Pamela Rojo | Universidad de los Andes (Chile) (original) (raw)
Papers by Pamela Rojo
Revista chilena de anestesia, Dec 31, 2022
Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca • Casos clínicos 44
Journal of Cardiothoracic Surgery, Sep 1, 2013
PubMed, 1991
Subject global assessment of nutritional status was performed on 175 patients admitted to the med... more Subject global assessment of nutritional status was performed on 175 patients admitted to the medical-surgical gastroenterology service of a general hospital by a first-year resident and a specialist in clinical nutrition who were not aware of each other's evaluation. Patients were classified as well nourished or moderately or severely undernourished. Simultaneously, anthropometry was performed, serum albumin measured, and two units of PPD inoculated. A 79% concordance between the global subjective assessments made by the residents and the specialists was found. Patients in the three groups had significantly different weight, midarm circumference, triceps skinfold, and serum albumin values, whereas the total lymphocyte count and the percentage of negative PPD reactions were not significantly different. Subjective global assessment is a useful tool for the evaluation of nutritional status, even when used by inexperienced professionals.
Journal of Heart and Lung Transplantation, Apr 1, 2015
Revista médica de Chile, 1992
77 variables with data from clinical, non invasive and invasive findings in 591 adult patients su... more 77 variables with data from clinical, non invasive and invasive findings in 591 adult patients submitted to cardiac catheterization and/or coronary arteriography from 1988 to 1991 were analyzed. 51% had coronary arteriography for suspected coronary artery disease: 15% had no or insignificant disease and 8% had main left disease. Among 92 patients with valvular heart disease, coronary angiography ruled out coronary disease in 80%. In this group, 3 vessel disease was found only in patients older than 62 years of age and main left disease was rare. The etiology of valve disease was rheumatic in 72%. Congenital heart disease was the indication for invasive study in 8% of patients, atrial septal defect being the most common entity.
Revista médica de Chile, 1997
Global hospital mortality for infective endocarditis ranges from 13 to 40%. To compare clinical, ... more Global hospital mortality for infective endocarditis ranges from 13 to 40%. To compare clinical, microbiological, echocardiographic factors and complications between patients that died during an episode of infective endocarditis and those who survived. We followed during their hospital stay, 129 patients, aged 14 to 74 years old, who had 131 episodes of infective endocarditis. Clinical assessment, echocardiography and microbiological study was done to all patients. Surgical indications were those derived from complications. Thirty three patients died during hospital stay (25.2%). There were no differences between survivors and deceased patients in the lapse between onset of symptoms and hospital admission, presence of fever, dyspnea or heart murmurs. Skin and mucosal septic manifestations occurred with higher frequency in deceased patients (57.1 and 24.3% respectively). Blood cultures were positive in 55% in survivors and 48% in those who died. The most frequent infecting organisms ...
Journal of the American College of Cardiology
Background: Risk assessment strategies in subjects with COVID-19 in Low-and-Middle-income nations... more Background: Risk assessment strategies in subjects with COVID-19 in Low-and-Middle-income nations are scarce, however they may be useful in the setting of limited resources. We aimed to compare clinical parameters vs. chest Computed Tomography (cCT) findings for predicting death and non-fatal cardiopulmonary complications in hospitalized patients in Latin American (LATAM). Methods: A clinical (BMI >30, Diabetes, Hypertension, Smoking, high LDH/CRP/D-dimer/ferritin) and a cCT model (>50% lung involvement, ground glass pattern, and peripheral distribution) were applied to subjects enrolled in RIMAC (Registry IMAging Cardiopulmonary among hospitalized COVID-19 patients in LATAM), a multicenter, multinational, prospective observational study. The predictive value of both models for death and non-fatal cardiopulmonary complications (Heart Failure/Myocarditis, arrest, VTE, mechanical ventilation, ECMO) was analyzed using receiving operating curve plots. Results: A total of 883 consecutive patients were included: 64% male; X age 57 yrs.; 26% mortality; 42% with non-fatal cardiopulmonary events. cCT findings predicted death and cardiopulmonary complications with an AUC of 0.80 and 0.76 respectively, whereas the clinical model did so with an AUC of 0.74 and 0.78 respectively. (Figure) Conclusion: In this multinational LATAM study of COVID-19 hospitalized patients, cCT was as accurate as clinical parameters in the prediction of death or non-fatal cardiopulmonary complications.
Journal of the American College of Cardiology
Background: Gender-related characteristics in COVID-19 infection have not been studied in develop... more Background: Gender-related characteristics in COVID-19 infection have not been studied in developing nations. We aim to evaluate the influence of sex on cardiopulmonary profiles and outcomes among hospitalized COVID-19 subjects in Latin America (LATAM). Methods: A post-hoc analysis of RIMAC (Registry IMAging Cardiopulmonary among hospitalized COVID-19 patients in LATAM), a multicenter, prospective, observational study from 12 high-complexity centers in 9 countries, was conducted to assess CV risk factors and predictors of death or complications on a composite model. Results: A total of 1435 patients were included: male 64%; X age 57±15yrs.; female 36%; X age 58±18yrs. The prevalence of ≥1 CV risk factor (65% vs. 64%), use of imaging modalities, chest CT findings, and mortality were similar, while men had longer ICU stay (X 14 vs. 11 days, p=0.045) and total hospitalization (X 18 vs. 15 days, p=0.024). Women suffered less renal failure and had lower rates of mechanical ventilation. Regression analysis shown. Conclusion: In this series, women hospitalized due to COVID-19 had overall similar outcomes compared to men; however, prior cardiomyopathy, COPD, and age >50 were stronger predictors of mortality than in men, while CAD predicted complications in men and age >50 in women. Future studies on gender disparities are needed to confirm our findings, so evidence-based initiatives directed at limiting gaps in healthcare are implemented.
The American Journal of Clinical Nutrition, 2009
Background: The subjective global assessment of nutritional status (SGA) is used to assess the nu... more Background: The subjective global assessment of nutritional status (SGA) is used to assess the nutritional status of chronic dialysis patients, but longitudinal data in relation to mortality risk are lacking. Objective: Our objective was to study the long-term and timedependent associations of the SGA with mortality risk in chronic dialysis patients. Design: In a prospective, longitudinal, observational, multicenter study of incident dialysis patients, the 7-point SGA [7 ¼ normal nutritional status; 1 ¼ severe protein-energy wasting (PEW)] was assessed 3 and 6 mo after the start of dialysis and subsequently every 6 mo during 7 y of follow-up. With Cox regression analysis, we calculated hazard ratios (HRs) of the baseline and time-dependent SGA measurements, adjusted for age, sex, treatment modality, primary kidney diseases, and comorbidity. Results: In total, 1601 patients were included [mean (6SD) age: 59 6 15 y; 61% men; 23% with moderate PEW (SGA 4-5), and 5% with severe PEW (SGA 1-3)]. There was a dose-dependent trend of the 7-point SGA with mortality. Compared with a normal nutritional status at baseline,
Circulation Research, Oct 27, 2017
Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitr... more Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow-derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has evaluated intravenous infusion of UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the intravenous infusion of UC-MSC in patients with chronic stable heart failure and reduced ejection fraction. Methods and Results: Patients with heart failure and reduced ejection fraction under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile; 1×10 6 cells/kg) or placebo (n=15 per group). UC-MSCs in vitro, compared with bone marrow-derived mesenchymal stem cells, displayed a 55-fold increase in the expression of hepatocyte growth factor, known to be involved in myogenesis, cell migration, and immunoregulation. UC-MSC-treated patients presented no adverse events related to the cell infusion, and none of the patients tested at 0, 15, and 90 days presented alloantibodies to the UC-MSCs (n=7). Only the UC-MSC-treated group exhibited significant improvements in left ventricular ejection fraction at 3, 6, and 12 months of follow-up assessed both through transthoracic echocardiography (P=0.0167 versus baseline) and cardiac MRI (P=0.025 versus baseline). Echocardiographic left ventricular ejection fraction change from baseline to month 12 differed significantly between groups (+7.07±6.22% versus +1.85±5.60%; P=0.028). In addition, at all follow-up time points, UC-MSC-treated patients displayed improvements of New York Heart Association functional class (P=0.0167 versus baseline) and Minnesota Living with Heart Failure Questionnaire (P<0.05 versus baseline). At study completion, groups did not differ in mortality, heart failure admissions, arrhythmias, or incident malignancy. Conclusions: Intravenous infusion of UC-MSC was safe in this group of patients with stable heart failure and reduced ejection fraction under optimal medical treatment. Improvements in left ventricular function, functional status, and quality of life were observed in patients treated with UC-MSCs.
European Heart Journal, 2016
umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart fail... more umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart failure (RIMECARD) Por:Bartolucci, J (Bartolucci, J.) 1 ] ; Verdugo, FJ (Verdugo, F. J.) 2 ] ; Larrea, R (Larrea, R.) 3 ] ; Abarzua, E (Abarzua, E.) 4 ] ; Goset, C(Goset, C.) 4 ] ; Rojo, P (Rojo, P.) 3 ] ; Palma, I (Palma, I.) 3 ] ; Gonzalez, PL (Gonzalez, P. L.) 2 ] ; Sanhueza, P (Sanhueza, P.) 5 ] ; Pedreros, P (Pedreros, P.) 4 ] ...Más
Circulation research, Jan 26, 2017
Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expan... more Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. While bone marrow-derived mesenchymal stem cells (BM-MSCs) have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction (HFrEF), no clinical trial has evaluated UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the infusion of UC-MSC in patients with chronic stable HFrEF. Methods and Results: HFrEF patients under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile) (1x10(6) cells/Kg) or placebo (n=15 per group). UC-MSCs <em>in vitro</em>, compared to BM-MSCs, displayed a 55-fold increase in the expression of Hepatocyte Growth Factor (HGF), known to be involved in myog...
Asian Cardiovascular and Thoracic Annals, 2017
Background Durable mechanical support devices are prohibitively expensive in our health system an... more Background Durable mechanical support devices are prohibitively expensive in our health system and may be unsuitable for critically ill patients. CentriMag is an alternative bridge to transplantation or recovery. Methods We retrospectively reviewed 28 patients (23 males) aged 13–60 years who received CentriMag support. The etiology was ischemic in 13 (46%), dilated cardiomyopathy in 8 (29%), and others in 7 (25%). All patients were in Interagency Registry for Mechanically Assisted Circulatory Support class I, and 27 (96%) had multiorgan failure; 2 (7%) were post-cardiotomy and 12 (43%) had a previous cardiac arrest (mean arrest time 21 ± 17 min). Results Thirty-day post-implant survival was 79% (22 patients). Twenty (71%) patients were successfully bridged to transplantation or recovery. The mean support time was 40 days; 12 (43%) patients had >4-weeks’ support (longest was 292 days). Eight (29%) patients died on support. Complications included bleeding in 10 (36%) cases, immedia...
The Journal of Heart and Lung Transplantation, 2015
Revista de Ecocardiografía Práctica y Otras Técnicas de Imagen Cardíaca
Se presenta el caso de un varón de 54 años de edad con síntomas sugerentes de insuficiencia cardí... more Se presenta el caso de un varón de 54 años de edad con síntomas sugerentes de insuficiencia cardíaca derecha. En el estudio se evidencia una gran masa auricular derecha, hipercaptante en la tomografía por emisión de positrones con tomografía computarizada, sin metástatis demostradas en ese examen. La cirugía de resección muestra un linfoma no Hodgkin de alto grado de estirpe de células B. Se completó el tratamiento con 6 ciclos de quimioterapia, no evidenciándose recidiva a los 6 meses del tratamiento.
Revista médica de Chile, 2020
Mg en Adm. en Salud. e E.M. Trabajo no recibió financiamiento. Los autores declaran no tener conf... more Mg en Adm. en Salud. e E.M. Trabajo no recibió financiamiento. Los autores declaran no tener conflictos de interés.
Objectives To describe the use and findings of cardiopulmonary imaging - chest X-ray (cX-ray), ec... more Objectives To describe the use and findings of cardiopulmonary imaging - chest X-ray (cX-ray), echocardiography (cEcho), chest CT (cCT), lung ultrasound (LUS)) and/or cardiac magnetic resonance imaging (cMRI) - in COVID-19-associated hospitalizations in Latin America (LATAM) Background The SARS-Cov-2 is one of the largest and most active threats to healthcare in living memory. There is an information gap on imaging services resources (ISR) used and their findings during the pandemic in LATAM. Methods This was a multicenter, prospective, observational study of COVID-19 inpatients conducted from March to December 2020 from 12 high-complexity centers in nine LATAM countries. Adults (> 18 yrs) with at least one imaging modality performed, followed from admission until discharge and/or in-hospital death, were included. Results We studied 1435 hospitalized patients (64% males) with a median age of 58 years classified into three regions: 262 from Mexico (Mx), 428 from Central America an...
Revista medica de Chile
Guidelines for the management of unstable angina (UA) and non ST elevation myocardial infarction ... more Guidelines for the management of unstable angina (UA) and non ST elevation myocardial infarction (NSTEMI) have been issued, however, current practices are unknown in Chile. To evaluate in a prospective cohort of NSTEMI patients the current practices, treatments and risk factors. One year prospective International non interventional registry, conducted in Chile between January 2005 and November 2006. Two hundred thirty three Chilean NSTEMI patients were enrolled. Mortality was 5.5% at the end of the follow-up. Mean age was 61.6 years, and 30.6% were female. Most of the patients had at least one risk factor (98%): hypertension (84%), previous myocardial infarction (33%), dyslipidemia (54%), diabetes (33%), current smoking (30%). Main procedures during the hospitalization were coronary angiogram (67%), angioplasty (33%; 88% with stent) and coronary bypass surgery (7%). During procedures, 31% of patients received clopidogrel, and 4.2% glycoprotein Ilb/IIIa antagonists. Medical managemen...
Revista chilena de cardiología, 2016
Revista chilena de anestesia, Dec 31, 2022
Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca • Casos clínicos 44
Journal of Cardiothoracic Surgery, Sep 1, 2013
PubMed, 1991
Subject global assessment of nutritional status was performed on 175 patients admitted to the med... more Subject global assessment of nutritional status was performed on 175 patients admitted to the medical-surgical gastroenterology service of a general hospital by a first-year resident and a specialist in clinical nutrition who were not aware of each other's evaluation. Patients were classified as well nourished or moderately or severely undernourished. Simultaneously, anthropometry was performed, serum albumin measured, and two units of PPD inoculated. A 79% concordance between the global subjective assessments made by the residents and the specialists was found. Patients in the three groups had significantly different weight, midarm circumference, triceps skinfold, and serum albumin values, whereas the total lymphocyte count and the percentage of negative PPD reactions were not significantly different. Subjective global assessment is a useful tool for the evaluation of nutritional status, even when used by inexperienced professionals.
Journal of Heart and Lung Transplantation, Apr 1, 2015
Revista médica de Chile, 1992
77 variables with data from clinical, non invasive and invasive findings in 591 adult patients su... more 77 variables with data from clinical, non invasive and invasive findings in 591 adult patients submitted to cardiac catheterization and/or coronary arteriography from 1988 to 1991 were analyzed. 51% had coronary arteriography for suspected coronary artery disease: 15% had no or insignificant disease and 8% had main left disease. Among 92 patients with valvular heart disease, coronary angiography ruled out coronary disease in 80%. In this group, 3 vessel disease was found only in patients older than 62 years of age and main left disease was rare. The etiology of valve disease was rheumatic in 72%. Congenital heart disease was the indication for invasive study in 8% of patients, atrial septal defect being the most common entity.
Revista médica de Chile, 1997
Global hospital mortality for infective endocarditis ranges from 13 to 40%. To compare clinical, ... more Global hospital mortality for infective endocarditis ranges from 13 to 40%. To compare clinical, microbiological, echocardiographic factors and complications between patients that died during an episode of infective endocarditis and those who survived. We followed during their hospital stay, 129 patients, aged 14 to 74 years old, who had 131 episodes of infective endocarditis. Clinical assessment, echocardiography and microbiological study was done to all patients. Surgical indications were those derived from complications. Thirty three patients died during hospital stay (25.2%). There were no differences between survivors and deceased patients in the lapse between onset of symptoms and hospital admission, presence of fever, dyspnea or heart murmurs. Skin and mucosal septic manifestations occurred with higher frequency in deceased patients (57.1 and 24.3% respectively). Blood cultures were positive in 55% in survivors and 48% in those who died. The most frequent infecting organisms ...
Journal of the American College of Cardiology
Background: Risk assessment strategies in subjects with COVID-19 in Low-and-Middle-income nations... more Background: Risk assessment strategies in subjects with COVID-19 in Low-and-Middle-income nations are scarce, however they may be useful in the setting of limited resources. We aimed to compare clinical parameters vs. chest Computed Tomography (cCT) findings for predicting death and non-fatal cardiopulmonary complications in hospitalized patients in Latin American (LATAM). Methods: A clinical (BMI >30, Diabetes, Hypertension, Smoking, high LDH/CRP/D-dimer/ferritin) and a cCT model (>50% lung involvement, ground glass pattern, and peripheral distribution) were applied to subjects enrolled in RIMAC (Registry IMAging Cardiopulmonary among hospitalized COVID-19 patients in LATAM), a multicenter, multinational, prospective observational study. The predictive value of both models for death and non-fatal cardiopulmonary complications (Heart Failure/Myocarditis, arrest, VTE, mechanical ventilation, ECMO) was analyzed using receiving operating curve plots. Results: A total of 883 consecutive patients were included: 64% male; X age 57 yrs.; 26% mortality; 42% with non-fatal cardiopulmonary events. cCT findings predicted death and cardiopulmonary complications with an AUC of 0.80 and 0.76 respectively, whereas the clinical model did so with an AUC of 0.74 and 0.78 respectively. (Figure) Conclusion: In this multinational LATAM study of COVID-19 hospitalized patients, cCT was as accurate as clinical parameters in the prediction of death or non-fatal cardiopulmonary complications.
Journal of the American College of Cardiology
Background: Gender-related characteristics in COVID-19 infection have not been studied in develop... more Background: Gender-related characteristics in COVID-19 infection have not been studied in developing nations. We aim to evaluate the influence of sex on cardiopulmonary profiles and outcomes among hospitalized COVID-19 subjects in Latin America (LATAM). Methods: A post-hoc analysis of RIMAC (Registry IMAging Cardiopulmonary among hospitalized COVID-19 patients in LATAM), a multicenter, prospective, observational study from 12 high-complexity centers in 9 countries, was conducted to assess CV risk factors and predictors of death or complications on a composite model. Results: A total of 1435 patients were included: male 64%; X age 57±15yrs.; female 36%; X age 58±18yrs. The prevalence of ≥1 CV risk factor (65% vs. 64%), use of imaging modalities, chest CT findings, and mortality were similar, while men had longer ICU stay (X 14 vs. 11 days, p=0.045) and total hospitalization (X 18 vs. 15 days, p=0.024). Women suffered less renal failure and had lower rates of mechanical ventilation. Regression analysis shown. Conclusion: In this series, women hospitalized due to COVID-19 had overall similar outcomes compared to men; however, prior cardiomyopathy, COPD, and age >50 were stronger predictors of mortality than in men, while CAD predicted complications in men and age >50 in women. Future studies on gender disparities are needed to confirm our findings, so evidence-based initiatives directed at limiting gaps in healthcare are implemented.
The American Journal of Clinical Nutrition, 2009
Background: The subjective global assessment of nutritional status (SGA) is used to assess the nu... more Background: The subjective global assessment of nutritional status (SGA) is used to assess the nutritional status of chronic dialysis patients, but longitudinal data in relation to mortality risk are lacking. Objective: Our objective was to study the long-term and timedependent associations of the SGA with mortality risk in chronic dialysis patients. Design: In a prospective, longitudinal, observational, multicenter study of incident dialysis patients, the 7-point SGA [7 ¼ normal nutritional status; 1 ¼ severe protein-energy wasting (PEW)] was assessed 3 and 6 mo after the start of dialysis and subsequently every 6 mo during 7 y of follow-up. With Cox regression analysis, we calculated hazard ratios (HRs) of the baseline and time-dependent SGA measurements, adjusted for age, sex, treatment modality, primary kidney diseases, and comorbidity. Results: In total, 1601 patients were included [mean (6SD) age: 59 6 15 y; 61% men; 23% with moderate PEW (SGA 4-5), and 5% with severe PEW (SGA 1-3)]. There was a dose-dependent trend of the 7-point SGA with mortality. Compared with a normal nutritional status at baseline,
Circulation Research, Oct 27, 2017
Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitr... more Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow-derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has evaluated intravenous infusion of UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the intravenous infusion of UC-MSC in patients with chronic stable heart failure and reduced ejection fraction. Methods and Results: Patients with heart failure and reduced ejection fraction under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile; 1×10 6 cells/kg) or placebo (n=15 per group). UC-MSCs in vitro, compared with bone marrow-derived mesenchymal stem cells, displayed a 55-fold increase in the expression of hepatocyte growth factor, known to be involved in myogenesis, cell migration, and immunoregulation. UC-MSC-treated patients presented no adverse events related to the cell infusion, and none of the patients tested at 0, 15, and 90 days presented alloantibodies to the UC-MSCs (n=7). Only the UC-MSC-treated group exhibited significant improvements in left ventricular ejection fraction at 3, 6, and 12 months of follow-up assessed both through transthoracic echocardiography (P=0.0167 versus baseline) and cardiac MRI (P=0.025 versus baseline). Echocardiographic left ventricular ejection fraction change from baseline to month 12 differed significantly between groups (+7.07±6.22% versus +1.85±5.60%; P=0.028). In addition, at all follow-up time points, UC-MSC-treated patients displayed improvements of New York Heart Association functional class (P=0.0167 versus baseline) and Minnesota Living with Heart Failure Questionnaire (P<0.05 versus baseline). At study completion, groups did not differ in mortality, heart failure admissions, arrhythmias, or incident malignancy. Conclusions: Intravenous infusion of UC-MSC was safe in this group of patients with stable heart failure and reduced ejection fraction under optimal medical treatment. Improvements in left ventricular function, functional status, and quality of life were observed in patients treated with UC-MSCs.
European Heart Journal, 2016
umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart fail... more umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart failure (RIMECARD) Por:Bartolucci, J (Bartolucci, J.) 1 ] ; Verdugo, FJ (Verdugo, F. J.) 2 ] ; Larrea, R (Larrea, R.) 3 ] ; Abarzua, E (Abarzua, E.) 4 ] ; Goset, C(Goset, C.) 4 ] ; Rojo, P (Rojo, P.) 3 ] ; Palma, I (Palma, I.) 3 ] ; Gonzalez, PL (Gonzalez, P. L.) 2 ] ; Sanhueza, P (Sanhueza, P.) 5 ] ; Pedreros, P (Pedreros, P.) 4 ] ...Más
Circulation research, Jan 26, 2017
Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expan... more Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. While bone marrow-derived mesenchymal stem cells (BM-MSCs) have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction (HFrEF), no clinical trial has evaluated UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the infusion of UC-MSC in patients with chronic stable HFrEF. Methods and Results: HFrEF patients under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile) (1x10(6) cells/Kg) or placebo (n=15 per group). UC-MSCs <em>in vitro</em>, compared to BM-MSCs, displayed a 55-fold increase in the expression of Hepatocyte Growth Factor (HGF), known to be involved in myog...
Asian Cardiovascular and Thoracic Annals, 2017
Background Durable mechanical support devices are prohibitively expensive in our health system an... more Background Durable mechanical support devices are prohibitively expensive in our health system and may be unsuitable for critically ill patients. CentriMag is an alternative bridge to transplantation or recovery. Methods We retrospectively reviewed 28 patients (23 males) aged 13–60 years who received CentriMag support. The etiology was ischemic in 13 (46%), dilated cardiomyopathy in 8 (29%), and others in 7 (25%). All patients were in Interagency Registry for Mechanically Assisted Circulatory Support class I, and 27 (96%) had multiorgan failure; 2 (7%) were post-cardiotomy and 12 (43%) had a previous cardiac arrest (mean arrest time 21 ± 17 min). Results Thirty-day post-implant survival was 79% (22 patients). Twenty (71%) patients were successfully bridged to transplantation or recovery. The mean support time was 40 days; 12 (43%) patients had >4-weeks’ support (longest was 292 days). Eight (29%) patients died on support. Complications included bleeding in 10 (36%) cases, immedia...
The Journal of Heart and Lung Transplantation, 2015
Revista de Ecocardiografía Práctica y Otras Técnicas de Imagen Cardíaca
Se presenta el caso de un varón de 54 años de edad con síntomas sugerentes de insuficiencia cardí... more Se presenta el caso de un varón de 54 años de edad con síntomas sugerentes de insuficiencia cardíaca derecha. En el estudio se evidencia una gran masa auricular derecha, hipercaptante en la tomografía por emisión de positrones con tomografía computarizada, sin metástatis demostradas en ese examen. La cirugía de resección muestra un linfoma no Hodgkin de alto grado de estirpe de células B. Se completó el tratamiento con 6 ciclos de quimioterapia, no evidenciándose recidiva a los 6 meses del tratamiento.
Revista médica de Chile, 2020
Mg en Adm. en Salud. e E.M. Trabajo no recibió financiamiento. Los autores declaran no tener conf... more Mg en Adm. en Salud. e E.M. Trabajo no recibió financiamiento. Los autores declaran no tener conflictos de interés.
Objectives To describe the use and findings of cardiopulmonary imaging - chest X-ray (cX-ray), ec... more Objectives To describe the use and findings of cardiopulmonary imaging - chest X-ray (cX-ray), echocardiography (cEcho), chest CT (cCT), lung ultrasound (LUS)) and/or cardiac magnetic resonance imaging (cMRI) - in COVID-19-associated hospitalizations in Latin America (LATAM) Background The SARS-Cov-2 is one of the largest and most active threats to healthcare in living memory. There is an information gap on imaging services resources (ISR) used and their findings during the pandemic in LATAM. Methods This was a multicenter, prospective, observational study of COVID-19 inpatients conducted from March to December 2020 from 12 high-complexity centers in nine LATAM countries. Adults (> 18 yrs) with at least one imaging modality performed, followed from admission until discharge and/or in-hospital death, were included. Results We studied 1435 hospitalized patients (64% males) with a median age of 58 years classified into three regions: 262 from Mexico (Mx), 428 from Central America an...
Revista medica de Chile
Guidelines for the management of unstable angina (UA) and non ST elevation myocardial infarction ... more Guidelines for the management of unstable angina (UA) and non ST elevation myocardial infarction (NSTEMI) have been issued, however, current practices are unknown in Chile. To evaluate in a prospective cohort of NSTEMI patients the current practices, treatments and risk factors. One year prospective International non interventional registry, conducted in Chile between January 2005 and November 2006. Two hundred thirty three Chilean NSTEMI patients were enrolled. Mortality was 5.5% at the end of the follow-up. Mean age was 61.6 years, and 30.6% were female. Most of the patients had at least one risk factor (98%): hypertension (84%), previous myocardial infarction (33%), dyslipidemia (54%), diabetes (33%), current smoking (30%). Main procedures during the hospitalization were coronary angiogram (67%), angioplasty (33%; 88% with stent) and coronary bypass surgery (7%). During procedures, 31% of patients received clopidogrel, and 4.2% glycoprotein Ilb/IIIa antagonists. Medical managemen...
Revista chilena de cardiología, 2016