Okan Caliyurt | Trakya University (original) (raw)
Papers by Okan Caliyurt
European Neuropsychopharmacology
Sleep and Biological Rhythms
Acute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial ... more Acute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) are mediators of neuronal plasticity and neurogenesis. These neurotrophins are involved in sleep and sleep disorders and are associated with sleep deprivation. In this study, it is aimed to investigate the changes of neurotrophin levels with total sleep deprivation in healthy individuals. Seventeen healthy young adults with a mean age of 19.8 (SD = 1.0) years underwent an experimental protocol consisting of 36 h of total sleep deprivation. Venous blood samples were obtained on Day1 at 09.00, on Day2 at 09.00, and at 21.00. Serum levels of neurotrophins were detected using the ELISA method. The participants were asked to mark the scores corresponding to their subjective energy, happiness, depression, tension levels on the visual analog scale; and sleepiness level on the Epworth Sleepiness Scale; during the course of the study. As a result of 36 h of sleep deprivation, serum GDNF, BDNF, and VEGF levels showed a statistically significant increase compared to the baseline values in the participants included in the study (P < 0.0001). While this increase was evident in 24 h, it continued after 36 h. In parallel, sleepiness levels, subjective depression, and tension levels increased, on the other hand, subjective energy and happiness scores decreased at a statistically significant level at the end of the study compared to basal values (P < 0.0001). The results show that acute sleep deprivation significantly affects and increases serum levels of neurotrophic factors, and it seems that these effects are likely to occur as an immediate response to the stress and disruption caused by sleep deprivation.
OBJECTIVE Bright light therapy is effective and well tolerated in seasonal affective disorder and... more OBJECTIVE Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. METHOD Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertraline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hami...
Turkish Journal of Psychiatry, 2019
The American journal of psychiatry, 2018
Current eye research, 2018
To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber l... more To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs. The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage. The mean duration of SSRI usage was 29.96 ± 27.19 (range 6-120) months. The foveal thickness was 253.48 ± 22.77µm in the patients' group and 266.60 ± 20.64 µm in the control group; the difference between the groups was statistic...
Turkiye Klinikleri Journal of Psychiatry Special Topics, 2012
Australian & New Zealand Journal of Psychiatry, 2015
![Research paper thumbnail of Treatment Options in Kleptomania [Kleptomanide Tedavi Seçenekleri]](https://attachments.academia-assets.com/78884796/thumbnails/1.jpg)
](Psikiyatride Guncel Yaklasimlar, 2009
Kleptomani temelde çalma dürtülerine karșı koyamamanın yer aldığı az rastlanan bir bozukluktur. B... more Kleptomani temelde çalma dürtülerine karșı koyamamanın yer aldığı az rastlanan bir bozukluktur. Bu bozukluğu olan kișiler genellikle önemsiz veya maddi değeri olmayan nesneleri çalmaya karșı zorlanmaktadırlar. Bu bozukluk genellikle ergenlik döneminde bașlar ve geç erișkinliğe kadar sürer, bazı olgularda ömür boyu sürebilir. Kleptomaniye genellikle bașka komorbid durumlar örneğin duygudurum bozuklukları gibi bozukluklar eșlik edebilmektedir. Bu bozukluğu olan hastalar çoğunlukla kleptoman için değil ama eșlik eden diğer komorbid durumları nedeni ile tedaviye yönlendirilirler. Diğer yandan kleptomani tedavisi konusunda yeterice çalıșma bulunmamaktadır. Geniș bir spektrumda tedavi stratejileri örneğin psikoanalitik yönelimli psikoterapiler, davranıșçı tedaviler ve farmakoterapiler gibi yaklașımlar önerilmiștir. Kleptomani hastalarının tedavisinde serotonin geri alım inihibitörleri, duygudurum düzenleyiciler ve opioid antagonistleri gibi ilaçlar kullanılmaktadır. Kleptomanide bilișsel davranıșçı tedavi yaklașımlarının etkinliğinin gösterildiği bir çok çalıșma bulunmaktadır ve psikodinamik veya psikoanalitik yönelimli psikoterapilerden daha bașarılı olduğu gösterilmiștir. Ayrıca bilișsel davranıșçı yaklașımlar eğer ilaç tedavisi ile birlikte kullanılırlarsa sadece ilaç tedavisi yapılan olgulardan daha etkin olmaktadır.
Turkiye Klinikleri Journal of Neurosurgery Special Topics, 2011
Journal of psychiatry & neuroscience: JPN
We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was a... more We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was admitted to hospital with the diagnosis of schizophreniform disorder. His presenting symptoms, which had started 1 month before hospital admission, were somatic delusions of gastrointestinal and cardiovascular malfunction and the absence of a stomach, which resulted in a decrease in weight from 75 kg to 63 kg in 1 month. Cranial computed tomographic images showed dilatation of the lateral and third ventricles, whereas magnetic resonance imaging revealed central atrophy and lateral ventricle dilatation. Singlephoton emission computed tomography demonstrated left temporal, left frontal and left parietal hypoperfusion. The patient did not respond to antipsychotic therapies, but he was successfully treated with electroconvulsive therapy. This report emphasizes that Cotard's syndrome may be accompanied by lesions of the left hemisphere and that electroconvulsive therapy could be the first-line therapy in such patients with psychotic disorder. Nous signalons un cas de syndrome de Cotard associé à des symptômes psychotiques. Un homme de 27 ans est admis à l'hôpital avec diagnostic de troubles schizophréniformes. Ses symptômes à l'admission (délires somatiques d'un dérèglement gastro-intestinal et cardiovasculaire et d'une absence d'estomac) avaient commencé un mois avant son hospitalisation et avaient causé une perte de poids (de 75 kg à 63 kg) durant cet intervalle d'un mois. Une tomodensitométrie crânienne a révélé une dilatation du ventricule latéral et du troisième ventricule, tandis qu'une imagerie par résonance magnétique indiquait une atrophie centrale et une dilatation du ventricule latéral. Une tomographie monophotonique d'émission a fait voir une hypoperfusion temporale gauche, frontale gauche et pariétale gauche. Le patient n'a pas réagi à des thérapies antipsychotiques, mais a été traité avec succès par électrochocs. Le présent rapport indique que le syndrome de Cotard peut s'accompagner de lésions de l'hémisphère gauche et que des électrochocs pourraient être la thérapie de première ligne chez de tels patients affectés d'un trouble psychotique.
Türk psikiyatri dergisi = Turkish journal of psychiatry, 2005
Bright light therapy is effective and well tolerated in seasonal affective disorder and some stud... more Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertraline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hamilton Anxiety Rati...
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2004
Nausea appears to be a dosagerelated side effect in as many as 26% of patients treated with selec... more Nausea appears to be a dosagerelated side effect in as many as 26% of patients treated with selective serotonin reuptake inhibitors (SSRIs) (1,2). SSRIs increase the concentration of serotonin (5-HT) at neuronal synapses. Emesis may result from subsequent activation of central or peripheral 5-HT 3 receptors (2,3). Antagonism of 5-HT 3 by drugs like ondansetron is known to reduce emesis in chemotherapy patients and may have some application in SSRI-induced nausea, but the effect is short-lived and the cost is prohibitive (2,3). The 5-HT antagonist cyproheptadine may have some efficacy for SSRI-induced nausea, but it has been associated with worsening of depressive symptoms when used to treat SSRI-induced sexual dysfunction (4). The antidepressant mirtazapine, an antagonist at presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors (where it enhances noradrenergic and serotonergic activity), is also a potent antagonist of 5-HT 2 and 5-HT 3 receptors (5). We report a case of SSRI-induced nausea successfully treated with mirtazapine.
Sleep, 2004
We investigated whether the hypernyctohemeral syndrome (non-24-hour sleep-wake syndrome) may show... more We investigated whether the hypernyctohemeral syndrome (non-24-hour sleep-wake syndrome) may show a clinical association with the delayed sleep phase syndrome (DSPS) in a 39-year-old woman who developed sleep disturbances following a traumatic brain injury. Sleep-wake log documentation and wrist-activity recordings for more than 6 consecutive months confirmed the patient's tendency to live on longer-than-24-hour "days." Episodes of relative coordination to the 24-hour day were also noted, suggesting that the patient was transiently in and out of phase with environmental synchronizers too weak to fully entrain her to the geophysical environment. Interestingly, we noted a tendency to initiate sleep between 3:00 am and 5:00 am and wake up from sleep between noon and 1:00 pm. These results support an association between the hypernyctohemeral syndrome and the DSPS. This association may carry implications for the treatment of circadian rhythms disorders.
Journal of psychiatry & neuroscience : JPN, 2004
We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man w... more We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was admitted to hospital with the diagnosis of schizophreniform disorder. His presenting symptoms, which had started 1 month before hospital admission, were somatic delusions of gastrointestinal and cardiovascular malfunction and the absence of a stomach, which resulted in a decrease in weight from 75 kg to 63 kg in 1 month. Cranial computed tomographic images showed dilatation of the lateral and third ventricles, whereas magnetic resonance imaging revealed central atrophy and lateral ventricle dilatation. Single- photon emission computed tomography demonstrated left temporal, left frontal and left parietal hypoperfusion. The patient did not respond to antipsychotic therapies, but he was successfully treated with electroconvulsive therapy. This report emphasizes that Cotard's syndrome may be accompanied by lesions of the left hemisphere and that electroconvulsive therapy could be the ...
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2003
effects in neurology (2) and BD (3) patients warrant caution. I describe a case of severe suicida... more effects in neurology (2) and BD (3) patients warrant caution. I describe a case of severe suicidal symptoms associated with topiramate in a BD patient.
Sleep and Quality of Life in Clinical Medicine, 2008
Major depression is a common disorder; nearly 10% of the population suffers from a depressive ill... more Major depression is a common disorder; nearly 10% of the population suffers from a depressive illness in any given year. There is a strong association between sleep disturbances and depression. The most common sleep disturbance associated with major depressive disorder is insomnia. The relationship between insomnia and depression is bidirectional in that insomnia is one of the symptoms of depression
European Neuropsychopharmacology
Sleep and Biological Rhythms
Acute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial ... more Acute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) are mediators of neuronal plasticity and neurogenesis. These neurotrophins are involved in sleep and sleep disorders and are associated with sleep deprivation. In this study, it is aimed to investigate the changes of neurotrophin levels with total sleep deprivation in healthy individuals. Seventeen healthy young adults with a mean age of 19.8 (SD = 1.0) years underwent an experimental protocol consisting of 36 h of total sleep deprivation. Venous blood samples were obtained on Day1 at 09.00, on Day2 at 09.00, and at 21.00. Serum levels of neurotrophins were detected using the ELISA method. The participants were asked to mark the scores corresponding to their subjective energy, happiness, depression, tension levels on the visual analog scale; and sleepiness level on the Epworth Sleepiness Scale; during the course of the study. As a result of 36 h of sleep deprivation, serum GDNF, BDNF, and VEGF levels showed a statistically significant increase compared to the baseline values in the participants included in the study (P < 0.0001). While this increase was evident in 24 h, it continued after 36 h. In parallel, sleepiness levels, subjective depression, and tension levels increased, on the other hand, subjective energy and happiness scores decreased at a statistically significant level at the end of the study compared to basal values (P < 0.0001). The results show that acute sleep deprivation significantly affects and increases serum levels of neurotrophic factors, and it seems that these effects are likely to occur as an immediate response to the stress and disruption caused by sleep deprivation.
OBJECTIVE Bright light therapy is effective and well tolerated in seasonal affective disorder and... more OBJECTIVE Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. METHOD Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertraline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hami...
Turkish Journal of Psychiatry, 2019
The American journal of psychiatry, 2018
Current eye research, 2018
To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber l... more To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs. The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage. The mean duration of SSRI usage was 29.96 ± 27.19 (range 6-120) months. The foveal thickness was 253.48 ± 22.77µm in the patients' group and 266.60 ± 20.64 µm in the control group; the difference between the groups was statistic...
Turkiye Klinikleri Journal of Psychiatry Special Topics, 2012
Australian & New Zealand Journal of Psychiatry, 2015
Psikiyatride Guncel Yaklasimlar, 2009
Kleptomani temelde çalma dürtülerine karșı koyamamanın yer aldığı az rastlanan bir bozukluktur. B... more Kleptomani temelde çalma dürtülerine karșı koyamamanın yer aldığı az rastlanan bir bozukluktur. Bu bozukluğu olan kișiler genellikle önemsiz veya maddi değeri olmayan nesneleri çalmaya karșı zorlanmaktadırlar. Bu bozukluk genellikle ergenlik döneminde bașlar ve geç erișkinliğe kadar sürer, bazı olgularda ömür boyu sürebilir. Kleptomaniye genellikle bașka komorbid durumlar örneğin duygudurum bozuklukları gibi bozukluklar eșlik edebilmektedir. Bu bozukluğu olan hastalar çoğunlukla kleptoman için değil ama eșlik eden diğer komorbid durumları nedeni ile tedaviye yönlendirilirler. Diğer yandan kleptomani tedavisi konusunda yeterice çalıșma bulunmamaktadır. Geniș bir spektrumda tedavi stratejileri örneğin psikoanalitik yönelimli psikoterapiler, davranıșçı tedaviler ve farmakoterapiler gibi yaklașımlar önerilmiștir. Kleptomani hastalarının tedavisinde serotonin geri alım inihibitörleri, duygudurum düzenleyiciler ve opioid antagonistleri gibi ilaçlar kullanılmaktadır. Kleptomanide bilișsel davranıșçı tedavi yaklașımlarının etkinliğinin gösterildiği bir çok çalıșma bulunmaktadır ve psikodinamik veya psikoanalitik yönelimli psikoterapilerden daha bașarılı olduğu gösterilmiștir. Ayrıca bilișsel davranıșçı yaklașımlar eğer ilaç tedavisi ile birlikte kullanılırlarsa sadece ilaç tedavisi yapılan olgulardan daha etkin olmaktadır.
Turkiye Klinikleri Journal of Neurosurgery Special Topics, 2011
Journal of psychiatry & neuroscience: JPN
We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was a... more We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was admitted to hospital with the diagnosis of schizophreniform disorder. His presenting symptoms, which had started 1 month before hospital admission, were somatic delusions of gastrointestinal and cardiovascular malfunction and the absence of a stomach, which resulted in a decrease in weight from 75 kg to 63 kg in 1 month. Cranial computed tomographic images showed dilatation of the lateral and third ventricles, whereas magnetic resonance imaging revealed central atrophy and lateral ventricle dilatation. Singlephoton emission computed tomography demonstrated left temporal, left frontal and left parietal hypoperfusion. The patient did not respond to antipsychotic therapies, but he was successfully treated with electroconvulsive therapy. This report emphasizes that Cotard's syndrome may be accompanied by lesions of the left hemisphere and that electroconvulsive therapy could be the first-line therapy in such patients with psychotic disorder. Nous signalons un cas de syndrome de Cotard associé à des symptômes psychotiques. Un homme de 27 ans est admis à l'hôpital avec diagnostic de troubles schizophréniformes. Ses symptômes à l'admission (délires somatiques d'un dérèglement gastro-intestinal et cardiovasculaire et d'une absence d'estomac) avaient commencé un mois avant son hospitalisation et avaient causé une perte de poids (de 75 kg à 63 kg) durant cet intervalle d'un mois. Une tomodensitométrie crânienne a révélé une dilatation du ventricule latéral et du troisième ventricule, tandis qu'une imagerie par résonance magnétique indiquait une atrophie centrale et une dilatation du ventricule latéral. Une tomographie monophotonique d'émission a fait voir une hypoperfusion temporale gauche, frontale gauche et pariétale gauche. Le patient n'a pas réagi à des thérapies antipsychotiques, mais a été traité avec succès par électrochocs. Le présent rapport indique que le syndrome de Cotard peut s'accompagner de lésions de l'hémisphère gauche et que des électrochocs pourraient être la thérapie de première ligne chez de tels patients affectés d'un trouble psychotique.
Türk psikiyatri dergisi = Turkish journal of psychiatry, 2005
Bright light therapy is effective and well tolerated in seasonal affective disorder and some stud... more Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertraline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hamilton Anxiety Rati...
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2004
Nausea appears to be a dosagerelated side effect in as many as 26% of patients treated with selec... more Nausea appears to be a dosagerelated side effect in as many as 26% of patients treated with selective serotonin reuptake inhibitors (SSRIs) (1,2). SSRIs increase the concentration of serotonin (5-HT) at neuronal synapses. Emesis may result from subsequent activation of central or peripheral 5-HT 3 receptors (2,3). Antagonism of 5-HT 3 by drugs like ondansetron is known to reduce emesis in chemotherapy patients and may have some application in SSRI-induced nausea, but the effect is short-lived and the cost is prohibitive (2,3). The 5-HT antagonist cyproheptadine may have some efficacy for SSRI-induced nausea, but it has been associated with worsening of depressive symptoms when used to treat SSRI-induced sexual dysfunction (4). The antidepressant mirtazapine, an antagonist at presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors (where it enhances noradrenergic and serotonergic activity), is also a potent antagonist of 5-HT 2 and 5-HT 3 receptors (5). We report a case of SSRI-induced nausea successfully treated with mirtazapine.
Sleep, 2004
We investigated whether the hypernyctohemeral syndrome (non-24-hour sleep-wake syndrome) may show... more We investigated whether the hypernyctohemeral syndrome (non-24-hour sleep-wake syndrome) may show a clinical association with the delayed sleep phase syndrome (DSPS) in a 39-year-old woman who developed sleep disturbances following a traumatic brain injury. Sleep-wake log documentation and wrist-activity recordings for more than 6 consecutive months confirmed the patient's tendency to live on longer-than-24-hour "days." Episodes of relative coordination to the 24-hour day were also noted, suggesting that the patient was transiently in and out of phase with environmental synchronizers too weak to fully entrain her to the geophysical environment. Interestingly, we noted a tendency to initiate sleep between 3:00 am and 5:00 am and wake up from sleep between noon and 1:00 pm. These results support an association between the hypernyctohemeral syndrome and the DSPS. This association may carry implications for the treatment of circadian rhythms disorders.
Journal of psychiatry & neuroscience : JPN, 2004
We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man w... more We report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was admitted to hospital with the diagnosis of schizophreniform disorder. His presenting symptoms, which had started 1 month before hospital admission, were somatic delusions of gastrointestinal and cardiovascular malfunction and the absence of a stomach, which resulted in a decrease in weight from 75 kg to 63 kg in 1 month. Cranial computed tomographic images showed dilatation of the lateral and third ventricles, whereas magnetic resonance imaging revealed central atrophy and lateral ventricle dilatation. Single- photon emission computed tomography demonstrated left temporal, left frontal and left parietal hypoperfusion. The patient did not respond to antipsychotic therapies, but he was successfully treated with electroconvulsive therapy. This report emphasizes that Cotard's syndrome may be accompanied by lesions of the left hemisphere and that electroconvulsive therapy could be the ...
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2003
effects in neurology (2) and BD (3) patients warrant caution. I describe a case of severe suicida... more effects in neurology (2) and BD (3) patients warrant caution. I describe a case of severe suicidal symptoms associated with topiramate in a BD patient.
Sleep and Quality of Life in Clinical Medicine, 2008
Major depression is a common disorder; nearly 10% of the population suffers from a depressive ill... more Major depression is a common disorder; nearly 10% of the population suffers from a depressive illness in any given year. There is a strong association between sleep disturbances and depression. The most common sleep disturbance associated with major depressive disorder is insomnia. The relationship between insomnia and depression is bidirectional in that insomnia is one of the symptoms of depression