P SUBATHIRADEVI | The Tamilnadu Dr. Mgr Medical University (original) (raw)

Papers by P SUBATHIRADEVI

World Journal of Pharmacy and Pharmaceutical Sciences, 2017

Peptic ulcer represents a serious medical condition, Approximately 500,000 new cases are reported... more Peptic ulcer represents a serious medical condition, Approximately 500,000 new cases are reported each year, with 5 million people alone affected in United states alone. The highest riskof contracting peptic ulcer disease are those generations born around the middle of the 20th century. Ulcer disease has become a disease predominantly affecting the older population, with the peak incidence occurring between 55 and 65 years of age. Patients with peptic ulcer disease may present with a range of symptoms, from mild abdominal discomfort to catastrophic perforation and bleeding. Most patients with peptic ulcer disease present with abdominal discomfort, pain, or nausea. The various herbal plants are claimed to posses anti ulcer. Preclincial experiments are done to screen the anti ulcer activity in various herbal drugs using various animal models discussed in screening assays

AYU (An International Quarterly Journal of Research in Ayurveda), 2013

Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage t... more Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other pressure. The purpose of the present study is to investigate the phytoconstituents and hepatoprotective and antioxidant activities of the Hydroalcoholic Extract of Mukia maderaspatana (Linn.) M. Roem (HEMM) leaves on Wistar albino rats. Preliminary phytochemical analysis of HEMM showed the presence or absence of Alkaloids, Carbohydrates, Flavonoids, Saponins, Tannins, Proteins, Steroids, Phenols, Gums and mucilage, Glycosides, Terpenes, and sterols. HEMM at the doses of 200mg/kg body weight and 400mg/kg body weight orally was administered to evaluate hepatoprotective and antioxidant activity against paracetamol-induced liver damage for 21 days in Wistar albino rats. Treatment with HEMM leaves showed h...

ABSTRACT The aim of present study is to analyze heavy metals and microbials in Neorise granules, ... more ABSTRACT The aim of present study is to analyze heavy metals and microbials in Neorise granules, which is herbal formulation developed as memory enhancer. For the exporting any herbal formulation outside the country, both these terminology have valuable importance. ...

INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES, 2019

Peptic ulcer represents a serious medical condition, Approximately 500,000 new cases are reported... more Peptic ulcer represents a serious medical condition, Approximately
500,000 new cases are reported each year, with 5 million people
alone affected in United States alone. The highest risks of
contracting peptic ulcer disease are those generations born around
the middle of the 20th century. Ulcer disease has become a disease
predominantly affecting the older population, with the peak
incidence occurring between 55 and 65 years of age. Thirty – five
percent of patients diagnosed with gastric ulcers will suffer serious
complications. Patients with peptic ulcer disease may present with
a range of symptoms, from mild abdominal discomfort to
catastrophic perforation and bleeding. Most patients with peptic
ulcer disease present with abdominal discomfort, pain, or nausea.
The various herbal plants are claimed to posses anti ulcer.
Preclinical experiments are done to screen the anti ulcer activity in
various herbal drugs using various animal models discussed in
screening assays.

INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES, 2019

Traditional system of medicine consist large number medicinal plants, which conveyed their potent... more Traditional system of medicine consist large number medicinal plants,
which conveyed their potential therapeutic utilities. Aegle marmelos (L)
Correa. is commonly known as Bael belongs to Rutaceae Family,
widely grown in India, tropical and subtropical countries. In India,
Aegle marmelos (L) Correa. possess great mythological significance
and medicinal significance in ancient system of medicine as well. A
priceless tank of bioactive molecule of the plant exploit its medicinal
properties such as Antibacterial, Antihistaminic, Antiinflammatory,
Antipyretic, Analgesic, Hepatoprotective, Insecticidal, Hypoglycemic,
Antioxidant, Immunomodulatory, Myocardial infarction, Testicular
activity, Cardiotonic, Antidepressant, Anxiolytic, Wound Healing,
Anticonvulsant, Antistress, Adaptogenic Antifertility, Antidiabetic,
Antihyperlipidemic, Cardioprotective, Antidiarrhoeal, Antidysentric,
Anticancer, Radioprotective, Antiviral, Antiulcer, Constipation,
Antifungal, Antimalarial, Contractile activity, Antifilarial,
Antiproliferative, Insect controlling properties, Antiarthritis activity,
Acute and subacute toxicity studies. Thus the purpose of their abstract
is to explore the pharmacological activity of some crude extracts of bael
fruit.

International Journal of Pharmacy & Pharmaceutical Research , 2019

Peptic ulcer is one of the major disorders of Gastrointestinal tract, for which a large number of... more Peptic ulcer is one of the major disorders of Gastrointestinal
tract, for which a large number of traditional and modern
medicines are being utilized. The purpose of the present study
is to investigate the phytoconstituents and anti-ulcer activities
of the Hydroalcoholic Extract of Aegle marmelos (L.) Correa.
(HAEAM) unripe fruit on wistar rats. Preliminary
phytochemical analysis of HAEAM showed the presence of
carbohydrates, alkaloids, triterpenoid, glycosides, steroids and
sterols, phenols, tannins, saponins, flavonoids, proteins and
amino acids, terpenes and also showed the absence of gums and
mucilage, oxalate, phytate, ascorbic acid. HAEAM at the doses
of 200 mg/kg body weight and 400 mg/kg body weight orally
was administered to evaluate Anti-ulcer activity by using
Indomethacin induced gastric ulcer for 14 days and Pylorus
ligation induced gastric ulcer for 16 days in Wistar rats.
Treatment with HAEAM decreased ulcer index in both Gastric
ulcer induced models. Treatment with HAEAM increased
Percentage inhibition of ulcer in both Gastric ulcer induced
models. HAEAM showed significant decrease in Total protein
(TP), Serum Glutamate Oxaloacetic acid Transaminase
(SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and
showed increased in Superoxide dismutase (SOD) and Catalase
(CAT) when compared to Indomethacin induced group.
HAEAM significantly decreased Free acidity, Total acidity and
Gastric volume, Serum Glutamate Oxaloacetic acid
Transaminase (SGOT), Serum Glutamate Pyruvate
Transaminase (SGPT) when compared to pylorus ligation
induced group.

American Journal of Bio-pharmacology Biochemistry and Life Sciences [AJBBL], 2018

Schizophrenia is an important health issue affecting almost 1% of the population withsignificant ... more Schizophrenia is an important health issue affecting almost 1% of the population withsignificant unmet medical needs. The classical drug targets for the treatment of schizophrenia are dopamine D2 receptors.Second generation ("Atypical") drugs block more receptors of the GPCR class 1 (e.g. Clozapineis a D(2)-5HT(2) antagonist). Here, new targets for GPCR as well as ligand-gated ion channelsare presented. An analysis of the opportunities for drug design offered by the structures solvedrecently is also presented. For drug design the availability of these protein structures, or the possibility to build highquality models, allows to shift the paradigm from ligand-based to target-based drug design. Theanalysis of drugs on the market and under development shows that numerous targets are beingconsidered which may reveal anambiguity on the ideal drug target. This situation might besimplified in the future thanks to integrative projects started recently: the 'Human Brain Project'and the 'Brain Activity Map' that aim at modeling the brain as well as the Allen Atlas. G-Protein Coupled Receptors and Ligand-Gated Ion Channels are potential targets to treat Schizophrenia. Structures have become available in the recent years for most of LGIC and GPCR receptors that are potential targets to treat schizophrenia.Structurebased drug design is tractable on these receptors.GPCR and LGIC are allosteric proteins.Integrative projects may help discriminate between the numerous potential targets in thefuture.

INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES, 2019

Hyperlipidemia is an elevation of lipids (fats) in the blood stream. These lipids includes choles... more Hyperlipidemia is an elevation of lipids (fats) in the blood stream. These
lipids includes cholesterol, cholesterol esters, phospholipids and
triglycerides. They are transported in blood in the form of large
molecules called lipoproteins. Hyperlipidemia usually has no noticeable
symptoms but however deposits of cholesterol known as xanthomas may
form under the skin especially under the eyes or around the Achilles
tendon in individual with the familial forms of disorder or in those with
very high levels of cholesterol in the blood. Individuals with
hypertriglyceridemia may develop numerous pimples like lesions across
the body. Higher levels are associated with lipemiaretinalis (white
appearance of the retina) eruptive xanthomas (small lumps in the skin,
sometimes itchy). Examples of Antihyperlipidemic drugs are HMG COA reductase, Fibrate, bile acid sequestrants, ezetimibe, nicotinic acids.
Many plants were used as anti-hyperlipidemic drug in herbal medicines.
The Syzygium samarangense (Blume) Merr & L.M.Perry belongs to
family Myrtaceae. The evaluation of anti-hyperlipidemic activity of
Syzygium samarangense (Blume) Merr&L.M.Perry performed by
following procedure. ALESS was subjected to preliminary
phytochemical screening, acute oral toxicity and antihyperlipidemic
study. The acute oral toxicity was performed as per OECD 423
guidelines. The animals were divided into 5 groups each constituting 6
rats. Group I were normal rats, Group II were induced HFD. Group III
animals were treated with simvastatin 10mg/kg b.w/p.o. Group IV, V
were treated with ALESS 200mg/kg, 400mg/kg b.w/p.o. for 14 days. On
31st day animals were sacrificed and biochemical estimation were
performed. Histopathology of liver and adipose tissue were carried out.

INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES, 2020

Peptic ulcer is a disorder of the upper gastrointestinal tract that is caused by gastric acid. Th... more Peptic ulcer is a disorder of the upper gastrointestinal tract that is caused by gastric acid. There are various chemical agents available for the treatment of peptic ulcers, but claim serious side effects. Herbal drugs are preferred over chemical agents due to their relatively less toxicity, better acceptability and better compatibility with human body. Lesser adverse effects, economical, effective and easy availability. The present research has been carried out to investigate antiulcer activity of Hydroalcoholic leaf extract of Pisonia grandis R.Br (HEPG) using Indomethacin induced gastric ulcer and Pylorus ligation induced gastric ulcer in wistar rats. Ulcer score, ulcer index and number of ulcers were determined for indomethacin and pylorus ligation induced gastric ulcers. Antiulcer effect of Pisonia grandis R.Br (HEPG) was compared with standard drug omepprazole (20mg/kg). These observations helped us to conclude that Hydroalcoholic leaf extract of Pisonia grandis R.Br had significant antiulcer properties.