Dr. JOEL T H O M A S PharmD, RPH | The Tamilnadu Dr MGR Medical University (original) (raw)
Papers by Dr. JOEL T H O M A S PharmD, RPH
LAP LAMBERT Academic Publishing (2018-05-08 ), 2018
Joel Thomas Dr.MGR Medical University New messages Feb 9 Joel Thomas HIIIIII 29 days ... more Joel Thomas
Dr.MGR Medical University
New messages
Feb 9
Joel Thomas
HIIIIII
29 days
Joel Thomas
https://mgrmu.academia.edu/JoelThomas
4 hours
Joel Thomas
The clinical pharmacist in oncology care team has a crucial role in patient care through improving use of chemotherapy and other high alert medications. As part of multidisciplinary team, clinical pharmacist needs to assure safe, effective, cost-effective and more patient-oriented drug therapy. Adverse Drug Reactions are noxious and unintended death causing factor in cancer treatment. Antineoplastic drugs were mostly prescribed for cancer patients, who has greater suspectability towards ADRs. Along with other onco healthcare professionals, clinical pharmacist intervention in the treatment planning of the cancer patients, can identify, detect, assess, educate, monitor, minimize, prevent & manage the ANAs induced ADRs by supportive antidote therapy & palliative care, that can produce a impact by minimize economic burden & improving QOL, which can be sudden & significant, the latter can be particularly important to patients who want to live as normally as possible after diagnosis. The p value of the current study was found to be 0.006 (highly significant). & Chi-square value was 18.04, which shows a directly proportional association b/w ADR probability scores & stages of cancer.
Doi: 10: 6202055170 EAN: 9786202055178 Book language: English By (author) : Dr. Joel Thomas Number of pages: 104 Published on: 2018-05-08 Category: Pharmacy
Issue: 1
Volume: 1
More Info:
Journal of Medical Pharmaceutical And Allied Science, 2018
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. A... more Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk.
ADRs leading to hospitalization or occurring during hospital stay contribute significantly to
cancer patient morbidity and mortality as well as representing an additional cost for healthcare
systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly
complex regimens and hence accounts to high susceptibility toward ADRs. In the present
scenario the death rate due to cancer is gradually increasing. It is one of the leading causes of
death in adult aged under 65 years. It was widely noted that 80-90% of the human cancer may be
attributable to environmental and life style factors. Estimations reveal that in the year 2000 over
6 million people died due to cancer and ADR is considered to contribute to the fatality rate. So
there is a need to create awareness among the physicians towards ADR monitoring in cancer
patients .Our present study is to analyze the pattern of Adverse Drug Reaction occurring in
cancer patients treated with anticancer agents and to suggest useful interventions to reduce the
incidence of ADR. The aim of the present study is to assess the adverse drug reactions in male
and female cancer patients in Government Head Quarters, Krishnagiri. This clinical relevant
study strictly states that the intervention of a clinical pharmacist in treatment team, which can
limit, predict, monitor, prevent and treat the occurrence of ADR on ANAs. The study was
conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of
incidence in sexually transmitted disease.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V7-I8, 795. December 2018, 2034-2044, 2018
To evaluate the clinical adverse drug reactions (ADRs) reported in cancer patients taking antica... more To evaluate the clinical adverse drug reactions (ADRs) reported in cancer patients taking
anticancer drugs in different stage of cancer. Adverse drug reactions (ADRs) are a global problem in different stages of cancer. Anti-cancer drugs are prone to cause ADRs and there is lack of Pharmacovigilance data on such drugs. Therefore the present prospective observational study was undertaken to monitor possible ADRs in the chemotherapy of different stage of cancer. Adverse drug interactions may enhance or diminish the antitumor effects and result in improvement or treatment failure; drug interactions may also increase or decrease the side-effect profile of the antineoplastic drug. Precaution must be taken when prescribing other therapeutic agents to patients
undergoing active anticancer therapy. The study is the clinical assessment of adverse drug reaction in cancer patients by Naranjo’s ADR probability scale after the clinical pharmacist intervention of
a government hospital. We have conducted the prospective study to analyze the ADRs in the oncology department for the period of six months from December 2015 to May 2016 in
Government Headquarters, Krishnagiri by the Doctor of Pharmacy (Pharm D) students. The study
population consists of 150 patients in total. Among them 54.6 % (n=82) of the patients were
females. On classifying the patients on age 32 % (n=48) of the patients were of age group 50-59. From the total prescription 34.66% (n=52) patients were diagnosed as stage II cancer. From this clinical study it may be concluded that chemotherapeutic agents have a narrow therapeutic index
and dosage needed to achieve a therapeutic response usually proves toxic to the bodies rapidly proliferative cells. However, early detection of drug toxicity helps to modify the doses or the drug
regimen to minimize toxic effects.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069Journal of Medical Pharmaceutical and Allied Sciences, V7-I7, 789. October 2018, 2000-2013 , 2018
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ... more Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk.
ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer
patient morbidity and mortality as well as representing an additional cost for healthcare systems.
Chemotherapy, a multimodal approach to oncological treatment, involves highly complex
regimens and hence accounts to high susceptibility toward ADRs. In the present scenario the death
rate due to cancer is gradually increasing. It is one of the leading causes of death in adult aged
under 65 years. It was widely noted that 80-90% of the human cancer may be attributable to
environmental and life style factors. Estimations reveal that in the year 2000 over 6 million people
died due to cancer and ADR is considered to contribute to the fatality rate. So there is a need to
create awareness among the physicians towards ADR monitoring in cancer patients .Our present
study is to analyze the pattern of Adverse Drug Reaction occurring in cancer patients treated with
anticancer agents and to suggest useful interventions to reduce the incidence of ADR. The aim of
the present study is to assess the adverse drug reactions in male and female cancer patients in
Government Head Quarters, Krishnagiri. This clinical relevant study strictly states that the
intervention of a clinical pharmacist in treatment team, which can limit, predict, monitor, prevent
and treat the occurrence of ADR on ANAs. The study was conducted in the North eastern part of
Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069, 2018
Pharmacovigilance plays a vital role in ensuring that cancer patients receive appropriate medical... more Pharmacovigilance plays a vital role in ensuring that cancer patients receive appropriate medical
products that are safe and effective, but very few studies has been done in past on Clinical
oncology setup. Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer patient morbidity and mortality as well as representing an additional cost for healthcare systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward ADRs. The study was
conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease. Understanding the underlying mechanisms by the
Clinical Pharmacist is critical for clinical diagnosis and management of different ADRs at its
early stage in oncology departments. The present study was conducted to assess the chemotherapy induced adverse drug reactions in patients of cancer of oncology department
patients in Government Head Quarters Hospital, Krishnagiri and Tamilnadu for a period of 6 months from December 2015 to May 2016.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 Journal of medical Pharmaceutical and allied sciences, V7 - I3, 757, April 2018, 1028-1035, 2018
Abnormal cell growth with the potential to spread or invade to different parts of the body is the... more Abnormal cell growth with the potential to spread or invade to different parts of the body is the primary symptom of cancer. These contrast with benign tumors, which do not spread to other
parts of the body it is important to finding out how much cancer is in a person’s body and what the location is?This process is called staging. In development of cancer it has different stages. Stage of cancer diagnosis may be expressed as numbers (I, II, III, and IV) or by terms such as localized, regional, and distant. The lower the number or the more localized the cancer, the better
a person’s chances of benefiting from treatment. Tracking the rates of late-stage (distant) cancers is a good way to monitor the impact of cancer screening. When more cancers are detected in early stages, fewer detected in late stages. In process to determine the amount of the cancer in the body, doctors first look at the primary tumor for its size, location, and whether it has grown into nearby areas. Different types tests are performed to figure out a cancer’s stage, Depending on
location of the cancer, the physical exam may give indications. Imaging tests like x-rays, CT scans, MRIs, ultrasound, and PET scans may also give information about how much and where
cancer is in the body. A biopsy is needed to confirm a cancer diagnosis.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418. Journal of medical Pharmaceutical and allied sciences, V 7 - I 2, 755, 2018, 1000-1007 Article 1523793728 jmpas march, 2018
Adverse drug reaction (ADR) is an unintended and unexpected effect can be caused by many drugs; t... more Adverse drug reaction (ADR) is an unintended and unexpected effect can be caused by many drugs; this definition is differing by the side effect. It is fourth leading cause of death in developed western countries and sixth leading cause of death in the world. An adverse drug reaction (ADRs) shows an important public health problem in animals, human beings and the environment which include less efficacy of drug, sensitivity like reactions. Pharmacovigilance is associated in the field of ADRs study. At present Cancer is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Globally, nearly 1 in 6 deaths is due to cancer uncontrolled growth of cells is called cancer. Cancer cells are also referred to as tumors or neoplasms. It is a heterogeneous group of diseases caused by the impairment of normal functioning of genes, which leads to genetic damage. Many treatment options for cancer exist with the primary ones including surgery, chemotherapy, radiation therapy and palliative care. These treatments are used depending upon the type, location and grade of the cancer. The most common medications affect mainly the fast-dividing cells of the body, such as blood cells and the cells lining the mouth, stomach, and intestines. Along with other oncology clinicians, intervention played by Clinical Pharmacist is vital and can therapeutically minimize, assess, monitor and manage ADRs of ANAs. Clinical Pharmacist should inform the clinicians about these adverse reactions during each administration time
LAP LAMBERT Academic Publishing (2018-05-08 ), 2018
Joel Thomas Dr.MGR Medical University New messages Feb 9 Joel Thomas HIIIIII 29 days ... more Joel Thomas
Dr.MGR Medical University
New messages
Feb 9
Joel Thomas
HIIIIII
29 days
Joel Thomas
https://mgrmu.academia.edu/JoelThomas
4 hours
Joel Thomas
The clinical pharmacist in oncology care team has a crucial role in patient care through improving use of chemotherapy and other high alert medications. As part of multidisciplinary team, clinical pharmacist needs to assure safe, effective, cost-effective and more patient-oriented drug therapy. Adverse Drug Reactions are noxious and unintended death causing factor in cancer treatment. Antineoplastic drugs were mostly prescribed for cancer patients, who has greater suspectability towards ADRs. Along with other onco healthcare professionals, clinical pharmacist intervention in the treatment planning of the cancer patients, can identify, detect, assess, educate, monitor, minimize, prevent & manage the ANAs induced ADRs by supportive antidote therapy & palliative care, that can produce a impact by minimize economic burden & improving QOL, which can be sudden & significant, the latter can be particularly important to patients who want to live as normally as possible after diagnosis. The p value of the current study was found to be 0.006 (highly significant). & Chi-square value was 18.04, which shows a directly proportional association b/w ADR probability scores & stages of cancer.
Doi: 10: 6202055170 EAN: 9786202055178 Book language: English By (author) : Dr. Joel Thomas Number of pages: 104 Published on: 2018-05-08 Category: Pharmacy
Issue: 1
Volume: 1
More Info:
Journal of Medical Pharmaceutical And Allied Science, 2018
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. A... more Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk.
ADRs leading to hospitalization or occurring during hospital stay contribute significantly to
cancer patient morbidity and mortality as well as representing an additional cost for healthcare
systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly
complex regimens and hence accounts to high susceptibility toward ADRs. In the present
scenario the death rate due to cancer is gradually increasing. It is one of the leading causes of
death in adult aged under 65 years. It was widely noted that 80-90% of the human cancer may be
attributable to environmental and life style factors. Estimations reveal that in the year 2000 over
6 million people died due to cancer and ADR is considered to contribute to the fatality rate. So
there is a need to create awareness among the physicians towards ADR monitoring in cancer
patients .Our present study is to analyze the pattern of Adverse Drug Reaction occurring in
cancer patients treated with anticancer agents and to suggest useful interventions to reduce the
incidence of ADR. The aim of the present study is to assess the adverse drug reactions in male
and female cancer patients in Government Head Quarters, Krishnagiri. This clinical relevant
study strictly states that the intervention of a clinical pharmacist in treatment team, which can
limit, predict, monitor, prevent and treat the occurrence of ADR on ANAs. The study was
conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of
incidence in sexually transmitted disease.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V7-I8, 795. December 2018, 2034-2044, 2018
To evaluate the clinical adverse drug reactions (ADRs) reported in cancer patients taking antica... more To evaluate the clinical adverse drug reactions (ADRs) reported in cancer patients taking
anticancer drugs in different stage of cancer. Adverse drug reactions (ADRs) are a global problem in different stages of cancer. Anti-cancer drugs are prone to cause ADRs and there is lack of Pharmacovigilance data on such drugs. Therefore the present prospective observational study was undertaken to monitor possible ADRs in the chemotherapy of different stage of cancer. Adverse drug interactions may enhance or diminish the antitumor effects and result in improvement or treatment failure; drug interactions may also increase or decrease the side-effect profile of the antineoplastic drug. Precaution must be taken when prescribing other therapeutic agents to patients
undergoing active anticancer therapy. The study is the clinical assessment of adverse drug reaction in cancer patients by Naranjo’s ADR probability scale after the clinical pharmacist intervention of
a government hospital. We have conducted the prospective study to analyze the ADRs in the oncology department for the period of six months from December 2015 to May 2016 in
Government Headquarters, Krishnagiri by the Doctor of Pharmacy (Pharm D) students. The study
population consists of 150 patients in total. Among them 54.6 % (n=82) of the patients were
females. On classifying the patients on age 32 % (n=48) of the patients were of age group 50-59. From the total prescription 34.66% (n=52) patients were diagnosed as stage II cancer. From this clinical study it may be concluded that chemotherapeutic agents have a narrow therapeutic index
and dosage needed to achieve a therapeutic response usually proves toxic to the bodies rapidly proliferative cells. However, early detection of drug toxicity helps to modify the doses or the drug
regimen to minimize toxic effects.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069Journal of Medical Pharmaceutical and Allied Sciences, V7-I7, 789. October 2018, 2000-2013 , 2018
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ... more Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk.
ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer
patient morbidity and mortality as well as representing an additional cost for healthcare systems.
Chemotherapy, a multimodal approach to oncological treatment, involves highly complex
regimens and hence accounts to high susceptibility toward ADRs. In the present scenario the death
rate due to cancer is gradually increasing. It is one of the leading causes of death in adult aged
under 65 years. It was widely noted that 80-90% of the human cancer may be attributable to
environmental and life style factors. Estimations reveal that in the year 2000 over 6 million people
died due to cancer and ADR is considered to contribute to the fatality rate. So there is a need to
create awareness among the physicians towards ADR monitoring in cancer patients .Our present
study is to analyze the pattern of Adverse Drug Reaction occurring in cancer patients treated with
anticancer agents and to suggest useful interventions to reduce the incidence of ADR. The aim of
the present study is to assess the adverse drug reactions in male and female cancer patients in
Government Head Quarters, Krishnagiri. This clinical relevant study strictly states that the
intervention of a clinical pharmacist in treatment team, which can limit, predict, monitor, prevent
and treat the occurrence of ADR on ANAs. The study was conducted in the North eastern part of
Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069, 2018
Pharmacovigilance plays a vital role in ensuring that cancer patients receive appropriate medical... more Pharmacovigilance plays a vital role in ensuring that cancer patients receive appropriate medical
products that are safe and effective, but very few studies has been done in past on Clinical
oncology setup. Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer patient morbidity and mortality as well as representing an additional cost for healthcare systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward ADRs. The study was
conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease. Understanding the underlying mechanisms by the
Clinical Pharmacist is critical for clinical diagnosis and management of different ADRs at its
early stage in oncology departments. The present study was conducted to assess the chemotherapy induced adverse drug reactions in patients of cancer of oncology department
patients in Government Head Quarters Hospital, Krishnagiri and Tamilnadu for a period of 6 months from December 2015 to May 2016.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 Journal of medical Pharmaceutical and allied sciences, V7 - I3, 757, April 2018, 1028-1035, 2018
Abnormal cell growth with the potential to spread or invade to different parts of the body is the... more Abnormal cell growth with the potential to spread or invade to different parts of the body is the primary symptom of cancer. These contrast with benign tumors, which do not spread to other
parts of the body it is important to finding out how much cancer is in a person’s body and what the location is?This process is called staging. In development of cancer it has different stages. Stage of cancer diagnosis may be expressed as numbers (I, II, III, and IV) or by terms such as localized, regional, and distant. The lower the number or the more localized the cancer, the better
a person’s chances of benefiting from treatment. Tracking the rates of late-stage (distant) cancers is a good way to monitor the impact of cancer screening. When more cancers are detected in early stages, fewer detected in late stages. In process to determine the amount of the cancer in the body, doctors first look at the primary tumor for its size, location, and whether it has grown into nearby areas. Different types tests are performed to figure out a cancer’s stage, Depending on
location of the cancer, the physical exam may give indications. Imaging tests like x-rays, CT scans, MRIs, ultrasound, and PET scans may also give information about how much and where
cancer is in the body. A biopsy is needed to confirm a cancer diagnosis.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418. Journal of medical Pharmaceutical and allied sciences, V 7 - I 2, 755, 2018, 1000-1007 Article 1523793728 jmpas march, 2018
Adverse drug reaction (ADR) is an unintended and unexpected effect can be caused by many drugs; t... more Adverse drug reaction (ADR) is an unintended and unexpected effect can be caused by many drugs; this definition is differing by the side effect. It is fourth leading cause of death in developed western countries and sixth leading cause of death in the world. An adverse drug reaction (ADRs) shows an important public health problem in animals, human beings and the environment which include less efficacy of drug, sensitivity like reactions. Pharmacovigilance is associated in the field of ADRs study. At present Cancer is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Globally, nearly 1 in 6 deaths is due to cancer uncontrolled growth of cells is called cancer. Cancer cells are also referred to as tumors or neoplasms. It is a heterogeneous group of diseases caused by the impairment of normal functioning of genes, which leads to genetic damage. Many treatment options for cancer exist with the primary ones including surgery, chemotherapy, radiation therapy and palliative care. These treatments are used depending upon the type, location and grade of the cancer. The most common medications affect mainly the fast-dividing cells of the body, such as blood cells and the cells lining the mouth, stomach, and intestines. Along with other oncology clinicians, intervention played by Clinical Pharmacist is vital and can therapeutically minimize, assess, monitor and manage ADRs of ANAs. Clinical Pharmacist should inform the clinicians about these adverse reactions during each administration time