Miguel Castelo-Branco Sousa | Universidade da Beira Interior (original) (raw)
Uploads
Papers by Miguel Castelo-Branco Sousa
Computer Science Review, 2021
![Research paper thumbnail of The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial](https://attachments.academia-assets.com/86637718/thumbnails/1.jpg)
](Lancet, Jan 23, 2012
Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 y... more Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of onset. The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to 6 h from stroke onset. In this international, multicentre, randomised, open-treatment trial, patients were allocated to 0·9 mg/kg intravenous recombinant tissue plasminogen activator (rt-PA) or to control. The primary analysis was of the proportion of patients alive and independent, as defined by an Oxford Handicap Score (OHS) of 0-2 at 6 months. The study is registered, ISRCTN25765518. 3035 patients were enrolled by 156 hospitals in 12 countries. All of these patients were included in the analyses (1515 in the rt-PA group vs 1520 in the control group), of whom 1617 (53%) were older than 80 years of age. At 6 months, 554 (37%) patients in the rt-PA group versus 534 (35%) in the control group were alive and independent (O...
Procedia Technology, 2013
Clinical pharmacology and therapeutics, Jan 5, 2017
Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensu... more Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of an uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. 129 experts from 27 European countries were asked to rate 307 learning outcomes. 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting. 232 learning outcomes from the original list, 15 newly suggested and 5 rephrased outcomes were included. These 252 learning outcomes should be included in undergraduate CPT curricula to ensure that European graduates are able to prescribe safely and effectively. We provide a blueprint of a European core curriculum describing when and how the learning outcomes might be acquired. This ar...
The open cardiovascular …, 2011
Background: Single-pill combinations of aliskiren/hydrochlorothiazide have recently been approved... more Background: Single-pill combinations of aliskiren/hydrochlorothiazide have recently been approved by the European Medicines Agency for the treatment of hypertension. Objective: This study aimed to assess the antihypertensive efficacy of aliskiren/hydrochlorothiazide ...
Journal of the International Society for Telemedicine and eHealth, 2017
Over the last few years, all over the world, telemedicine has been gaining momentum, and became m... more Over the last few years, all over the world, telemedicine has been gaining momentum, and became more accepted by both health workers and patients as an essential tool in medicine. There have been a considerable number of studies whose results show the benefits of telemedicine programmes, not only in cost reduction and decreasing the number of exacerbations and hospital admissions, but also in improving health outcomes, with the patients having a better understanding of their illness and how they can manage it. This study is based on a tele monitoring programme being carried out in the village of Sabugueiro in Portugal. This village is one the first “Smart mountain villages” in the world, and besides having the concept of Internet of Things” applied to its infrastructure, it also has a tele-monitoring component, where blood pressure, blood glucose levels and weight of part of the population are monitored, in both healthy and unhealthy individuals. Abnormal changes of these parameters...
International journal of clinical …, 2011
Objective Studies have demonstrated that hypertension remains inadequately managed throughout the... more Objective Studies have demonstrated that hypertension remains inadequately managed throughout the world, with lack of adherence to BP-lowering medication being a major factor. The aim of the present study was to evaluate if a pharmaceutical care ...
Surgical Endoscopy
The prevalence of obesity has steadily risen in North America and Western Europe over the past 25... more The prevalence of obesity has steadily risen in North America and Western Europe over the past 25 years. This has been linked to a parallel rise in all associated illnesses, mainly type II diabetes, hypertension, sleep apnoea, musculoskeletal disorders, respiratory and cardiovascular diseases. To adequately serve the purposes of prevention and treatment of obesity and its related diseases multidisciplinary Bariatric centres, ideally linked to Academic Centres are extremely important. Portugal has a scarcity of specialist Medical care in the interior of the country. In spite of the lack of published statistics it is estimated that the prevalence of obesity in these interior regions is at least as high as it is in the coastal areas where the main Medical Centres and the Classical Universities are located. To provide adequate care to the increasing obese population of this region a new multidisciplinary Bariatric Centre has been established in an area of the interior, connected to the ...
Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 2013
ABSTRACT In this paper a new and reliable method to detect and segment the exudates in retinal fu... more ABSTRACT In this paper a new and reliable method to detect and segment the exudates in retinal fundus images is presented. The introduced approach is based in the computation of the noise map distribution, and on the use of morphological operators and adaptive ...
Frontiers in cellular neuroscience, 2018
Studies in health technology and informatics, 2017
The Universidade da Beira Interior (UBI), Covilhã, Portugal in the medical degree course uses sim... more The Universidade da Beira Interior (UBI), Covilhã, Portugal in the medical degree course uses simulation in an integrated and comprehensive program as a pedagogical tool.
Proceedings of the Ophthalmic Medical Image Analysis First International Workshop
Acta Médica Portuguesa, 2014
Computer Science Review, 2021
Lancet, Jan 23, 2012
Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 y... more Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of onset. The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to 6 h from stroke onset. In this international, multicentre, randomised, open-treatment trial, patients were allocated to 0·9 mg/kg intravenous recombinant tissue plasminogen activator (rt-PA) or to control. The primary analysis was of the proportion of patients alive and independent, as defined by an Oxford Handicap Score (OHS) of 0-2 at 6 months. The study is registered, ISRCTN25765518. 3035 patients were enrolled by 156 hospitals in 12 countries. All of these patients were included in the analyses (1515 in the rt-PA group vs 1520 in the control group), of whom 1617 (53%) were older than 80 years of age. At 6 months, 554 (37%) patients in the rt-PA group versus 534 (35%) in the control group were alive and independent (O...
Procedia Technology, 2013
Clinical pharmacology and therapeutics, Jan 5, 2017
Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensu... more Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of an uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. 129 experts from 27 European countries were asked to rate 307 learning outcomes. 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting. 232 learning outcomes from the original list, 15 newly suggested and 5 rephrased outcomes were included. These 252 learning outcomes should be included in undergraduate CPT curricula to ensure that European graduates are able to prescribe safely and effectively. We provide a blueprint of a European core curriculum describing when and how the learning outcomes might be acquired. This ar...
The open cardiovascular …, 2011
Background: Single-pill combinations of aliskiren/hydrochlorothiazide have recently been approved... more Background: Single-pill combinations of aliskiren/hydrochlorothiazide have recently been approved by the European Medicines Agency for the treatment of hypertension. Objective: This study aimed to assess the antihypertensive efficacy of aliskiren/hydrochlorothiazide ...
Journal of the International Society for Telemedicine and eHealth, 2017
Over the last few years, all over the world, telemedicine has been gaining momentum, and became m... more Over the last few years, all over the world, telemedicine has been gaining momentum, and became more accepted by both health workers and patients as an essential tool in medicine. There have been a considerable number of studies whose results show the benefits of telemedicine programmes, not only in cost reduction and decreasing the number of exacerbations and hospital admissions, but also in improving health outcomes, with the patients having a better understanding of their illness and how they can manage it. This study is based on a tele monitoring programme being carried out in the village of Sabugueiro in Portugal. This village is one the first “Smart mountain villages” in the world, and besides having the concept of Internet of Things” applied to its infrastructure, it also has a tele-monitoring component, where blood pressure, blood glucose levels and weight of part of the population are monitored, in both healthy and unhealthy individuals. Abnormal changes of these parameters...
International journal of clinical …, 2011
Objective Studies have demonstrated that hypertension remains inadequately managed throughout the... more Objective Studies have demonstrated that hypertension remains inadequately managed throughout the world, with lack of adherence to BP-lowering medication being a major factor. The aim of the present study was to evaluate if a pharmaceutical care ...
Surgical Endoscopy
The prevalence of obesity has steadily risen in North America and Western Europe over the past 25... more The prevalence of obesity has steadily risen in North America and Western Europe over the past 25 years. This has been linked to a parallel rise in all associated illnesses, mainly type II diabetes, hypertension, sleep apnoea, musculoskeletal disorders, respiratory and cardiovascular diseases. To adequately serve the purposes of prevention and treatment of obesity and its related diseases multidisciplinary Bariatric centres, ideally linked to Academic Centres are extremely important. Portugal has a scarcity of specialist Medical care in the interior of the country. In spite of the lack of published statistics it is estimated that the prevalence of obesity in these interior regions is at least as high as it is in the coastal areas where the main Medical Centres and the Classical Universities are located. To provide adequate care to the increasing obese population of this region a new multidisciplinary Bariatric Centre has been established in an area of the interior, connected to the ...
Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 2013
ABSTRACT In this paper a new and reliable method to detect and segment the exudates in retinal fu... more ABSTRACT In this paper a new and reliable method to detect and segment the exudates in retinal fundus images is presented. The introduced approach is based in the computation of the noise map distribution, and on the use of morphological operators and adaptive ...
Frontiers in cellular neuroscience, 2018
Studies in health technology and informatics, 2017
The Universidade da Beira Interior (UBI), Covilhã, Portugal in the medical degree course uses sim... more The Universidade da Beira Interior (UBI), Covilhã, Portugal in the medical degree course uses simulation in an integrated and comprehensive program as a pedagogical tool.
Proceedings of the Ophthalmic Medical Image Analysis First International Workshop
Acta Médica Portuguesa, 2014