Javier Sanchez | Universitat Abat Oliba CEU (original) (raw)

Papers by Javier Sanchez

Research paper thumbnail of Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial

Journal of the American College of Cardiology, 2016

Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...

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Research paper thumbnail of Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia

Journal of the American College of Cardiology, 2016

Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...

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Research paper thumbnail of Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children

Clinical Biochemistry, May 31, 2008

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Research paper thumbnail of Abstract 12143: Association of Biomarkers with Pre-Existent Left Atrial Myocardial Scar in Atrial Fibrillation Patients Undergoing Catheter Ablation

Circulation, Nov 22, 2011

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Research paper thumbnail of Difference in thermodynamics between two types of esophageal temperature probes: Insights from an experimental study

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016

Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...

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Research paper thumbnail of Abstract 15576: Long-Term Catheter Ablation Outcome in Females with Metabolic Syndrome

Circulation, Nov 20, 2012

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Research paper thumbnail of Abstract 14277: Catheter Ablation of Atrial Fibrillation Without Dabigratan Discontinuation: Preliminary Safety and Efficacy Data

Circulation, Nov 22, 2011

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Research paper thumbnail of Abstract 12600: Microrna From Atrial Tissue Harvested During Transseptal Puncture as a Predictor for Non-pv Trigger in Patients Undergoing Af Ablation: Preliminary Results From a Pilot Study

Circulation, Nov 25, 2014

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Research paper thumbnail of Abstract 15834: Stimulation Within the Scar is Superior to Right Ventricular Stimulation for the Induction of Clinical Arrhythmias in Patients with Post-Infarction Ventricular Tachycardia

Circulation, Nov 20, 2012

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Research paper thumbnail of Abstract 18588: Baseline Neutrophil/Lymphocyte Ratio Predicts Recurrences After Radiofrequency Catheter Ablation: Results From Prospective Study on Paroxysmal Atrial Fibrillation

Circulation, Nov 26, 2013

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Research paper thumbnail of Somatic and Germ-Line Mosaicism of Deletion 15q11.2-q13 in a Mother of Dyzigotic Twins With Angelman Syndrome

American Journal of Medical Genetics Part a, Dec 5, 2013

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Research paper thumbnail of A pharmacokinetic study to evaluate the profile of droxicam in elderly healthy volunteers after a single oral dose of 20mg

European Journal of Rheumatology and Inflammation, Feb 1, 1991

A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.

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Research paper thumbnail of Abstract 15313: Novel Single-Nucleotide Polymorphisms Predict Inverse Association With Non-Pulmonary Vein Triggers in Patients With Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)

Circulation, Nov 25, 2014

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Research paper thumbnail of Abstract 15835: Safety of Catheter Ablation of Ventricular Arrhythmias Originating from the Coronary Cusps Guided by Intracardiac Echo: A Multicenter Experience

Circulation, Nov 20, 2012

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Research paper thumbnail of Chemotherapy-Induced Surface Degradation and Thrombogenicity of Intravascular Catheters : A Preliminary In-Vitro Study with Focus on Breast Cancer

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Research paper thumbnail of DWDM fiber-wireless access system with centralized optical frequency comb-based RF carrier generation

2013 Optical Fiber Communication Conference and Exposition and the National Fiber Optic Engineers Conference, Mar 17, 2013

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Research paper thumbnail of Symmetric Optical Flow

Eurocast, 2007

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Research paper thumbnail of Abstract 14381: Preliminary Results from the SPECULATE Randomized Study: Effect of Amiodarone on the Procedure Outcome in Long-Standing Persistent Atrial Fibrillation Undergoing Extended Pulmonary Vein Antrum Isolation

Circulation, Nov 22, 2011

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Research paper thumbnail of Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder

Data Revues 09249338 00220008 07013648, Nov 27, 2007

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Research paper thumbnail of Regularizing a Set of Unstructured 3D Points from a Sequence of Stereo Images

Scale Space, 2003

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Research paper thumbnail of Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial

Journal of the American College of Cardiology, 2016

Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In add... more Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48...

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Research paper thumbnail of Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia

Journal of the American College of Cardiology, 2016

Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standar... more Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear. The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population. Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricula...

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Research paper thumbnail of Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children

Clinical Biochemistry, May 31, 2008

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Research paper thumbnail of Abstract 12143: Association of Biomarkers with Pre-Existent Left Atrial Myocardial Scar in Atrial Fibrillation Patients Undergoing Catheter Ablation

Circulation, Nov 22, 2011

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Research paper thumbnail of Difference in thermodynamics between two types of esophageal temperature probes: Insights from an experimental study

Heart rhythm : the official journal of the Heart Rhythm Society, Jan 20, 2016

Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes... more Luminal esophageal temperature (LET) monitoring is performed with a variety of temperature probes, but little is known on the relationship between the structure of a given probe and its thermodynamic characteristics. To evaluate the difference in thermodynamics between a 9F standard esophageal probe and an 18F esophageal stethoscope. In the experimental setting, each probe was submerged in a constant temperature water bath maintained at 42 °C; in the patient setting, we monitored the temperature with both probes at the same time. The time constant of the stethoscope was higher than that of the probe (33.5 s vs 8.3 s). Compared to the probe, the mean temperature measured by the stethoscope at 10 seconds was significantly lower (22.5 ± 0.4 °C vs 33.5 ± 0.3 °C; P < 0.0001), while the time to reach the peak temperature was significantly longer (132.6 ± 5.9 s 38.8 ± 1.0 s; P < 0.0001). Even in the ablation cases we observed that when the esophageal probe reached a peak temperature ...

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Research paper thumbnail of Abstract 15576: Long-Term Catheter Ablation Outcome in Females with Metabolic Syndrome

Circulation, Nov 20, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 14277: Catheter Ablation of Atrial Fibrillation Without Dabigratan Discontinuation: Preliminary Safety and Efficacy Data

Circulation, Nov 22, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 12600: Microrna From Atrial Tissue Harvested During Transseptal Puncture as a Predictor for Non-pv Trigger in Patients Undergoing Af Ablation: Preliminary Results From a Pilot Study

Circulation, Nov 25, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 15834: Stimulation Within the Scar is Superior to Right Ventricular Stimulation for the Induction of Clinical Arrhythmias in Patients with Post-Infarction Ventricular Tachycardia

Circulation, Nov 20, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 18588: Baseline Neutrophil/Lymphocyte Ratio Predicts Recurrences After Radiofrequency Catheter Ablation: Results From Prospective Study on Paroxysmal Atrial Fibrillation

Circulation, Nov 26, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Somatic and Germ-Line Mosaicism of Deletion 15q11.2-q13 in a Mother of Dyzigotic Twins With Angelman Syndrome

American Journal of Medical Genetics Part a, Dec 5, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A pharmacokinetic study to evaluate the profile of droxicam in elderly healthy volunteers after a single oral dose of 20mg

European Journal of Rheumatology and Inflammation, Feb 1, 1991

A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performe... more A single oral dose pharmacokinetic study in a group of 10 elderly healthy volunteers was performed to evaluate the pharmacokinetic profile and the potential effect of age on the absorption, distribution and elimination of droxicam. After complete medical screening, and informed written consent, one dose (20mg) of droxicam was administered to all volunteers, under medical supervision. A complete pharmacokinetic profile of the obtained blood plasma levels was evaluated over 120 hours. All volunteers completed the study and in none did droxicam cause intolerance or side effects. The results showed that droxicam absorption, distribution and elimination did not differ substantially from reference studies done with young healthy volunteers. The peak mean plasma concentration was at 10 hours 1.38 +/- 0.29 microgram/ml, declining slowly, reaching 0.24 +/- 0.20 microgram/ml at 120 hours, with a half life of 50.23 +/- 17.19 hours and an elimination rate constant of 0.015 +/- 0.005 microgram/ml.h-1. In comparison to the healthy, young volunteers, the variation was minimal. It can be concluded from this study that age causes minimal variations in the absorption and distribution of droxicam.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 15313: Novel Single-Nucleotide Polymorphisms Predict Inverse Association With Non-Pulmonary Vein Triggers in Patients With Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)

Circulation, Nov 25, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abstract 15835: Safety of Catheter Ablation of Ventricular Arrhythmias Originating from the Coronary Cusps Guided by Intracardiac Echo: A Multicenter Experience

Circulation, Nov 20, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Chemotherapy-Induced Surface Degradation and Thrombogenicity of Intravascular Catheters : A Preliminary In-Vitro Study with Focus on Breast Cancer

Bookmarks Related papers MentionsView impact

Research paper thumbnail of DWDM fiber-wireless access system with centralized optical frequency comb-based RF carrier generation

2013 Optical Fiber Communication Conference and Exposition and the National Fiber Optic Engineers Conference, Mar 17, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Symmetric Optical Flow

Eurocast, 2007

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Research paper thumbnail of Abstract 14381: Preliminary Results from the SPECULATE Randomized Study: Effect of Amiodarone on the Procedure Outcome in Long-Standing Persistent Atrial Fibrillation Undergoing Extended Pulmonary Vein Antrum Isolation

Circulation, Nov 22, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder

Data Revues 09249338 00220008 07013648, Nov 27, 2007

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Regularizing a Set of Unstructured 3D Points from a Sequence of Stereo Images

Scale Space, 2003

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