Javier Sanchez - Profile on Academia.edu (original) (raw)
Papers by Javier Sanchez
Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial
Journal of the American College of Cardiology, 2016
Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...
Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia
Journal of the American College of Cardiology, 2016
Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...
Clinical Biochemistry, May 31, 2008
Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtrat... more Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (Cl Tc ) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD.
Abstract 12143: Association of Biomarkers with Pre-Existent Left Atrial Myocardial Scar in Atrial Fibrillation Patients Undergoing Catheter Ablation
Circulation, Nov 22, 2011
Difference in thermodynamics between two types of esophageal temperature probes: Insights from an experimental study
Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016
Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...
Abstract 15576: Long-Term Catheter Ablation Outcome in Females with Metabolic Syndrome
Circulation, Nov 20, 2012
Abstract 14277: Catheter Ablation of Atrial Fibrillation Without Dabigratan Discontinuation: Preliminary Safety and Efficacy Data
Circulation, Nov 22, 2011
Abstract 12600: Microrna From Atrial Tissue Harvested During Transseptal Puncture as a Predictor for Non-pv Trigger in Patients Undergoing Af Ablation: Preliminary Results From a Pilot Study
Circulation, Nov 25, 2014
Abstract 15834: Stimulation Within the Scar is Superior to Right Ventricular Stimulation for the Induction of Clinical Arrhythmias in Patients with Post-Infarction Ventricular Tachycardia
Circulation, Nov 20, 2012
Abstract 18588: Baseline Neutrophil/Lymphocyte Ratio Predicts Recurrences After Radiofrequency Catheter Ablation: Results From Prospective Study on Paroxysmal Atrial Fibrillation
Circulation, Nov 26, 2013
American Journal of Medical Genetics Part a, Dec 5, 2013
Angelman syndrome (AS, OMIM105830) is a neurogenetic disorder caused by different genetic mechani... more Angelman syndrome (AS, OMIM105830) is a neurogenetic disorder caused by different genetic mechanisms. Determining the genetic mechanism is essential to establish the recurrence risk and the accuracy of genetic/reproductive counseling. The majority of AS patients present with a deletion of the 15q11.2-q13 region on the maternally derived chromosome. The other genetic mechanisms are: paternal disomy of chromosome 15, imprinting center defects, and mutations in the ubiquitin-protein ligase E3A gene (UBE3A). Different recurrence risks are associated with each specific genetic mechanism involved. We report on the study of dizygotic twins with classic phenotypic AS due to deletion of the same maternally derived chromosome 15. The mother presented with hypopigmented macular lesions on the inner side of both arms. Fibroblast culture studies of the maternal hypopigmented skin areas from both arms showed mosaicism for a normal cell line and for a second cell line with a 15q11.2-q13 deletion. This family represents the first demonstrated case of maternal somatic and germ line mosaicism for 15q11.2-q13 deletion as the cause of AS.
A pharmacokinetic study to evaluate the profile of droxicam in elderly healthy volunteers after a single oral dose of 20mg
European Journal of Rheumatology and Inflammation, Feb 1, 1991
A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.
Abstract 15313: Novel Single-Nucleotide Polymorphisms Predict Inverse Association With Non-Pulmonary Vein Triggers in Patients With Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)
Circulation, Nov 25, 2014
Abstract 15835: Safety of Catheter Ablation of Ventricular Arrhythmias Originating from the Coronary Cusps Guided by Intracardiac Echo: A Multicenter Experience
Circulation, Nov 20, 2012
Chemotherapy-Induced Surface Degradation and Thrombogenicity of Intravascular Catheters : A Preliminary In-Vitro Study with Focus on Breast Cancer
2013 Optical Fiber Communication Conference and Exposition and the National Fiber Optic Engineers Conference, Mar 17, 2013
We propose and experimentally demonstrate an optical wireless DWDM system at 60 GHz with optical ... more We propose and experimentally demonstrate an optical wireless DWDM system at 60 GHz with optical incoherent heterodyne up-conversion using an optical frequency comb. Multiple users with wireline and wireless services are simultaneously supported.
Eurocast, 2007
One of the main technique used to recover motion analysis from two images or to register them is ... more One of the main technique used to recover motion analysis from two images or to register them is variational optical flow, where the pixels of one image are matched to the pixels of the second image by minimizing an energy functional. In the standard formulation of variational optical flow, the estimated motion vector field depends on the reference image and is asymmetric. However, in most application the solution should be independent of the reference image. Only few symmetrical formulations of the optical flow has been proposed in the literature, where the solution is constraint to be symmetric using a combination of the flow in both directions. We propose a new symmetric variational formulation of the optical flow problem, where the flow is naturally symmetric. Results on the Yosemite sequence show an improved accuracy of our symmetric flow with respect to standard optical flow algorithm.
Abstract 14381: Preliminary Results from the SPECULATE Randomized Study: Effect of Amiodarone on the Procedure Outcome in Long-Standing Persistent Atrial Fibrillation Undergoing Extended Pulmonary Vein Antrum Isolation
Circulation, Nov 22, 2011
Data Revues 09249338 00220008 07013648, Nov 27, 2007
Objectives. e A study of N-acetyl-aspartate (NAA) can provide data of interest about cortical alt... more Objectives. e A study of N-acetyl-aspartate (NAA) can provide data of interest about cortical alterations in psychotic illnesses. Although a decreased NAA level in the cerebral cortex is a replicated finding in chronic schizophrenia, the data are less consistent for bipolar disease. On the other hand, it is likely that NAA values in schizophrenia may differ in men and women.
Scale Space, 2003
In this paper we present a method for the regularization of a set of unstructured 3D points obtai... more In this paper we present a method for the regularization of a set of unstructured 3D points obtained from a sequence of stereo images. This method takes into account the information supplied by the disparity maps computed between pairs of images to constraint the regularization of the set of 3D points. We propose a model based on an energy which is composed of two terms: an attachment term that minimizes the distance from 3D points to the projective lines of camera points, and a second term that allows for the regularization of the set of 3D points by preserving discontinuities presented on the disparity maps. We embed this energy in a 2D finite element method. After minimizing, this method results in a large system of equations that can be optimized for fast computations. We derive an efficient implicit numerical scheme which reduces the number of calculations and memory allocations.
Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial
Journal of the American College of Cardiology, 2016
Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...
Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia
Journal of the American College of Cardiology, 2016
Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...
Clinical Biochemistry, May 31, 2008
Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtrat... more Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (Cl Tc ) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD.
Abstract 12143: Association of Biomarkers with Pre-Existent Left Atrial Myocardial Scar in Atrial Fibrillation Patients Undergoing Catheter Ablation
Circulation, Nov 22, 2011
Difference in thermodynamics between two types of esophageal temperature probes: Insights from an experimental study
Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016
Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...
Abstract 15576: Long-Term Catheter Ablation Outcome in Females with Metabolic Syndrome
Circulation, Nov 20, 2012
Abstract 14277: Catheter Ablation of Atrial Fibrillation Without Dabigratan Discontinuation: Preliminary Safety and Efficacy Data
Circulation, Nov 22, 2011
Abstract 12600: Microrna From Atrial Tissue Harvested During Transseptal Puncture as a Predictor for Non-pv Trigger in Patients Undergoing Af Ablation: Preliminary Results From a Pilot Study
Circulation, Nov 25, 2014
Abstract 15834: Stimulation Within the Scar is Superior to Right Ventricular Stimulation for the Induction of Clinical Arrhythmias in Patients with Post-Infarction Ventricular Tachycardia
Circulation, Nov 20, 2012
Abstract 18588: Baseline Neutrophil/Lymphocyte Ratio Predicts Recurrences After Radiofrequency Catheter Ablation: Results From Prospective Study on Paroxysmal Atrial Fibrillation
Circulation, Nov 26, 2013
American Journal of Medical Genetics Part a, Dec 5, 2013
Angelman syndrome (AS, OMIM105830) is a neurogenetic disorder caused by different genetic mechani... more Angelman syndrome (AS, OMIM105830) is a neurogenetic disorder caused by different genetic mechanisms. Determining the genetic mechanism is essential to establish the recurrence risk and the accuracy of genetic/reproductive counseling. The majority of AS patients present with a deletion of the 15q11.2-q13 region on the maternally derived chromosome. The other genetic mechanisms are: paternal disomy of chromosome 15, imprinting center defects, and mutations in the ubiquitin-protein ligase E3A gene (UBE3A). Different recurrence risks are associated with each specific genetic mechanism involved. We report on the study of dizygotic twins with classic phenotypic AS due to deletion of the same maternally derived chromosome 15. The mother presented with hypopigmented macular lesions on the inner side of both arms. Fibroblast culture studies of the maternal hypopigmented skin areas from both arms showed mosaicism for a normal cell line and for a second cell line with a 15q11.2-q13 deletion. This family represents the first demonstrated case of maternal somatic and germ line mosaicism for 15q11.2-q13 deletion as the cause of AS.
A pharmacokinetic study to evaluate the profile of droxicam in elderly healthy volunteers after a single oral dose of 20mg
European Journal of Rheumatology and Inflammation, Feb 1, 1991
A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.
Abstract 15313: Novel Single-Nucleotide Polymorphisms Predict Inverse Association With Non-Pulmonary Vein Triggers in Patients With Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)
Circulation, Nov 25, 2014
Abstract 15835: Safety of Catheter Ablation of Ventricular Arrhythmias Originating from the Coronary Cusps Guided by Intracardiac Echo: A Multicenter Experience
Circulation, Nov 20, 2012
Chemotherapy-Induced Surface Degradation and Thrombogenicity of Intravascular Catheters : A Preliminary In-Vitro Study with Focus on Breast Cancer
2013 Optical Fiber Communication Conference and Exposition and the National Fiber Optic Engineers Conference, Mar 17, 2013
We propose and experimentally demonstrate an optical wireless DWDM system at 60 GHz with optical ... more We propose and experimentally demonstrate an optical wireless DWDM system at 60 GHz with optical incoherent heterodyne up-conversion using an optical frequency comb. Multiple users with wireline and wireless services are simultaneously supported.
Eurocast, 2007
One of the main technique used to recover motion analysis from two images or to register them is ... more One of the main technique used to recover motion analysis from two images or to register them is variational optical flow, where the pixels of one image are matched to the pixels of the second image by minimizing an energy functional. In the standard formulation of variational optical flow, the estimated motion vector field depends on the reference image and is asymmetric. However, in most application the solution should be independent of the reference image. Only few symmetrical formulations of the optical flow has been proposed in the literature, where the solution is constraint to be symmetric using a combination of the flow in both directions. We propose a new symmetric variational formulation of the optical flow problem, where the flow is naturally symmetric. Results on the Yosemite sequence show an improved accuracy of our symmetric flow with respect to standard optical flow algorithm.
Abstract 14381: Preliminary Results from the SPECULATE Randomized Study: Effect of Amiodarone on the Procedure Outcome in Long-Standing Persistent Atrial Fibrillation Undergoing Extended Pulmonary Vein Antrum Isolation
Circulation, Nov 22, 2011
Data Revues 09249338 00220008 07013648, Nov 27, 2007
Objectives. e A study of N-acetyl-aspartate (NAA) can provide data of interest about cortical alt... more Objectives. e A study of N-acetyl-aspartate (NAA) can provide data of interest about cortical alterations in psychotic illnesses. Although a decreased NAA level in the cerebral cortex is a replicated finding in chronic schizophrenia, the data are less consistent for bipolar disease. On the other hand, it is likely that NAA values in schizophrenia may differ in men and women.
Scale Space, 2003
In this paper we present a method for the regularization of a set of unstructured 3D points obtai... more In this paper we present a method for the regularization of a set of unstructured 3D points obtained from a sequence of stereo images. This method takes into account the information supplied by the disparity maps computed between pairs of images to constraint the regularization of the set of 3D points. We propose a model based on an energy which is composed of two terms: an attachment term that minimizes the distance from 3D points to the projective lines of camera points, and a second term that allows for the regularization of the set of 3D points by preserving discontinuities presented on the disparity maps. We embed this energy in a 2D finite element method. After minimizing, this method results in a large system of equations that can be optimized for fast computations. We derive an efficient implicit numerical scheme which reduces the number of calculations and memory allocations.