Roberto Saenz | Universidad Autónoma de Sinaloa (original) (raw)

Papers by Roberto Saenz

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Enalapril-induced regression of hypertensive left ventricular hypertrophy, regional ischemia, and microvascular angina

American Journal of Cardiology, 1995

Our findings suggest that treatment of arterial hypertension with enalapril not only reduces LV m... more Our findings suggest that treatment of arterial hypertension with enalapril not only reduces LV mass, but also corrects microvascular ischemia and subsequent angina pectoris, and improves exercise performance. ... 9. RB Devereux, DR Alonso, EM Lutas, GJ Gottlieb, E Campo, I ...

Research paper thumbnail of Water and temperature relations and microconidial germination of Fusarium moniliforme and Fusarium proliferatum from maize

Canadian Journal of Microbiology, 1996

The effects of water activity (aW, 0.994-0.85 = 0.4-21.0 (-)MPa water potential), temperature (5-... more The effects of water activity (aW, 0.994-0.85 = 0.4-21.0 (-)MPa water potential), temperature (5-42 degrees C), and their interactions on microconidial germination of three isolates each of Fusarium moniliforme and Fusarium proliferatum were determined in vitro on a maize meal extract medium. Temporal germination rates of microconidia of isolates of both species were significantly influenced by both aW and temperature. Germination was very rapid at > 0.94 aW with an almost linear increase with time. Germination rates of microconidia of F. moniliforme were slower than those of F. proliferatum isolates at marginal aW levels and 5-25 degrees C, while at higher temperature (30-37 degrees C), the former germinated more rapidly than the latter. The aW minima for germination of isolates of both species was 0.88, with none occurring at 0.85 aW over a 40-day incubation period. At 37 degrees C, isolates of F. moniliforme had slightly lower aW minima than those of F. proliferatum. The narrowest range of aW for germination was at 5 degrees C, and none occurred at 42 degrees C. The effect of aW x temperature interactions on the lag phases (h) prior to germination and the germination rates (h-1) were estimated using the Gompertz model and the Zwietering equation. This showed that lag phases were shorter at 25-30 degrees C and 0.994-0.98 aW, and were increased to 10-500 h at marginal temperatures (5-10 degrees C) for F. proliferatum and longer for F. moniliforme. At marginal aW levels (0.92-0.90), lag times were increased to > 250 h. Germination rates (h-1) were different for the two species. Microconidia of F. moniliforme germinated optimally at 25-37 degrees C and 0.96-0.98 aW, but this changed to 30 degrees C at 0.90-0.94 aW, while germination of microconidia of F. proliferatum remained optimum at 30 degrees C, regardless of aW. There were statistically significant (P < 0.01) effects of aW, temperature, isolate, and two- and three-way interactions for F. proliferatum, but there were no intraisolate effects for F. moniliforme. The ecological significance of these data for understanding colonization patterns of these important fumonisin-producing fungi are discussed.

Research paper thumbnail of Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis*1

American Journal of Medicine, 1990

PURPOSE,PATIENTS,ANDMETHODS: Theclassic agent for cutaneous leishmaniasis is pentavalent antimony... more PURPOSE,PATIENTS,ANDMETHODS: Theclassic agent for cutaneous leishmaniasis is pentavalent antimony. However, there are no reports of the efficacy of antimony versus placebo or of the efficacy of any alternative therapy versus either antimony or placebo. In the present report, the oral antifungal agent ketoconazole (600 n&day for 28 days) was compared to a recommended regimen of intramuscular Pentostam (20 mg antimony/kg, with a maximum of 850 mg antimony/day, for 20 days) in a randomized study of the treatment of Panama&n cutaneous leishmaniasis due to L&IImauia bradiensis paname& A separate group of patients with this disease was administered placebo.

Research paper thumbnail of PROY 5D PARCIAL Autoguardado

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia

Diabetes Care, 2002

OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous intersti... more OBJECTIVE -The MiniMed Continuous Glucose Monitoring System (CGMS) measures subcutaneous interstitial glucose levels that are calibrated against three or more fingerstick glucose levels daily. The objective of the present study was to examine whether the relationship between plasma and interstitial fluid glucose is altered by changes in plasma glucose and insulin levels and how such alterations might influence CGMS performance.

Research paper thumbnail of Enalapril-induced regression of hypertensive left ventricular hypertrophy, regional ischemia, and microvascular angina

American Journal of Cardiology, 1995

Our findings suggest that treatment of arterial hypertension with enalapril not only reduces LV m... more Our findings suggest that treatment of arterial hypertension with enalapril not only reduces LV mass, but also corrects microvascular ischemia and subsequent angina pectoris, and improves exercise performance. ... 9. RB Devereux, DR Alonso, EM Lutas, GJ Gottlieb, E Campo, I ...

Research paper thumbnail of Water and temperature relations and microconidial germination of Fusarium moniliforme and Fusarium proliferatum from maize

Canadian Journal of Microbiology, 1996

The effects of water activity (aW, 0.994-0.85 = 0.4-21.0 (-)MPa water potential), temperature (5-... more The effects of water activity (aW, 0.994-0.85 = 0.4-21.0 (-)MPa water potential), temperature (5-42 degrees C), and their interactions on microconidial germination of three isolates each of Fusarium moniliforme and Fusarium proliferatum were determined in vitro on a maize meal extract medium. Temporal germination rates of microconidia of isolates of both species were significantly influenced by both aW and temperature. Germination was very rapid at > 0.94 aW with an almost linear increase with time. Germination rates of microconidia of F. moniliforme were slower than those of F. proliferatum isolates at marginal aW levels and 5-25 degrees C, while at higher temperature (30-37 degrees C), the former germinated more rapidly than the latter. The aW minima for germination of isolates of both species was 0.88, with none occurring at 0.85 aW over a 40-day incubation period. At 37 degrees C, isolates of F. moniliforme had slightly lower aW minima than those of F. proliferatum. The narrowest range of aW for germination was at 5 degrees C, and none occurred at 42 degrees C. The effect of aW x temperature interactions on the lag phases (h) prior to germination and the germination rates (h-1) were estimated using the Gompertz model and the Zwietering equation. This showed that lag phases were shorter at 25-30 degrees C and 0.994-0.98 aW, and were increased to 10-500 h at marginal temperatures (5-10 degrees C) for F. proliferatum and longer for F. moniliforme. At marginal aW levels (0.92-0.90), lag times were increased to > 250 h. Germination rates (h-1) were different for the two species. Microconidia of F. moniliforme germinated optimally at 25-37 degrees C and 0.96-0.98 aW, but this changed to 30 degrees C at 0.90-0.94 aW, while germination of microconidia of F. proliferatum remained optimum at 30 degrees C, regardless of aW. There were statistically significant (P < 0.01) effects of aW, temperature, isolate, and two- and three-way interactions for F. proliferatum, but there were no intraisolate effects for F. moniliforme. The ecological significance of these data for understanding colonization patterns of these important fumonisin-producing fungi are discussed.

Research paper thumbnail of Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis*1

American Journal of Medicine, 1990

PURPOSE,PATIENTS,ANDMETHODS: Theclassic agent for cutaneous leishmaniasis is pentavalent antimony... more PURPOSE,PATIENTS,ANDMETHODS: Theclassic agent for cutaneous leishmaniasis is pentavalent antimony. However, there are no reports of the efficacy of antimony versus placebo or of the efficacy of any alternative therapy versus either antimony or placebo. In the present report, the oral antifungal agent ketoconazole (600 n&day for 28 days) was compared to a recommended regimen of intramuscular Pentostam (20 mg antimony/kg, with a maximum of 850 mg antimony/day, for 20 days) in a randomized study of the treatment of Panama&n cutaneous leishmaniasis due to L&IImauia bradiensis paname& A separate group of patients with this disease was administered placebo.

Research paper thumbnail of PROY 5D PARCIAL Autoguardado