Eduardo Domínguez - Academia.edu (original) (raw)

Eduardo Domínguez

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Papers by Eduardo Domínguez

Research paper thumbnail of Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics

Bioorganic & Medicinal Chemistry Letters, 2007

We describe the synthesis and binding affinities on D2, 5-HT2A and 5-HT2C receptors of 6-aminomet... more We describe the synthesis and binding affinities on D2, 5-HT2A and 5-HT2C receptors of 6-aminomethyl-6,7-dihydro-1H-indazol-4(5H)-ones and 6-aminomethyl-6,7-dihydro-3-methyl-benzo[d]isoxazol-4(5H)-ones, as conformationally constrained butyrophenone analogues. One of the new compounds showed good in vitro binding features, and a Meltzer’s ratio characteristic of an atypical antipsychotic profile.

Research paper thumbnail of EMPERADORES AUGUSTO TIBERIO CALÍGULA

Research paper thumbnail of Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics

Bioorganic & Medicinal Chemistry Letters, 2007

We describe the synthesis and binding affinities on D2, 5-HT2A and 5-HT2C receptors of 6-aminomet... more We describe the synthesis and binding affinities on D2, 5-HT2A and 5-HT2C receptors of 6-aminomethyl-6,7-dihydro-1H-indazol-4(5H)-ones and 6-aminomethyl-6,7-dihydro-3-methyl-benzo[d]isoxazol-4(5H)-ones, as conformationally constrained butyrophenone analogues. One of the new compounds showed good in vitro binding features, and a Meltzer’s ratio characteristic of an atypical antipsychotic profile.

Research paper thumbnail of EMPERADORES AUGUSTO TIBERIO CALÍGULA

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