nafiseh baheiraei | Tehran University of Medical Sciences (original) (raw)

Papers by nafiseh baheiraei

Journal of Materials Chemistry B, 2023

Graphene and its derivatives have many desirable characteristics that make them suitable for use ... more Graphene and its derivatives have many desirable characteristics that make them suitable for use in cardiac tissue engineering.

Computer Methods in Biomechanics and Biomedical Engineering, Apr 26, 2022

The development of computer-aided facilities has contributed to the optimization of tissue engine... more The development of computer-aided facilities has contributed to the optimization of tissue engineering techniques due to the reduction in necessary practical assessments and the removal of animal or human-related ethical issues. Herein, a bone scaffold based on poly (2-hydroxyethyl methacrylate) (PHEMA), gelatin and graphene oxide (GO), was simulated by SOLIDWORKS and ABAQUS under a normal compression force using finite element method (FEM). Concerning the mechanotransduction impact, GO could support the stability of the structure and reduce the possibility of the failure resulting in the integrity and durability of the scaffold efficiency which would be beneficial for osteogenic differentiation.

Journal of Tissue Science and Engineering, Sep 20, 2017

Scientific Reports, May 3, 2023

The original version of this Article contained errors in the Results section resulting from an in... more The original version of this Article contained errors in the Results section resulting from an incomplete revision of the text to reflect changes in the figures during review. Figure legends and the Results section were corrected accordingly.

InTech eBooks, Mar 22, 2011

Pathobiology Research, Aug 10, 2017

International journal of women's health and reproduction sciences, Jun 3, 2016

Objectives: Although the fertilization and cleavage rate of implanted embryos is about 70%-90% in... more Objectives: Although the fertilization and cleavage rate of implanted embryos is about 70%-90% in most patients, only a small number of embryos grown in vitro have the potential to implant. This indicates that many factors are responsible for a successful implantation, including obtaining viable embryos for transfer. This study aimed to examine the clinical results of pregnancy and implantation rates between day 2 and day 3 embryo transfer (ET) in women under the age of 40 experiencing fresh intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles. Materials and Methods: In a retrospective study, a total of 284 ETs were examined from March 2013 to December 2014. The transfer was done according to physician's preference, patient characteristics or number of embryos available. Results: The data suggested that clinical (35.4% vs. 28.9%, P = 0.26) or ongoing pregnancy (32.5% vs. 23.7%, P = 0.11) or implantation rate (0.267 ± 0.2 vs. 0.216, P = 0.09) was slightly better and the miscarriage rate (3.1% vs. 7%, P = 0.153) was slightly lower on day 3 ET vs. day 2, however, this difference was not significant. Although most of the baseline characteristics were similar between groups, the number of high-quality embryos (5.29 ± 3.9 vs. 4.47 ± 3.05, P = 0.011) and average embryo cleavage score (2.85 ± 0.4 vs. 2.25 ± 0.3, P < 0.001) was significantly higher in the day 3 ET in comparison to the day 2 ET. Conclusion: A similar clinical outcome between ET performed on days 2 and 3 in women younger than 40 years undergoing fresh ICSI-ET is suggested by the results of this study.

PubMed, May 13, 2017

Cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caus... more Cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. Natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. Tissue engineering and regenerative medicine is a promising strategy to repair bone and articular cartilage defects and rehabilitate joint functions by focusing on the optimal combination of cells, material scaffolds, and signaling molecules. The unique physical and topographical properties of nanofibrous structures allow them to mimic the extracellular matrix of native cartilage, making an appropriate resemblance to induce cartilage tissue regeneration and reconstruction. To improve simulation of native cartilage, the incorporation of nanofibrous scaffolds with suitable corresponsive cells could be effective. In this review article, an attempt was made to present the current state of cartilage tissue engineering using nanofibrous scaffolds and stem cells as high proliferative immune privilege cells with chondrogenic differentiation ability. The comprehensive information was retrieved by search of relevant subject headings in Medline/Pubmed and Elsevier databases.

International Journal of Biological Macromolecules, Jun 1, 2021

Injectable hydrogels which mimic the physicochemical and electromechanical properties of cardiac ... more Injectable hydrogels which mimic the physicochemical and electromechanical properties of cardiac tissue is advantageous for cardiac tissue engineering. Here, a newly-developed in situ forming double-network hydrogel derived from biological macromolecules (oxidized alginate (OA) and myocardial extracellular matrix (ECM)) with improved mechanical properties and electrical conductivity was optimized. 3-(2-aminoethyl amino) propyltrimethoxysilane (APTMS)-functionalized reduced graphene oxide (Amine-rGO) was added to this system with varied concentrations to promote electromechanical properties of the hydrogel. Alginate was partially oxidized with an oxidation degree of 5% and the resulting OA was cross-linked via calcium ions which was reacted with amine groups of ECM and Amine-rGO through Schiff-base reaction. In situ forming hydrogels composed of 4% w/v OA and 0.8% w/v ECM showed appropriate gelation time and tensile Young's modulus. The electroactive hydrogels showed electrical conductivity in the range of semi-conductors and a suitable biodegradation profile for cardiac tissue engineering. Cytocompatibility analysis was performed by MTT assay against human umbilical vein endothelial cells (HUVECs), and the optimal hydrogel with 25 μg/ml concentration of Amine-rGO showed higher cell viability than that for other samples. The results of this study present the potential of OA/myocardial ECM-based hydrogel incorporated with Amine-rGO to provide a desirable platform for cardiac tissue engineering.

Applied Materials Today, Sep 1, 2020

Ceramics International, May 1, 2012

In the present study, silver-doped silica thin films on glazed surface of ceramic tiles were well... more In the present study, silver-doped silica thin films on glazed surface of ceramic tiles were well prepared by sol-gel method to achieve antibacterial activity. Thermal treatment was done in the air at 1100 8C for two hours. The Ag/SiO 2 thin films were investigated through Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and wavelength dispersive spectrometry (WDS). Atomic absorption spectroscopy (AAS) was used for the quantitative determination of the silver ion concentration being released from Ag/ SiO 2 films over a 24 day period. The antibacterial effects of Ag/SiO 2 thin films against Escherichia coli and Staphylococcus aureus were also examined. From the analysis results, it was found that high temperature treated coating consists of two phases of SiO 2 and Ag based on the trapping of the Ag phase in the silica matrix. The presence of Ag elements on the surface of the coated tiles, were also observed. Thermal treatment at high temperatures caused sharp XRD peaks and high crystallinity in this system. Ag + ions were released constantly and the mean release rate (AESD) was 0.104 AE0.01 mg/ml during 24 days. Coating films exhibited an excellent antibacterial performance against both bacterium.

Materials Science and Engineering: C, 2018

In bone tissue regeneration, the use of biomineralized scaffolds to create the 3D porous structur... more In bone tissue regeneration, the use of biomineralized scaffolds to create the 3D porous structure needed for well-fitting with defect size and appropriate cell interactions, is a promising alternative to autologous and heterologous bone grafts. Biomineralized polyurethane (PU) foams are here investigated as scaffold for bone tissue regeneration. Biomineralization of the foams was carried out by activation of PU surface by a two steps procedure performed for different times (1 to 4 weeks). Scaffolds were investigated for morphological, chemico-physical and mechanical properties, as well as for in vitro interaction with rat Bone Marrow Mesenchymal Stem Cells (BMSCs). Untreated and biomineralized PU samples showed a homogenous morphology and regular pore size (average Ø = 407 μm). Phase and structure of formed calcium phosphates (CaPs) layer onto the PU foam were analyzed by Fourier Transform Infrared spectroscopy and X-ray diffraction, proving the formation of bone-like nano hydroxyapatite. Biomineralization caused a significant increase of mechanical properties of treated foams compared to untreated ones. Biomineralization also affected the PU scaffold cytocompatibility providing a more appropriate surface for cell attachment and proliferation. Considering the obtained results, the proposed scaffold can be considered suitable for bone tissue regeneration.

Research Square (Research Square), Mar 20, 2020

Journal of Polymers and the Environment, Nov 27, 2023

Ceramics International, Aug 1, 2018

Saeedeh zare jalise, Nafiseh Baheiraei and Fatemeh Baghery, The effects of strontium incorporatio... more Saeedeh zare jalise, Nafiseh Baheiraei and Fatemeh Baghery, The effects of strontium incorporation on a novel gelatin/bioactive glass bone g r a f t : in vitro and in vivo characterization, Ceramics International,

Biomaterials Research

Background Cardiovascular diseases, particularly myocardial infarction (MI), are the leading caus... more Background Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is a promising approach for preventing functional damage or improving cardiac function after MI. We aimed to introduce a novel electroactive cardiac patch based on reduced graphene oxide-coated alginate scaffolds due to the promising functional behavior of electroactive biomaterials to regulate cell proliferation, biocompatibility, and signal transition. Methods The fabrication of novel electroactive cardiac patches based on alginate (ALG) coated with different concentrations of reduced graphene oxide (rGO) using sodium hydrosulfite is described here. The prepared scaffolds were thoroughly tested for their physicochemical properties and cytocompatibility. ALG-rGO scaffolds were also tested for their antimicrobial and antioxidant properties. Subcutaneous implantation in mice was used to evaluate the sca...

The Lancet Gastroenterology & Hepatology, Dec 1, 2019

Background Data about the global, regional, and country-specific variations in the levels and tre... more Background Data about the global, regional, and country-specific variations in the levels and trends of colorectal cancer are required to understand the impact of this disease and the trends in its burden to help policy makers allocate resources. Here we provide a status report on the incidence, mortality, and disability caused by colorectal cancer in 195 countries and territories between 1990 and 2017. Methods Vital registration, sample vital registration, verbal autopsy, and cancer registry data were used to generate incidence, death, and disability-adjusted life-year (DALY) estimates of colorectal cancer at the global, regional, and national levels. We also determined the association between development levels and colorectal cancer age-standardised DALY rates, and calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. All of the estimates are reported as counts and age-standardised rates per 100 000 person-years, with some estimates also presented by sex and 5-year age groups. Findings In 2017, there were 1•8 million (95% UI 1•8-1•9) incident cases of colorectal cancer globally, with an agestandardised incidence rate of 23•2 (22•7-23•7) per 100 000 person-years that increased by 9•5% (4•5-13•5) between 1990 and 2017. Globally, colorectal cancer accounted for 896 000 (876 300-915 700) deaths in 2017, with an agestandardised death rate of 11•5 (11•3-11•8) per 100 000 person-years, which decreased between 1990 and 2017 (-13•5% [-18•4 to-10•0]). Colorectal cancer was also responsible for 19•0 million (18•5-19•5) DALYs globally in 2017, with an age-standardised rate of 235•7 (229•7-242•0) DALYs per 100 000 person-years, which decreased between 1990 and 2017 (-14•5% [-20•4 to-10•3]). Slovakia, the Netherlands, and New Zealand had the highest age-standardised incidence rates in 2017. Greenland, Hungary, and Slovakia had the highest age-standardised death rates in 2017. Numbers of incident cases and deaths were higher among males than females up to the ages of 80-84 years, with the highest rates observed in the oldest age group (≥95 years) for both sexes in 2017. There was a non-linear association between the Socio-demographic Index and the Healthcare Access and Quality Index and age-standardised DALY rates. In 2017, the three largest contributors to DALYs at the global level, for both sexes, were diet low in calcium (20•5% [12•9-28•9]), alcohol use (15•2% [12•1-18•3]), and diet low in milk (14•3% [5•1-24•8]). Interpretation There is substantial global variation in the burden of colorectal cancer. Although the overall colorectal cancer age-standardised death rate has been decreasing at the global level, the increasing age-standardised incidence rate in most countries poses a major public health challenge across the world. The results of this study could be useful for policy makers to carry out cost-effective interventions and to reduce exposure to modifiable risk factors, particularly in countries with high incidence or increasing burden. Funding Bill & Melinda Gates Foundation.

International Journal of Applied Ceramic Technology, Nov 4, 2013

In this study, diffusional method was used to prepare a calcium phosphate/gelatin nanocomposite a... more In this study, diffusional method was used to prepare a calcium phosphate/gelatin nanocomposite as a scaffold for bone tissue repair. Incorporation of magnesium (Mg) into mineral phase of the scaffold was also investigated. Addition of Mg ions to the synthesis process caused formation of magnesium phosphate (MgP) and hydroxyapatite (HAp). However, analyses data for the sample lacking Mg showed that the mineral formed within GEL had a low crystalline nature, consisting of HAp and octacalcium phosphate (OCP). With addition of Mg within the structure of precipitated minerals, morphology of minerals was dramatically changed toward being irregular and less ordered.

Journal of Bioactive and Compatible Polymers, Jul 1, 2020

The benefits of combined cell/material therapy appear promising for myocardial infarction treatme... more The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical properties. In this study, the reduced graphene oxide incorporation effect within alginate hydrogels was investigated for cardiac repair application. Reduced graphene oxide reinforced alginate properties, resulting in an increase in gel stiffness. The cytocompatibility of the hydrogels prepared with human bone marrow-derived mesenchymal stem cells was assessed by the 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay. Following reduced graphene oxide addition, alginatereduced graphene oxide retained significantly higher cell viability compared to that of alginate and cells cultured on tissue culture plates. Acridine orange/propidium iodide staining was also used to identify both viable and necrotic human bone marrow-derived mesenchymal stem cells within the prepared hydrogels. After a 72-h culture, the percentage of viable cells was twice as much as those cultured on either alginate or tissue culture plate, reaching approximately 80%. Quantitative reverse transcription polymerase chain reaction analysis was performed to assess gene expression of neonatal rat cardiac cells encapsulated on hydrogels for TrpT-2, Conx43, and Actn4 after 7 days. The expression of all genes in alginate-reduced graphene oxide increased significantly compared to that in alginate or tissue culture plate. The results obtained confirmed that the presence of reduced graphene oxide, as an electro