Marina Daskalopoulou | University College London (original) (raw)

Uploads

Papers by Marina Daskalopoulou

Research paper thumbnail of Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men

Depression is associated with coronary heart disease and stroke, but associations with a range of... more Depression is associated with coronary heart disease and stroke, but associations with a range of pathologically diverse cardiovascular diseases are not well understood. We examine the risk of 12 cardiovascular diseases according to depression status (history or new onset).

Research paper thumbnail of Prevalence of recreational drug use is indiscriminate across antiretroviral regimens of differing drug-drug interactions among MSM

Research paper thumbnail of Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study

Lancet HIV, 2014

Background Recreational drug use in men who have sex with men (MSM) is of concern because it migh... more Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other sexually transmitted infections. Evidence about drug use in HIV-diagnosed MSM in the UK is limited by representativeness of the study populations. We describe patterns of drug use and associations with sexual behaviours in HIV-diagnosed MSM in the UK.

Research paper thumbnail of Neurocognitive Change Observed in the CHARTER HIV Cohort Could Be Due to Chance, and May Be a Cause as Well as a Consequence of Detectable Viremia

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jan 2, 2015

Research paper thumbnail of Minimal Cognitive Impairment in UK HIV-Positive Men Who Have Sex With Men

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014

Research paper thumbnail of Sexual behaviour, recreational drug use and hepatitis C co-infection in HIV-diagnosed men who have sex with men in the United Kingdom: results from the ASTRA study

Journal of the International AIDS Society, 2014

Background Recreational drug use in men who have sex with men (MSM) is of concern because it migh... more Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other sexually transmitted infections. Evidence about drug use in HIV-diagnosed MSM in the UK is limited by representativeness of the study populations. We describe patterns of drug use and associations with sexual behaviours in HIV-diagnosed MSM in the UK.

Research paper thumbnail of Attitudes of people in the UK with HIV who are antiretroviral (ART) naïve to starting art at high CD4 counts for potential health benefit or to prevent HIV transmission

Objective: To assess if a strategy of early ART to prevent HIV transmission is acceptable to ART ... more Objective: To assess if a strategy of early ART to prevent HIV transmission is acceptable to ART naïve people with HIV with high CD4 counts.

Research paper thumbnail of Acute mastitis induces upregulation of expression of plasminogen activator-related genes by blood monocytes and neutrophils in dairy ewes

Veterinary Immunology and Immunopathology, 2010

The main objective of the present study was to examine whether genes implicated in the plasminoge... more The main objective of the present study was to examine whether genes implicated in the plasminogen activating cascade: urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitors type 1 (PAI-1) and type 2 (PAI-2) are expressed in a differential manner in ovine blood monocytes and neutrophils obtained from healthy and mastitic dairy ewes. A total of 48 blood samples were collected from 8 healthy and 8 mastitic dairy ewes over a period of 3 weeks. Streptococcus agalactiae was detected in milk samples isolated from mastitic animals. Results indicated that expression of all four genes was very low in monocytes and neutrophils isolated from healthy animals. In contrast, there was a 2-to 5-fold increase (P < 0.05) in expression of all four genes in monocytes and an 18-to 38-fold increase (P < 0.01) in neutrophils isolated from mastitic animals. In conclusion, upregulation of expression of u-PA and u-PAR by monocytes and neutrophils is probably related to the rapidity of migration of these cells towards the mammary gland, while the upregulation of PAI-1 and PAI-2 is a rather enigmatic observation and it is probably related to the successful localization of the infection.

Conference posters by Marina Daskalopoulou

Research paper thumbnail of Minimal Cognitive Impairment in UK HIV Positive Men who have Sex with Men: Comparison with the General Population and Across Classification Systems

Research paper thumbnail of Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men

Depression is associated with coronary heart disease and stroke, but associations with a range of... more Depression is associated with coronary heart disease and stroke, but associations with a range of pathologically diverse cardiovascular diseases are not well understood. We examine the risk of 12 cardiovascular diseases according to depression status (history or new onset).

Research paper thumbnail of Prevalence of recreational drug use is indiscriminate across antiretroviral regimens of differing drug-drug interactions among MSM

Research paper thumbnail of Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study

Lancet HIV, 2014

Background Recreational drug use in men who have sex with men (MSM) is of concern because it migh... more Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other sexually transmitted infections. Evidence about drug use in HIV-diagnosed MSM in the UK is limited by representativeness of the study populations. We describe patterns of drug use and associations with sexual behaviours in HIV-diagnosed MSM in the UK.

Research paper thumbnail of Neurocognitive Change Observed in the CHARTER HIV Cohort Could Be Due to Chance, and May Be a Cause as Well as a Consequence of Detectable Viremia

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jan 2, 2015

Research paper thumbnail of Minimal Cognitive Impairment in UK HIV-Positive Men Who Have Sex With Men

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014

Research paper thumbnail of Sexual behaviour, recreational drug use and hepatitis C co-infection in HIV-diagnosed men who have sex with men in the United Kingdom: results from the ASTRA study

Journal of the International AIDS Society, 2014

Background Recreational drug use in men who have sex with men (MSM) is of concern because it migh... more Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other sexually transmitted infections. Evidence about drug use in HIV-diagnosed MSM in the UK is limited by representativeness of the study populations. We describe patterns of drug use and associations with sexual behaviours in HIV-diagnosed MSM in the UK.

Research paper thumbnail of Attitudes of people in the UK with HIV who are antiretroviral (ART) naïve to starting art at high CD4 counts for potential health benefit or to prevent HIV transmission

Objective: To assess if a strategy of early ART to prevent HIV transmission is acceptable to ART ... more Objective: To assess if a strategy of early ART to prevent HIV transmission is acceptable to ART naïve people with HIV with high CD4 counts.

Research paper thumbnail of Acute mastitis induces upregulation of expression of plasminogen activator-related genes by blood monocytes and neutrophils in dairy ewes

Veterinary Immunology and Immunopathology, 2010

The main objective of the present study was to examine whether genes implicated in the plasminoge... more The main objective of the present study was to examine whether genes implicated in the plasminogen activating cascade: urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitors type 1 (PAI-1) and type 2 (PAI-2) are expressed in a differential manner in ovine blood monocytes and neutrophils obtained from healthy and mastitic dairy ewes. A total of 48 blood samples were collected from 8 healthy and 8 mastitic dairy ewes over a period of 3 weeks. Streptococcus agalactiae was detected in milk samples isolated from mastitic animals. Results indicated that expression of all four genes was very low in monocytes and neutrophils isolated from healthy animals. In contrast, there was a 2-to 5-fold increase (P < 0.05) in expression of all four genes in monocytes and an 18-to 38-fold increase (P < 0.01) in neutrophils isolated from mastitic animals. In conclusion, upregulation of expression of u-PA and u-PAR by monocytes and neutrophils is probably related to the rapidity of migration of these cells towards the mammary gland, while the upregulation of PAI-1 and PAI-2 is a rather enigmatic observation and it is probably related to the successful localization of the infection.

Research paper thumbnail of Minimal Cognitive Impairment in UK HIV Positive Men who have Sex with Men: Comparison with the General Population and Across Classification Systems

Log In