Kazem Khalagi | Tehran University of Medical Sciences (original) (raw)

Papers by Kazem Khalagi

Journal of Diabetes & Metabolic Disorders, Aug 28, 2023

DARU Journal of Pharmaceutical Sciences, Dec 21, 2023

Osteoporosis and Sarcopenia, Nov 30, 2023

Calcified Tissue International, Jan 4, 2023

Research Square (Research Square), Jul 6, 2023

Background Despite the availability of diagnostic equipment and effective drugs to diagnose and t... more Background Despite the availability of diagnostic equipment and effective drugs to diagnose and treat osteoporosis, only a minority of women are cared. The aim of this study was to investigate of the osteoporosis care gaps among postmenopausal women. Methods This cross-sectional observational study in one the province of Iran, collected data from women aged ≥ 50 years. Initially, participants were surveyed through FRAX. Then, a questionnaire was developed in 3 concepts (socioeconomic, diagnosis and medication initiation). Medication adherence was assessed using the validated OS-MMAS-8 questionnaire. Results A total of 998 women with a mean age of 64.6 ± 10.4 participated in this study. Overall, 346(34.6%) women were at high risk of fragility fractures through FRAX. 130(37.5%) women at high fracture risk underwent BMD, and 109 (31.5%) were diagnosed with osteoporosis. 44 (44.9%) patients adhere to the treatment and 54 (55.1%) patients did not. Overall, 9(20.5%), 35(79.5%) and 0 had low, medium, and high OS-MMAS-8 scores. The diagnosis and treatment gaps were 68.

Background: Iran's population is aging. One of the most common problems in Iranian public health ... more Background: Iran's population is aging. One of the most common problems in Iranian public health is the high prevalence of cardio-metabolic risk factors. The purpose of this study was to investigate the relationship between cardio-metabolic and demographic risk factors and disability in people 60 years and older in Iran. Methods: Data from the Bushehr Elderly Health (BEH) program was used in the analysis. Demographic characteristics, as well as the history of diabetes and other chronic diseases, and smoking were measured using standardized questionnaires. Anthropometric measurements and laboratory tests were performed under standard conditions. Dependency was determined by the questionnaires of basic activities of daily living (BADL) and instrumental activities of daily living (IADL) using Barthel and Lawton scales respectively. Multiple logistic regression was used in the analysis. Results: Mean (Standard Deviation) of the participants' age was 69.34 (6.4) years (range: 60 and 96 years), and 48.06% of the participants were men. After adjusting for potential confounders, being older, being female (OR (95%CI): 2.33 (1.89-2.86)), having a lower education level, a history of diabetes mellitus (OR: 1.43 (1.17-1.74)) and past smoking (OR: 1.25 (1.00-1.55)), and no physical activity (OR: 1.54 (1.23-1.87)) were signi cantly associated with dependency in IADL. Also, being older and female (OR: 2.38 (1.85-3.03)), having a lower education level, no physical activity (OR: 2.17 (1.61-2.86)) and low daily intake of calories were associated with dependency in BADL. Conclusion: Age, gender, education level and physical activity are risk factors of the dependency in both of BADL and IADL in the elderly people. Diabetes mellitus and past smoking are risk factors of the dependency in IADL, and low HDL cholesterol and low daily intake of calories are risk factors of the dependency in BADL.

BMC Geriatrics, Jan 11, 2022

Background: Osteosarcopenia, defined as sarcopenia plus osteopenia/osteoporosis, may increase the... more Background: Osteosarcopenia, defined as sarcopenia plus osteopenia/osteoporosis, may increase the risk of fractures and affects morbidity and mortality in the older population. Falling is also common in the elderly and increases the risk of fractures and mortality. We examined the association of cardio-metabolic risk factors with a history of falling in osteosarcopenic men. Methods: We used the baseline data of the Bushehr Elderly Health (BEH) program. Osteosarcopenia was defined as having both sarcopenia (reduced skeletal muscle mass plus low physical performance and/or low muscle strength) and osteopenia/osteoporosis (T-score ≤ − 1.0). Falling was defined as a self-reported history of an unintentional down on the ground during the previous year before the study. We used logistic regression analysis to estimate the adjusted odds ratio (AOR) with a 95% Confidence Interval (CI) to quantify the associations. Results: All elderly men diagnosed with osteosarcopenia (n = 341), with a mean age of 73.3(±7.4) years, were included. Almost 50(14.7%) participants reported falling. Age showed a positive association with falling (AOR: 1.09, 95%CI: 1.04-1.14). An increase of 10 mmHg in systolic blood pressure(SBP), reduces the odds of falling by 26%(AOR:0.74, 95%CI:0.62-0.89), while a positive association was detected for fasting plasma glucose (FPG), as 10 mg/ dl increase in the FPG, raises the chance of falling by 14%(AOR = 1.14, 95%CI:1.06,1.23). Hypertriglyceridemia was inversely associated with falling (AOR = 0.33, 95% CI: 0.12, 0.89). Conclusions: Falling is a major public health problem in rapidly aging countries, especially in individuals with a higher risk of fragility fractures. Older age-raised fasting plasma glucose and low SBP are associated with falling in osteosarcopenic patients. Considering the higher risk of fracture in osteosarcopenic men, comprehensive strategies are needed to prevent fallrelated injuries in this high-risk population.

Frontiers in Cardiovascular Medicine

BackgroundThe intermediate metabolites associated with the development of atherosclerotic cardiov... more BackgroundThe intermediate metabolites associated with the development of atherosclerotic cardiovascular disease (ASCVD) remain largely unknown. Thus, we conducted a large panel of metabolomics profiling to identify the new candidate metabolites that were associated with 10-year ASCVD risk.MethodsThirty acylcarnitines and twenty amino acids were measured in the fasting plasma of 1,102 randomly selected individuals using a targeted FIA-MS/MS approach. The 10-year ASCVD risk score was calculated based on 2013 ACC/AHA guidelines. Accordingly, the subjects were stratified into four groups: low-risk (n = 620), borderline-risk (n = 110), intermediate-risk (n = 225), and high-risk (n = 147). 10 factors comprising collinear metabolites were extracted from principal component analysis.ResultsC4DC, C8:1, C16OH, citrulline, histidine, alanine, threonine, glycine, glutamine, tryptophan, phenylalanine, glutamic acid, arginine, and aspartic acid were significantly associated with the 10-year ASCV...

Clinical Reviews in Bone and Mineral Metabolism

Journal of Diabetes & Metabolic Disorders

Journal of biostatistics and epidemiology, Aug 29, 2022

Background: Osteoporosis is one of the most important health problems in the country due to fract... more Background: Osteoporosis is one of the most important health problems in the country due to fracture. Osteoporosis Research Center with more than 20 years of experience in this field tries to present achievements and activities of the management and treatment of osteoporosis in the country while introducing this center. This review aims to overview the osteoporosis research center activities on osteoporosis. Methods: In these conventional review national and international databases were investigated on osteoporosis without any restriction on time and language. Also, other activities that are not reflected in the papers were obtained from the professional website and official reports. Results: According to the strategic plan of the osteoporosis research center, the achievements of this center provided in in three areas of research (population-based studies, clinical studies, basic science studies and health system studies), technology (diagnostic, therapeutic technologies, service de...

Osteoporosis International

Journal of diabetes and metabolic disorders, Oct 24, 2022

BMC Geriatrics

Background This paper presents the protocol of the 4th round of Iranian Multi-center Osteoporosis... more Background This paper presents the protocol of the 4th round of Iranian Multi-center Osteoporosis Study (IMOS), a national survey with the primary objective of estimating the prevalence of osteoporosis and sarcopenia and their risk factors in a representative sample of urban and rural populations. Methods The target population of the survey is all individuals ≥ 50 years in Iran. A multi-stage random sampling method has been used in the study. We stratified the 31 provinces of the country into 5 strata based on the distribution of their potential risk factors for osteoporosis and randomly selected one or two provinces from each stratum. Then, we invited 2530 people aged ≥ 50 years recruited in the 8th National Survey of None Communicable Diseases (NCD) Risk Factors (STEPs-2021) in the selected provinces to participate in IMOS. Body composition measurements including bone mineral density, muscle mass, and fat mass are measured through Dual-energy X-ray Absorptiometry (DXA) method usin...