azaiez ben akacha | University of Tunis El Manar (original) (raw)
Papers by azaiez ben akacha
Russian Journal of Bioorganic Chemistry, 2021
The aim of this work was to synthesize a diethyl phenylcarbamothioyl phosphonate (EThmP) and eval... more The aim of this work was to synthesize a diethyl phenylcarbamothioyl phosphonate (EThmP) and evaluate its biological activities. ThmP has been prepared with high yields and its conformation was determined. This phosphonothioamidate derivative was characterized by IR, and NMR Spectroscopy ( 1 H, 13 C, and 31 P). On the component of EThmP, the Hirshfeld surface analysis indicates that the major contributions for the crystal packing are H···H (53.3%), H···O (12.9%) H···S (14.5%), and C···H (17.6%) interactions. An anti-nociceptive test (the formaline test) showed that the EThmP modulates the pain during the early and late phases proved by rat behavior characterized by absence of licking, biting and shaking of the affected paw. The modulation of pain by the EThmP may be due to its anti-inflammatory effect. The Hot Plate test showed that the pretreatment with the EThmP did not modulate the pain nociception induced by maintaining the rat at a fixed temperature of 48°C. The treated rats’ b...
Journal of Molecular Structure, 2021
A series of phosphonoamidates and phosphonoamidines derivatives have been prepared with high yiel... more A series of phosphonoamidates and phosphonoamidines derivatives have been prepared with high yields and their conformations were determined. All compounds were characterized by IR, NMR Spectroscopy (1H, 13C, and 31P) and in some cases by elemental analysis and evolution study by 31P-NMR in an external lock with D2O. A DFT calculations studies was performed to identify the stability of all forms (Cis and Trans) (Syn and Anti) at the B3LYP/6-311G** level. The most stable geometry with an Anti-conformation. A comparison with the experimental results validates the level of theory. The biological activity of dimethyl cyclohexyl carbamoylphosphonate (MAmP) and diethyl cyclohexyl carbamoylphosphonate (EAmP) was evaluated. Only the association of ethyl group with phosphorus in amide gives antimicrobial capacity against S. aureus. The evaluation of the analgesic activity following a thermal stimulus showed that the rats treated with the MAmP do not present any sensation of pain. The MAmP mol...
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract The phosphonothioamidates (EtO)2P(=O)C(=S)N(H)R (L1 R = Cy; L2 R = Bz) have been prepare... more Abstract The phosphonothioamidates (EtO)2P(=O)C(=S)N(H)R (L1 R = Cy; L2 R = Bz) have been prepared by nucleophilic addition of K[(EtO)2P(=O)] to R–N = C=S and crystallographically analyzed. Both compounds are associated pairwise through strong intermolecular N–H···O bonding giving rise to 10-membered supramolecular macrocycles. This intermolecular bonding has also been studied by Hirshfeld analysis of L1 and L2. Complexation of L on CuI in MeCN solution affords the dinuclear rhomboid-shaped thione complexes [{Cu(μ2-I)2Cu}(η1-L)2] (1a,b). Crystallographic characterization of 1a reveals that L1 is ligated exclusively via the thione function to the trigonal Cu(I) centers, which are interconnected through a short Cu–Cu bond of 2.6207(4) Å. In the solid state, individual dimeric complexes are associated through intermolecular N–H···O bonding generating a supramolecular 1D ribbon. The dinuclear complexes [{XHg(μ2-X)2HgX}(η1-L)2] (2a X = Br, L = Cy; 2b X = Br, L = Bz; 2c X = I, L = Bz) were formed by stoichiometric addition of L to HgX2. The molecular structures of 2b and 2c have been elucidated by X-ray diffraction studies, which show that individual complexes are connected through intermolecular N–H···O bonding generating a supramolecular 1D ribbon. Treatment of L1 with two equivalents of HgBr2 produces the tetranuclear compound [Hg4Br8(κ1-L1)2] 3, whose unusual bromide-bridged architecture has been elucidated by X-ray crystallography. GRAPHICAL ABSTRACT
Journal of Molecular Structure
Toxicology in Vitro
Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its cli... more Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its clinical use despite its devastating impact on highly proliferating cells. The present work was designed to develop a new approach which aims to protect male germ cells from DOX cytotoxicity. Thus, an assessment of the protective potential of a new thioamide analog (thiocyanoacetamide; TA) compared to selenium (Se) was performed in rat sperms exposed to DOX in vitro. Oxygen consumption rate (OCR) was measured after exposure to three different doses (0.5, 1, 1.5 and 2 μM) of DOX, Se or TA, and the suitable concentrations were selected for further studies afterwards. Motility, OCR in a time-dependent manner, glucose extracellular concentration and lipid peroxidation (LPO) were measured. Fatty acid (FA) content was assessed by gas chromatography (GC-FID). Cell death, superoxide anion (O2-), mitochondrial membrane potential (MMP), and DNA damage were evaluated by flow cytometry. TA association with DOX increased OCR and glucose uptake, improved cell survival and decreased DNA damage. The co-administration of DOX with Se increased OCR, significantly prevented O2- overproduction, and decreased LPO. Collected data brought new insights regarding this transformed TA, which showed better efficiency than Se in reducing DOX cytotoxic stress in sperms.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Thioamides (Thm) have diverse biological activities. This work presents the development and valid... more Thioamides (Thm) have diverse biological activities. This work presents the development and validation of simple, rapid and accurate spectrophotometric method for the analysis of Thm derivatives in pure form and in plasma. This spectrophotometric method has not been used before for determination of Thm. A review of the literature revealed that the monitoring of S- group assay is based on the reaction with DTNB according to the Ellman method to form a yellow complex which absorbs at 412 nm. To assay the thioamides according to this method it is necessary to make the basic medium have S- to react with the DTNB. Experimental conditions affecting the color development were studied and optimized. The proposed spectrophotometric procedures were effectively validated with respect to linearity, ranges, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curves of the formed colored product with DTNB showed good linear relationships over the concentration ranges (0, 50, 100, 500, 1000, 1500 mg/L). The proposed method was successfully applied to the assay of Thm monitoring with good accuracy. The principal advantages of the proposed method were rapidity and suitability for the routine quality control assay of the drug alone and in monitoring form without interference.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2017
GRAPHICAL ABSTRACT ABSTRACT 1,3-Diol reacts with phosphorus trichloride to produce diastereomeric... more GRAPHICAL ABSTRACT ABSTRACT 1,3-Diol reacts with phosphorus trichloride to produce diastereomeric 1,3,2-dioxaphosphorinanes. To find the predominant conformations, the influence of the diol precursors is studied and density functional theory calculation (DFT) is used. Then, hydrolysis of chlorophosphite leads to two cyclodialcoxyphosphites which are identified by NMR (31P, 1 H, 13C, MR-SM). Also, the steps of synthesis of hydrazone 1-(5,5-diethyl-2-oxo-1,3,2-dioxaphosphoranyl)-3-phenyl-propanone are studied by 31P NMR. Résumé La conformation de départ du 1,3-diol influe sur la conformation des dérivés de 1,3,2-dioxaphosphorinane. En effet, l'addition du 1,3-diol sur le trichlorure de phosphore fournit un chloro-phosphite sous forme d'un mélange de diastéréoisomères. L'hydrolyse des deux chloro-phosphites conduit à deux cyclodialcoxyphosphites qui sont identifiés par RMN (31P, 1H, 13C, GC-MS). Une étude de la synthèse de l'hydrazone β–phosphonatée est suivie par RMN du phosphore-31.
Biomedicine & Pharmacotherapy, 2017
Despite its deleterious effect on healthy cells and highly regenerating cells such as spermatozoa... more Despite its deleterious effect on healthy cells and highly regenerating cells such as spermatozoa, Doxorubicin (DOX) is still one of the most used anticancer drugs in the last decades. The present work aimed to investigate the ability of the selenium (Se) and the thiocyanoacetamide (T) to reduce DOX toxicity in gonad. Adult male rats were treated with DOX intravenously (i.v.) at 3.7mg/kg/week associated with Se intragastrically (i.g.) at 0.2mg/kg/day or with T at 10mg/kg/day i.g. After 47days of treatment, sperm quality, biochemical parameters, blood cell count and histological changes in liver, testis and epididymis were assessed. The results showed a poor sperm quality, a perturbation of ionic stability and a significant alteration of lipid metabolism and hematological parameters after the sub-chronic administration of DOX. In testis, DOX exerted serious epithelium damage and numerous seminiferous tubules did not present a normal spermatogenesis. In epididymis, epithelium was altered and mastocytes infiltrated the interstitium. DOX did not exert any significant change in liver except dilatations of sinusoid capillaries. DOX association with Se or T reduced its toxicity on some hematological and biochemical parameters. Both combined treatment improved sperm quality and partially restored spermatogenesis as well as testis and epididymis' normal aspect. These findings brought new sights regarding the effect of Se and a new derivative of T in a combined treatment with DOX on germ cells, gonad and liver. The support of these relevant outcomes with further in vitro studies is necessary to highlight the accurate process involved in Se or T protection against DOX induced damages.
Journal of Fluorine Chemistry, 2003
Ten phosphorylated β-hydrazones of structure R2P(O)C(NNHRF)CHR2′ were prepared in 54–91% yield b... more Ten phosphorylated β-hydrazones of structure R2P(O)C(NNHRF)CHR2′ were prepared in 54–91% yield by heating the allenes R2P(O)CHCCR2′ with fluorinated hydrazines H2NNHRF in chloroform or methanol [R=Ph, OCH2C(Me)2CH2O or OCH2C(Me)(Pr)CH2O, R′=H or Me and RF=CH2CF3 or C6F5]. Two cyclohexyl derivatives were prepared similarly from R2P(O)CHCCy. The triphenyl derivatives Ph2P(O)CH2C(NNHCH2CF3)Ph and Ph2P(O)CH2C(NNHC6F5)Ph were made in 91 and 68% yield by heating the ketones
Biomedicine & Pharmacotherapy, 2017
Chemical Physics Letters, 2016
Phosphorus Sulfur and Silicon and the Related Elements, May 31, 2013
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
Phosphorus, Sulfur, and Silicon and the Related Elements, 1995
The monoacylhydrazides, as well as hydrazines, react with phosphoallenic derivatives 1 to lead to... more The monoacylhydrazides, as well as hydrazines, react with phosphoallenic derivatives 1 to lead to the δ-N-2 acyl 3-dimethylamino 3-oxo-1,2,3-diazaphospholine 2. The reaction of ring opening in δ-N-2 acyl-3-dimethylamino-3-oxo-1,2,3-diazaphospholine by different alcohols leads to the β-phosphonyl-hydrazide 3. The structure of products (2 and 3) is further confirmed by IR, H, NMR, P NMR, C NMR spectra.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2013
The addition of hydrazine and its derivatives to cycloalkoxyphosphinallenes leads to β−(5,5-dialk... more The addition of hydrazine and its derivatives to cycloalkoxyphosphinallenes leads to β−(5,5-dialkyl-2-oxo-1,3,2-dioxaphosphoranyl)-hydrazones in good yields. The structure of the obtained compounds were elucidated by NMR (H, C, P) spectroscopy and DFT calculations at B3LYP/6–311++G (2d, 2p) level of theory.
… Section C: Crystal …, Jan 1, 2010
In the title compound, C(11)H(21)N(2)O(5)P, one of the two carbazate N atoms is involved in the C... more In the title compound, C(11)H(21)N(2)O(5)P, one of the two carbazate N atoms is involved in the C=N double bond and the H atom of the second N atom is engaged in an intramolecular hydrogen bond with an O atom from the dimethylphosphorin-2-yl group, which is in an uncommon cis position with respect to the carbamate group. The cohesion of the crystal structure is also reinforced by weak intermolecular hydrogen bonds. Density functional theory (DFT) calculations at the B3LYP/6-311++g(2d,2p) level revealed the lowest energy structure to have a Z configuration at the C=N bond, which is consistent with the configuration found in the X-ray crystal structure, as well as a less stable E counterpart which lies 2.0 kcal mol(-1) higher in potential energy. Correlations between the experimental and computational studies are discussed.
Phosphorus, Sulfur, and Silicon, Jan 1, 2003
Page 1. October 8, 2003 18:20 GPSS TJ829-06 Phosphorus, Sulfur, and Silicon, 178:2349–2356, 2003 ... more Page 1. October 8, 2003 18:20 GPSS TJ829-06 Phosphorus, Sulfur, and Silicon, 178:2349–2356, 2003 Copyright C Taylor & Francis Inc. ISSN: 1042-6507 print / 1563-5325 online DOI: 10.1080/10426500390234759 1-(2 ,2 ...
Russian Journal of Bioorganic Chemistry, 2021
The aim of this work was to synthesize a diethyl phenylcarbamothioyl phosphonate (EThmP) and eval... more The aim of this work was to synthesize a diethyl phenylcarbamothioyl phosphonate (EThmP) and evaluate its biological activities. ThmP has been prepared with high yields and its conformation was determined. This phosphonothioamidate derivative was characterized by IR, and NMR Spectroscopy ( 1 H, 13 C, and 31 P). On the component of EThmP, the Hirshfeld surface analysis indicates that the major contributions for the crystal packing are H···H (53.3%), H···O (12.9%) H···S (14.5%), and C···H (17.6%) interactions. An anti-nociceptive test (the formaline test) showed that the EThmP modulates the pain during the early and late phases proved by rat behavior characterized by absence of licking, biting and shaking of the affected paw. The modulation of pain by the EThmP may be due to its anti-inflammatory effect. The Hot Plate test showed that the pretreatment with the EThmP did not modulate the pain nociception induced by maintaining the rat at a fixed temperature of 48°C. The treated rats’ b...
Journal of Molecular Structure, 2021
A series of phosphonoamidates and phosphonoamidines derivatives have been prepared with high yiel... more A series of phosphonoamidates and phosphonoamidines derivatives have been prepared with high yields and their conformations were determined. All compounds were characterized by IR, NMR Spectroscopy (1H, 13C, and 31P) and in some cases by elemental analysis and evolution study by 31P-NMR in an external lock with D2O. A DFT calculations studies was performed to identify the stability of all forms (Cis and Trans) (Syn and Anti) at the B3LYP/6-311G** level. The most stable geometry with an Anti-conformation. A comparison with the experimental results validates the level of theory. The biological activity of dimethyl cyclohexyl carbamoylphosphonate (MAmP) and diethyl cyclohexyl carbamoylphosphonate (EAmP) was evaluated. Only the association of ethyl group with phosphorus in amide gives antimicrobial capacity against S. aureus. The evaluation of the analgesic activity following a thermal stimulus showed that the rats treated with the MAmP do not present any sensation of pain. The MAmP mol...
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract The phosphonothioamidates (EtO)2P(=O)C(=S)N(H)R (L1 R = Cy; L2 R = Bz) have been prepare... more Abstract The phosphonothioamidates (EtO)2P(=O)C(=S)N(H)R (L1 R = Cy; L2 R = Bz) have been prepared by nucleophilic addition of K[(EtO)2P(=O)] to R–N = C=S and crystallographically analyzed. Both compounds are associated pairwise through strong intermolecular N–H···O bonding giving rise to 10-membered supramolecular macrocycles. This intermolecular bonding has also been studied by Hirshfeld analysis of L1 and L2. Complexation of L on CuI in MeCN solution affords the dinuclear rhomboid-shaped thione complexes [{Cu(μ2-I)2Cu}(η1-L)2] (1a,b). Crystallographic characterization of 1a reveals that L1 is ligated exclusively via the thione function to the trigonal Cu(I) centers, which are interconnected through a short Cu–Cu bond of 2.6207(4) Å. In the solid state, individual dimeric complexes are associated through intermolecular N–H···O bonding generating a supramolecular 1D ribbon. The dinuclear complexes [{XHg(μ2-X)2HgX}(η1-L)2] (2a X = Br, L = Cy; 2b X = Br, L = Bz; 2c X = I, L = Bz) were formed by stoichiometric addition of L to HgX2. The molecular structures of 2b and 2c have been elucidated by X-ray diffraction studies, which show that individual complexes are connected through intermolecular N–H···O bonding generating a supramolecular 1D ribbon. Treatment of L1 with two equivalents of HgBr2 produces the tetranuclear compound [Hg4Br8(κ1-L1)2] 3, whose unusual bromide-bridged architecture has been elucidated by X-ray crystallography. GRAPHICAL ABSTRACT
Journal of Molecular Structure
Toxicology in Vitro
Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its cli... more Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its clinical use despite its devastating impact on highly proliferating cells. The present work was designed to develop a new approach which aims to protect male germ cells from DOX cytotoxicity. Thus, an assessment of the protective potential of a new thioamide analog (thiocyanoacetamide; TA) compared to selenium (Se) was performed in rat sperms exposed to DOX in vitro. Oxygen consumption rate (OCR) was measured after exposure to three different doses (0.5, 1, 1.5 and 2 μM) of DOX, Se or TA, and the suitable concentrations were selected for further studies afterwards. Motility, OCR in a time-dependent manner, glucose extracellular concentration and lipid peroxidation (LPO) were measured. Fatty acid (FA) content was assessed by gas chromatography (GC-FID). Cell death, superoxide anion (O2-), mitochondrial membrane potential (MMP), and DNA damage were evaluated by flow cytometry. TA association with DOX increased OCR and glucose uptake, improved cell survival and decreased DNA damage. The co-administration of DOX with Se increased OCR, significantly prevented O2- overproduction, and decreased LPO. Collected data brought new insights regarding this transformed TA, which showed better efficiency than Se in reducing DOX cytotoxic stress in sperms.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Thioamides (Thm) have diverse biological activities. This work presents the development and valid... more Thioamides (Thm) have diverse biological activities. This work presents the development and validation of simple, rapid and accurate spectrophotometric method for the analysis of Thm derivatives in pure form and in plasma. This spectrophotometric method has not been used before for determination of Thm. A review of the literature revealed that the monitoring of S- group assay is based on the reaction with DTNB according to the Ellman method to form a yellow complex which absorbs at 412 nm. To assay the thioamides according to this method it is necessary to make the basic medium have S- to react with the DTNB. Experimental conditions affecting the color development were studied and optimized. The proposed spectrophotometric procedures were effectively validated with respect to linearity, ranges, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curves of the formed colored product with DTNB showed good linear relationships over the concentration ranges (0, 50, 100, 500, 1000, 1500 mg/L). The proposed method was successfully applied to the assay of Thm monitoring with good accuracy. The principal advantages of the proposed method were rapidity and suitability for the routine quality control assay of the drug alone and in monitoring form without interference.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2017
GRAPHICAL ABSTRACT ABSTRACT 1,3-Diol reacts with phosphorus trichloride to produce diastereomeric... more GRAPHICAL ABSTRACT ABSTRACT 1,3-Diol reacts with phosphorus trichloride to produce diastereomeric 1,3,2-dioxaphosphorinanes. To find the predominant conformations, the influence of the diol precursors is studied and density functional theory calculation (DFT) is used. Then, hydrolysis of chlorophosphite leads to two cyclodialcoxyphosphites which are identified by NMR (31P, 1 H, 13C, MR-SM). Also, the steps of synthesis of hydrazone 1-(5,5-diethyl-2-oxo-1,3,2-dioxaphosphoranyl)-3-phenyl-propanone are studied by 31P NMR. Résumé La conformation de départ du 1,3-diol influe sur la conformation des dérivés de 1,3,2-dioxaphosphorinane. En effet, l'addition du 1,3-diol sur le trichlorure de phosphore fournit un chloro-phosphite sous forme d'un mélange de diastéréoisomères. L'hydrolyse des deux chloro-phosphites conduit à deux cyclodialcoxyphosphites qui sont identifiés par RMN (31P, 1H, 13C, GC-MS). Une étude de la synthèse de l'hydrazone β–phosphonatée est suivie par RMN du phosphore-31.
Biomedicine & Pharmacotherapy, 2017
Despite its deleterious effect on healthy cells and highly regenerating cells such as spermatozoa... more Despite its deleterious effect on healthy cells and highly regenerating cells such as spermatozoa, Doxorubicin (DOX) is still one of the most used anticancer drugs in the last decades. The present work aimed to investigate the ability of the selenium (Se) and the thiocyanoacetamide (T) to reduce DOX toxicity in gonad. Adult male rats were treated with DOX intravenously (i.v.) at 3.7mg/kg/week associated with Se intragastrically (i.g.) at 0.2mg/kg/day or with T at 10mg/kg/day i.g. After 47days of treatment, sperm quality, biochemical parameters, blood cell count and histological changes in liver, testis and epididymis were assessed. The results showed a poor sperm quality, a perturbation of ionic stability and a significant alteration of lipid metabolism and hematological parameters after the sub-chronic administration of DOX. In testis, DOX exerted serious epithelium damage and numerous seminiferous tubules did not present a normal spermatogenesis. In epididymis, epithelium was altered and mastocytes infiltrated the interstitium. DOX did not exert any significant change in liver except dilatations of sinusoid capillaries. DOX association with Se or T reduced its toxicity on some hematological and biochemical parameters. Both combined treatment improved sperm quality and partially restored spermatogenesis as well as testis and epididymis' normal aspect. These findings brought new sights regarding the effect of Se and a new derivative of T in a combined treatment with DOX on germ cells, gonad and liver. The support of these relevant outcomes with further in vitro studies is necessary to highlight the accurate process involved in Se or T protection against DOX induced damages.
Journal of Fluorine Chemistry, 2003
Ten phosphorylated β-hydrazones of structure R2P(O)C(NNHRF)CHR2′ were prepared in 54–91% yield b... more Ten phosphorylated β-hydrazones of structure R2P(O)C(NNHRF)CHR2′ were prepared in 54–91% yield by heating the allenes R2P(O)CHCCR2′ with fluorinated hydrazines H2NNHRF in chloroform or methanol [R=Ph, OCH2C(Me)2CH2O or OCH2C(Me)(Pr)CH2O, R′=H or Me and RF=CH2CF3 or C6F5]. Two cyclohexyl derivatives were prepared similarly from R2P(O)CHCCy. The triphenyl derivatives Ph2P(O)CH2C(NNHCH2CF3)Ph and Ph2P(O)CH2C(NNHC6F5)Ph were made in 91 and 68% yield by heating the ketones
Biomedicine & Pharmacotherapy, 2017
Chemical Physics Letters, 2016
Phosphorus Sulfur and Silicon and the Related Elements, May 31, 2013
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
Phosphorus, Sulfur, and Silicon and the Related Elements, 1995
The monoacylhydrazides, as well as hydrazines, react with phosphoallenic derivatives 1 to lead to... more The monoacylhydrazides, as well as hydrazines, react with phosphoallenic derivatives 1 to lead to the δ-N-2 acyl 3-dimethylamino 3-oxo-1,2,3-diazaphospholine 2. The reaction of ring opening in δ-N-2 acyl-3-dimethylamino-3-oxo-1,2,3-diazaphospholine by different alcohols leads to the β-phosphonyl-hydrazide 3. The structure of products (2 and 3) is further confirmed by IR, H, NMR, P NMR, C NMR spectra.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2013
The addition of hydrazine and its derivatives to cycloalkoxyphosphinallenes leads to β−(5,5-dialk... more The addition of hydrazine and its derivatives to cycloalkoxyphosphinallenes leads to β−(5,5-dialkyl-2-oxo-1,3,2-dioxaphosphoranyl)-hydrazones in good yields. The structure of the obtained compounds were elucidated by NMR (H, C, P) spectroscopy and DFT calculations at B3LYP/6–311++G (2d, 2p) level of theory.
… Section C: Crystal …, Jan 1, 2010
In the title compound, C(11)H(21)N(2)O(5)P, one of the two carbazate N atoms is involved in the C... more In the title compound, C(11)H(21)N(2)O(5)P, one of the two carbazate N atoms is involved in the C=N double bond and the H atom of the second N atom is engaged in an intramolecular hydrogen bond with an O atom from the dimethylphosphorin-2-yl group, which is in an uncommon cis position with respect to the carbamate group. The cohesion of the crystal structure is also reinforced by weak intermolecular hydrogen bonds. Density functional theory (DFT) calculations at the B3LYP/6-311++g(2d,2p) level revealed the lowest energy structure to have a Z configuration at the C=N bond, which is consistent with the configuration found in the X-ray crystal structure, as well as a less stable E counterpart which lies 2.0 kcal mol(-1) higher in potential energy. Correlations between the experimental and computational studies are discussed.
Phosphorus, Sulfur, and Silicon, Jan 1, 2003
Page 1. October 8, 2003 18:20 GPSS TJ829-06 Phosphorus, Sulfur, and Silicon, 178:2349–2356, 2003 ... more Page 1. October 8, 2003 18:20 GPSS TJ829-06 Phosphorus, Sulfur, and Silicon, 178:2349–2356, 2003 Copyright C Taylor & Francis Inc. ISSN: 1042-6507 print / 1563-5325 online DOI: 10.1080/10426500390234759 1-(2 ,2 ...