Nicolas Badran | Universidad Autònoma del Caribe (Barranquilla,Colombia) (original) (raw)

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Papers by Nicolas Badran

Kalach N, Badran AM, Jaffray P, Campeotto F, Benhamou PH, Dupont C. Correlation between gastric a... more Kalach N, Badran AM, Jaffray P, Campeotto F, Benhamou PH, Dupont C. Correlation between gastric acid secretion and severity of acid reflux in children. Turk J Pediatr 2003; 45: 6-10.

Journal of Pediatric Gastroenterology and Nutrition, 2004

Medical Principles and Practice, 2011

have prepregnancy dental checkups had a significantly higher incidence of PTB. Fewer mothers in t... more have prepregnancy dental checkups had a significantly higher incidence of PTB. Fewer mothers in the PTB group visited dentists during their last pregnancy compared with controls. Conclusions: Oral health, especially healthy periodontium, is one reliable indicator for predicting a safe pregnancy outcome.

Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2010

The metabolism of cells is studied by scientists using a number of cells high enough to have a si... more The metabolism of cells is studied by scientists using a number of cells high enough to have a signal in the regular differential scanning calorimetry (DSC). Currently the number of cells necessary for thermal analysis is on the order of hundreds of thousands. The cell metabolism researchers have been trying to reduce this number with an eye on the final prize of sample size of one. In this paper, we report a novel MEMS_DSC (Micro Electro Mechanical System-Differential Scanning Calorimetry), which reduces the number of cells needed for analysis by about two orders of magnitude. It uses the Seebeck effect generated by a polysilicon n-gold junction to convert the temperature measured from cells directly into a voltage signal. To characterize the device a laser was used to heat the sensor; a lock-in amplifier, coupled with an optical chopper, allowed us to measure a very low heat power (25.5 nW).

Annals of Hematology, 2007

Apoptosis has a crucial role in myelodysplastic syndromes (MDS), being responsible of the ineffec... more Apoptosis has a crucial role in myelodysplastic syndromes (MDS), being responsible of the ineffective hematopoiesis characteristic of the disease. Apoptosis rate is elevated in “early phase” MDS, whereas it diminishes during disease progression to acute leukemia, consensually to the acquisition of independent growth features. Survivin is a member of the inhibitor of the apoptosis (IAP) family, with the bifunctional role of suppressing apoptosis while facilitating cell cycle progression. We investigated Survivin mRNA levels by real-time quantitative reverse transcriptase PCR analysis and Survivin protein expression by immunohistochemistry in 49 bone marrow (BM) aspirates and in 17 BM biopsies (BMB) from MDS patients. Survivin mRNA levels were higher in MDS than in control group (1.68 ± 1.46 vs 0.25 ± 0.22; p < 0.0001). MDS patients with low or INT1 International Scoring System for Evaluating Prognosis (IPSS) displayed higher levels of Survivin mRNA in comparison to INT2 or high IPSS (1.91 ± 1.51 vs 0.88 ± 0.95; p = 0.0058). Survivin protein immunoreactivity was evaluated as Survivin index S (i) and calculated according to the formula: S (i) = % of Survivin positive cells × BMB cellularity / 100. Survivin index was higher in the MDS group than in normal BM (p = 0.05). Moreover, in eight cases in which BM aspirates and trephine biopsy were available, we found a significant association between the level of Survivin mRNA and protein expression (p = 0.011). In conclusion, this study demonstrates increased levels of Survivin in MDS compared to normal controls. Moreover, higher levels of transcripts are related to “low-risk” MDS. Our results suggest an active role of Survivin in normal and in myelodysplastic hematopoiesis.

Pago de intereses M.V., T.V., S.V. M.V, TV, S.V

Kalach N, Badran AM, Jaffray P, Campeotto F, Benhamou PH, Dupont C. Correlation between gastric a... more Kalach N, Badran AM, Jaffray P, Campeotto F, Benhamou PH, Dupont C. Correlation between gastric acid secretion and severity of acid reflux in children. Turk J Pediatr 2003; 45: 6-10.

Journal of Pediatric Gastroenterology and Nutrition, 2004

Medical Principles and Practice, 2011

have prepregnancy dental checkups had a significantly higher incidence of PTB. Fewer mothers in t... more have prepregnancy dental checkups had a significantly higher incidence of PTB. Fewer mothers in the PTB group visited dentists during their last pregnancy compared with controls. Conclusions: Oral health, especially healthy periodontium, is one reliable indicator for predicting a safe pregnancy outcome.

Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2010

The metabolism of cells is studied by scientists using a number of cells high enough to have a si... more The metabolism of cells is studied by scientists using a number of cells high enough to have a signal in the regular differential scanning calorimetry (DSC). Currently the number of cells necessary for thermal analysis is on the order of hundreds of thousands. The cell metabolism researchers have been trying to reduce this number with an eye on the final prize of sample size of one. In this paper, we report a novel MEMS_DSC (Micro Electro Mechanical System-Differential Scanning Calorimetry), which reduces the number of cells needed for analysis by about two orders of magnitude. It uses the Seebeck effect generated by a polysilicon n-gold junction to convert the temperature measured from cells directly into a voltage signal. To characterize the device a laser was used to heat the sensor; a lock-in amplifier, coupled with an optical chopper, allowed us to measure a very low heat power (25.5 nW).

Annals of Hematology, 2007

Apoptosis has a crucial role in myelodysplastic syndromes (MDS), being responsible of the ineffec... more Apoptosis has a crucial role in myelodysplastic syndromes (MDS), being responsible of the ineffective hematopoiesis characteristic of the disease. Apoptosis rate is elevated in “early phase” MDS, whereas it diminishes during disease progression to acute leukemia, consensually to the acquisition of independent growth features. Survivin is a member of the inhibitor of the apoptosis (IAP) family, with the bifunctional role of suppressing apoptosis while facilitating cell cycle progression. We investigated Survivin mRNA levels by real-time quantitative reverse transcriptase PCR analysis and Survivin protein expression by immunohistochemistry in 49 bone marrow (BM) aspirates and in 17 BM biopsies (BMB) from MDS patients. Survivin mRNA levels were higher in MDS than in control group (1.68 ± 1.46 vs 0.25 ± 0.22; p < 0.0001). MDS patients with low or INT1 International Scoring System for Evaluating Prognosis (IPSS) displayed higher levels of Survivin mRNA in comparison to INT2 or high IPSS (1.91 ± 1.51 vs 0.88 ± 0.95; p = 0.0058). Survivin protein immunoreactivity was evaluated as Survivin index S (i) and calculated according to the formula: S (i) = % of Survivin positive cells × BMB cellularity / 100. Survivin index was higher in the MDS group than in normal BM (p = 0.05). Moreover, in eight cases in which BM aspirates and trephine biopsy were available, we found a significant association between the level of Survivin mRNA and protein expression (p = 0.011). In conclusion, this study demonstrates increased levels of Survivin in MDS compared to normal controls. Moreover, higher levels of transcripts are related to “low-risk” MDS. Our results suggest an active role of Survivin in normal and in myelodysplastic hematopoiesis.

Pago de intereses M.V., T.V., S.V. M.V, TV, S.V

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