Monica Aguirre | Universidad Central del Ecuador (UCE) (original) (raw)
Papers by Monica Aguirre
Seminars in Pediatric Infectious Diseases, 2005
System modeling, analysis and visualization are becoming a common practice for the design of dist... more System modeling, analysis and visualization are becoming a common practice for the design of distributed intelligent systems since the wide adoption of the Unified Modeling Language (UML). However, UML cannot describe important behavioral properties such as context awareness as required for ubiquitous computing. In this paper, we present Context Aware UML Sequence diagrams (CA UML-S), an experimental visual programming language that extends UML sequence diagrams with data/ object spaces to represent computational context awareness. The programming language provides the means to describe the event-condition-action (ECA) rules that govern complex nomadic user behavior and to visualize their effect. The ECA rules are compiled into common concurrent programming abstractions by introducing structuring notions of object creation, synchronization, and communication, along with sequential and selective composition of simpler rules. The contribution of this work is in providing programming abstractions that facilitate the design of context-aware applications for ubiquitous and nomadic computing.
Science, 2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2004
Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observa... more Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above . The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far.
Annals of Diagnostic Pathology, 2009
![Research paper thumbnail of New findings in the alkylation and N-deprotection of (4 S)-4-methyl-2-benzyl-2,4-dihydro-1 H-pyrazino[2,1- b]quinazoline-3,6-diones](https://attachments.academia-assets.com/47948929/thumbnails/1.jpg)
](Tetrahedron-asymmetry, 1998
European Child & Adolescent Psychiatry, 2007
Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperact... more Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community—a very well described, genetically isolated group—we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children’s mothers or grandmothers filled out a questionnaire on each child’s exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratio ≥ 2, P P ADHD must include these environmental factors as covariates.
Chromosome Research, 2001
Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed ... more Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed to explain chromosomal evolution within killifishes of the aplocheiloid group belonging to the order Cyprinodontiforms. In the present work we describe the karyotypes of four Cynolebias species and analyze chromosome changes by means of mitochondrial phylogenetic studies, including 10 taxa of this genus. Diploid numbers varied from 48 to 44 and the number of chromosome arms from 50 to 54. Molecular phylogenetic analyses allow us to corroborate previous hypothesis about chromosome evolution in aplocheiloid fishes. The tree topology based on a combined dataset of mitochondrial cytochrome b and 12S genes shows that recent cladogenetic events within the genus Cynolebias could have occurred by allopatric or ‘in-situ’ differentiation involving chromosomal rearrangements. Our analyses of approximately 10% of mitochondrial genome can be helpful in determining these recent cladogenetic events but it showed limited phylogenetic resolution at intermediate levels of divergence. This can be explained in part by the high levels of DNA sequence divergence (ranging from 0.015 to 0.245) detected at intrageneric level. Different methodological approaches suggest that chromosomal changes in Cynolebias have occurred during their differentiation, supporting the hypothesis that the unresolved basal polytomy could be the result of rapid speciation events, like a true ‘star polytomy’.
Ecological Engineering, 2010
Seminars in Pediatric Infectious Diseases, 2005
System modeling, analysis and visualization are becoming a common practice for the design of dist... more System modeling, analysis and visualization are becoming a common practice for the design of distributed intelligent systems since the wide adoption of the Unified Modeling Language (UML). However, UML cannot describe important behavioral properties such as context awareness as required for ubiquitous computing. In this paper, we present Context Aware UML Sequence diagrams (CA UML-S), an experimental visual programming language that extends UML sequence diagrams with data/ object spaces to represent computational context awareness. The programming language provides the means to describe the event-condition-action (ECA) rules that govern complex nomadic user behavior and to visualize their effect. The ECA rules are compiled into common concurrent programming abstractions by introducing structuring notions of object creation, synchronization, and communication, along with sequential and selective composition of simpler rules. The contribution of this work is in providing programming abstractions that facilitate the design of context-aware applications for ubiquitous and nomadic computing.
Science, 2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2004
Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observa... more Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above . The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far.
Annals of Diagnostic Pathology, 2009
Tetrahedron-asymmetry, 1998
European Child & Adolescent Psychiatry, 2007
Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperact... more Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community—a very well described, genetically isolated group—we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children’s mothers or grandmothers filled out a questionnaire on each child’s exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratio ≥ 2, P P ADHD must include these environmental factors as covariates.
Chromosome Research, 2001
Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed ... more Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed to explain chromosomal evolution within killifishes of the aplocheiloid group belonging to the order Cyprinodontiforms. In the present work we describe the karyotypes of four Cynolebias species and analyze chromosome changes by means of mitochondrial phylogenetic studies, including 10 taxa of this genus. Diploid numbers varied from 48 to 44 and the number of chromosome arms from 50 to 54. Molecular phylogenetic analyses allow us to corroborate previous hypothesis about chromosome evolution in aplocheiloid fishes. The tree topology based on a combined dataset of mitochondrial cytochrome b and 12S genes shows that recent cladogenetic events within the genus Cynolebias could have occurred by allopatric or ‘in-situ’ differentiation involving chromosomal rearrangements. Our analyses of approximately 10% of mitochondrial genome can be helpful in determining these recent cladogenetic events but it showed limited phylogenetic resolution at intermediate levels of divergence. This can be explained in part by the high levels of DNA sequence divergence (ranging from 0.015 to 0.245) detected at intrageneric level. Different methodological approaches suggest that chromosomal changes in Cynolebias have occurred during their differentiation, supporting the hypothesis that the unresolved basal polytomy could be the result of rapid speciation events, like a true ‘star polytomy’.
Ecological Engineering, 2010