Nabil Brahmi | Abou bekr bel kaid University,Tlemcen (original) (raw)
Papers by Nabil Brahmi
Comparative EPR studies of Cu(ii)-conjugated phosphorous-dendrimers in the absence and presence of normal and cancer cells
RSC Adv., 2014
EPR analysis revealed peculiar structural and dynamical properties of anticancer-activeG3B–Cu(ii)... more EPR analysis revealed peculiar structural and dynamical properties of anticancer-activeG3B–Cu(ii) in absence and presence of normal and cancer cells.
ChemInform Abstract: Advances in Direct C-H Arylation of 5,5- 6,5- and 6,6-Fused-Heterocycles Containing Heteroatoms (N, O, S)
ChemInform, 2015
RSC Advances, 2015
Hybrid carbosilane–viologen–phosphorus dendrimers were prepared, as an example of the synthetic “... more Hybrid carbosilane–viologen–phosphorus dendrimers were prepared, as an example of the synthetic “onion peel” approach, on the search of new physical–chemical and biological properties, respecting traditional dendritic architectures.
RSC Advances, 2015
This report aims to review the advances made in C–H arylation of 5,6, 6,6 and 5,5 fused-heterocyc... more This report aims to review the advances made in C–H arylation of 5,6, 6,6 and 5,5 fused-heterocyclic systems.
Original Multivalent Copper(II)-Conjugated Phosphorus Dendrimers and Corresponding Mononuclear Copper(II) Complexes with Antitumoral Activities
Molecular Pharmaceutics, 2013
Novel multivalent copper(II)-conjugated phosphorus dendrimers and their corresponding mononuclear... more Novel multivalent copper(II)-conjugated phosphorus dendrimers and their corresponding mononuclear copper(II) complexes were synthesized, characterized, and screened for antiproliferative activity against human cancer cell lines. Selected copper ligands were grafted on the surface of phosphorus dendrimers of generation G(n) (n = 1 to 3): N-(pyridin-2-ylmethylene)ethanamine for dendrimers 1G(n), N-(di(pyridin-2-yl)methylene)ethanamine for dendrimers 2G(n), and 2-(2-methylenehydrazinyl)pyridine for dendrimers 3G(n). The results indicated that the most potent derivatives are 1G(n) and 1G(n)-Cu versus 2G(n), 2G(n)-Cu, and 3G(n), 3G(n)-Cu. A direct relationship between the growth inhibitory effect and the number of terminal moieties or the amount of copper complexed to the dendrimer was observed in copper-complexed 1 series and noncomplexed 1 series. These data clearly suggested that cytotoxicity increased with the number of terminal moieties available and was boosted by the presence of complexed Cu atoms. Importantly, no cytotoxic effect was observed with CuCl2 at the same concentrations. Finally, 1G3 and 1G3-Cu have been selected for antiproliferative studies against a panel of tumor cell lines: 1G3 and 1G3-Cu demonstrated potent antiproliferative activities with IC50 values ranging 0.3-1.6 μM. Interestingly, the complexation of the terminal ligands of 1G3 dendrimers by copper(II) metal strongly increased the IC50 values in noncancer cells lines referred to as "safety" cell lines.
Applied Organometallic Chemistry, 2009
Four novel ON donor Schiff bases (E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol (HL 1),(E)-... more Four novel ON donor Schiff bases (E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol (HL 1),(E)-3-((4-(4-biphenyloxy)phenyliminomethyl)benzene-1,2-diol (HL 2), (E)-3-((4naphthoxyphenylimino)methyl)benzene-1,2-diol (HL 3), (E)-3-((4-(2naphthoxy)phenylimino)methyl)benzene-1,2-diol (HL 4) and their copper(II) complexes bis((E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 1) 2) bis((E)-3-((4-(4biphenyloxy)phenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 2) 2), bis((E)-3-((4naphthoxyphenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 3) 2), bis((E)-3-((4-(2naphthoxy)phenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 4) 2) have been synthesized and characterized by spectroscopic (FTIR, NMR, UV-visible) and elemental analysis. The crystal structures of HL 1 , HL 2 , HL 3 and HL 4 have been determined, which reveal intramolecular N-H…O (HL 1 , HL 2 , HL 3 and HL 4) hydrogen bonds in the solid-state. Keto-amine and enolimine tautomerism is exhibited by the Schiff bases in solid and solution states. The Schiff bases and their copper(II) complexes have been screened for their biological activities. In antimicrobial assays (antibacterial and antifungal) HL 4 showed promising results against all strains through
![Research paper thumbnail of Bis[1-benzyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole-κ2N2,N3]dichloridocobalt(II)](https://attachments.academia-assets.com/105296826/thumbnails/1.jpg)
](Acta Crystallographica Section E Structure Reports Online, 2012
metal-organic compounds m6 Gueddar et al. [CoCl 2 (C 17 H 13 N 3 S) 2 ] Acta Cryst. (2013). E69, ... more metal-organic compounds m6 Gueddar et al. [CoCl 2 (C 17 H 13 N 3 S) 2 ] Acta Cryst. (2013). E69, m5-m6 supporting information sup-1
Acta Crystallographica Section E Structure Reports Online, 2009
Key indicators: single-crystal X-ray study; T = 295 K; mean (C-C) = 0.005 Å; R factor = 0.056; wR... more Key indicators: single-crystal X-ray study; T = 295 K; mean (C-C) = 0.005 Å; R factor = 0.056; wR factor = 0.185; data-to-parameter ratio = 13.1. organic compounds o2320 El Brahmi et al.
Acta Crystallographica Section E Structure Reports Online, 2011
Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles
Current Organic Chemistry, 2013
Comparative EPR studies of Cu(ii)-conjugated phosphorous-dendrimers in the absence and presence of normal and cancer cells
RSC Adv., 2014
EPR analysis revealed peculiar structural and dynamical properties of anticancer-activeG3B–Cu(ii)... more EPR analysis revealed peculiar structural and dynamical properties of anticancer-activeG3B–Cu(ii) in absence and presence of normal and cancer cells.
ChemInform Abstract: Advances in Direct C-H Arylation of 5,5- 6,5- and 6,6-Fused-Heterocycles Containing Heteroatoms (N, O, S)
ChemInform, 2015
RSC Advances, 2015
Hybrid carbosilane–viologen–phosphorus dendrimers were prepared, as an example of the synthetic “... more Hybrid carbosilane–viologen–phosphorus dendrimers were prepared, as an example of the synthetic “onion peel” approach, on the search of new physical–chemical and biological properties, respecting traditional dendritic architectures.
RSC Advances, 2015
This report aims to review the advances made in C–H arylation of 5,6, 6,6 and 5,5 fused-heterocyc... more This report aims to review the advances made in C–H arylation of 5,6, 6,6 and 5,5 fused-heterocyclic systems.
Original Multivalent Copper(II)-Conjugated Phosphorus Dendrimers and Corresponding Mononuclear Copper(II) Complexes with Antitumoral Activities
Molecular Pharmaceutics, 2013
Novel multivalent copper(II)-conjugated phosphorus dendrimers and their corresponding mononuclear... more Novel multivalent copper(II)-conjugated phosphorus dendrimers and their corresponding mononuclear copper(II) complexes were synthesized, characterized, and screened for antiproliferative activity against human cancer cell lines. Selected copper ligands were grafted on the surface of phosphorus dendrimers of generation G(n) (n = 1 to 3): N-(pyridin-2-ylmethylene)ethanamine for dendrimers 1G(n), N-(di(pyridin-2-yl)methylene)ethanamine for dendrimers 2G(n), and 2-(2-methylenehydrazinyl)pyridine for dendrimers 3G(n). The results indicated that the most potent derivatives are 1G(n) and 1G(n)-Cu versus 2G(n), 2G(n)-Cu, and 3G(n), 3G(n)-Cu. A direct relationship between the growth inhibitory effect and the number of terminal moieties or the amount of copper complexed to the dendrimer was observed in copper-complexed 1 series and noncomplexed 1 series. These data clearly suggested that cytotoxicity increased with the number of terminal moieties available and was boosted by the presence of complexed Cu atoms. Importantly, no cytotoxic effect was observed with CuCl2 at the same concentrations. Finally, 1G3 and 1G3-Cu have been selected for antiproliferative studies against a panel of tumor cell lines: 1G3 and 1G3-Cu demonstrated potent antiproliferative activities with IC50 values ranging 0.3-1.6 μM. Interestingly, the complexation of the terminal ligands of 1G3 dendrimers by copper(II) metal strongly increased the IC50 values in noncancer cells lines referred to as "safety" cell lines.
Applied Organometallic Chemistry, 2009
Four novel ON donor Schiff bases (E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol (HL 1),(E)-... more Four novel ON donor Schiff bases (E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol (HL 1),(E)-3-((4-(4-biphenyloxy)phenyliminomethyl)benzene-1,2-diol (HL 2), (E)-3-((4naphthoxyphenylimino)methyl)benzene-1,2-diol (HL 3), (E)-3-((4-(2naphthoxy)phenylimino)methyl)benzene-1,2-diol (HL 4) and their copper(II) complexes bis((E)-3-((4-phenoxyphenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 1) 2) bis((E)-3-((4-(4biphenyloxy)phenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 2) 2), bis((E)-3-((4naphthoxyphenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 3) 2), bis((E)-3-((4-(2naphthoxy)phenylimino)methyl)benzene-1,2-diol) copper(II) (Cu(L 4) 2) have been synthesized and characterized by spectroscopic (FTIR, NMR, UV-visible) and elemental analysis. The crystal structures of HL 1 , HL 2 , HL 3 and HL 4 have been determined, which reveal intramolecular N-H…O (HL 1 , HL 2 , HL 3 and HL 4) hydrogen bonds in the solid-state. Keto-amine and enolimine tautomerism is exhibited by the Schiff bases in solid and solution states. The Schiff bases and their copper(II) complexes have been screened for their biological activities. In antimicrobial assays (antibacterial and antifungal) HL 4 showed promising results against all strains through
Acta Crystallographica Section E Structure Reports Online, 2012
metal-organic compounds m6 Gueddar et al. [CoCl 2 (C 17 H 13 N 3 S) 2 ] Acta Cryst. (2013). E69, ... more metal-organic compounds m6 Gueddar et al. [CoCl 2 (C 17 H 13 N 3 S) 2 ] Acta Cryst. (2013). E69, m5-m6 supporting information sup-1
Acta Crystallographica Section E Structure Reports Online, 2009
Key indicators: single-crystal X-ray study; T = 295 K; mean (C-C) = 0.005 Å; R factor = 0.056; wR... more Key indicators: single-crystal X-ray study; T = 295 K; mean (C-C) = 0.005 Å; R factor = 0.056; wR factor = 0.185; data-to-parameter ratio = 13.1. organic compounds o2320 El Brahmi et al.
Acta Crystallographica Section E Structure Reports Online, 2011
Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles
Current Organic Chemistry, 2013