Krisztina Boda | University of Szeged (original) (raw)
Papers by Krisztina Boda
Results: 7KHSUHYDOHQFHRISUHK\SHUWHQVLRQDQGK\SHUWHQVLRQDWWKH� oUVW� screening were 7.9% (male;8.5%... more Results: 7KHSUHYDOHQFHRISUHK\SHUWHQVLRQDQGK\SHUWHQVLRQDWWKH� oUVW� screening were 7.9% (male;8.5%, female;7.2%) and 10.6% (male;12.9%, fe- male;8.2%), respectively. There was a difference of the prevalence of hyperten- sion between male and female adolescents with the difference of the prevalence of obesity. The prevalence of overweight and obese subjects were 12.9% (male; 13.7%, female;12.1%) and 8.3%(male;8.8%, female;7.8%), respectively. Over- ZHLJKWDQGREHVHVXEMHFWVKDGDVLJQLoFDQWO\�KLJKHUSUHYDOHQFHRIKLJK�%3�WKDQ� normal body weight children and adolescents in both male and female in each age group. In male with normal body weight, the distribution of BP were 83.5% of normal BP, 7.5% of prehypertension and 9% of hypertension, respectively. However in male subjects with overweight and obesity, normal BP, 67.4% and 52%, prehypertension 11.3% and 13.2%, hypertension 21.3% and 34.8%, re- spectively. In female subjects with normal body weight, the distribution of BP
Canadian Journal of Gastroenterology, 2003
GOALS: To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and aft... more GOALS: To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and after pancreatic enzyme replacement therapy in a prospective, multicentre, follow-up study.STUDY: Two groups of patients were evaluated. Group 1 consisted of 31 patients with newly diagnosed chronic pancreatitis who had never been treated with pancreatic enzyme preparations. Group 2 consisted of 39 patients whose disease was diagnosed on average 3.4 years before the start of the study. The latter group of patients had undergone pancreatic enzyme replacement therapy, but during follow-up this treatment proved to be insufficient. The dose of pancreatic enzyme replacement therapy was tailored in accordance with the degree of pancreatic exocrine insufficiency measured by means of exocrine pancreatic function tests. A modified European Organizaton for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) was used to assess QoL.RESULTS: The social functioning and ...
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, Jan 25, 2016
A higher rate of embolization is considered a disadvantage of carotid stenting (CAS), when compar... more A higher rate of embolization is considered a disadvantage of carotid stenting (CAS), when compared with carotid endarterectomy. Plaques in the aortic arch (AA) and the common carotid artery (CCA) may be additional sources of embolization to stented internal carotid plaques during CAS. In this study, we aimed to investigate the relationship between these plaques and intracerebral embolization. We analyzed the occurrence and composition of plaques in the AA and CCA by computed tomography angiography (CTA) in 101 consecutive cases of CAS. Cases of peri-procedural embolization were detected on diffusion-weighted imaging as lesions demonstrating diffusion restriction. We applied the χ(2) and Fisher's exact tests, as well as logistic regression models. The occurrence of plaques in the AA and CCA was significantly related to the appearance of new diffusion-weighted imaging lesions (p = 0.013 and p = 0.004, respectively). Patients with soft plaques in the AA or CCA had a significantly ...
The Open Respiratory Medicine Journal, 2016
Background: The non-invasive assessment of pulmonary haemodynamics during exercise provides compl... more Background: The non-invasive assessment of pulmonary haemodynamics during exercise provides complementary data for the evaluation of exercise tolerance in patients with COPD. Methods: Exercise echocardiography in the semi-supine position was performed in 27 patients with COPD (C) with a forced expiratory volume in one second (FEV1) of 36±12% predicted and 13 age and gender-matched non-COPD subjects (NC). COPD patients also underwent cardiopulmonary exercise testing with gas exchange detection (CPET). Furthermore, serum high sensitive C-reactive protein (hsCRP), a marker of systemic inflammation, was also measured. Results: The maximal work rate (WRmax) and aerobic capacity (VO2peak) were significantly reduced (WRmax: 77±33 Watt, VO2peak: 50±14 %pred) in COPD. Pulmonary arterial systolic pressure (PAPs) was higher in COPD versus controls both at rest (39±5 vs. 31±2 mmHg, p<0.001), and at peak exercise (72±12 vs. 52±8 mmHg, p<0.001). In 19 (70%) COPD patients, the increase in PA...
Lymphology, 2007
The removal of wisdom teeth is often associated with severe postoperative edema and pain, and ope... more The removal of wisdom teeth is often associated with severe postoperative edema and pain, and operation on the third molar can cause local inflammation that impairs lymph transport. The objective of the study was to assess the efficacy of manual lymph drainage (MLD) in reducing swelling following bilateral wisdom tooth removal. Ten consecutive patients with bilateral impacted wisdom teeth that required surgical removal were enrolled in the study. Each patient was postoperatively treated with MLD (after Vodder's method) on one side of the neck region with the untreated contralateral side as a control. Swelling was evaluated using a tape-measure placed in contact with the skin. The six landmarks of measurement included tragus-lip junction, tragus-pogonion, mandibular angle-external corner of eye, mandibular angle-ala nasi, mandibular angle-lip junction, and mandibular angle-median point of chin. Subjective assessment of MLD was conducted with self-evaluation using a visual analogu...
Orvosi hetilap, Jan 31, 1986
Ideggyógyászati szemle, Jan 30, 2013
Mild cognitive impairment (MCI) is a heterogenous syndrome considered as a prodromal state of dem... more Mild cognitive impairment (MCI) is a heterogenous syndrome considered as a prodromal state of dementia with clinical importance in the early detection of Alzheimer's Disease. We are currently developing an MCI screening instrument, the Early Mental Test (EMT) suitable to the needs of primary care physicians. The present study describes the validation process of the 6.2 version of the test. Only subjects (n = 132, female 95, male 37) over the age of 55 (mean age 69.2 years (SD = 6.59)) scoring at least 20 points on Mini-Mental State Examination (MMSE), mean education 11.17 years (SD = 3.86) were included in the study. The psychometric evaluation consisted of Alzheimer's Disease Assessment Scale Cognitive subscale (ADAS-Cog) and the 6.2 version of EMT. The statistical analyses were carried out using the 17.00 version of SPSS statistical package. The optimalised cut-off point was found to be 3.45 points with corresponding 69% sensitivity, 69% specificity and 69% accuracy measur...
Orvosi hetilap, 2002
Echocardiographic parameters for predicting cardioversion (CV) outcome and long-term sinus rhythm... more Echocardiographic parameters for predicting cardioversion (CV) outcome and long-term sinus rhythm (SR) maintenance in patients with nonvalvular atrial fibrillation (AF) are not accurately defined. The authors aim was to evaluate the role of left atrial appendage (LAA) flow velocity detected by transesophageal echocardiography before CV for prediction of short and long-term (1 year) outcome of CV in patients with nonvalvular AF. One hundred and nine patients (66 males, mean age: 57 +/- 13 years) with nonvalvular AF lasting more than 48 hours but less than 1-year duration underwent transthoracic and transesophageal echocardiography before either electrical or pharmacological CV attempt. Cardioversion was successful in restoring SR rhythm in 83 (76%) and unsuccessful in patients 26 (24%). Mean LAA peak emptying flow was higher in patients with successful than in those with unsuccessful CV (36.7 +/- 14.7 vs 26.3 +/- 9.2 cm/sec; p < 0.01). At multivariate analysis the left LAA emptyin...
Respiratory Medicine, 2007
Background: Endurance training is an effective component of pulmonary rehabilitation in COPD. Con... more Background: Endurance training is an effective component of pulmonary rehabilitation in COPD. Controversy exists regarding whether different modalities of supervised exercise training (continuous (C) or interval (I)) or self-paced (S) programs are equally beneficial. Methods: Seventy-one patients with COPD (average FEV 1 ¼ 55% predicted) were assigned to 8 weeks of C, I or S training, 45 min/session, 3 times/week. Group C (n ¼ 22) exercised at 80% of pre-training peak work rate in an incremental cycle ergometer test. In group I (n ¼ 17), training consisted of 30 min of cycling 2 min at 90% followed by 1 min at 50% peak work rate bracketed by 7.5 min at 50% peak work rate. The S group (n ¼ 32) was instructed to cycle, climb stairs and walk in their home with the same periodicity and time intervals. Results: Improvement in incremental test peak work rate was significant in both C and I groups, but not in S. Peak oxygen uptake and lactic acidosis threshold improved significantly in the supervised groups, but differences among groups did not achieve significance. Scores in an activity questionnaire improved in all groups without significant differences among groups. Conclusions: In COPD patients, continuous and interval training have similar physiologic effects; by some measures of endurance exercise performance, they are superior to selfpaced training. However, all were effective in improving patient-perceived activity.
Radiotherapy and Oncology, 2011
It has been used a homemade application that, using as data the DICOM-RTDose calculated before an... more It has been used a homemade application that, using as data the DICOM-RTDose calculated before and after the update, calculates histograms with the quantities shown in the figure. D1,i and D2,i are the doses at point i for the 4.60 and 4.40 algorithms, and D0 is the prescription dose. Moreover, if nj is the number of points with dose D1in the 4.40 treatment planning and DD k with k=1..nj are the values of the differences between the two algorithms, it has been calculated the mean value
PLoS ONE, 2013
Background: Psychosocial stress and activation of neutrophil granulocytes are increasingly recogn... more Background: Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamicpituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol-and ACTH-associated changes in granulocyte activation in patients undergoing PCI. Methodology/Principal Findings: Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre-and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p#0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p,0.01, ACS: p#0.0001). In ACS, elevated pre-PCI cortisol decreased considerably a day after stenting (p,0.01); in pre-PCI samples, cortisol correlated with plasma lactoferrin (r,0.5, p,0.05). In 1d-PCI samples of both groups, ACTH showed negative associations with the ratio of lactoferrin-bearing neutrophils
International Journal of Geriatric Psychiatry, 2011
European Neuropsychopharmacology, 2007
European Neuropsychopharmacology, 2007
Cancer Research, 2009
#4125 Some data suggest that adjuvant systemic therapies like tamoxifen and paclitaxel play a rol... more #4125 Some data suggest that adjuvant systemic therapies like tamoxifen and paclitaxel play a role in the development of radiogenic lung toxicity. Early and late radiogenic lung sequelae were prospectively studied in patients receiving sequential taxane-based chemotherapy (Tax), concomittant hormone therapy with tamoxifen (Tam) or aromatase inhibitor (AI), or no systemic therapy (C) according to the institutional guidelines. Clinical signs, radiologic abnormalities and the mean lung density changes measured at the level of the left heart ventricle (MDCLHV) and the head of the clavicle (MDCHC) of the irradiated lung on CT were evaluated according to Kahan et al., Int. J. Radiat. Oncol. Biol. Phys., 2007. The incidence of pneumonitis grade I with or without clinical symptoms did not significantly differ between the 4 groups. None of the patients developed symptomatic radiogenic lung fibrosis one year after the radiotherapy, however, radiogenic CT changes were significantly more freq...
Canadian Journal of Cardiology, 2012
Archives of Neurology, 2000
Context: The participation of an immune/inflammatory process in the pathomechanism of sporadic Al... more Context: The participation of an immune/inflammatory process in the pathomechanism of sporadic Alzheimer disease (AD) has been suggested by evidence for activated microglia and the potential therapeutic benefit of antiinflammatory medication. Objective: To define a possible role for IgG in the immune/inflammatory process of AD in humans, we assayed the ability of IgG samples from patients with AD to target the injury to cholinergic neurons in rat basal forebrain in vivo. Design: IgG purified from the serum or plasma from patients with AD and patients with other neurological disease who were used as control (DC) patients was injected stereotaxically into the medial septum of adult rats. Four weeks later coronal sections of the whole medial septum-diagonal bands of Broca region were immunostained for choline acetyltransferase (ChAT) to identify cholinergic neuronal cells. Setting: University medical centers. Patients: Blood samples were collected from 8 patients with probable and definite AD and from 6 agematched DC patients. Main Outcome Measure: Detection of changes in the number of ChAT immunopositive cell profiles in sections and statistical evaluation. Results: Four weeks after the injections, IgG samples from patients with AD significantly reduced the number of ChAT-immunostained cell profiles in the whole medial septum-diagonal bands of Broca region compared with IgGs from DC patients. Neither DC IgGs nor saline solution significantly decreased the number of ChAT-immunopositive neuronal cell profiles. Conclusion: Data document that IgG from patients with AD can target a stereotaxically induced immune/ inflammatory injury to cholinergic neurons in the rat basal forebrain in vivo.
AJP: Heart and Circulatory Physiology, 2011
Insulin resistance (IR) impairs cerebrovascular responses to several stimuli in Zucker obese (ZO)... more Insulin resistance (IR) impairs cerebrovascular responses to several stimuli in Zucker obese (ZO) rats. However, cerebral artery responses after subarachnoid hemorrhage (SAH) have not been described in IR. We hypothesized that IR worsens vascular reactions after a mild SAH. Hemolyzed blood (300 μl) or saline was infused (10 μl/min) into the cisterna magna of 11–13-wk-old ZO ( n = 25) and Zucker lean (ZL) rats ( n = 25). One day later, dilator responses of the basilar artery (BA) and its side branch (BA-Br) to acetylcholine (ACh, 10−6 M), cromakalim (10−7 M, 10−6 M), and sodium nitroprusside (10−7 M) were recorded with intravital videomicroscopy. The baseline diameter of the BA was increased both in the ZO and ZL rats 24 h after the hemolysate injection. Saline-injected ZO animals showed reduced dilation to ACh (BA = 9 ± 3 vs. 22 ± 4%; and BA-Br = 23 ± 5 vs. 37 ± 7%) compared with ZL rats. Hemolysate injection blunted the response to ACh in both the ZO (BA = 4 ± 2%; and BA-Br = 12 ± ...
Acta Oncologica, 2007
Introduction. A retrospective analysis of the relation between the presence of casting-type calci... more Introduction. A retrospective analysis of the relation between the presence of casting-type calcifications on the mammogram and the prognosis of breast cancer was performed. Materials and methods. The mammographic tumor features and other characteristics (invasive tumor size, histological tumor type, grade, nodal, hormone receptor and HER2 status, presence of lymphovascular invasion) of 55 high-risk breast cancers were studied. Results. After a median follow-up time of 29.1 months, the median relapse-free survival and overall survival times among breast cancer patients with tumors associated with casting calcifications were 26.6 and 29.6 months, respectively. The corresponding parameters among patients with tumors not accompanied by casting calcifications were 54.4 and 58.5 months, respectively. Significant associations were found between the presence of casting calcifications and the risks of relapse (HR03.048, 95% CI: 1.116Á8.323, p00.030) or death (HR03.504, 95% CI: 1.074Á11.427, p00.038). Positive associations were found between casting calcifications and ER/PR negativity (p00.015 and p 00.003, respectively) and HER2 overexpression (p00.019). Discussion. Our findings support the theory that breast tumors associated with casting-type calcifications at mammography comprise a disease entity which exhibits significantly more aggressive behavior and a poorer outcome than do cancers with other mammographic tumor features.
Results: 7KHSUHYDOHQFHRISUHK\SHUWHQVLRQDQGK\SHUWHQVLRQDWWKH� oUVW� screening were 7.9% (male;8.5%... more Results: 7KHSUHYDOHQFHRISUHK\SHUWHQVLRQDQGK\SHUWHQVLRQDWWKH� oUVW� screening were 7.9% (male;8.5%, female;7.2%) and 10.6% (male;12.9%, fe- male;8.2%), respectively. There was a difference of the prevalence of hyperten- sion between male and female adolescents with the difference of the prevalence of obesity. The prevalence of overweight and obese subjects were 12.9% (male; 13.7%, female;12.1%) and 8.3%(male;8.8%, female;7.8%), respectively. Over- ZHLJKWDQGREHVHVXEMHFWVKDGDVLJQLoFDQWO\�KLJKHUSUHYDOHQFHRIKLJK�%3�WKDQ� normal body weight children and adolescents in both male and female in each age group. In male with normal body weight, the distribution of BP were 83.5% of normal BP, 7.5% of prehypertension and 9% of hypertension, respectively. However in male subjects with overweight and obesity, normal BP, 67.4% and 52%, prehypertension 11.3% and 13.2%, hypertension 21.3% and 34.8%, re- spectively. In female subjects with normal body weight, the distribution of BP
Canadian Journal of Gastroenterology, 2003
GOALS: To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and aft... more GOALS: To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and after pancreatic enzyme replacement therapy in a prospective, multicentre, follow-up study.STUDY: Two groups of patients were evaluated. Group 1 consisted of 31 patients with newly diagnosed chronic pancreatitis who had never been treated with pancreatic enzyme preparations. Group 2 consisted of 39 patients whose disease was diagnosed on average 3.4 years before the start of the study. The latter group of patients had undergone pancreatic enzyme replacement therapy, but during follow-up this treatment proved to be insufficient. The dose of pancreatic enzyme replacement therapy was tailored in accordance with the degree of pancreatic exocrine insufficiency measured by means of exocrine pancreatic function tests. A modified European Organizaton for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) was used to assess QoL.RESULTS: The social functioning and ...
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, Jan 25, 2016
A higher rate of embolization is considered a disadvantage of carotid stenting (CAS), when compar... more A higher rate of embolization is considered a disadvantage of carotid stenting (CAS), when compared with carotid endarterectomy. Plaques in the aortic arch (AA) and the common carotid artery (CCA) may be additional sources of embolization to stented internal carotid plaques during CAS. In this study, we aimed to investigate the relationship between these plaques and intracerebral embolization. We analyzed the occurrence and composition of plaques in the AA and CCA by computed tomography angiography (CTA) in 101 consecutive cases of CAS. Cases of peri-procedural embolization were detected on diffusion-weighted imaging as lesions demonstrating diffusion restriction. We applied the χ(2) and Fisher's exact tests, as well as logistic regression models. The occurrence of plaques in the AA and CCA was significantly related to the appearance of new diffusion-weighted imaging lesions (p = 0.013 and p = 0.004, respectively). Patients with soft plaques in the AA or CCA had a significantly ...
The Open Respiratory Medicine Journal, 2016
Background: The non-invasive assessment of pulmonary haemodynamics during exercise provides compl... more Background: The non-invasive assessment of pulmonary haemodynamics during exercise provides complementary data for the evaluation of exercise tolerance in patients with COPD. Methods: Exercise echocardiography in the semi-supine position was performed in 27 patients with COPD (C) with a forced expiratory volume in one second (FEV1) of 36±12% predicted and 13 age and gender-matched non-COPD subjects (NC). COPD patients also underwent cardiopulmonary exercise testing with gas exchange detection (CPET). Furthermore, serum high sensitive C-reactive protein (hsCRP), a marker of systemic inflammation, was also measured. Results: The maximal work rate (WRmax) and aerobic capacity (VO2peak) were significantly reduced (WRmax: 77±33 Watt, VO2peak: 50±14 %pred) in COPD. Pulmonary arterial systolic pressure (PAPs) was higher in COPD versus controls both at rest (39±5 vs. 31±2 mmHg, p<0.001), and at peak exercise (72±12 vs. 52±8 mmHg, p<0.001). In 19 (70%) COPD patients, the increase in PA...
Lymphology, 2007
The removal of wisdom teeth is often associated with severe postoperative edema and pain, and ope... more The removal of wisdom teeth is often associated with severe postoperative edema and pain, and operation on the third molar can cause local inflammation that impairs lymph transport. The objective of the study was to assess the efficacy of manual lymph drainage (MLD) in reducing swelling following bilateral wisdom tooth removal. Ten consecutive patients with bilateral impacted wisdom teeth that required surgical removal were enrolled in the study. Each patient was postoperatively treated with MLD (after Vodder's method) on one side of the neck region with the untreated contralateral side as a control. Swelling was evaluated using a tape-measure placed in contact with the skin. The six landmarks of measurement included tragus-lip junction, tragus-pogonion, mandibular angle-external corner of eye, mandibular angle-ala nasi, mandibular angle-lip junction, and mandibular angle-median point of chin. Subjective assessment of MLD was conducted with self-evaluation using a visual analogu...
Orvosi hetilap, Jan 31, 1986
Ideggyógyászati szemle, Jan 30, 2013
Mild cognitive impairment (MCI) is a heterogenous syndrome considered as a prodromal state of dem... more Mild cognitive impairment (MCI) is a heterogenous syndrome considered as a prodromal state of dementia with clinical importance in the early detection of Alzheimer's Disease. We are currently developing an MCI screening instrument, the Early Mental Test (EMT) suitable to the needs of primary care physicians. The present study describes the validation process of the 6.2 version of the test. Only subjects (n = 132, female 95, male 37) over the age of 55 (mean age 69.2 years (SD = 6.59)) scoring at least 20 points on Mini-Mental State Examination (MMSE), mean education 11.17 years (SD = 3.86) were included in the study. The psychometric evaluation consisted of Alzheimer's Disease Assessment Scale Cognitive subscale (ADAS-Cog) and the 6.2 version of EMT. The statistical analyses were carried out using the 17.00 version of SPSS statistical package. The optimalised cut-off point was found to be 3.45 points with corresponding 69% sensitivity, 69% specificity and 69% accuracy measur...
Orvosi hetilap, 2002
Echocardiographic parameters for predicting cardioversion (CV) outcome and long-term sinus rhythm... more Echocardiographic parameters for predicting cardioversion (CV) outcome and long-term sinus rhythm (SR) maintenance in patients with nonvalvular atrial fibrillation (AF) are not accurately defined. The authors aim was to evaluate the role of left atrial appendage (LAA) flow velocity detected by transesophageal echocardiography before CV for prediction of short and long-term (1 year) outcome of CV in patients with nonvalvular AF. One hundred and nine patients (66 males, mean age: 57 +/- 13 years) with nonvalvular AF lasting more than 48 hours but less than 1-year duration underwent transthoracic and transesophageal echocardiography before either electrical or pharmacological CV attempt. Cardioversion was successful in restoring SR rhythm in 83 (76%) and unsuccessful in patients 26 (24%). Mean LAA peak emptying flow was higher in patients with successful than in those with unsuccessful CV (36.7 +/- 14.7 vs 26.3 +/- 9.2 cm/sec; p < 0.01). At multivariate analysis the left LAA emptyin...
Respiratory Medicine, 2007
Background: Endurance training is an effective component of pulmonary rehabilitation in COPD. Con... more Background: Endurance training is an effective component of pulmonary rehabilitation in COPD. Controversy exists regarding whether different modalities of supervised exercise training (continuous (C) or interval (I)) or self-paced (S) programs are equally beneficial. Methods: Seventy-one patients with COPD (average FEV 1 ¼ 55% predicted) were assigned to 8 weeks of C, I or S training, 45 min/session, 3 times/week. Group C (n ¼ 22) exercised at 80% of pre-training peak work rate in an incremental cycle ergometer test. In group I (n ¼ 17), training consisted of 30 min of cycling 2 min at 90% followed by 1 min at 50% peak work rate bracketed by 7.5 min at 50% peak work rate. The S group (n ¼ 32) was instructed to cycle, climb stairs and walk in their home with the same periodicity and time intervals. Results: Improvement in incremental test peak work rate was significant in both C and I groups, but not in S. Peak oxygen uptake and lactic acidosis threshold improved significantly in the supervised groups, but differences among groups did not achieve significance. Scores in an activity questionnaire improved in all groups without significant differences among groups. Conclusions: In COPD patients, continuous and interval training have similar physiologic effects; by some measures of endurance exercise performance, they are superior to selfpaced training. However, all were effective in improving patient-perceived activity.
Radiotherapy and Oncology, 2011
It has been used a homemade application that, using as data the DICOM-RTDose calculated before an... more It has been used a homemade application that, using as data the DICOM-RTDose calculated before and after the update, calculates histograms with the quantities shown in the figure. D1,i and D2,i are the doses at point i for the 4.60 and 4.40 algorithms, and D0 is the prescription dose. Moreover, if nj is the number of points with dose D1in the 4.40 treatment planning and DD k with k=1..nj are the values of the differences between the two algorithms, it has been calculated the mean value
PLoS ONE, 2013
Background: Psychosocial stress and activation of neutrophil granulocytes are increasingly recogn... more Background: Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamicpituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol-and ACTH-associated changes in granulocyte activation in patients undergoing PCI. Methodology/Principal Findings: Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre-and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p#0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p,0.01, ACS: p#0.0001). In ACS, elevated pre-PCI cortisol decreased considerably a day after stenting (p,0.01); in pre-PCI samples, cortisol correlated with plasma lactoferrin (r,0.5, p,0.05). In 1d-PCI samples of both groups, ACTH showed negative associations with the ratio of lactoferrin-bearing neutrophils
International Journal of Geriatric Psychiatry, 2011
European Neuropsychopharmacology, 2007
European Neuropsychopharmacology, 2007
Cancer Research, 2009
#4125 Some data suggest that adjuvant systemic therapies like tamoxifen and paclitaxel play a rol... more #4125 Some data suggest that adjuvant systemic therapies like tamoxifen and paclitaxel play a role in the development of radiogenic lung toxicity. Early and late radiogenic lung sequelae were prospectively studied in patients receiving sequential taxane-based chemotherapy (Tax), concomittant hormone therapy with tamoxifen (Tam) or aromatase inhibitor (AI), or no systemic therapy (C) according to the institutional guidelines. Clinical signs, radiologic abnormalities and the mean lung density changes measured at the level of the left heart ventricle (MDCLHV) and the head of the clavicle (MDCHC) of the irradiated lung on CT were evaluated according to Kahan et al., Int. J. Radiat. Oncol. Biol. Phys., 2007. The incidence of pneumonitis grade I with or without clinical symptoms did not significantly differ between the 4 groups. None of the patients developed symptomatic radiogenic lung fibrosis one year after the radiotherapy, however, radiogenic CT changes were significantly more freq...
Canadian Journal of Cardiology, 2012
Archives of Neurology, 2000
Context: The participation of an immune/inflammatory process in the pathomechanism of sporadic Al... more Context: The participation of an immune/inflammatory process in the pathomechanism of sporadic Alzheimer disease (AD) has been suggested by evidence for activated microglia and the potential therapeutic benefit of antiinflammatory medication. Objective: To define a possible role for IgG in the immune/inflammatory process of AD in humans, we assayed the ability of IgG samples from patients with AD to target the injury to cholinergic neurons in rat basal forebrain in vivo. Design: IgG purified from the serum or plasma from patients with AD and patients with other neurological disease who were used as control (DC) patients was injected stereotaxically into the medial septum of adult rats. Four weeks later coronal sections of the whole medial septum-diagonal bands of Broca region were immunostained for choline acetyltransferase (ChAT) to identify cholinergic neuronal cells. Setting: University medical centers. Patients: Blood samples were collected from 8 patients with probable and definite AD and from 6 agematched DC patients. Main Outcome Measure: Detection of changes in the number of ChAT immunopositive cell profiles in sections and statistical evaluation. Results: Four weeks after the injections, IgG samples from patients with AD significantly reduced the number of ChAT-immunostained cell profiles in the whole medial septum-diagonal bands of Broca region compared with IgGs from DC patients. Neither DC IgGs nor saline solution significantly decreased the number of ChAT-immunopositive neuronal cell profiles. Conclusion: Data document that IgG from patients with AD can target a stereotaxically induced immune/ inflammatory injury to cholinergic neurons in the rat basal forebrain in vivo.
AJP: Heart and Circulatory Physiology, 2011
Insulin resistance (IR) impairs cerebrovascular responses to several stimuli in Zucker obese (ZO)... more Insulin resistance (IR) impairs cerebrovascular responses to several stimuli in Zucker obese (ZO) rats. However, cerebral artery responses after subarachnoid hemorrhage (SAH) have not been described in IR. We hypothesized that IR worsens vascular reactions after a mild SAH. Hemolyzed blood (300 μl) or saline was infused (10 μl/min) into the cisterna magna of 11–13-wk-old ZO ( n = 25) and Zucker lean (ZL) rats ( n = 25). One day later, dilator responses of the basilar artery (BA) and its side branch (BA-Br) to acetylcholine (ACh, 10−6 M), cromakalim (10−7 M, 10−6 M), and sodium nitroprusside (10−7 M) were recorded with intravital videomicroscopy. The baseline diameter of the BA was increased both in the ZO and ZL rats 24 h after the hemolysate injection. Saline-injected ZO animals showed reduced dilation to ACh (BA = 9 ± 3 vs. 22 ± 4%; and BA-Br = 23 ± 5 vs. 37 ± 7%) compared with ZL rats. Hemolysate injection blunted the response to ACh in both the ZO (BA = 4 ± 2%; and BA-Br = 12 ± ...
Acta Oncologica, 2007
Introduction. A retrospective analysis of the relation between the presence of casting-type calci... more Introduction. A retrospective analysis of the relation between the presence of casting-type calcifications on the mammogram and the prognosis of breast cancer was performed. Materials and methods. The mammographic tumor features and other characteristics (invasive tumor size, histological tumor type, grade, nodal, hormone receptor and HER2 status, presence of lymphovascular invasion) of 55 high-risk breast cancers were studied. Results. After a median follow-up time of 29.1 months, the median relapse-free survival and overall survival times among breast cancer patients with tumors associated with casting calcifications were 26.6 and 29.6 months, respectively. The corresponding parameters among patients with tumors not accompanied by casting calcifications were 54.4 and 58.5 months, respectively. Significant associations were found between the presence of casting calcifications and the risks of relapse (HR03.048, 95% CI: 1.116Á8.323, p00.030) or death (HR03.504, 95% CI: 1.074Á11.427, p00.038). Positive associations were found between casting calcifications and ER/PR negativity (p00.015 and p 00.003, respectively) and HER2 overexpression (p00.019). Discussion. Our findings support the theory that breast tumors associated with casting-type calcifications at mammography comprise a disease entity which exhibits significantly more aggressive behavior and a poorer outcome than do cancers with other mammographic tumor features.