HFSS simulated results are compared with measured and CST Microwave Studio. Good agreement is obtained between simulated and measured results.
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Bmc Genomics, Nov 10, 2012
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A seed document may be determined, and at least one document may be selected from a plurality of ... more A seed document may be determined, and at least one document may be selected from a plurality of documents. A similarity analysis may be performed between the seed document and the at least one document, the similarity analysis including a difference-based analysis. A similarity measure between the at least one document and the seed document may be determined, based on the similarity analysis.
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To achieve acceptable performance for AI tasks, one can either use sophisticated feature extracti... more To achieve acceptable performance for AI tasks, one can either use sophisticated feature extraction methods as the first layer in a two-layered supervised learning model, or learn the features directly using a deep (multi-layered) model. While the first approach is very problem-specific, the second approach has computational overheads in learning multiple layers and fine-tuning of the model. In this paper, we propose an approach called wide learning based on arc-cosine kernels, that learns a single layer of infinite width. We propose exact and inexact learning strategies for wide learning and show that wide learning with single layer outperforms single layer as well as deep architectures of finite width for some benchmark datasets.
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The spectrum of LSS 3378 was obtained on 2002 June 19 with the 4-m Blanco telescope and the Casse... more The spectrum of LSS 3378 was obtained on 2002 June 19 with the 4-m Blanco telescope and the Cassegrain echelle spectrograph at Cerro Tololo Inter-American Observatory (CTIO) in Chile. Three exposures of 25-min each, spectra covering the wavelength interval 50008200{AA} without gaps, were recorded at a resolving power of R=30000. The Image Reduction and Analysis Facility (IRAF) software packages were used to reduce the recorded spectra. (1 data file).
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A document similarity detector may be used to determine a family of documents based on a similari... more A document similarity detector may be used to determine a family of documents based on a similarity analysis between content of a seed document and content of the family of documents, the content of the seed document associated with at least one database object having at least one field. A content extraction system may be used to determine a ranking of a plurality of terms from within at least one document of the family of documents, based on a relative frequency with which each of the plurality of terms appears within the family of ...
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2014 Annual Ieee India Conference, Dec 1, 2014
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The Journal of Association of Chest Physicians, 2016
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Tij S Research Journal of Economics Business Studies Rjebs, Jul 26, 2014
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Frontiers in bioengineering and biotechnology, 2015
A genetic interaction (GI) is a type of interaction where the effect of one gene is modified by t... more A genetic interaction (GI) is a type of interaction where the effect of one gene is modified by the effect of one or several other genes. These interactions are important for delineating functional relationships among genes and their corresponding proteins, as well as elucidating complex biological processes and diseases. An important type of GI - synthetic sickness or synthetic lethality - involves two or more genes, where the loss of either gene alone has little impact on cell viability, but the combined loss of all genes leads to a severe decrease in fitness (sickness) or cell death (lethality). The identification of GIs is an important problem for it can help delineate pathways, protein complexes, and regulatory dependencies. Synthetic lethal interactions have important clinical and biological significance, such as providing therapeutically exploitable weaknesses in tumors. While near systematic high-content screening for GIs is possible in single cell organisms such as yeast, t...
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Journal of Optical Communications, 2016
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IEEE Journal of Selected Topics in Quantum Electronics, 2016
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Optical and Quantum Electronics, 2015
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Journal of Cellular Biochemistry, 2016
Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic hum... more Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic humans and animals. We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. To elucidate the mechanism, we examined human proximal tubule cells (hPTC) and C57BL/6 mice fed with high-fat diet (HFD, 60% fat for 20 weeks). Immunoblotting revealed a significantly lower protein level of IR in HFD compare to normal chow diet (NCD). Furthermore, a blunted rise in p-AKT(308) levels in the kidney cortex of HFD mice was observed in response to acute insulin (0.75 IU/kg body weight, i.p) relative to NCD n = 8/group, P < 0.05). Moreover, we found significantly higher transcript levels of phosphoenolpyruvate carboxykinase (PEPCK, a key gluconeogenic enzyme) in the kidney cortex from HFD, relative to mice on NCD. The higher level of PEPCK in HFD was confirmed by immunoblotting. However, no significant differences were observed in cortical glucose-6-phosphatase (G6Pase) or fructose-1,6, bisphosphosphatase (FBPase) enzyme transcript levels. Furthermore, we demonstrated insulin inhibited glucose production in hPTC treated with cyclic AMP and dexamethasone (cAMP/DEXA) to stimulate gluconeogenesis. Transcript levels of the gluconeogenic enzyme PEPCK were significantly increased in cAMP/DEXA-stimulated hPTC cells (n = 3, P < 0.05), and insulin attenuated this upregulation Furthermore, the effect of insulin on cAMP/DEXA-induced gluconeogenesis and PEPCK induction was significantly attenuated in IR (siRNA) silenced hPTC (n = 3, P < 0.05). Overall the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis. J. Cell. Biochem. 9999: 1-10, 2016. © 2016 Wiley Periodicals, Inc.
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ABSTRACT A tri-band slot loaded microstrip antenna is proposed. The tri-band characteristics of a... more ABSTRACT A tri-band slot loaded microstrip antenna is proposed. The tri-band characteristics of antenna are achieved by incorporating a combination of symmetrical Y-shaped and asymmetrical U-shaped slot. The Y-shaped slot is placed symmetrically where as U-shaped slot is placed asymmetrically to the center of the patch to achieve the desired tri-band characteristics. Proposed antenna is able to achieve lower frequency ratio of 1.55 (second resonant frequency /first resonant frequency) and 1.37 (third resonant frequency/second resonant frequency), respectively. The return loss characteristics shows that the percentage impedance bandwidth achieved for global positioning system (GPS), wireless fidelity (Wi-Fi), and wireless metropolitan area networks (WiMAX) bands are 1.78%, 5.29%, and 10.37%, respectively. The parametric study of the antenna is presented. The HFSS simulated results are compared with measured and CST Microwave Studio. Good agreement is obtained between simulated and measured results.
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Bmc Genomics, Nov 10, 2012
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A seed document may be determined, and at least one document may be selected from a plurality of ... more A seed document may be determined, and at least one document may be selected from a plurality of documents. A similarity analysis may be performed between the seed document and the at least one document, the similarity analysis including a difference-based analysis. A similarity measure between the at least one document and the seed document may be determined, based on the similarity analysis.
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Bookmarks Related papers MentionsView impact
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To achieve acceptable performance for AI tasks, one can either use sophisticated feature extracti... more To achieve acceptable performance for AI tasks, one can either use sophisticated feature extraction methods as the first layer in a two-layered supervised learning model, or learn the features directly using a deep (multi-layered) model. While the first approach is very problem-specific, the second approach has computational overheads in learning multiple layers and fine-tuning of the model. In this paper, we propose an approach called wide learning based on arc-cosine kernels, that learns a single layer of infinite width. We propose exact and inexact learning strategies for wide learning and show that wide learning with single layer outperforms single layer as well as deep architectures of finite width for some benchmark datasets.
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The spectrum of LSS 3378 was obtained on 2002 June 19 with the 4-m Blanco telescope and the Casse... more The spectrum of LSS 3378 was obtained on 2002 June 19 with the 4-m Blanco telescope and the Cassegrain echelle spectrograph at Cerro Tololo Inter-American Observatory (CTIO) in Chile. Three exposures of 25-min each, spectra covering the wavelength interval 50008200{AA} without gaps, were recorded at a resolving power of R=30000. The Image Reduction and Analysis Facility (IRAF) software packages were used to reduce the recorded spectra. (1 data file).
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A document similarity detector may be used to determine a family of documents based on a similari... more A document similarity detector may be used to determine a family of documents based on a similarity analysis between content of a seed document and content of the family of documents, the content of the seed document associated with at least one database object having at least one field. A content extraction system may be used to determine a ranking of a plurality of terms from within at least one document of the family of documents, based on a relative frequency with which each of the plurality of terms appears within the family of ...
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2014 Annual Ieee India Conference, Dec 1, 2014
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