JUAN MANUEL URIA DEL OLMO | Universidad de Burgos (original) (raw)
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Papers by JUAN MANUEL URIA DEL OLMO
Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, 2013
In our burgeoning world of ubiquitous sensors and affordable data storage, records of timestamped... more In our burgeoning world of ubiquitous sensors and affordable data storage, records of timestamped events are being produced across nearly every domain of personal and professional computing. The resulting data surge has created an overarching need to search these records for meaningful patterns of events. This paper reports on a two-part user study, as well as a series of early tests and interviews with clinical researchers, that informed the development of two temporal query interfaces: a basic, menu-based interface and an advanced, graphic-based interface. While the scope of temporal query is very broad, this work focuses on two particularly complex and critical facets of temporal event sequences: intervals (events with both a start time and an end time), and the absence of an event. We describe how users encounter a common set of difficulties when specifying such queries, and propose solutions to help overcome them. Finally, we report on two case studies with epidemiologists at the US Army Pharmacovigilance Center, illustrating how both query interfaces were used to study patterns of drug use.
Hepatology, 2002
Apoptosis plays an important role in the progression of alcohol-induced liver disease to cirrhosi... more Apoptosis plays an important role in the progression of alcohol-induced liver disease to cirrhosis. Oxidative stress is an early event in the development of apoptosis. The major aim of this study was to study the conditions in which oxidative stress occurs in chronic alcoholism and its relationship with apoptosis of hepatocytes. We have found that oxidative stress is associated with chronic ethanol consumption in humans and in rats, in the former independently of the existence of alcohol-induced liver disease. Ethanol or acetaldehyde induces apoptosis in hepatocytes isolated from alcoholic rats, but not in those from control rats.
Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, 2013
In our burgeoning world of ubiquitous sensors and affordable data storage, records of timestamped... more In our burgeoning world of ubiquitous sensors and affordable data storage, records of timestamped events are being produced across nearly every domain of personal and professional computing. The resulting data surge has created an overarching need to search these records for meaningful patterns of events. This paper reports on a two-part user study, as well as a series of early tests and interviews with clinical researchers, that informed the development of two temporal query interfaces: a basic, menu-based interface and an advanced, graphic-based interface. While the scope of temporal query is very broad, this work focuses on two particularly complex and critical facets of temporal event sequences: intervals (events with both a start time and an end time), and the absence of an event. We describe how users encounter a common set of difficulties when specifying such queries, and propose solutions to help overcome them. Finally, we report on two case studies with epidemiologists at the US Army Pharmacovigilance Center, illustrating how both query interfaces were used to study patterns of drug use.
Hepatology, 2002
Apoptosis plays an important role in the progression of alcohol-induced liver disease to cirrhosi... more Apoptosis plays an important role in the progression of alcohol-induced liver disease to cirrhosis. Oxidative stress is an early event in the development of apoptosis. The major aim of this study was to study the conditions in which oxidative stress occurs in chronic alcoholism and its relationship with apoptosis of hepatocytes. We have found that oxidative stress is associated with chronic ethanol consumption in humans and in rats, in the former independently of the existence of alcohol-induced liver disease. Ethanol or acetaldehyde induces apoptosis in hepatocytes isolated from alcoholic rats, but not in those from control rats.