Mahgol Farjadnia | Tehran University of Medical Sciences (original) (raw)

Papers by Mahgol Farjadnia

Research paper thumbnail of Hybrid driven based robust stabilization for networked control systems

2017 IEEE 4th International Conference on Knowledge-Based Engineering and Innovation (KBEI), 2017

This paper considers robust stabilization controller design for networked control systems with co... more This paper considers robust stabilization controller design for networked control systems with communication delay and bounded system uncertainties under a hybrid framework. Hybrid-driven scheme is used to reduce the transmission data. The closed-loop system with a networked state feedback controller is modeled as a system with delayed control input. Criteria for exponential stability in the mean-square sense of the closed-loop system is derived in terms of Linear Matrix Inequalities (LMIs) and a feedback controller to reach a robust stability is designed. Finally, the effectiveness of the proposed method is demonstrated by simulation results.

Research paper thumbnail of Is There a Correlation Between the Clinical, Radiological and Ultra-Sonographic Findings of Osteoarthritis of the Knee?

International Journal of Pharmaceutical and Clinical Research, 2017

Objectives: The association between the severity of knee pain and the clinical and radiological f... more Objectives: The association between the severity of knee pain and the clinical and radiological findings can help to assess the severity of knee osteoarthritis. The present study aimed to assess the relationship between knee pain severity and clinical, radiological and ultra-sonographic findings in patients with knee osteoarthritis. Methods: We recruited 52 patients with primary osteoarthritis. Physical examination and ultrasonography were done. Plain radiography was done within 3 weeks of clinical examination. Results: The average age of participants was 59.27 ± 9.85 years. Using multivariable linear regression modeling, pain severity had no significant association with any of the covariates including epidemiological, clinical and ultrasound findings. The severity of clinical symptoms and stiffness was associated with the ultrasound finding of Baker’s cyst as well as with tenderness of internal compartment and suprapatellar effusion. In addition, the level of daily function remaine...

Research paper thumbnail of Surgical approach to posterior dislocation of the elbow combined with radial head and coronoid fractures (terrible triad): report of 19 cases

cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tu... more cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tures (terrible triad): report of 19 cases. Shafa Orthop J. 2013.1(1):2-7. Abstract Background: Terrible triad injury of the elbow has been a real challenge for surgeons. New standard methods of treatment have significantly improved outcomes, but yet complications occur frequently and rate of reopera-tion is still noticeable. Methods: The outcomes of lateral surgical approach in 19 patients with terrible triad injury were evaluated through Mayo Elbow Performance Score (MEPS) and Disabilities of the Arm, Shoulder and Hand (DASH) score. Results: A concentric congruency was achieved for 18 cases. The average of MEPS was 87.11±12.05. There-fore, 17 patients had excellent and good and two fair and poor results. Average of DASH score was 17±13.83. Due to early postoperative dislocation joint stiffness occurred in one patient. Conclusion: In our experience, lateral approach provides an adequate v...

Research paper thumbnail of Corneal aberrations in normal and keratoconic eyes using an OPD-Scan Ⅱ

Guoji Yanke Zazhi, 2018

AIM: To evaluate higher order aberrations(HOAs)of the corneal surface in normal and keratoconic e... more AIM: To evaluate higher order aberrations(HOAs)of the corneal surface in normal and keratoconic eyes.<p>METHODS: Using an OPD-Scan Ⅱ wavefront analyzer, aberrometric parameters of the corneal surface in one eye of 80 patients with keratoconus(KC)and 91 participants with normal eyes were evaluated. The Zernike coefficients from third- to sixth-order as well as root mean square(RMS)of primary coma, coma-like aberrations, and total HOA were calculated and compared between both groups.<p>RESULTS: Statistically significant differences were found in all aberrometric parameters between the measurements of the KC and normal participants(<i>P</i><0.001). All of the aberrometric parameters were significantly higher in the KC patients compared to the normal group(<i>P</i><0.001).<p>CONCLUSION: Corneal wavefront measurements by means of OPD-Scan Ⅱ were significantly higher in keratoconic corneas than normal corneas.

Research paper thumbnail of Ocular, corneal, and internal aberrations in eyes with keratoconus, forme fruste keratoconus, and healthy eyes

International ophthalmology, Jan 24, 2017

The purpose of this study is to evaluate ocular, corneal, and internal aberration parameters in e... more The purpose of this study is to evaluate ocular, corneal, and internal aberration parameters in eyes with keratoconus (KC), forme fruste keratoconus (FFKC), and normal eyes. In a prospective study, one eye of 110 patients with KC, 60 FFKC patients, and 150 healthy participants was evaluated using OPD-Scan II. Ocular, corneal, and internal higher-order aberrations were measured through a sixth-order Zernike polynomial decomposition. Receiver operating characteristic analysis was performed to evaluate the diagnostic ability of the aberration parameters in discriminating KC and FFKC from normal eyes. The root mean square of the all ocular aberration measurements was significantly higher in the KC and FFKC patients than that of normal participants (p < 0.05). All of the corneal aberration measurements were significantly higher in KC patients than those of normal patients (p < 0.05); however, only corneal total higher-order aberration (HOA), vertical and total coma, and higher-orde...

Research paper thumbnail of Prevalence of Eyelid Laxity and its Association with Ophthalmic Findings and Disease Severity in Patients with Keratoconus

European Journal of Ophthalmology, 2017

Purpose To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal... more Purpose To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal and keratoconic eyes and the correlations of these findings with ophthalmic parameters and disease severity in patients with keratoconus (KC). Methods In a prospective case-control study, prevalence of eyelid laxity and eyelid measurements were evaluated in 53 patients with KC and the same number of matched healthy controls. The eyelid measurements were compared between the groups, as well as mean keratometry (K), central and thinnest corneal thickness (CCT and TCT), astigmatism, manifest refraction spherical equivalent (MRSE), best spectacle-corrected visual acuity (BCVA), and severity of KC according to the Keratoconus Severity Score. Results Prevalence of eyelid laxity was 71.7% (38 patients) in patients with KC and 20.8% (11 patients) in normal participants (p<0.001, odds ratio 9.673 [95% confidence interval 3.959 to 23.631]). Comparison of the eyelid measurements in the patients...

Research paper thumbnail of Clinical biomicroscopy and retinoscopy findings of keratoconus in a Middle Eastern population

Clinical and Experimental Optometry, 2017

Background: The present work was conducted to investigate the prevalence of clinical biomicroscop... more Background: The present work was conducted to investigate the prevalence of clinical biomicroscopy and retinoscopy findings of corneas with keratoconus (KC) at first presentation and their relationship with disease severity. Method: In a prospective cross-sectional study, 371 consecutive KC patients were examined by slitlamp biomicroscopy and retinoscopy at the time of diagnosis. This research evaluates the prevalence of clinical findings such as a corneal protrusion, Vogt's striae, Fleischer's ring, Munson's sign, Rizzuti's sign, corneal scars, as well as any additional KC signs such as prominent nerve fibres, scissoring reflex and Charleaux 'oil droplet' sign on retinoscopy. Keratometry (mean K), central and thinnest corneal thickness (CCT and TCT), anterior and posterior elevation (AE and PE), and astigmatism by means of Pentacam, and visual acuity (VA) were recorded for each patient. The severity of KC was graded on the basis of the Keratoconus Severity Score. Results: Corneal protrusion, scissoring reflex, corneal thinning, Fleischer's ring, and prominent nerve fibres were the most prevalent findings in the keratoconic corneas (71.7 per cent, 64.2 per cent, 56.6 per cent, 55.5 per cent and 54.7 per cent, respectively). Those KC patients with these clinical findings had significantly higher mean K, AE and PE, while having significantly lower CCT, TCT and VA compared to those who did not present these signs (p < 0.05). The presence of clinical findings was associated with more severe disease (p < 0.001, all comparisons). Wearing contact lenses was associated with the increase in the risk of corneal scarring (p = 0.009, odds ratio = 1.761, 95 per cent confidence interval = 1.126 to 2.755). Conclusion: This study provided information regarding the presence of the clinical slitlamp biomicroscopic and retinoscopic findings with severity of KC. A positive association was found between the presence of clinical signs and topographic parameters. In addition, wearing contact lenses was associated with the increase in the risk of corneal scarring.

Research paper thumbnail of Is keratoconus more severe in pediatric population?

International Ophthalmology, 2016

To compare the ophthalmic parameters and the severity of keratoconus (KC) in pediatrics and adult... more To compare the ophthalmic parameters and the severity of keratoconus (KC) in pediatrics and adults at the time of initial diagnosis in an Iranian population. KC was diagnosed via slit-lamp examination and Pentacam imaging. In a retrospective observational study, consecutive patients were divided into two groups of pediatrics (&amp;amp;amp;amp;amp;amp;lt;18 years old) and adults (&amp;amp;amp;amp;amp;amp;gt;18 years old). Topographic, keratometric, and tomographic parameters, and severity of KC at the time of diagnosis were compared in both groups. Severity of KC was classified according to Amsler-Krumeich classification. One hundred fifty-eight eyes of 158 pediatric patients and 343 eyes of 343 adults with KC were studied. The mean ages of the pediatric and adult patients were 15 ± 1.9 and 22 ± 1.9 years, respectively (p &amp;amp;amp;amp;amp;amp;lt; 0.001). The results revealed that pediatric patients had significantly higher values of anterior and posterior mean, flat and steep keratometry, astigmatism, and maximum elevation and significantly lower central and thinnest corneal thickness (p &amp;amp;amp;amp;amp;amp;lt; 0.05). No significant difference was found regarding sphere, cylinder, manifest refraction spherical equivalent, and uncorrected and best-spectacle corrected visual acuity between the groups (p &amp;amp;amp;amp;amp;amp;gt; 0.05). Pediatric patients had a significantly more severe KC than adult patients according to Amsler-Krumeich classification (p = 0.001). Our findings suggest that KC is more severe in pediatrics, hence the fact that they should be closely monitored and intensively treated.

Research paper thumbnail of Higher order aberration comparison between two aspherical intraocular lenses: MC6125AS and Akreos advanced optics

International journal of ophthalmology, 2015

To compare higher order aberrations in two aspherical intraocular lenses (IOLs): Akreos advanced ... more To compare higher order aberrations in two aspherical intraocular lenses (IOLs): Akreos advanced optics (AO) and Dr. Schmidt Microcrystalline 6125 aspheric anterior surface (MC6125AS) with each other. Forty eyes of 39 patients underwent phacoemulsification and Akreos AO and MC6125AS were implanted in their eyes in a random manner. Three months post-operatively, higher order aberrations including spherical aberration, coma aberration, and total aberrations were measured and compared. The total aberration was 0.24±0.17 in eyes with Dr. Schmidt and 0.20±0.01 in eyes with Akreos AO (P=0.361). The mean of coma aberration was 0.17±0.21 and 0.09±0.86 in Dr. Schmidt and Akreos lenses, respectively (P=0.825). Total spherical aberration was almost the same in both groups (Mean: 0.05, P=0.933). Best corrected visual acuity in Akreos AO (0.10±0.68) and Dr. Schmidt (0.09±0.67) did not differ significantly (P=0.700). There is no statistically significant difference in the higher order aberrations...

Research paper thumbnail of Maternal Morbidities and Occurrence of Intraventricular Hemorrhage in Preterm Infants

Journal of pediatric intensive care, 2015

Intraventricular hemorrhage (IVH) is one of the most serious neurological morbidities in preterm ... more Intraventricular hemorrhage (IVH) is one of the most serious neurological morbidities in preterm infants. Several prenatal, intrapartum, and neonatal risk factors have been detected in different studies. However, maternal conditions that may render the neonates to IVH have been the subject of very few studies. Preterm infants with and without IVH were included in the study, and maternal obstetrics and general health clinical files were reviewed for any kind of morbidity. Data were then analyzed with statistical software to assess the association between maternal conditions and IVH. A total of 115 neonates with IVH and 120 infants without IVH were recruited. Among all maternal conditions, prolonged rupture of membrane (p = 0.00), laparoscopic surgery for infertility (p = 0.001), and in vitro fertilization (IVF) (p = 0.00) increased the risk of IVH in neonates significantly. IVF remained strongly associated with IVH even after controlling for confounding variables (odds ratio: 9.75; c...

Research paper thumbnail of Corneal cross-linking treatment of keratoconus

Oman Journal of Ophthalmology, 2015

Keratoconus as the most common cause of ectasia is one of the leading cause of corneal transplant... more Keratoconus as the most common cause of ectasia is one of the leading cause of corneal transplants worldwide. The current available therapies do not modify the underlying pathogenesis of the disease, and none of the available approaches but corneal transplant hinder the ongoing ectasia. Several studies document Crosslink defect between collagen fibrils in the pathogenesis of keratoconus. Collagen cross link is a relatively new approach that with the application of the riboflavin and ultraviolet A, new covalent bands reform. Subjective and objective results following this method seem to be promising. Endothelial damage besides other deep structural injury, which is the major concern of this technique have not yet been reported, when applying the standard method.

Research paper thumbnail of Gene therapy in keratoconus

Oman Journal of Ophthalmology, 2015

Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal tran... more Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal transplant. Therapeutic strategies that can arrest the progression of this disease and modify the underlying pathogenesis are getting more and more popularity among scientists. Cumulating data represent strong evidence of a genetic role in the pathogenesis of KC. Different loci have been identified, and certain mutations have also been mapped for this disease. Moreover, Biophysical properties of the cornea create an appropriate candidate of this tissue for gene therapy. Immune privilege, transparency and ex vivo stability are among these properties. Recent advantage in vectors, besides the ability to modulate the corneal milieu for accepting the target gene for a longer period and fruitful translation, make a big hope for stupendous results reasonable.

Research paper thumbnail of Surgical approach to posterior dislocation of the elbow combined with radial head and coronoid fractures (terrible triad): report of 19 cases

cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tu... more cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tures (terrible triad): report of 19 cases. Shafa Orthop J. 2013.1(1):2-7. Abstract Background: Terrible triad injury of the elbow has been a real challenge for surgeons. New standard methods of treatment have significantly improved outcomes, but yet complications occur frequently and rate of reopera-tion is still noticeable. Methods: The outcomes of lateral surgical approach in 19 patients with terrible triad injury were evaluated through Mayo Elbow Performance Score (MEPS) and Disabilities of the Arm, Shoulder and Hand (DASH) score. Results: A concentric congruency was achieved for 18 cases. The average of MEPS was 87.11±12.05. There-fore, 17 patients had excellent and good and two fair and poor results. Average of DASH score was 17±13.83. Due to early postoperative dislocation joint stiffness occurred in one patient. Conclusion: In our experience, lateral approach provides an adequate v...

Research paper thumbnail of Hybrid driven based robust stabilization for networked control systems

2017 IEEE 4th International Conference on Knowledge-Based Engineering and Innovation (KBEI), 2017

This paper considers robust stabilization controller design for networked control systems with co... more This paper considers robust stabilization controller design for networked control systems with communication delay and bounded system uncertainties under a hybrid framework. Hybrid-driven scheme is used to reduce the transmission data. The closed-loop system with a networked state feedback controller is modeled as a system with delayed control input. Criteria for exponential stability in the mean-square sense of the closed-loop system is derived in terms of Linear Matrix Inequalities (LMIs) and a feedback controller to reach a robust stability is designed. Finally, the effectiveness of the proposed method is demonstrated by simulation results.

Research paper thumbnail of Is There a Correlation Between the Clinical, Radiological and Ultra-Sonographic Findings of Osteoarthritis of the Knee?

International Journal of Pharmaceutical and Clinical Research, 2017

Objectives: The association between the severity of knee pain and the clinical and radiological f... more Objectives: The association between the severity of knee pain and the clinical and radiological findings can help to assess the severity of knee osteoarthritis. The present study aimed to assess the relationship between knee pain severity and clinical, radiological and ultra-sonographic findings in patients with knee osteoarthritis. Methods: We recruited 52 patients with primary osteoarthritis. Physical examination and ultrasonography were done. Plain radiography was done within 3 weeks of clinical examination. Results: The average age of participants was 59.27 ± 9.85 years. Using multivariable linear regression modeling, pain severity had no significant association with any of the covariates including epidemiological, clinical and ultrasound findings. The severity of clinical symptoms and stiffness was associated with the ultrasound finding of Baker’s cyst as well as with tenderness of internal compartment and suprapatellar effusion. In addition, the level of daily function remaine...

Research paper thumbnail of Surgical approach to posterior dislocation of the elbow combined with radial head and coronoid fractures (terrible triad): report of 19 cases

cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tu... more cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tures (terrible triad): report of 19 cases. Shafa Orthop J. 2013.1(1):2-7. Abstract Background: Terrible triad injury of the elbow has been a real challenge for surgeons. New standard methods of treatment have significantly improved outcomes, but yet complications occur frequently and rate of reopera-tion is still noticeable. Methods: The outcomes of lateral surgical approach in 19 patients with terrible triad injury were evaluated through Mayo Elbow Performance Score (MEPS) and Disabilities of the Arm, Shoulder and Hand (DASH) score. Results: A concentric congruency was achieved for 18 cases. The average of MEPS was 87.11±12.05. There-fore, 17 patients had excellent and good and two fair and poor results. Average of DASH score was 17±13.83. Due to early postoperative dislocation joint stiffness occurred in one patient. Conclusion: In our experience, lateral approach provides an adequate v...

Research paper thumbnail of Corneal aberrations in normal and keratoconic eyes using an OPD-Scan Ⅱ

Guoji Yanke Zazhi, 2018

AIM: To evaluate higher order aberrations(HOAs)of the corneal surface in normal and keratoconic e... more AIM: To evaluate higher order aberrations(HOAs)of the corneal surface in normal and keratoconic eyes.<p>METHODS: Using an OPD-Scan Ⅱ wavefront analyzer, aberrometric parameters of the corneal surface in one eye of 80 patients with keratoconus(KC)and 91 participants with normal eyes were evaluated. The Zernike coefficients from third- to sixth-order as well as root mean square(RMS)of primary coma, coma-like aberrations, and total HOA were calculated and compared between both groups.<p>RESULTS: Statistically significant differences were found in all aberrometric parameters between the measurements of the KC and normal participants(<i>P</i><0.001). All of the aberrometric parameters were significantly higher in the KC patients compared to the normal group(<i>P</i><0.001).<p>CONCLUSION: Corneal wavefront measurements by means of OPD-Scan Ⅱ were significantly higher in keratoconic corneas than normal corneas.

Research paper thumbnail of Ocular, corneal, and internal aberrations in eyes with keratoconus, forme fruste keratoconus, and healthy eyes

International ophthalmology, Jan 24, 2017

The purpose of this study is to evaluate ocular, corneal, and internal aberration parameters in e... more The purpose of this study is to evaluate ocular, corneal, and internal aberration parameters in eyes with keratoconus (KC), forme fruste keratoconus (FFKC), and normal eyes. In a prospective study, one eye of 110 patients with KC, 60 FFKC patients, and 150 healthy participants was evaluated using OPD-Scan II. Ocular, corneal, and internal higher-order aberrations were measured through a sixth-order Zernike polynomial decomposition. Receiver operating characteristic analysis was performed to evaluate the diagnostic ability of the aberration parameters in discriminating KC and FFKC from normal eyes. The root mean square of the all ocular aberration measurements was significantly higher in the KC and FFKC patients than that of normal participants (p < 0.05). All of the corneal aberration measurements were significantly higher in KC patients than those of normal patients (p < 0.05); however, only corneal total higher-order aberration (HOA), vertical and total coma, and higher-orde...

Research paper thumbnail of Prevalence of Eyelid Laxity and its Association with Ophthalmic Findings and Disease Severity in Patients with Keratoconus

European Journal of Ophthalmology, 2017

Purpose To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal... more Purpose To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal and keratoconic eyes and the correlations of these findings with ophthalmic parameters and disease severity in patients with keratoconus (KC). Methods In a prospective case-control study, prevalence of eyelid laxity and eyelid measurements were evaluated in 53 patients with KC and the same number of matched healthy controls. The eyelid measurements were compared between the groups, as well as mean keratometry (K), central and thinnest corneal thickness (CCT and TCT), astigmatism, manifest refraction spherical equivalent (MRSE), best spectacle-corrected visual acuity (BCVA), and severity of KC according to the Keratoconus Severity Score. Results Prevalence of eyelid laxity was 71.7% (38 patients) in patients with KC and 20.8% (11 patients) in normal participants (p<0.001, odds ratio 9.673 [95% confidence interval 3.959 to 23.631]). Comparison of the eyelid measurements in the patients...

Research paper thumbnail of Clinical biomicroscopy and retinoscopy findings of keratoconus in a Middle Eastern population

Clinical and Experimental Optometry, 2017

Background: The present work was conducted to investigate the prevalence of clinical biomicroscop... more Background: The present work was conducted to investigate the prevalence of clinical biomicroscopy and retinoscopy findings of corneas with keratoconus (KC) at first presentation and their relationship with disease severity. Method: In a prospective cross-sectional study, 371 consecutive KC patients were examined by slitlamp biomicroscopy and retinoscopy at the time of diagnosis. This research evaluates the prevalence of clinical findings such as a corneal protrusion, Vogt's striae, Fleischer's ring, Munson's sign, Rizzuti's sign, corneal scars, as well as any additional KC signs such as prominent nerve fibres, scissoring reflex and Charleaux 'oil droplet' sign on retinoscopy. Keratometry (mean K), central and thinnest corneal thickness (CCT and TCT), anterior and posterior elevation (AE and PE), and astigmatism by means of Pentacam, and visual acuity (VA) were recorded for each patient. The severity of KC was graded on the basis of the Keratoconus Severity Score. Results: Corneal protrusion, scissoring reflex, corneal thinning, Fleischer's ring, and prominent nerve fibres were the most prevalent findings in the keratoconic corneas (71.7 per cent, 64.2 per cent, 56.6 per cent, 55.5 per cent and 54.7 per cent, respectively). Those KC patients with these clinical findings had significantly higher mean K, AE and PE, while having significantly lower CCT, TCT and VA compared to those who did not present these signs (p < 0.05). The presence of clinical findings was associated with more severe disease (p < 0.001, all comparisons). Wearing contact lenses was associated with the increase in the risk of corneal scarring (p = 0.009, odds ratio = 1.761, 95 per cent confidence interval = 1.126 to 2.755). Conclusion: This study provided information regarding the presence of the clinical slitlamp biomicroscopic and retinoscopic findings with severity of KC. A positive association was found between the presence of clinical signs and topographic parameters. In addition, wearing contact lenses was associated with the increase in the risk of corneal scarring.

Research paper thumbnail of Is keratoconus more severe in pediatric population?

International Ophthalmology, 2016

To compare the ophthalmic parameters and the severity of keratoconus (KC) in pediatrics and adult... more To compare the ophthalmic parameters and the severity of keratoconus (KC) in pediatrics and adults at the time of initial diagnosis in an Iranian population. KC was diagnosed via slit-lamp examination and Pentacam imaging. In a retrospective observational study, consecutive patients were divided into two groups of pediatrics (&amp;amp;amp;amp;amp;amp;lt;18 years old) and adults (&amp;amp;amp;amp;amp;amp;gt;18 years old). Topographic, keratometric, and tomographic parameters, and severity of KC at the time of diagnosis were compared in both groups. Severity of KC was classified according to Amsler-Krumeich classification. One hundred fifty-eight eyes of 158 pediatric patients and 343 eyes of 343 adults with KC were studied. The mean ages of the pediatric and adult patients were 15 ± 1.9 and 22 ± 1.9 years, respectively (p &amp;amp;amp;amp;amp;amp;lt; 0.001). The results revealed that pediatric patients had significantly higher values of anterior and posterior mean, flat and steep keratometry, astigmatism, and maximum elevation and significantly lower central and thinnest corneal thickness (p &amp;amp;amp;amp;amp;amp;lt; 0.05). No significant difference was found regarding sphere, cylinder, manifest refraction spherical equivalent, and uncorrected and best-spectacle corrected visual acuity between the groups (p &amp;amp;amp;amp;amp;amp;gt; 0.05). Pediatric patients had a significantly more severe KC than adult patients according to Amsler-Krumeich classification (p = 0.001). Our findings suggest that KC is more severe in pediatrics, hence the fact that they should be closely monitored and intensively treated.

Research paper thumbnail of Higher order aberration comparison between two aspherical intraocular lenses: MC6125AS and Akreos advanced optics

International journal of ophthalmology, 2015

To compare higher order aberrations in two aspherical intraocular lenses (IOLs): Akreos advanced ... more To compare higher order aberrations in two aspherical intraocular lenses (IOLs): Akreos advanced optics (AO) and Dr. Schmidt Microcrystalline 6125 aspheric anterior surface (MC6125AS) with each other. Forty eyes of 39 patients underwent phacoemulsification and Akreos AO and MC6125AS were implanted in their eyes in a random manner. Three months post-operatively, higher order aberrations including spherical aberration, coma aberration, and total aberrations were measured and compared. The total aberration was 0.24±0.17 in eyes with Dr. Schmidt and 0.20±0.01 in eyes with Akreos AO (P=0.361). The mean of coma aberration was 0.17±0.21 and 0.09±0.86 in Dr. Schmidt and Akreos lenses, respectively (P=0.825). Total spherical aberration was almost the same in both groups (Mean: 0.05, P=0.933). Best corrected visual acuity in Akreos AO (0.10±0.68) and Dr. Schmidt (0.09±0.67) did not differ significantly (P=0.700). There is no statistically significant difference in the higher order aberrations...

Research paper thumbnail of Maternal Morbidities and Occurrence of Intraventricular Hemorrhage in Preterm Infants

Journal of pediatric intensive care, 2015

Intraventricular hemorrhage (IVH) is one of the most serious neurological morbidities in preterm ... more Intraventricular hemorrhage (IVH) is one of the most serious neurological morbidities in preterm infants. Several prenatal, intrapartum, and neonatal risk factors have been detected in different studies. However, maternal conditions that may render the neonates to IVH have been the subject of very few studies. Preterm infants with and without IVH were included in the study, and maternal obstetrics and general health clinical files were reviewed for any kind of morbidity. Data were then analyzed with statistical software to assess the association between maternal conditions and IVH. A total of 115 neonates with IVH and 120 infants without IVH were recruited. Among all maternal conditions, prolonged rupture of membrane (p = 0.00), laparoscopic surgery for infertility (p = 0.001), and in vitro fertilization (IVF) (p = 0.00) increased the risk of IVH in neonates significantly. IVF remained strongly associated with IVH even after controlling for confounding variables (odds ratio: 9.75; c...

Research paper thumbnail of Corneal cross-linking treatment of keratoconus

Oman Journal of Ophthalmology, 2015

Keratoconus as the most common cause of ectasia is one of the leading cause of corneal transplant... more Keratoconus as the most common cause of ectasia is one of the leading cause of corneal transplants worldwide. The current available therapies do not modify the underlying pathogenesis of the disease, and none of the available approaches but corneal transplant hinder the ongoing ectasia. Several studies document Crosslink defect between collagen fibrils in the pathogenesis of keratoconus. Collagen cross link is a relatively new approach that with the application of the riboflavin and ultraviolet A, new covalent bands reform. Subjective and objective results following this method seem to be promising. Endothelial damage besides other deep structural injury, which is the major concern of this technique have not yet been reported, when applying the standard method.

Research paper thumbnail of Gene therapy in keratoconus

Oman Journal of Ophthalmology, 2015

Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal tran... more Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal transplant. Therapeutic strategies that can arrest the progression of this disease and modify the underlying pathogenesis are getting more and more popularity among scientists. Cumulating data represent strong evidence of a genetic role in the pathogenesis of KC. Different loci have been identified, and certain mutations have also been mapped for this disease. Moreover, Biophysical properties of the cornea create an appropriate candidate of this tissue for gene therapy. Immune privilege, transparency and ex vivo stability are among these properties. Recent advantage in vectors, besides the ability to modulate the corneal milieu for accepting the target gene for a longer period and fruitful translation, make a big hope for stupendous results reasonable.

Research paper thumbnail of Surgical approach to posterior dislocation of the elbow combined with radial head and coronoid fractures (terrible triad): report of 19 cases

cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tu... more cal approach to posterior dislocation of the elbow combined with radial head and coronoid frac-tures (terrible triad): report of 19 cases. Shafa Orthop J. 2013.1(1):2-7. Abstract Background: Terrible triad injury of the elbow has been a real challenge for surgeons. New standard methods of treatment have significantly improved outcomes, but yet complications occur frequently and rate of reopera-tion is still noticeable. Methods: The outcomes of lateral surgical approach in 19 patients with terrible triad injury were evaluated through Mayo Elbow Performance Score (MEPS) and Disabilities of the Arm, Shoulder and Hand (DASH) score. Results: A concentric congruency was achieved for 18 cases. The average of MEPS was 87.11±12.05. There-fore, 17 patients had excellent and good and two fair and poor results. Average of DASH score was 17±13.83. Due to early postoperative dislocation joint stiffness occurred in one patient. Conclusion: In our experience, lateral approach provides an adequate v...