Pilar Drake | Universidad de Alcala (original) (raw)

Papers by Pilar Drake

Research paper thumbnail of Keratocyte Density after Laser-Assisted Subepithelial Keratectomy with Mitomycin C

American Journal of Ophthalmology, 2010

Research paper thumbnail of Comparison Between Femtosecond Laser-Assisted Sub-Bowman Keratomileusis vs Laser Subepithelial Keratectomy to Correct Myopia

American Journal of Ophthalmology, 2009

PURPOSE: To compare femtosecond laser sub-Bowman keratomileusis (FSBK) vs laser subepithelial ker... more PURPOSE: To compare femtosecond laser sub-Bowman keratomileusis (FSBK) vs laser subepithelial keratectomy (LASEK) to correct myopia. • DESIGN: Retrospective, nonrandomized, interventional, comparative case series. • METHODS: Two thousand one hundred and eight eyes were included in the study. We compared 1,072 eyes treated with FSBK vs 1,036 eyes treated with LASEK with or without mitomycin C (MMC). Visual and refractive results were evaluated 1 day, 1 week, and 1 and 3 months postoperatively. • RESULTS: Preoperative mean sphere and best spectaclecorrected visual acuity (BSCVA) were ؊3.93 diopters (D) vs ؊3.87 D (P ‫؍‬ .5) and 1.12 vs 1.12 (P ‫؍‬ .8) in FSBK and LASEK, respectively. Uncorrected visual acuity (UCVA) was 0.92 vs 0.62, 0.98 vs 0.78, 0.96 vs 0.91, and 1.06 vs 1.03 in FSBK and LASEK, respectively, at 1 day, 1 week, and 1 and 3 months after surgery (P < .01 for all comparisons). Three months postoperatively, BSCVA was 1.13 and 1.10, respectively (P ‫؍‬ .001). At that moment, 20 eyes (1.93%) in the LASEK group vs 9 eyes (0.84%) in the FSBK group had lost 2 or more lines of BSCVA. Ten eyes (0.96%) in the LASEK group gained 2 or more lines of BSCVA, whereas 3 eyes (0.28%) in the FSBK group gained 2 lines. Six months postoperatively, only 2 LASEK eyes (0.19%) showed loss of 2 or more lines of BSCVA, compared to 3 FSBK-treated eyes (0.28%). • CONCLUSION: Both FSBK and LASEK are safe and effective procedures to correct myopia. Slightly better visual and refractive results were observed in FSBKtreated eyes in a 3-month follow-up. (Am J Ophthalmol 2009;148:830 -836.

Research paper thumbnail of Keratocyte Density 3 Months, 15 Months, and 3 Years After Corneal Surface Ablation With Mitomycin C

American Journal of Ophthalmology, 2012

PURPOSE: To study the effects of surface ablation with mitomycin C (MMC) on keratocyte population... more PURPOSE: To study the effects of surface ablation with mitomycin C (MMC) on keratocyte population. • DESIGN: Prospective, nonrandomized, interventional, comparative case series. • METHODS: Thirty two eyes treated with surface ablation with 0.02% MMC were compared with nontreated eyes at Vissum Santa Hortensia, Madrid, Spain. Keratocyte density was measured with the Heidelberg Retina Tomograph II (Rostock Cornea Module) 3, 15, and 36 to 42 months after the surgery in the anterior, mid, and posterior stroma, and compared with control eyes. • RESULTS: Three months postoperatively, we found a lower stromal bed density compared to controls (16 993 ؎ 8001 vs 29 660 ؎ 5904 cells/mm 3 , P ‫؍‬ .0001), while there was a significantly higher cell density in the mid (30 783 ؎ 9300 vs 18 505 ؎ 1996 cells/mm 3 , P ‫؍‬ .0001) and deep stroma (30 268 ؎ 8321 vs 18 438 ؎ 2139 cells/mm 3 , P ‫؍‬ .0001). Three years after the surgery, the cellularity in the stromal bed had not significantly changed from the 3-month follow-up, but the density in the mid (18 889 ؎ 3474 cells/mm 3 ) and posterior stroma (18 992 ؎ 3402 cells/mm 3 ) had decreased to show no difference from controls. The mean cell density between the anterior, mid, and posterior stroma was not significantly different from controls 15 months and 3 years after the surgery. • CONCLUSION: Our study suggests that there is a reorganization of the stromal cell population soon after surface ablation with MMC, with a decrease in the stromal bed compensated initially with an increase in the mid and posterior stroma. Corneal cellularity tends to normalize over time, and 3 years postoperatively the mean cell density throughout the cornea seems to maintain normal values. (Am J Ophthalmol 2012;153: 17-23.

Research paper thumbnail of Keratocyte Density after Laser-Assisted Subepithelial Keratectomy with Mitomycin C

American Journal of Ophthalmology, 2010

Research paper thumbnail of Comparison Between Femtosecond Laser-Assisted Sub-Bowman Keratomileusis vs Laser Subepithelial Keratectomy to Correct Myopia

American Journal of Ophthalmology, 2009

PURPOSE: To compare femtosecond laser sub-Bowman keratomileusis (FSBK) vs laser subepithelial ker... more PURPOSE: To compare femtosecond laser sub-Bowman keratomileusis (FSBK) vs laser subepithelial keratectomy (LASEK) to correct myopia. • DESIGN: Retrospective, nonrandomized, interventional, comparative case series. • METHODS: Two thousand one hundred and eight eyes were included in the study. We compared 1,072 eyes treated with FSBK vs 1,036 eyes treated with LASEK with or without mitomycin C (MMC). Visual and refractive results were evaluated 1 day, 1 week, and 1 and 3 months postoperatively. • RESULTS: Preoperative mean sphere and best spectaclecorrected visual acuity (BSCVA) were ؊3.93 diopters (D) vs ؊3.87 D (P ‫؍‬ .5) and 1.12 vs 1.12 (P ‫؍‬ .8) in FSBK and LASEK, respectively. Uncorrected visual acuity (UCVA) was 0.92 vs 0.62, 0.98 vs 0.78, 0.96 vs 0.91, and 1.06 vs 1.03 in FSBK and LASEK, respectively, at 1 day, 1 week, and 1 and 3 months after surgery (P < .01 for all comparisons). Three months postoperatively, BSCVA was 1.13 and 1.10, respectively (P ‫؍‬ .001). At that moment, 20 eyes (1.93%) in the LASEK group vs 9 eyes (0.84%) in the FSBK group had lost 2 or more lines of BSCVA. Ten eyes (0.96%) in the LASEK group gained 2 or more lines of BSCVA, whereas 3 eyes (0.28%) in the FSBK group gained 2 lines. Six months postoperatively, only 2 LASEK eyes (0.19%) showed loss of 2 or more lines of BSCVA, compared to 3 FSBK-treated eyes (0.28%). • CONCLUSION: Both FSBK and LASEK are safe and effective procedures to correct myopia. Slightly better visual and refractive results were observed in FSBKtreated eyes in a 3-month follow-up. (Am J Ophthalmol 2009;148:830 -836.

Research paper thumbnail of Keratocyte Density 3 Months, 15 Months, and 3 Years After Corneal Surface Ablation With Mitomycin C

American Journal of Ophthalmology, 2012

PURPOSE: To study the effects of surface ablation with mitomycin C (MMC) on keratocyte population... more PURPOSE: To study the effects of surface ablation with mitomycin C (MMC) on keratocyte population. • DESIGN: Prospective, nonrandomized, interventional, comparative case series. • METHODS: Thirty two eyes treated with surface ablation with 0.02% MMC were compared with nontreated eyes at Vissum Santa Hortensia, Madrid, Spain. Keratocyte density was measured with the Heidelberg Retina Tomograph II (Rostock Cornea Module) 3, 15, and 36 to 42 months after the surgery in the anterior, mid, and posterior stroma, and compared with control eyes. • RESULTS: Three months postoperatively, we found a lower stromal bed density compared to controls (16 993 ؎ 8001 vs 29 660 ؎ 5904 cells/mm 3 , P ‫؍‬ .0001), while there was a significantly higher cell density in the mid (30 783 ؎ 9300 vs 18 505 ؎ 1996 cells/mm 3 , P ‫؍‬ .0001) and deep stroma (30 268 ؎ 8321 vs 18 438 ؎ 2139 cells/mm 3 , P ‫؍‬ .0001). Three years after the surgery, the cellularity in the stromal bed had not significantly changed from the 3-month follow-up, but the density in the mid (18 889 ؎ 3474 cells/mm 3 ) and posterior stroma (18 992 ؎ 3402 cells/mm 3 ) had decreased to show no difference from controls. The mean cell density between the anterior, mid, and posterior stroma was not significantly different from controls 15 months and 3 years after the surgery. • CONCLUSION: Our study suggests that there is a reorganization of the stromal cell population soon after surface ablation with MMC, with a decrease in the stromal bed compensated initially with an increase in the mid and posterior stroma. Corneal cellularity tends to normalize over time, and 3 years postoperatively the mean cell density throughout the cornea seems to maintain normal values. (Am J Ophthalmol 2012;153: 17-23.