Javier Sanchez | Universitat Abat Oliba CEU (original) (raw)
Papers by Javier Sanchez
Journal of the American College of Cardiology, 2016
Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...
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Journal of the American College of Cardiology, 2016
Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...
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Clinical Biochemistry, May 31, 2008
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Circulation, Nov 22, 2011
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Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016
Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...
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Circulation, Nov 20, 2012
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American Journal of Medical Genetics Part a, Dec 5, 2013
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European Journal of Rheumatology and Inflammation, Feb 1, 1991
A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.
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Circulation, Nov 25, 2014
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2013 Optical Fiber Communication Conference and Exposition and the National Fiber Optic Engineers Conference, Mar 17, 2013
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Data Revues 09249338 00220008 07013648, Nov 27, 2007
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Journal of the American College of Cardiology, 2016
Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...
Bookmarks Related papers MentionsView impact
Journal of the American College of Cardiology, 2016
Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...
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Clinical Biochemistry, May 31, 2008
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Circulation, Nov 22, 2011
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Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016
Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...
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Circulation, Nov 20, 2012
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Circulation, Nov 25, 2014
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Circulation, Nov 26, 2013
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American Journal of Medical Genetics Part a, Dec 5, 2013
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European Journal of Rheumatology and Inflammation, Feb 1, 1991
A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.
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Circulation, Nov 25, 2014
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Data Revues 09249338 00220008 07013648, Nov 27, 2007
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