Tatsuya Yamasoba | The University of Tokyo (original) (raw)

Papers by Tatsuya Yamasoba

ORL; journal for oto-rhino-laryngology and its related specialties, Jan 9, 2015

Otosclerosis is an abnormal bone growth in the otic capsule that can result in hearing loss. In t... more Otosclerosis is an abnormal bone growth in the otic capsule that can result in hearing loss. In this study, we compared postoperative hearing outcomes and vestibular symptoms between patients treated with laser-assisted stapedotomy versus stapedectomy. The medical charts of 99 ears treated with stapes surgery were retrospectively reviewed. A stapedotomy, partial stapedectomy, or total stapedectomy was conducted in 77, 16, and 56 ears, respectively. The ears treated with partial- and total stapedectomies were unified into one stapedectomy group. The postoperative changes in the air-bone gap after stapedotomies were significantly larger than those after stapedectomies at 1, 2, and 4 kHz. The postoperative changes in the air conduction threshold after stapedotomies were significantly larger than those after stapedectomies at 1, 2, 4, and 8 kHz. The postoperative changes in the bone conduction threshold at 0.5, 1, 2, and 4 kHz did not differ between the groups. The postoperative vertigo...

Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo), Mar 20, 2023

Journal of clinical & experimental pathology, 2015

ORL, 1992

Two cases of vestibular disturbance caused by residual oily contrast medium in the internal audit... more Two cases of vestibular disturbance caused by residual oily contrast medium in the internal auditory canals after myelography are reported. Nystagmus towards the affected side and normal caloric responses were observed; therefore, contrast media are considered to act as irritants to the vestibular nerve.

Journal of Clinical Medicine, Jun 26, 2023

Background: Few studies have reported on the etiology, severity, or device usage of unilateral se... more Background: Few studies have reported on the etiology, severity, or device usage of unilateral sensorineural hearing loss (UHL) compared to bilateral hearing loss. Therefore, this study investigated the characteristics of UHL in adults and children. Methods: We performed a survey using questionnaires for secondary and tertiary otolaryngology institutions. Results: We included 15,981 patients (1549 children and 14,432 adults) from 196 institutions with otolaryngology residency programs and 2844 patients (336 children and 2508 adults) from 27 institutions with board members of the Japan Audiology Society. The latter submitted audiological data. Among children, most diagnoses were made at age 0. Approximately half of them had profound hearing loss, and 37 children (2.2%) used hearing devices. Among adults, the number of cases increased with age, but decreased when people reached their 80s and 90s. More than half of them had moderate hearing loss. Sudden sensorineural hearing loss was the most common cause of UHL of all ages; 4.4% of UHL patients used hearing devices, and most of the device users (98.6%) selected a conventional hearing aid. Conclusions: Hearing aid use is limited in children and adults with UHL in Japan. There could be many candidates with UHL for intervention such as a cochlear implant.

Auris Nasus Larynx, Apr 1, 2023

Hereditary gelsolin amyloidosis (HGA) is an autosomal dominant systemic amyloidosis, characterize... more Hereditary gelsolin amyloidosis (HGA) is an autosomal dominant systemic amyloidosis, characterized by cranial and sensory peripheral neuropathy, corneal lattice dystrophy, and cutis laxa. We report a case of HGA presenting with bilateral facial palsy. A 70-year-old Japanese man presented with slowly progressive bilateral facial palsy and facial twitching, which had started in his 40s. His mother also had the same symptoms due to an unknown cause but rest of the family did not. He showed incomplete facial palsy with no frontal muscle movement and partial movement of the orbicularis oris and orbicularis oculi muscles. The patient showed no synkinesis. Electroneurography revealed symmetric low compound motor action potential amplitude of the orbicularis oris muscle, and a nerve excitability test showed a symmetric increase in the response threshold. Despite the partial voluntary movement of the orbicularis oculi muscle, bilateral blink reflexes were absent. He also showed facial spasms after contraction of the orbicularis oris muscle. Genetic testing revealed a heterozygous c.640G>A mutation (p. Asp214Asn); therefore, the patient was diagnosed with HGA. HGA related facial palsy showed moderate bilateral, upper blanch-dominant axonal degeneration of the facial nerve without reinnervation, and trigeminal nerve neuropathy.

Research Square (Research Square), Jan 27, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-lasting an... more Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-lasting anosmia, but the impact of SARS-CoV-2 infection, which can spread to the nasal cavity via the oral route, on the olfactory receptor neuron (ORN) lineage and olfactory bulb (OB) remains undetermined. Using Syrian hamsters, we explored whether oral SARS-CoV-2 inoculation can lead to nasal viral infection, examined how SARS-CoV-2 affects the ORN lineage by site, and investigated whether SARS-CoV-2 infection can spread to the OB and induce in ammation. On post-inoculation day 7, SARS-CoV-2 presence was con rmed in the lateral area (OCAM-positive) but not the nasal septum of NQO1-positive and OCAM-positive areas. The virus was observed partially in ltrating the olfactory epithelium, and ORN progenitor cells, immature ORNs, and mature ORNs were fewer than in controls. The virus was found in the olfactory nerve bundles to the OB, suggesting the nasal cavity as a route for SARS-CoV-2 brain infection. We demonstrated that transoral SARS-CoV-2 infection can spread from the nasal cavity to the central nervous system and the possibility of central olfactory dysfunction due to SARS-CoV-2 infection. The virus was localized at the infection site and could damage all ORN-lineage cells.

Otolaryngology online journal, 2016

Objective: We previously suggested that aberrations of the carotid arteries, which may occur when... more Objective: We previously suggested that aberrations of the carotid arteries, which may occur when the neck is bent forward, should be considered as new risk factors for ischemic stroke. We analyzed the results of carotid artery ultrasound examination in previous case and control groups, focusing in particular on the atherosclerotic risk factor in stroke, to determine the significance of arterial aberration and its relation to ischemic stroke. Data Sources and Review Methods: We analyzed the original data from our previous 235 casecontrol study patients among those who underwent complete routine cervical ultrasound and had all cholesterol data available. Results: Although plaque was present in the CCA in about one-half of the control group, none had experienced a stroke. At the same time, two-thirds of the case (stroke) patients had plaque in the CCA. This indicates that plaque tends to be a risk for stroke, although the difference between the two groups was not statistically significant. Conclusion: The results of the present analysis indicate that: 1) the degree of atherosclerosis was the same in both the case and control groups, because there were no statistically significant differences between them in cholesterol values; 2) the only difference between the two groups was the aberration of the carotid artery; and 3) aberration of the carotid artery tends to be a risk factor for stroke. The mechanism of cerebral infarction is speculated to be artery-to-artery embolism from the carotid plaque. The aberration of the carotid artery occurs, which triggered by plaque reaching the cerebellum.

Rhinology, Sep 1, 2014

Aim: To describe the features of chronic sinusitis associated with the use of tumour necrosis fac... more Aim: To describe the features of chronic sinusitis associated with the use of tumour necrosis factor (TNF) inhibitors. Methodology: A retrospective review of the medical records between 2003 and 2011 revealed that five patients had developed chronic sinusitis after the start of TNF inhibitor administration and required rhinological evaluation and treatment. Results: The incidence of refractory sinusitis associated with TNF inhibitors was approximately 2%. Of the five patients identified, four patients were medicated with etanercept and one with infliximab. The maxillary sinus was most commonly involved and cultures of the sinus discharge revealed Pseudomonas aeruginosa in three cases. Two patients showed improvement of sinusitis with antibiotic medication, despite the continuous use of TNF inhibitor, while in two other patients, sinusitis was resistant to antibiotic medication. Another patient who had developed recurrence of sinusitis after complete remission of previous chronic sinusitis by endoscopic sinus surgery showed remission only after cessation of TNF inhibitor. Conclusion: Chronic sinusitis associated with TNF inhibitors is considered to be a new disease entity, and it will become more common due to the increasing use of TNF inhibitors.

Objective: Patients with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory ... more Objective: Patients with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit not only respiratory symptoms but also symptoms of chemo-sensitive disorders and kidney failure. Cellular entry of SARS-CoV-2 depends on the binding of its spike protein to a cellular receptor named angiotensinconverting enzyme 2 (ACE2), and the subsequent spike protein-priming by host cell proteases, including transmembrane protease serine 2 (TMPRSS2). Thus, high expression of ACE2 and TMPRSS2 are considered to enhance the invading capacity of SARS-CoV-2. Methods: To elucidate the underlying histological mechanisms of the aerodigestive disorders caused by SARS-CoV-2, we investigated the expression of ACE2 and TMPRSS2 proteins in the aerodigestive tracts of the tongue, hard palate with partial nasal tissue, larynx with hypopharynx, trachea, esophagus, lung, and kidney of rats through immunohistochemistry. Results: Strong co-expression of ACE2 and TMPRSS2 proteins was observed in the nasal respiratory epithelium, trachea, bronchioles, alveoli, kidney, and taste buds of the tongue. Remarkably, TMPRSS2 expression was much stronger in the peripheral alveoli than in the central alveoli. These results coincide with the reported clinical symptoms of COVID-19, such as the loss of taste, loss of olfaction, respiratory dysfunction, and acute nephropathy.

Antioxidants, Jul 27, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Annals of Otology, Rhinology, and Laryngology, Nov 1, 1993

Sudden deafness is acute onset of impaired hearing which develops within hours to few days. The c... more Sudden deafness is acute onset of impaired hearing which develops within hours to few days. The commonly accepted audiometric criterion is a decrease in hearing of C30 dB, affecting at least three consecutive frequencies. Hearing loss is thought to involve several causative factors, including internal ear circulatory disturbances. We report the case of a female with an internal carotid artery (ICA) pseudoaneurysm in the distal cervical tract and unilateral sudden sensorineural hearing loss (SSNHL). As putative risk vascular factor, the patient had history of migraine since youth. Extensive screenings for autoimmune, rheumatic diseases, virological, and microbiological infections were negative. The patient denied recent cervical trauma. Furosemide and oral prednisone were given with initial benefit and withdrawn in 3 weeks. The patient experienced short-lasting episodes of headache, tinnitus, vertigo. Five weeks after first onset, she underwent magnetic resonance imaging (MRI) angiogram which revealed fusiform dilatation of left ICA in the cervical tract. It can be proposed, but it remains to be proved, that the pseudoaneurysm of the cervical ICA plays a role in the patient SSNHL in relation to turbulent flow or thromboembolism of branches to the inner ear.

Auris Nasus Larynx, Aug 1, 2023

Antioxidants, Apr 24, 2019

Mitochondrial dysfunction is associated with the etiologies of sensorineural hearing loss, such a... more Mitochondrial dysfunction is associated with the etiologies of sensorineural hearing loss, such as age-related hearing loss, noise-and ototoxic drug-induced hearing loss, as well as hearing loss due to mitochondrial gene mutation. Mitochondria are the main sources of reactive oxygen species (ROS) and ROS-induced oxidative stress is involved in cochlear damage. Moreover, the release of ROS causes further damage to mitochondrial components. Antioxidants are thought to counteract the deleterious effects of ROS and thus, may be effective for the treatment of oxidative stress-related diseases. The administration of mitochondria-targeted antioxidants is one of the drug delivery systems targeted to mitochondria. Mitochondria-targeted antioxidants are expected to help in the prevention and/or treatment of diseases associated with mitochondrial dysfunction. Of the various mitochondria-targeted antioxidants, the protective effects of MitoQ and SkQR1 against ototoxicity have been previously evaluated in animal models and/or mouse auditory cell lines. MitoQ protects against both gentamicin-and cisplatin-induced ototoxicity. SkQR1 also provides auditory protective effects against gentamicin-induced ototoxicity. On the other hand, decreasing effect of MitoQ on gentamicin-induced cell apoptosis in auditory cell lines has been controversial. No clinical studies have been reported for otoprotection using mitochondrial-targeted antioxidants. High-quality clinical trials are required to reveal the therapeutic effect of mitochondria-targeted antioxidants in terms of otoprotection in patients.

Journal of Clinical Medicine, Mar 29, 2023

Journal of the Neurological Sciences, Oct 1, 2019

with SRN were shorter than these without SRN (p = 0.016 and 0.034). In HC-BPPV, the maxSPV of ips... more with SRN were shorter than these without SRN (p = 0.016 and 0.034). In HC-BPPV, the maxSPV of ipsilesional geotropic nystagmus was also greater on the group with SRN than those without SRN (114.3 ± 56.8°/sec vs. 59.3 ± 41.8°/sec, p = 0.003). The estimated cutoff value of maxSPV for spontaneous reversal is 85.5°/sec in PC BPPV and 56.7°/sec in HC BPPV. The SRN did not affect to the treatment outcomes in PC-and HC-BPPV. Conclusion The SRN is common in both PC-and HC-BPPV. The velocity storage system may contribute these short-term adaptive responses with telescopic strategy to the acute abnormal vestibular asymmetry.

Life, Apr 6, 2022

ORL, 1993

A congenital cholesteatoma arising from the petrous pyramid is rarely encountered, and we report ... more A congenital cholesteatoma arising from the petrous pyramid is rarely encountered, and we report a case of such a cholesteatoma in a 23-year-old male. This cholesteatoma was successfully removed by a middle cranial fossa approach. The cholesteatoma showed a unique mode of spread, that is, it originated from the pyramidal apex and extended in two directions: through the facial canal to the tympanic sinus, and along the tympanic tegmen to the mastoid antrum. We discuss the importance of CT and MRI for achieving a diagnosis, as well as the merits of using a middle cranial fossa approach for the surgical excision of this cholesteatoma.

PLOS ONE, Oct 25, 2013

Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesti... more Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans.

Laryngoscope, 1998

The authors investigated the effects of chronic kanamycin (KM) administration on the basement mem... more The authors investigated the effects of chronic kanamycin (KM) administration on the basement membrane (BM) anionic sites in the ampulla by studying the binding of cationic polyethyleneimine (PEI). KM sulfate was administered intramuscularly to guinea pigs with normal Preyer's reflexes daily for 10 or 17 days. The PEI distribution was unchanged on the subepithelial BM in the dark cell region and on the capillary BM in the crista ampullaris. However, PEI binding decreased significantly on the subepithelial BM in the sensory cell and transitional cell regions of those guinea pigs administered KM for 17 days. In the sensory cell region, the PEI distribution did not recover until 6 weeks after KM treatment. Findings suggest that chronic administration of KM severely alters the number of subepithelial BM anionic sites in the sensory cell region.