Monica Aguirre - Profile on Academia.edu (original) (raw)
Papers by Monica Aguirre
Seminars in Pediatric Infectious Diseases, 2005
System modeling, analysis and visualization are becoming a common practice for the design of dist... more System modeling, analysis and visualization are becoming a common practice for the design of distributed intelligent systems since the wide adoption of the Unified Modeling Language (UML). However, UML cannot describe important behavioral properties such as context awareness as required for ubiquitous computing. In this paper, we present Context Aware UML Sequence diagrams (CA UML-S), an experimental visual programming language that extends UML sequence diagrams with data/ object spaces to represent computational context awareness. The programming language provides the means to describe the event-condition-action (ECA) rules that govern complex nomadic user behavior and to visualize their effect. The ECA rules are compiled into common concurrent programming abstractions by introducing structuring notions of object creation, synchronization, and communication, along with sequential and selective composition of simpler rules. The contribution of this work is in providing programming abstractions that facilitate the design of context-aware applications for ubiquitous and nomadic computing.
Science, 2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.
Properties and performance of the prototype instrument for the Pierre Auger Observatory
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2004
Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observa... more Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above . The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far.
emancipação ELEMENTOS DE LOS SISTEMAS SOCIALES QUE FAVORECEN LA APARICIÓN DE LA VIOLENCIA
Annals of Diagnostic Pathology, 2009
The objective of this study was to analyze the type of diseases associated with HIV infection fro... more The objective of this study was to analyze the type of diseases associated with HIV infection from a survey of the surgical pathology material accessioned at a large general hospital in Mexico City. From the archives of the pathology unit of the General Hospital of Mexico (Ministry of Health), we compiled data on biopsies and surgical specimen from different organs and tissues of HIV-infected patients (HIV/AIDS) . We found a total of 52 cases, 41 men and 11 women. The main affected anatomical organ was the lymphatic nodes in 33 cases (63.4%), 7 corresponded to the digestive tract (13.46), 3 corresponded to bone marrow (5.76%), 3 corresponded to the perianal region (5.76%), 2 cases corresponded to the hard palate (3.84%), and 1 case each corresponded to the following regions: peritoneum, breast, and lung. The most frequent diagnoses were non-Hodgkin's large B-cell lymphoma in 11 cases (21.12%) and its morphological variants, 8 reactive lymphadenopathy cases (15.38%), 5 atypical mycobacterioses (9.61%), 2 nonspecific granulomatous lesions (3.84%), 2 Burkitt's lymphoma (3.84%), 3 Kaposi sarcoma (5.76%), 1 mixed cellularity Hodgkin's lymphoma (1.92%), 1 Kaposiform hemangioendothelioma (1.92%), and 1 with infection by cytomegalovirus + cryptosporidiosis in the duodenum (1.92%). In this series, the most affected organ in patients with HIV/AIDS was the lymphatic nodes. The most common neoplasm was the non-Hodgkin's lymphoma followed by Kaposi sarcoma. Mycobacterioses were the main infectious diseases, followed by mycotic and viral infections.
![Research paper thumbnail of New findings in the alkylation and N-deprotection of (4 S)-4-methyl-2-benzyl-2,4-dihydro-1 H-pyrazino[2,1- b]quinazoline-3,6-diones](https://attachments.academia-assets.com/47948929/thumbnails/1.jpg)
](Tetrahedron-asymmetry, 1998
Alkyl halides behave differently to benzyl halides in C-1 alkylation of the title compounds. The ... more Alkyl halides behave differently to benzyl halides in C-1 alkylation of the title compounds. The syn and anti 1,4disubstituted diastereomers thus obtained show different regioselectivity by further alkylation leading to the 1,4,4and 1,1,4-trisubstituted compounds, respectively. Alkylation is always directed anti with respect to the bulkier substituent at C-1 or C-4. Debenzylation attempts on 2-benzyl-derivatives 1b by treatment with HCOOH and C/Pd or H 2 /C-Pd/MeOH/H + led to C-1 oxidised or 7,8,9,10-tetrahydro-derivatives. Deprotection of 2-p-methoxybenzyland 2-(2,4-dimethoxybenzyl)-derivatives with CAN and with TFA/anisole, respectively, was successful, but in the latter case epimerization at C-1 occurred. with LHMDS and either methyl iodide or p-methylbenzyl bromide. The stereochemistry of the 1,4,4trialkyl derivatives thus obtained (compounds 11d and 12d, Scheme 3) showed that the diastereoselection is imposed by the C-1 centre. The stereochemistry of the 1,1,4,4-tetra-alkyl compound 20d also showed that additional alkylation of 12d is controlled by the bulkier substituent at C-4. An additional reactivity confirmation for the syn-1,4-disubstituted derivatives was obtained when syn-9c was alkylated with pmethylbenzyl bromide and 13c was produced. The configuration of all compounds was determined by NOE experiments (see Experimental and .
RUNNING HEAD: PERCEPTIONS OF GOOGLE SCHOLAR 3 INTRODUCTION Searching for information has become e... more RUNNING HEAD: PERCEPTIONS OF GOOGLE SCHOLAR 3 INTRODUCTION Searching for information has become easier with the increase use of new technology and access to numerous sources online. However, current trends among college students suggest that instead of using traditional sources to access information (ex. libraries), they are turning to free online search engines like Google Scholar in order to access various publications for their course work and research assignments, including journal articles, news reports, among others. The purpose of this study is to better understand how university students use Google Scholar in their academic research while attending college. The researchers also want to determine what are the perceptions that undergraduate students have about Google Scholar as a credible source information on various topics. This study is a work-in progress piece; here the researchers will be reporting the results of the pilot study among 7 students at a southeastern university. Primary results and implications towards the information science discipline will be discussed in this research paper.
Environmental influences that affect attention deficit/hyperactivity disorder
European Child & Adolescent Psychiatry, 2007
Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperact... more Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community—a very well described, genetically isolated group—we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children’s mothers or grandmothers filled out a questionnaire on each child’s exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratio ≥ 2, P P ADHD must include these environmental factors as covariates.
Few professions have seen as rapid change over the past several decades as the field of library a... more Few professions have seen as rapid change over the past several decades as the field of library and information science (LIS), due mainly to information technologies. Computers not only provide the backbone of today's libraries and information agencies but they are also changing in fundamental ways how these organizations operate. Dennis Lee et. al. in their article "Critical Skills and Knowledge Requirements of IS Professionals" (1995) espouse the view that these changes in information technologies and their use create different demands on and new expectations for the jobs of information professionals in such organizations as libraries and other information environments. Employers, educators as well as students have raised concerns regarding the knowledge and skills that are required for information professionals to function effectively in these changing environments, as well as how university and corporate training must be revised to meet the changing needs. Two areas useful for building the needed skill sets are knowledge management (KM) and project management (PM). The purpose of this paper is to investigate the application of KM and PM practices best suited to meet the challenges confronting librarians and information professionals in today's workplace. Four broad categories of critical KM and PM knowledge/skills will be examined. 1) technical knowledge; 2) administrative knowledge 3) social knowledge; and 4) system knowledge.
Chromosome Research, 2001
Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed ... more Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed to explain chromosomal evolution within killifishes of the aplocheiloid group belonging to the order Cyprinodontiforms. In the present work we describe the karyotypes of four Cynolebias species and analyze chromosome changes by means of mitochondrial phylogenetic studies, including 10 taxa of this genus. Diploid numbers varied from 48 to 44 and the number of chromosome arms from 50 to 54. Molecular phylogenetic analyses allow us to corroborate previous hypothesis about chromosome evolution in aplocheiloid fishes. The tree topology based on a combined dataset of mitochondrial cytochrome b and 12S genes shows that recent cladogenetic events within the genus Cynolebias could have occurred by allopatric or ‘in-situ’ differentiation involving chromosomal rearrangements. Our analyses of approximately 10% of mitochondrial genome can be helpful in determining these recent cladogenetic events but it showed limited phylogenetic resolution at intermediate levels of divergence. This can be explained in part by the high levels of DNA sequence divergence (ranging from 0.015 to 0.245) detected at intrageneric level. Different methodological approaches suggest that chromosomal changes in Cynolebias have occurred during their differentiation, supporting the hypothesis that the unresolved basal polytomy could be the result of rapid speciation events, like a true ‘star polytomy’.
The mission of the Total Quality Leadership (TQL) Office, Office of the Under Secretary of the Na... more The mission of the Total Quality Leadership (TQL) Office, Office of the Under Secretary of the Navy is to assist the Department of the Navy leaders in their quality-focused improvement efforts through education, consultation, information sharing, networking, and technical advice.
ARTÍCULO 89.-El Ministerio de Educación, Ciencia y Tecnología, en acuerdo con el Consejo Federal ... more ARTÍCULO 89.-El Ministerio de Educación, Ciencia y Tecnología, en acuerdo con el Consejo Federal de Educación, dispondrá las medidas necesarias para proveer la educación ambiental en todos los niveles y modalidades del Sistema Educativo Nacional, con la finalidad de promover valores, comportamientos y actitudes que
Seminars in Pediatric Infectious Diseases, 2005
System modeling, analysis and visualization are becoming a common practice for the design of dist... more System modeling, analysis and visualization are becoming a common practice for the design of distributed intelligent systems since the wide adoption of the Unified Modeling Language (UML). However, UML cannot describe important behavioral properties such as context awareness as required for ubiquitous computing. In this paper, we present Context Aware UML Sequence diagrams (CA UML-S), an experimental visual programming language that extends UML sequence diagrams with data/ object spaces to represent computational context awareness. The programming language provides the means to describe the event-condition-action (ECA) rules that govern complex nomadic user behavior and to visualize their effect. The ECA rules are compiled into common concurrent programming abstractions by introducing structuring notions of object creation, synchronization, and communication, along with sequential and selective composition of simpler rules. The contribution of this work is in providing programming abstractions that facilitate the design of context-aware applications for ubiquitous and nomadic computing.
Science, 2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a... more Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.
Properties and performance of the prototype instrument for the Pierre Auger Observatory
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2004
Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observa... more Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above . The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far.
emancipação ELEMENTOS DE LOS SISTEMAS SOCIALES QUE FAVORECEN LA APARICIÓN DE LA VIOLENCIA
Annals of Diagnostic Pathology, 2009
The objective of this study was to analyze the type of diseases associated with HIV infection fro... more The objective of this study was to analyze the type of diseases associated with HIV infection from a survey of the surgical pathology material accessioned at a large general hospital in Mexico City. From the archives of the pathology unit of the General Hospital of Mexico (Ministry of Health), we compiled data on biopsies and surgical specimen from different organs and tissues of HIV-infected patients (HIV/AIDS) . We found a total of 52 cases, 41 men and 11 women. The main affected anatomical organ was the lymphatic nodes in 33 cases (63.4%), 7 corresponded to the digestive tract (13.46), 3 corresponded to bone marrow (5.76%), 3 corresponded to the perianal region (5.76%), 2 cases corresponded to the hard palate (3.84%), and 1 case each corresponded to the following regions: peritoneum, breast, and lung. The most frequent diagnoses were non-Hodgkin's large B-cell lymphoma in 11 cases (21.12%) and its morphological variants, 8 reactive lymphadenopathy cases (15.38%), 5 atypical mycobacterioses (9.61%), 2 nonspecific granulomatous lesions (3.84%), 2 Burkitt's lymphoma (3.84%), 3 Kaposi sarcoma (5.76%), 1 mixed cellularity Hodgkin's lymphoma (1.92%), 1 Kaposiform hemangioendothelioma (1.92%), and 1 with infection by cytomegalovirus + cryptosporidiosis in the duodenum (1.92%). In this series, the most affected organ in patients with HIV/AIDS was the lymphatic nodes. The most common neoplasm was the non-Hodgkin's lymphoma followed by Kaposi sarcoma. Mycobacterioses were the main infectious diseases, followed by mycotic and viral infections.
Tetrahedron-asymmetry, 1998
Alkyl halides behave differently to benzyl halides in C-1 alkylation of the title compounds. The ... more Alkyl halides behave differently to benzyl halides in C-1 alkylation of the title compounds. The syn and anti 1,4disubstituted diastereomers thus obtained show different regioselectivity by further alkylation leading to the 1,4,4and 1,1,4-trisubstituted compounds, respectively. Alkylation is always directed anti with respect to the bulkier substituent at C-1 or C-4. Debenzylation attempts on 2-benzyl-derivatives 1b by treatment with HCOOH and C/Pd or H 2 /C-Pd/MeOH/H + led to C-1 oxidised or 7,8,9,10-tetrahydro-derivatives. Deprotection of 2-p-methoxybenzyland 2-(2,4-dimethoxybenzyl)-derivatives with CAN and with TFA/anisole, respectively, was successful, but in the latter case epimerization at C-1 occurred. with LHMDS and either methyl iodide or p-methylbenzyl bromide. The stereochemistry of the 1,4,4trialkyl derivatives thus obtained (compounds 11d and 12d, Scheme 3) showed that the diastereoselection is imposed by the C-1 centre. The stereochemistry of the 1,1,4,4-tetra-alkyl compound 20d also showed that additional alkylation of 12d is controlled by the bulkier substituent at C-4. An additional reactivity confirmation for the syn-1,4-disubstituted derivatives was obtained when syn-9c was alkylated with pmethylbenzyl bromide and 13c was produced. The configuration of all compounds was determined by NOE experiments (see Experimental and .
RUNNING HEAD: PERCEPTIONS OF GOOGLE SCHOLAR 3 INTRODUCTION Searching for information has become e... more RUNNING HEAD: PERCEPTIONS OF GOOGLE SCHOLAR 3 INTRODUCTION Searching for information has become easier with the increase use of new technology and access to numerous sources online. However, current trends among college students suggest that instead of using traditional sources to access information (ex. libraries), they are turning to free online search engines like Google Scholar in order to access various publications for their course work and research assignments, including journal articles, news reports, among others. The purpose of this study is to better understand how university students use Google Scholar in their academic research while attending college. The researchers also want to determine what are the perceptions that undergraduate students have about Google Scholar as a credible source information on various topics. This study is a work-in progress piece; here the researchers will be reporting the results of the pilot study among 7 students at a southeastern university. Primary results and implications towards the information science discipline will be discussed in this research paper.
Environmental influences that affect attention deficit/hyperactivity disorder
European Child & Adolescent Psychiatry, 2007
Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperact... more Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community—a very well described, genetically isolated group—we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children’s mothers or grandmothers filled out a questionnaire on each child’s exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratio ≥ 2, P P ADHD must include these environmental factors as covariates.
Few professions have seen as rapid change over the past several decades as the field of library a... more Few professions have seen as rapid change over the past several decades as the field of library and information science (LIS), due mainly to information technologies. Computers not only provide the backbone of today's libraries and information agencies but they are also changing in fundamental ways how these organizations operate. Dennis Lee et. al. in their article "Critical Skills and Knowledge Requirements of IS Professionals" (1995) espouse the view that these changes in information technologies and their use create different demands on and new expectations for the jobs of information professionals in such organizations as libraries and other information environments. Employers, educators as well as students have raised concerns regarding the knowledge and skills that are required for information professionals to function effectively in these changing environments, as well as how university and corporate training must be revised to meet the changing needs. Two areas useful for building the needed skill sets are knowledge management (KM) and project management (PM). The purpose of this paper is to investigate the application of KM and PM practices best suited to meet the challenges confronting librarians and information professionals in today's workplace. Four broad categories of critical KM and PM knowledge/skills will be examined. 1) technical knowledge; 2) administrative knowledge 3) social knowledge; and 4) system knowledge.
Chromosome Research, 2001
Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed ... more Extensive chromosome variation involving Robertsonian and non-Robertsonian changes were proposed to explain chromosomal evolution within killifishes of the aplocheiloid group belonging to the order Cyprinodontiforms. In the present work we describe the karyotypes of four Cynolebias species and analyze chromosome changes by means of mitochondrial phylogenetic studies, including 10 taxa of this genus. Diploid numbers varied from 48 to 44 and the number of chromosome arms from 50 to 54. Molecular phylogenetic analyses allow us to corroborate previous hypothesis about chromosome evolution in aplocheiloid fishes. The tree topology based on a combined dataset of mitochondrial cytochrome b and 12S genes shows that recent cladogenetic events within the genus Cynolebias could have occurred by allopatric or ‘in-situ’ differentiation involving chromosomal rearrangements. Our analyses of approximately 10% of mitochondrial genome can be helpful in determining these recent cladogenetic events but it showed limited phylogenetic resolution at intermediate levels of divergence. This can be explained in part by the high levels of DNA sequence divergence (ranging from 0.015 to 0.245) detected at intrageneric level. Different methodological approaches suggest that chromosomal changes in Cynolebias have occurred during their differentiation, supporting the hypothesis that the unresolved basal polytomy could be the result of rapid speciation events, like a true ‘star polytomy’.
The mission of the Total Quality Leadership (TQL) Office, Office of the Under Secretary of the Na... more The mission of the Total Quality Leadership (TQL) Office, Office of the Under Secretary of the Navy is to assist the Department of the Navy leaders in their quality-focused improvement efforts through education, consultation, information sharing, networking, and technical advice.
ARTÍCULO 89.-El Ministerio de Educación, Ciencia y Tecnología, en acuerdo con el Consejo Federal ... more ARTÍCULO 89.-El Ministerio de Educación, Ciencia y Tecnología, en acuerdo con el Consejo Federal de Educación, dispondrá las medidas necesarias para proveer la educación ambiental en todos los niveles y modalidades del Sistema Educativo Nacional, con la finalidad de promover valores, comportamientos y actitudes que